TCM Prescription: Bai Dian Feng Capsules



Prescription Description
Prescription IDTCMF2988
Pinyin NameBai Dian Feng Jiao Nang
Chinese Name白癜风胶囊
English NameBai Dian Feng Capsules
Function Description白驳风
IndicationsVitiligo
Disease ICD-11 Category ED63.0 [Vitiligo, 白癫风 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2195 Zaocys 乌梢蛇 TCMH2195
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HASPIN, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TYR, XDH 12.8659
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.8195
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, FUT7, HSPA1A, NISCH, PIM1, PPARA, PPARG, SOAT1, SOAT2, TYR, XDH 12.2689
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0029
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HASPIN, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TYR, XDH 11.865
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 11.2355
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 11.1664
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PPARG, SOAT1, SOAT2 10.6682
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, PPARG, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 9.22332
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KCNH2, KDR, MAOA, MET, NISCH, PPARA, PPARG, SLC6A2, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, XDH 8.59073
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, ESR1, HSD17B1, HSD17B2, SOAT1, SOAT2 8.41989
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PPARG, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 8.35562
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, XDH 8.19165
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.87944
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PPARG, SOAT1, SOAT2 7.8321
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARG, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.65912
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.64006
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PPARG 7.50613
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.40033
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 7.38601
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 7.33045
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NISCH, NUAK1, PPARG, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.32895
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.25865
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NISCH, NUAK1, PPARG, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.21033
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, PPARA, PPARG, RORC, SLC6A4, SRC, TEK, TYR 7.129
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.01669
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, FLT3, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.98463
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.82062
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, XDH 6.81586
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, F2, FABP4, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.74343
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, INSR, KCNH2, MET, PPARG, SMAD3, SOAT1, SOAT2, SRC, TERT 6.66736
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HASPIN, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TYR, XDH 6.39224
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.20566
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK2, EGFR, F2, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, NISCH, PPARA, PPARG, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 6.1985
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.16863
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, HSP90AB1, RORC 6.16863
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, CA3, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 6.13924
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HASPIN, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TYR, XDH 6.10807
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B2, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, RORC, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TYR 6.05202
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARG, RORC, SLC6A4, SMAD3, SRC, TERT 6.01228
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 5.94633
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, PPARG, SLC6A4, SRC, TEK 5.94168
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG 5.92207
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 5.89916
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.86842
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.85113
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, XDH 5.81164
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.78188
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, CA3, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.77669
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK, TYR 5.77669
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F2, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.72659
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PPARG, SLC6A4, SMAD3, SRC, TEK 5.70872
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, HSD17B2, MAOA, PPARG, TYR, XDH 5.60614
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, XDH 5.5908
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TYR, XDH 5.49122
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PPARG, RORC, SLC6A4, SRC, TYR 5.46754
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 5.46754
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSP90AB1, PPARG, RORC, SLC6A4, SRC, TEK, TYR 5.43606
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.43606
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, XDH 5.37448
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.34908
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA, PPARG 5.3099
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F2, FLT3, GPR35, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.30867
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.2574
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.23803
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, XDH 5.23803
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 5.21971
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA3, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ESR1, ESRRA, F2, FABP3, FABP4, FLT3, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PPARG, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.20594
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, SMAD3, SRC, TEK, TERT 5.10389
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CYP19A1, DYRK2, EGFR, F2, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KCNH2, MMP12, MMP9, PPARA, PPARG, PTPN1, SLC6A4, SMAD3, SRC, TERT 4.92393
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, F2, FABP3, FLT3, HCAR2, PPARA, PPARG, RORC, SRC, TEK 4.89413
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.83491
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PPARG, RORC, SRC 4.81285
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.7575
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, SMAD3, SRC, TEK, TERT 4.74378
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F2, FLT3, GPR35, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.74378
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT 4.70721
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG 4.70721
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC, SRC 4.70285
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 4.69152
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.65296
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, KCNH2, MET, PPARG, SMAD3, SOAT1, SOAT2 4.64919
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 4.60416
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HCAR2, HSP90AB1, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NISCH, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.55236
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, EGFR, F2, HCAR2, HSP90AB1, INSR, KCNH2, MMP12, PPARG, SLC6A4, SMAD3, SRC, TERT 4.53506
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, MAOA, SLC6A2, SLC6A4, SMAD3 4.51109
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F2, FABP4, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TYR 4.50457
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.49737
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 4.46962
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP2, PPARG, RORC, SLC6A4, SMAD3, SRC 4.40064
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSP90AB1, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NISCH, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.38011
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, F2, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK, TERT 4.36852
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.36319
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, SMAD3, SRC, TEK, TERT 4.33703
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, HSP90AB1, HSPA1A, MMP12, MMP2, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 4.33236
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, SMAD3, SRC, TEK, TERT 4.3245
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 4.3245
[BP] GO:0010907 None DYRK2, ESRRB, INSR, PPARA, SRC 4.306
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, PPARG, RORC, SLC6A4, SRC 4.14448
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.14143
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, EGFR, HSPA1A, MAOA 4.12825
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, RORC, SMAD3, SOAT1, SRC, TERT 4.11857
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, RORC, SMAD3, SOAT1, SRC, TERT 4.06841
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PPARG, SLC6A4, SMAD3, SRC, TEK, TERT 4.06257
[BP] GO:0042493 response to drug AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HSP90AB1, KCNH2, KDR, PPARG, SLC6A2, SLC6A4, SRC 4.00681
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC, SRC 3.9885
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, PPARG, SMAD3, TEK 3.97908
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, HSP90AA1, HSP90AB1, INSR, SMAD3, XDH 3.95497
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, F2, MMP12, PPARA, PPARG, SMAD3, TEK 3.91911
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PPARG, TYR 3.89351
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.87975
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.87975
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIM1, PPARA, PPARG, RORC, SMAD3, SRC, TEK, TYR 3.85048
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.82138
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PPARG, SRC, TEK 3.81242
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, HSP90AB1, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.81242
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, HSP90AB1, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.81242
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, F2, PPARA, SMAD3 3.79891
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.77422
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CSNK2A1, DYRK1A, EGFR, ESR1, F2, FLT3, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PTPN1, SMAD3, SOAT1, SRC, TEK, XDH 3.76063
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.75986
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.70163
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, PTPN1, SRC, TEK 3.65662
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.61408
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, MAOA, SOAT1, SOAT2, TYR 3.60971
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 3.59249
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 3.55605
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.53969
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 3.49865
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.47793
[BP] GO:0090077 None PPARG, SOAT1, SOAT2 3.47793
[BP] GO:0010742 None PPARG, SOAT1, SOAT2 3.47793
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.47793
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, PPARG, RORC, SLC6A4, SRC 3.43078
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.43078
[BP] GO:0010676 None DYRK2, ESRRB, INSR, PPARA, SRC 3.43078
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SMAD3, SRC, TERT, XDH 3.42693
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PPARG, TYR 3.41743
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40734
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.39605
[BP] GO:0030335 positive regulation of cell migration ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 3.38351
[BP] GO:0010906 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 3.34132
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PPARG, TYR 3.33022
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, CDC25B, EGFR, ESR1, ESR2, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.29847
[BP] GO:0080135 regulation of cellular response to stress DUSP3, DYRK1A, DYRK3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTPN1, TERT, XDH 3.2629
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 3.2556
[BP] GO:2000147 positive regulation of cell motility ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 3.2518
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, F2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PPARG, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 3.2518
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AB1, INSR, SLC6A4, SRC, TERT 3.25003
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SLC6A4, SRC, TEK, TYR 3.23003
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, ESRRB, F2, FLT3, HSP90AB1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.21445
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, DYRK1A, EGFR, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.21392
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.18761
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, MMP12, PPARA, PPARG, RORC, SMAD3, SOAT1, SRC, TERT 3.18264
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.1797
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F2, FLT3, FUT7, HASPIN, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.1722
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 3.16139
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 3.16139
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 3.10832
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PPARG, SMAD3, TEK 3.10419
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.08904
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, DYRK1A, EGFR, ESR1, F2, FLT3, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 3.08303
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, GPR35, HCAR2, HSP90AB1, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARG, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 3.08303
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.06761
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, F2, FLT3, HSP90AA1, HSP90AB1, INSR, PTPN1, SRC, TEK 3.05634
[BP] GO:0040017 positive regulation of locomotion ADRA2A, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 3.03459
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, EGFR, ESR1, F2, FABP3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, KCNH2, MMP12, MMP9, NISCH, PPARA, PPARG, SLC6A2, SLC6A4, SOAT1, SOAT2, SRC, TERT, XDH 3.00359
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, ESR1, F2, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, XDH 2.98974
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CA3, CES1, CYP1A1, CYP1B1, HSP90AA1, KDR, SLC6A4, SRC 2.98974
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 2.96842
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 2.96192
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, SLC6A4, SRC 2.94296
[BP] GO:0045913 None DYRK2, ESRRB, INSR, PPARA, SRC 2.93635
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.91481
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SLC6A4, SRC, TEK, TYR 2.90867
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TERT 2.90867
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.87611
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.87149
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, EGFR, F2, FLT3, HSP90AB1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.86641
[BP] GO:0010675 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.85149
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, DYRK1A, DYRK3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.83808
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, EGFR, F2, FABP3, HSP90AA1, HSP90AB1, HSPA1A, KCNH2, MMP12, MMP9, NISCH, PPARA, PPARG, SLC6A2, SLC6A4, SOAT1, SOAT2, SRC, TERT, XDH 2.81561
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.80792
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.78652
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, EGFR 2.78348
[BP] GO:0009115 None AOX1, XDH 2.78328
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AB1, IGF1R, INSR, PTPN1, SRC, TEK 2.7821
[BP] GO:0051098 regulation of binding AURKB, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC, TERT 2.77025
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, HCAR2, HSP90AB1, MET, PPARA, SMAD3 2.7549
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.74779
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.74779
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PPARG, TERT 2.74383
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7194
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, F2, HSP90AB1, SMAD3, SRC, TERT 2.70901
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.70808
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PPARG, RORC, SLC6A4, SRC 2.69025
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 2.68656
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.66584
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, F2, FLT3, HSP90AB1, INSR, PTPN1, SRC, TEK 2.64601
[BP] GO:0008283 cell proliferation ACHE, AURKB, CLK1, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 2.63393
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.63082
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, F2, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP2, PPARG, PTPN1, SMAD3, SRC 2.62808
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, XDH 2.62808
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3 2.61036
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, CA2, CYP1B1, EGFR, ESRRB, F2, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PPARG, SMAD3, SRC, TEK, TERT 2.60783
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 2.57573
[BP] GO:0043393 regulation of protein binding AURKB, HSP90AB1, MET, MMP9, PPARA, SRC, TERT 2.57573
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, XDH 2.57434
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HSP90AB1, KCNH2, KDR, SRC 2.5729
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SRC, TEK, TERT, XDH 2.5527
[BP] GO:0045725 None DYRK2, ESRRB, INSR 2.5527
[BP] GO:0051937 None NISCH, SLC6A2, SLC6A4 2.5527
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, KDR, MET, MMP12, PPARA, PPARG, SMAD3, TEK 2.54494
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.53624
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 2.50993
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HASPIN, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK 2.50882
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HSP90AA1, MMP12, NISCH, PPARA, PPARG, SLC6A2, SLC6A4, SOAT1, SOAT2 2.50492
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC 2.49148
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PPARG, SLC6A4, SMAD3, SRC 2.48895
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.48895
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.48895
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.48895
[BP] GO:0070920 None EGFR, ESR1, TERT 2.48895
[BP] GO:0070875 None DYRK2, ESRRB, INSR 2.48895
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, EGFR, F2, HCAR2, KDR, SRC 2.48895
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNH2, PPARA, PPARG, SLC6A2, SLC6A4 2.47519
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.4745
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.45266
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, DYRK2, EGFR, F2, HCAR2, HSP90AB1, MMP12, PTPN1, SMAD3, SRC 2.41581
[BP] GO:1900180 regulation of protein localization to nucleus DYRK2, EGFR, F2, HSP90AB1, SMAD3, SRC, TERT 2.41347
[BP] GO:0019538 protein metabolic process ACHE, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F2, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 2.40461
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.40121
[BP] GO:0034435 None SOAT1, SOAT2 2.40121
[BP] GO:0034433 None SOAT1, SOAT2 2.40121
[BP] GO:0034434 None SOAT1, SOAT2 2.40121
[BP] GO:0046110 None AOX1, XDH 2.40121
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40121
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, SLC6A4, SRC, TEK 2.36261
[BP] GO:0003006 developmental process involved in reproduction AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, INSR, PPARG, SRC 2.36261
[BP] GO:0007004 None HSP90AA1, HSP90AB1, TERT 2.35707
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, CDC25B, DYRK1A, EGFR, F2, FLT3, HSP90AB1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.33579
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.32874
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HSP90AB1, IGF1R, INSR, PTPN1, SRC 2.31357
[BP] GO:0001775 cell activation ADRA2A, ALOX5, AXL, EGFR, F2, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, RORC, SMAD3, SRC 2.30313
[BP] GO:0006810 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, F2, FABP3, HSP90AA1, HSP90AB1, HSPA1A, KCNH2, MMP12, MMP9, NISCH, PPARA, PPARG, SLC6A2, SLC6A4, SOAT1, SOAT2, SRC, XDH 2.26952
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.2669
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.2669
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT 2.2659
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.25854
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.25854
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.25854
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.25854
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.21551
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.21551
[BP] GO:0001959 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.20957
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.19002
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SOAT1, SRC, TEK, XDH 2.19002
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F2, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 2.19002
[BP] GO:0015844 None NISCH, SLC6A2, SLC6A4 2.17947
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SRC, TEK, TERT, XDH 2.16892
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.16498
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.15064
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.14996
[BP] GO:0006145 None AOX1, XDH 2.14996
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.14996
[BP] GO:0015874 None NISCH, SLC6A2 2.14996
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.14996
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.14732
[BP] GO:0006109 regulation of carbohydrate metabolic process DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.13959
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.13959
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.13959
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.13959
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.13959
[BP] GO:0060759 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.12801
[BP] GO:0055088 None FABP3, FABP4, PPARG, SOAT1, SOAT2 2.1221
[BP] GO:1901796 None AURKB, CSNK2A1, DYRK1A, DYRK2, DYRK3, NUAK1 2.11687
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TERT 2.09963
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.09616
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PPARG, SRC 2.09363
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.09105
[BP] GO:0051172 None ADRA2A, AURKB, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSP90AB1, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.06929
[BP] GO:0006464 cellular protein modification process AURKB, AXL, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F2, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.0684
[BP] GO:0036211 protein modification process AURKB, AXL, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F2, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.0684
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, SMAD3, TERT 2.0684
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, MAOA 2.06682
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.06682
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, PPARG, SRC, TEK 2.06075
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.06075
[BP] GO:0051894 None KDR, SMAD3, TEK 2.04971
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.04971
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.04971
[BP] GO:0044267 cellular protein metabolic process AURKB, AXL, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F2, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK 2.04971
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, HSP90AB1, INSR, PTPN1, SRC 2.04971
[BP] GO:0051726 regulation of cell cycle AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, SLC6A4, SMAD3, SRC, TERT 2.03551
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, INSR, PTPN1, SRC 2.03318
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DYRK2, EGFR, F2, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.02704
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK 2.01869
[BP] GO:0048869 cellular developmental process ACHE, AXL, CBR1, CDC25B, CES1, CYP1A1, DYRK3, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PPARG, RORC, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT 2.01702
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, PPARG, RORC, SLC6A4, SRC 2.01702
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSP90AB1, IGF1R, INSR, PTPN1, SRC 2.01702
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, HSP90AB1, TEK 3.68661
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TERT, TYR, XDH 2.81234
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, DYRK2, DYRK3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KCNH2, KDR, MAOA, MMP2, MMP9, NISCH, PIM1, PPARG, PTPN1, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TERT, TYR, XDH 2.66369
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AURKB, CA4, CA5A, CA5B, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, KDR, MAOA, MMP12, MMP2, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TERT, TYR, XDH 2.09105
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, EGFR, F2, FLT3, HSD17B2, PTPN1, SOAT1, SOAT2 2.0684
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, AOX1, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, SOAT1, SOAT2, SRC, TERT, TYR, XDH 2.04018
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK2, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TYR, XDH 19.2982
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.0477
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, TYR, XDH 16.2883
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F2, FLT3, FUT7, HASPIN, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SOAT1, SOAT2, SRC, TEK, TERT, TYR, XDH 15.4496
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.865
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 11.375
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.4596
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PPARG, PTPN1, RORC, SMAD3 9.22332
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, SLC6A4, SRC, TEK 9.22332
[MF] GO:0004672 protein kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 9.1998
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 7.82271
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 7.31496
[MF] GO:0016301 kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 7.24807
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, XDH 7.19208
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TYR, XDH 7.09629
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.84856
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 6.83276
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.65133
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 6.27928
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A4, SMAD3, SRC 6.27928
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.27166
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 6.16863
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 6.16863
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.13924
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, HSD17B2, MAOA, TYR, XDH 6.10807
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC, SOAT1, SOAT2 5.89916
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 5.70872
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 5.61338
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.49837
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F2, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NISCH, NUAK1, PIM1, PPARG, SOAT1, SOAT2, SRC, TEK, XDH 5.41817
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, SOAT1, SOAT2, SRC, TEK, XDH 5.40455
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.20976
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, NISCH, PPARA, PPARG, RORC, SOAT1, SOAT2 5.10987
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19 5.04045
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.01341
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, TEK 4.79555
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC 4.74378
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F2, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 4.63152
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, SRC 4.53103
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, HSD17B1, SOAT1, SOAT2, SRC, XDH 4.50457
[MF] GO:0005524 ATP binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.35479
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP9, NISCH, PPARG, SLC6A4, SMAD3, TERT, TYR, XDH 4.25772
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19 4.24462
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.20554
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, TYR 4.20554
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.16243
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, TEK 4.02455
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, SMAD3, TEK 3.91881
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, TEK 3.82333
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH 3.55165
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 3.54762
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 3.54628
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SOAT1, SOAT2, SRC, TEK, TERT, XDH 3.43812
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, NUAK1, PIM1 3.29053
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.16139
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.08458
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.94384
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.90867
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.90162
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F2, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.89595
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, KCNH2, MET, PPARA, PPARG, PTPN1, SLC6A4, SMAD3, SRC, TEK 2.84796
[MF] GO:0034736 None SOAT1, SOAT2 2.78328
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.78328
[MF] GO:0004772 None SOAT1, SOAT2 2.78328
[MF] GO:0008389 None CYP2A13, CYP2A6 2.78328
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.54902
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.5024
[MF] GO:0016740 transferase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SOAT1, SOAT2, SRC, TEK, TERT 2.50239
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 2.49007
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PPARG, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.44382
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.41581
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.41581
[MF] GO:0005330 None SLC6A2, SLC6A4 2.40121
[MF] GO:0047374 None CES1, CES2 2.40121
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 2.24645
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.23339
[MF] GO:0043621 protein self-association ACHE, DYRK1A, FLT3, PPARG 2.21551
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR 2.19002
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, EGFR, FLT3, HSP90AA1, HSP90AB1, KCNH2, PPARG, SLC6A4, SMAD3, TERT, TYR, XDH 2.16892
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.14996
[MF] GO:0032795 None ADORA1, ADRA2A 2.14996
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.14996
[MF] GO:1901567 None PPARG, SOAT1, SOAT2 2.09105
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, PTPN1, SMAD3, SRC 2.0684
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.01869


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.12
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5774
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.731
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4658
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19 5.7652
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, SMAD3, HSP90AB1, FLT3, MMP1, MMP2, PPARG, MMP9, MET, EGFR, IGF1R 4.8925
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.3791
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.9112
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9112
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.5194
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, AKR1B1, TYR, CYP2C19, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 4.3766
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9112
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.5177
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP2C19 3.9519
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, HSP90AB1, INSR, KDR, TEK, MET, EGFR, IGF1R 3.0742
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 3.9519
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0543
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, ALOX15, CYP2C19, SLC6A4 3.0543
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.5864
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.4182
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, CYP2C19 2.9987
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9389
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, EGFR, IGF1R 2.488
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.3468
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.2818
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.0871
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.2759
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.0871
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.9469
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.0871
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9469
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2A 1.6975
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, F2, ADRA2A 1.6411
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9031
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8674
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8614
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8969
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6299
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.5436
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5789
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.6105
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 1.8011
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4716
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1907
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.7878
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, IGF1R 1.3304
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1907
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.1907
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1795
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, HSPA1A 1.0882
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 0.9326
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 0.8755
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9326
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7452
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7452
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.7452
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7387
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6912
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7261
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.697
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.919
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 0.9303
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6912
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6859
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6912
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0046
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.657
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.6857
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1286
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6394
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1907
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6394
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.522
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2334
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2583
Legionellosis_Homo sapiens_hsa05134 CLK1, HSPA1A 1.1907
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.2472
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2534
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1655
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2583
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2583
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2583
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2583
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1233
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2532
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2917
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.4241
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3306
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3324
Platelet activation_Homo sapiens_hsa04611 SRC 0.346
Axon guidance_Homo sapiens_hsa04360 MET 0.3387
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1286
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.3367
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.346
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.1907
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1795
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3741
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3741
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3967
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3899
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3967
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3967
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.3972
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4013
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4011
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4096
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4054
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4145
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4145
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4241
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4141
Peroxisome_Homo sapiens_hsa04146 XDH 0.4241
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4571
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.4355
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4558
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4651
Bile secretion_Homo sapiens_hsa04976 CA2 0.4636
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4794
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.4776
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4831
Shigellosis_Homo sapiens_hsa05131 SRC 0.4812
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4996
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.4911
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.522
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5423
Malaria_Homo sapiens_hsa05144 MET 0.5571
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.5571
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5535
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6205
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5571
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5571
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5571
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9112
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6211
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5038
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5849
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6507
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6155
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.6912
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.697
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8011
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6857
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6912
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7007
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 1.8834
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6891
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.697
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7261
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8368
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1854


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)