TCM Prescription: Chang Tong Shu Infusion



Prescription Description
Prescription IDTCMF3115
Pinyin NameChang Tong Shu Chong Ji
Chinese Name常通舒冲剂
English NameChang Tong Shu Infusion
Function Description便秘, 产后大便难
IndicationsConstipation disorder, Constipation
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
ME05.0 [Constipation, 便秘 ];
Human Tissues Associated with IndicationLarge Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH1005 Cannabis sativa 火麻仁 TCMH1005 ITSAJ4165-14
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2004
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2581
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR2C, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 10.628
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR2C, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 10.628
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSPA1A, HTR2C, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 10.2897
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 10.0653
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, HTR2C, PIK3CA, PPARA, PPARD, PTGS1, PTGS2, XDH 9.51027
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 8.64595
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 8.54677
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.31246
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.22117
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PTGS2, SRC, TEK, XDH 8.21124
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 8.20628
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, PIK3CA, PIK3CB, PPARD, PTGS2, SRC, TEK, XDH 8.20628
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 8.20628
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 7.77622
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 7.65998
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, CNR1, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, HTR2C, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 7.41515
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 7.41515
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SRC, TEK 7.08872
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARD, PTGS2, SMAD3, SRC, TEK 7.06037
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 6.84144
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 6.83467
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 6.65488
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARD 6.62792
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.44779
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.35241
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARD, PTGS2, SMAD3, SRC, TEK 6.24757
[BP] GO:0006690 icosanoid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.24757
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 6.21968
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 6.14849
[BP] GO:0006631 fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 6.11124
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 6.08592
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, CA2, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK 6.07166
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 6.0406
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARD, PTGS2, SMAD3, TEK 6.0221
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARD, PTGS2, SMAD3, SRC, TEK 5.93435
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 5.9071
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HTR2C, PPARD 5.76001
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 5.73332
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.73106
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 5.65781
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PPARD, PTGS2, SMAD3, SRC, TEK 5.48747
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARD 5.45964
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARD, PTGS2, SMAD3, SRC 5.44261
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 5.44261
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 5.44214
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.41793
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PPARD, PTGS2, SMAD3, TEK 5.41395
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2C, PPARA, PTGS2, SRC, TEK 5.35603
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 5.32385
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, CA2, CA7, CHRM1, CNR1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, HTR2C, INSR, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC 5.32385
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 5.32385
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.27567
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3 5.22942
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 5.20842
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.19822
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 5.16903
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 5.15952
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.15952
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 5.1537
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 5.12005
[BP] GO:0033993 response to lipid CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, PPARD, PTGS2, SRC 5.08262
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC, TEK 5.05585
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PPARD, PTGS2, SMAD3, SRC, TEK 4.953
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.953
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PPARD, SMAD3, TEK 4.87788
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PPARD, PTGS2, TEK 4.86239
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD, SMAD3, TEK 4.81428
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1, PPARD 4.81428
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX15, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, HTR2C, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 4.81016
[BP] GO:0048513 animal organ development ACHE, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, INSR, KDR, PIK3CA, PPARA, PPARD, SMAD3, SRC, TEK 4.77971
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, PPARD, SMAD3 4.75183
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 4.66471
[BP] GO:0030335 positive regulation of cell migration EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.66471
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2C, PPARA, PTGS2, SRC, TEK 4.64985
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARD, PTGS2, SMAD3, SRC 4.64985
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.64929
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, PIK3CA, PIK3CB, PPARD, PTGS1, PTGS2 4.64699
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 4.6133
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.60824
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 4.58215
[BP] GO:2000147 positive regulation of cell motility EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.54275
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK 4.50685
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, EGFR, FABP3, FLT3, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.50471
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, EGFR, FABP3, FLT3, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.50471
[BP] GO:0051272 positive regulation of cellular component movement EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.44439
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, HTR2C, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK 4.42251
[BP] GO:0032844 regulation of homeostatic process ADORA1, CA2, CA7, CNR1, EGFR, HCAR2, HTR2C, KDR, PIK3CB, PTGS2, SRC 4.41521
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, SRC, TEK 4.39885
[BP] GO:0032787 None ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 4.38992
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, HTR2C, IGF1R, INSR, KDR, PIK3CB, SRC, TEK, XDH 4.35597
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PPARD, PTGS2, SMAD3, SRC, TEK 4.32717
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 4.32717
[BP] GO:0040017 positive regulation of locomotion EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.32717
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC, TEK 4.32223
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.31643
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, PPARD, SRC, XDH 4.25608
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.24969
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.21478
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, DUSP3, EGFR, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TEK, XDH 4.17563
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, HTR2C, INSR, KDR, PIK3CB, SRC, TEK, XDH 4.16221
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, CA2, CHRM1, CHRM2, CNR1, CYP1B1, EGFR, ESR1, GPR35, HCAR2, HSPA1A, HTR2C, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 4.14632
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PPARD, PTGS1, PTGS2, XDH 4.12942
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK 4.12942
[BP] GO:0003018 None ADORA1, CHRM1, EGFR, PPARD, PTGS2, SRC, TEK 4.10464
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 4.06144
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, CA2, CA9, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 4.05317
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, DUSP3, EGFR, FABP4, FLT3, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.02543
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.00774
[BP] GO:0008283 cell proliferation ACHE, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PPARD, SRC, TEK 4.00774
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, EGFR, FLT3, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 3.87148
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 3.86382
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PPARD, PTGS2, SRC, TEK, XDH 3.85049
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.84834
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.84834
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, EGFR, HCAR2, HTR2C, MMP12, PPARD, PTGS2, SMAD3, SRC 3.84834
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.83827
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.83231
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, INSR, KDR, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 3.82734
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK 3.80619
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.78026
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 3.76226
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 3.74724
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, GPR35, HCAR2, HTR2C, INSR, PIK3CA, PIK3CB, SRC 3.74553
[BP] GO:0016477 cell migration CNR2, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC, TEK 3.74081
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1 3.71905
[BP] GO:0009895 negative regulation of catabolic process ADORA1, CNR1, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 3.71122
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, EGFR, FLT3, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 3.69611
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PPARD, PTGS2, SMAD3, SRC 3.66954
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.66716
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PPARD, PTGS2, SRC, TEK, XDH 3.59497
[BP] GO:0044092 negative regulation of molecular function ADORA3, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PPARA, PTGS2, SRC 3.59497
[BP] GO:0042493 response to drug AKR1B1, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HTR2C, KDR, PTGS2, SRC 3.54297
[BP] GO:0040011 locomotion CNR2, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC, TEK 3.53699
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.5169
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 3.5169
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, EGFR, ESR1, FLT3, HSPA1A, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.48868
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PPARD, PTGS2 3.46359
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARD, PTGS2, SRC 3.4534
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, SRC, TEK 3.4534
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, SMAD3, SRC, TEK 3.4366
[BP] GO:0003013 None ADORA1, CHRM1, EGFR, PPARD, PTGS2, SRC, TEK 3.40583
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.3973
[BP] GO:0009894 regulation of catabolic process ADORA1, CNR1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, SMAD3 3.3606
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.35105
[BP] GO:0048870 cell motility CNR2, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC, TEK 3.34976
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR, PTGS2 3.33671
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR, PTGS2 3.33671
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.33671
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, EGFR, GPR35, HCAR2, HTR2C, PTGS2, SMAD3 3.33671
[BP] GO:0042060 None ALOX15, EGFR, PPARA, PPARD, SMAD3 3.33671
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 3.19785
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.18998
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.17435
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.17435
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, EGFR, HCAR2, PIK3CB, PTGS2 3.17021
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, MMP12, PPARD, PTGS2, SMAD3, SRC 3.15275
[BP] GO:0008217 None ADORA1, CNR1, PPARA, PTGS1, PTGS2, SMAD3 3.13931
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 3.13268
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2C 3.10359
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 3.08504
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 3.08504
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 3.03973
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.02132
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.01323
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 3.00777
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, SRC 3.00382
[BP] GO:0002791 None ACHE, ADORA1, CNR1, EGFR, HCAR2, HTR2C, MMP12, PPARD, SRC 2.99783
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 2.99722
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK 2.99722
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.99722
[BP] GO:0006979 response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 2.9861
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 2.98412
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.9383
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HCAR2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, SMAD3, SRC 2.9383
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.92331
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, PPARD, TEK 2.91466
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MMP12, PPARD, SRC 2.88167
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 2.87707
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.87448
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, EGFR, HSPA1A, HTR2C, MET, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 2.83897
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, EGFR, FLT3, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 2.83897
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.83897
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, EGFR, HCAR2, MMP12, PPARD, PTGS2, SMAD3, SRC 2.81768
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HTR2C, PPARD 2.81006
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, PIK3CB, SMAD3, SRC, TEK 2.80662
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, CA1, CHRM4, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 2.7895
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.7895
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 2.74788
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 2.74756
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, PPARD 2.74048
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.74048
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.74048
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.72485
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 2.72268
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HTR2C, KDR, SRC, TEK 2.71951
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2 2.71951
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MMP12, PPARD, SRC 2.70632
[BP] GO:0032496 response to lipopolysaccharide CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 2.69558
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.69244
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.69244
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, PPARA, PPARD, SMAD3, TEK 2.6841
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, KDR, MET, PTGS2, SMAD3 2.6841
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, KDR, PIK3CB, SMAD3, SRC, TEK 2.66892
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.65941
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.63715
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, CHRM1, EGFR, HCAR2, MMP12, PPARD, PTGS2, SMAD3, SRC 2.63313
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.63185
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.62653
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.6238
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.6238
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.61196
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HTR2C, KDR, SRC, TEK 2.57618
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, PTGS2 2.57069
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.5705
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 2.56263
[BP] GO:0009892 negative regulation of metabolic process ADORA1, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, XDH 2.55583
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HTR2C, PPARA, PPARD 2.55583
[BP] GO:0002237 response to molecule of bacterial origin CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 2.55583
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.54791
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.54574
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, MET, PIK3CA, PIK3CB, PPARD 2.54574
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HTR2C, PIK3CB, SMAD3 2.54466
[BP] GO:0097746 None ADORA1, CHRM1, EGFR, PPARD, PTGS2 2.50143
[BP] GO:0035296 None ADORA1, CHRM1, EGFR, PPARD, PTGS2 2.50143
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.49592
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.49409
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PTGS2, SRC 2.49076
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, PPARD 2.49076
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HTR2C, MMP12, PPARD, SRC 2.48707
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 2.4839
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, HTR2C, KDR, SRC 2.47964
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, PTGS2 2.46448
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.45252
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.45252
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.45252
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.4452
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, PTGS2 2.4452
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.42702
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, PPARD, TEK 2.42481
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.4161
[BP] GO:0043549 regulation of kinase activity ADORA1, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, SRC, TEK 2.4161
[BP] GO:0051894 None KDR, SMAD3, TEK 2.41123
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.41123
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.41123
[BP] GO:0050880 None ADORA1, CHRM1, EGFR, PPARD, PTGS2 2.40811
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.40675
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.40675
[BP] GO:0038171 None CNR1, CNR2 2.40675
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.40675
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.40647
[BP] GO:0035150 None ADORA1, CHRM1, EGFR, PPARD, PTGS2 2.4008
[BP] GO:0009888 tissue development ALOX15, CYP1B1, INSR, KDR, PIK3CA, PPARA, PPARD, PTGS2, SMAD3 2.39868
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 2.38853
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 2.38853
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, PTGS2, SRC 2.38544
[BP] GO:0006928 movement of cell or subcellular component CNR2, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, SRC, TEK 2.33482
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.3324
[BP] GO:1903393 None KDR, SMAD3, TEK 2.32631
[BP] GO:0050678 None EGFR, KDR, MMP12, PPARD, SMAD3, TEK, XDH 2.32522
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway KDR, PIK3CA, PIK3CB, SRC 2.30795
[BP] GO:0043271 negative regulation of ion transport ADORA1, CNR1, GPR35, MMP9, PTGS2 2.29511
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.28713
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.28414
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, MET, PIK3CA, PIK3CB 2.28414
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HTR2C, MMP12, PPARD, SRC 2.27828
[BP] GO:0050714 None ACHE, EGFR, HCAR2, MMP12, PPARD, SRC 2.24274
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.24232
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.23518
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4 2.23045
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, PIK3CA, PPARD 2.21085
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.20227
[BP] GO:0043065 positive regulation of apoptotic process CNR1, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.19248
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3 2.18297
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, SMAD3, SRC, TEK, XDH 2.18255
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 2.18255
[BP] GO:0030258 lipid modification CYP1A1, EGFR, MET, PIK3CA, PIK3CB, PPARD 2.17694
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.17628
[BP] GO:0043068 positive regulation of programmed cell death CNR1, CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.16879
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.16879
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.16879
[BP] GO:0010638 positive regulation of organelle organization ALOX15, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.16195
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.16195
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, HCAR2, MMP12, PPARD, SRC 2.1556
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.14391
[BP] GO:1901890 None KDR, SMAD3, TEK 2.13536
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.13536
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.13536
[BP] GO:0050673 epithelial cell proliferation ESR1, PIK3CB, PPARD, TEK 2.13321
[BP] GO:0033273 response to vitamin CYP1A1, EGFR, PPARD, PTGS2 2.13321
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.13321
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.13321
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, CA1, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.13321
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1 2.13321
[BP] GO:0006468 protein phosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, SRC, TEK 2.11121
[BP] GO:0019217 None CNR1, FABP3, PPARA, PTGS2 2.09582
[BP] GO:0051223 None ACHE, CHRM1, CNR1, EGFR, HCAR2, MMP12, PPARD, PTGS2, SMAD3, SRC 2.0903
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, PTGS2, SMAD3 2.0903
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, CSNK2A1, HTR2C, PIK3CA, PIK3CB, PPARD, PTGS2 2.0903
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PTGS2, TEK 2.08395
[BP] GO:0033029 regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.08395
[BP] GO:0032229 None ADORA1, CNR2 2.08395
[BP] GO:0043436 oxoacid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 2.07559
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.07559
[BP] GO:1902893 None PPARA, PPARD, SMAD3 2.07559
[BP] GO:0010907 None INSR, PPARA, SRC 2.07559
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.07276
[BP] GO:0045859 regulation of protein kinase activity ADORA1, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, SRC 2.07251
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.07251
[BP] GO:0008654 phospholipid biosynthetic process ACHE, ALOX15, CSNK2A1, PIK3CA, PIK3CB, PPARD 2.05848
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, EGFR, ESR1, GPR35, HTR2C, PIK3CB, SMAD3 2.05694
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.05599
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, SRC 2.05386
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PIK3CB, SRC 2.02814
[BP] GO:0006082 organic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 2.02068
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.00522
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, SMAD3, SRC, TEK 4.1488
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DUSP3, EGFR, F10, FLT3, GPR35, HTR2C, IGF1R, INSR, KDR, MET, PTGS2, SRC, TEK 4.10464
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, EGFR, INSR, MET, PTGS2, SRC, TEK 3.74081
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, FLT3, GPR35, HTR2C, IGF1R, INSR, KDR, MET, TEK 3.71122
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TEK 3.63697
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2, SMAD3, SRC, TEK 2.84646
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GPR35, HTR2C, IGF1R, INSR, KDR, MET, TEK 2.76151
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.69001
[CC] GO:0045121 membrane raft CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.57294
[CC] GO:0098857 membrane microdomain CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.56048
[CC] GO:0098589 membrane region CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.16708
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.6107
[MF] GO:0046914 transition metal ion binding ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARD, SMAD3, XDH 12.6943
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2652
[MF] GO:0043167 ion binding ACHE, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 10.2955
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2312
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TEK, XDH 9.3401
[MF] GO:0008144 drug binding ACHE, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PPARA, PPARD, SRC, TEK 8.62959
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARD, SMAD3 7.65998
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.95615
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.84144
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.81281
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 6.62325
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.34146
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, PPARA, PPARD, TEK 5.9354
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.73106
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.52994
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, PPARA, PPARD, SMAD3, TEK 5.22828
[MF] GO:0043169 cation binding ACHE, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, HTR2C, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PPARA, PPARD, PTGS1, PTGS2, SMAD3, XDH 5.20842
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, PPARA, PPARD, TEK 5.20842
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.16397
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.15952
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.14489
[MF] GO:0005506 iron ion binding ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.07791
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, PPARA, PPARD, TEK 5.05072
[MF] GO:0004713 protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.719
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, TEK 4.50685
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, FLT3, GPR35, HCAR2, HTR2C, IGF1R, INSR, KDR, MET, TEK 4.50685
[MF] GO:0046872 metal ion binding ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PPARA, PPARD, PTGS1, PTGS2, SMAD3, XDH 4.39785
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.34462
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.32609
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.31643
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, XDH 4.31203
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.11703
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.52934
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.36603
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 3.30519
[MF] GO:0004672 protein kinase activity CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, SRC, TEK 3.28097
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.25913
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR2C 3.19785
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.05045
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.01323
[MF] GO:0008389 None CYP2A13, CYP2A6 3.01323
[MF] GO:0016301 kinase activity CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.9748
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.72485
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.70797
[MF] GO:0036094 small molecule binding ADORA1, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PPARD, SRC, TEK, XDH 2.65941
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.63185
[MF] GO:0004949 None CNR1, CNR2 2.63185
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR2C 2.6238
[MF] GO:0043168 anion binding ALOX15, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PPARD, SRC, TEK, XDH 2.5147
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.48707
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.42698
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.42481
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, SRC, TEK 2.40946
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.37381
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.28414
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.27055
[MF] GO:0043559 insulin binding IGF1R, INSR 2.21766
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08395
[MF] GO:0035258 None ESR1, FLT3, SMAD3, SRC 2.03955


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.1171
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.9893
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.7875
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.8055
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R, PPARD 7.3977
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 7.7875
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 7.7875
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3598
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.9718
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, GPR35, CNR1, ADORA3, CHRM4, ADORA1, HTR2C 5.7178
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.399
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.7178
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, PIK3CB 5.057
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.6872
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 5.1942
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.0518
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA 4.8374
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.9706
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.8318
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.1111
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.8931
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB, EGFR 4.7172
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.8318
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.7825
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.1906
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.8505
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.8041
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, PIK3CB, MMP9 3.4616
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.6684
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.3251
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIK3CB, PPARD 3.8798
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.6564
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.5214
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 3.2372
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 3.252
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, EGFR, IGF1R 3.2372
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2C, PIK3CB 3.1027
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, CYP1B1, PTGS2, MMP9, MET, EGFR 3.0547
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIK3CB 3.0793
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.4116
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 3.1568
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.967
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, INSR, PIK3CB, PPARA 2.9722
Serotonergic synapse_Homo sapiens_hsa04726 ALOX15, HTR2C, PTGS2, PTGS1 2.9462
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.8496
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.8871
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.8871
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.8681
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.8392
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, FUT7, HSD17B1, ALOX15, CYP1A2, CYP1A1, AKR1B1, PTGS2, CYP19A1, XDH, PTGS1 2.6214
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.712
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.7404
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.6488
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.6641
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.5998
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1, HTR2C, EGFR 2.3456
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3456
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.1982
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.8204
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.1982
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.5669
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.2776
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PPARD 1.8005
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, INSR, PIK3CB 1.8204
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 2.1727
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.4161
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, PIK3CB, HSPA1A 1.9948
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.5057
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 2.1425
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.5146
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3687
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3791
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3897
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.7642
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3784
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.8428
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4204
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.2163
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.3355
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 1.208
Gap junction_Homo sapiens_hsa04540 SRC, HTR2C, EGFR 2.313
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 3.1027
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4636
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, PIK3CB 2.6651
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.0355
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9974
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4852
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4852
Axon guidance_Homo sapiens_hsa04360 MET 0.4796
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0368
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.9024
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0549
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIK3CB 0.9646
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0678
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.6214
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.137
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2208
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5541
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3021
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2314
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2535
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.6269
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.265
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.2501
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5709
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX15, PTGS2, PTGS1 2.6651
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5701
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5839
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.319
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.5972
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5902
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.3021
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0802
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5902
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.6015
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5891
Peroxisome_Homo sapiens_hsa04146 XDH 0.6028
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.6185
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.639
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6251
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6371
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6486
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4785
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.517
Bile secretion_Homo sapiens_hsa04976 CA2 0.6465
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4963
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6741
Shigellosis_Homo sapiens_hsa05131 SRC 0.6741
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6953
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6741
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.5099
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.6098
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6983
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.7226
Malaria_Homo sapiens_hsa05144 MET 0.7655
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7786
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.8233
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.8204
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8918
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9442
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9344
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9801
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8837
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9248
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.988
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9801
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 2.1748
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.5333
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3394


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)