TCM Prescription: Bai Zi Zi Xin Pills



Prescription Description
Prescription IDTCMF3057
Pinyin NameBai Zi Zi Xin Wan
Chinese Name柏子滋心丸
English NameBai Zi Zi Xin Pills
Function Description怔忡, 惊悸, 健忘, 遗精
IndicationsInducible palpitation disorder, Spontaneous palpitation disorder, Involuntary ejaculation disorder, Forgetfulness disorder
Disease ICD-11 Category SA10 [Inducible palpitation disorder (TM1), 惊悸 (TM1) ];
SA11 [Spontaneous palpitation disorder (TM1), 怔忡 (TM1) ];
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
Human Tissues Associated with IndicationHeart, Brain, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9002
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.99
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.73926
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.70148
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.15579
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, HMGCR, PPARA, PTAFR, TYR, XDH 7.80785
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA 7.52354
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, PTAFR, TYR 7.05464
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, PTAFR, SLC1A1, TNKS, TNKS2, XDH 6.92786
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.8559
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.2918
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.28617
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 6.09837
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.89556
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.78502
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.34433
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.23209
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, PTAFR, TYR 5.21631
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.21631
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.10715
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 4.91211
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.90866
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.87771
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.71984
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.71984
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, MMP2, PPARA, PTAFR, TYR 4.70374
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.661
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.661
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.661
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.55145
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.37307
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.27666
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.14536
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.14536
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, PPARA, PTAFR 4.1325
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.84525
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, PTAFR, TYR 3.77469
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, GRM5, HSD11B2, MMP2, PPARA, PTAFR 3.7557
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, PTAFR, TYR 3.7414
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 3.7414
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 3.7414
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 3.65932
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.61758
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.59876
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.59876
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.59267
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, PTAFR, TYR 3.58021
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53664
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.51128
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.51128
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALPL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTAFR, TNKS2, TYR 3.43471
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.43471
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.35714
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PPARA, PTAFR, PTPN1, TNKS, TNKS2, TYR, XDH 3.31816
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTAFR 3.25713
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, HMGCR, PPARA 3.23437
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.22488
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.19149
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, HMGCR, MMP2, MMP9, PTAFR, XDH 3.08286
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.06001
[BP] GO:0007154 None ADORA1, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.02358
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 2.97134
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.94732
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, MMP1, MMP2, MMP9, PPARA, PTAFR, PTPN1, SLC1A1, TNKS, TNKS2, XDH 2.90346
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, MMP2, MMP9, PPARA, PTAFR, PTPN1, TNKS, TNKS2 2.87144
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 2.83231
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7402
[BP] GO:0009115 None AOX1, XDH 2.70751
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, MMP1, MMP2, MMP9, PPARA, PTAFR, PTPN1, TNKS, TNKS2, XDH 2.70493
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.64246
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.51944
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, GRM1, HCAR2, HMGCR, MMP9, PTPN1, TNKS, TNKS2, XDH 2.5085
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, XDH 2.49175
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, GRM1, HCAR2, HMGCR, MMP9, PTPN1, TNKS, TNKS2, XDH 2.49142
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.46891
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.38979
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, HCAR2, HMGCR, TNKS, TNKS2 2.3798
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.34941
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, TYR 2.34886
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, HMGCR, MMP2, MMP9, PTAFR 2.32529
[BP] GO:0099566 None GRM1, GRM5 2.30424
[BP] GO:0046110 None AOX1, XDH 2.30424
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30424
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRM5, ESRRB, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HMGCR, MMP9, PPARA, PTAFR, PTPN1, XDH 2.2627
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.24377
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRM5, ESRRB, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HMGCR, MMP9, PPARA, PTAFR, PTPN1, XDH 2.22734
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, MMP1, MMP2, PPARA, PTAFR, PTPN1, TNKS, TNKS2, TYR, XDH 2.21197
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, PTAFR, SLC1A1 2.20071
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, BCL2, CA1, CSNK2A1, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MMP2, MMP9, PTAFR, PTPN1, TNKS, TNKS2 2.14922
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, PTAFR, SLC1A1 2.14146
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.11399
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, MMP2, MMP9, PPARA, TNKS2, TYR 2.10495
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.10495
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.10495
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.0942
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.0942
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, MMP9, PPARA, TYR 2.0942
[BP] GO:0070213 None TNKS, TNKS2 2.06953
[BP] GO:0006145 None AOX1, XDH 2.06953
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06953
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 2.06351
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05992
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR 2.05641
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.04693
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.02049
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, HMGCR, PTAFR 2.00744
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.00365
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.00365
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.7625
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC1A1 4.46573
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.88663
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.81422
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.34113
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, MMP2, PTAFR, PTPN1, SLC1A1, TNKS, TNKS2, TYR 3.00857
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTAFR, PTPN1, SLC1A1, TYR 2.83145
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.80493
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5 2.14922
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5 2.14922
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5 2.11399
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, F3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, MMP2, PTAFR, PTPN1, SLC1A1 2.05429
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.05429
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F3, GRIA2, GRM1, GRM3, GRM5, GRM8, PTAFR, SLC1A1 2.04693
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.3081
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TYR, XDH 14.0701
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.99
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.73926
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.1956
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 7.80785
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.92072
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.56046
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 6.29363
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.29363
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.28617
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.23208
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.95612
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PTAFR 5.92154
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PTAFR 5.56246
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.17926
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PTAFR 5.11784
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.84606
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HMGCR, HSD17B1, MMP1, MMP2, MMP9, PPARA, PTAFR, PTPN1, SLC1A1, TNKS, TNKS2, TYR, XDH 4.71984
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, SLC1A1, TNKS, TNKS2, TYR, XDH 4.71289
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.62513
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PTAFR 4.53448
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.29301
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.93707
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.88663
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.86843
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B2, HSD17B1, XDH 3.8071
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, SLC1A1, TNKS, TNKS2, TYR, XDH 3.7557
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.7557
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.7557
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.64988
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.43471
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.35714
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR 3.27457
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, F3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR 3.27457
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25592
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.20822
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.06001
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.00962
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.89994
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.84012
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.70751
[MF] GO:0003845 None HSD11B1, HSD11B2 2.70751
[MF] GO:0008389 None CYP2A13, CYP2A6 2.70751
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PTAFR 2.65568
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.62619
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8, HCAR2, PTAFR 2.3798
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.32705
[MF] GO:0099583 None GRM1, GRM5 2.30424
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.30424
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.30424
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.24377
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.06953
[MF] GO:0004971 None GRIA2, GRIA4 2.06953
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.02076


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.9052
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, PTAFR, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 10.9694
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.322
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.0496
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.5312
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.7807
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.0859
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 4.7493
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3069
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, PTAFR, GRM1 4.7242
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 4.4726
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, GRM1, ESR2 3.8529
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1285
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.347
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6832
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.273
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.1272
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.6832
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, MMP9, CDC25B 1.8633
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1253
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0907
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, F3 1.6953
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, CHRM5 1.6578
Pathways in cancer_Homo sapiens_hsa05200 CDK6, MMP1, MMP2, BCL2, MMP9 1.4785
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5666
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.4083
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, BCL2 1.2054
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9, ESR1 1.1531
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3427
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2399
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.2054
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1 1.3086
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2054
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3111
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.1353
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6953
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4168
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.2054
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2054
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0626
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1158
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4083
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9792
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.616
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.547
Gap junction_Homo sapiens_hsa04540 GRM5, GRM1 1.1062
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4567
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.071
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0626
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8804
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9259
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8548
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9031
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2694
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.7775
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6284
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7498
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6602
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6073
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8719
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2513
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3475
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3384
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3121
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3236
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.313
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.3384
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3333
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3944
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3384
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3944
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1 0.3969
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.3944
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3842
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3812
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.3944
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3969
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4389
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.4817
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3944
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.4634
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4206
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR 0.4132
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4223
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4613
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.4585
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4223
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4613
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.4817
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4817
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4817
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4817
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4703
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4817
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4817
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5163
Peroxisome_Homo sapiens_hsa04146 XDH 0.4817
Melanoma_Homo sapiens_hsa05218 CDK6 0.5217
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4817
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4911
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5219
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5339
Glioma_Homo sapiens_hsa05214 CDK6 0.5343
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5222
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5349
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5417
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5761
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5761
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6284
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.626
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6284
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6857
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7673
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7817
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7817
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8066
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7978
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.862
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9241
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0072
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2399


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)