TCM Prescription: Ba Bao Rui Sheng Pills



Prescription Description
Prescription IDTCMF2973
Pinyin NameBa Bao Rui Sheng Wan
Chinese Name八宝瑞生丸
English NameBa Bao Rui Sheng Pills
Function Description腹胀, 腹痛
IndicationsAbdominal pain disorder, Dyspepsia, Enteritis
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH216 Fructus tsaoko 草果 TCMH216 GQ118666
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
TCMH214 Alpinia katsumadai 草豆蔻 TCMH214 KY454001
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT303 KCNA3 Voltage-gated potassium channel subunit Kv1.3 Ion channel P22001
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTGES, RELA, RORC, SRC, TYR 12.8575
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.3438
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F2, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 12.3176
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F2, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 12.3176
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, RELA, RORC, SRC, TYR 12.1951
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.741
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, RELA, RORC, SRC, TYR 11.4628
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PRKCE, PRKCG, PTGES, RELA, RORC, SRC, TYR 11.254
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR7, KDR, MAOA, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, SRC, TNKS, TNKS2, XDH 10.3732
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.2665
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.2665
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES 9.80869
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 9.73199
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MMP2, MMP9, PIM1, PRKCA, PTGES, RELA, SRC, XDH 9.63858
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, PRKCE, PTGES, RELA, RORC, SRC, TYR 9.61097
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, DRD2, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, PRKCA, PRKCB, PRKCE, PTPN1, RELA, SRC, XDH 9.49662
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, DRD1, DRD2, DRD3, F2, HCAR2, HTR2A, HTR2B, KDR, PRKCE, SRC, TNKS, TNKS2 9.14997
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GBA2, HSD17B3, HTR2B, PIM1, PPARA, PTGES, TYR, XDH 9.12612
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, PRKCE, SRC 9.05455
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 8.98761
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, PRKCA, PRKCE 8.68743
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, BCL2, CA3, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, KDR, PRKCD, PRKCE, PRKCG, RELA, SRC 8.60794
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, XDH 8.51958
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.51559
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 8.36426
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SIGMAR1, SRC, TNKS, TNKS2 8.26428
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.93579
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, MMP2, PPARA, PRKCD, PRKCE, RELA, SRC 7.92858
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCD, RELA, RORC, SIGMAR1, SRC, TNKS2, TYR 7.8937
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.8851
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, PPARA, PRKCD, PRKCE, RELA, SRC 7.84566
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.82772
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 7.59572
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, RELA 7.27915
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 7.15055
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TYR 7.14306
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 7.05705
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 7.05705
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F2, F3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KCNA3, KDR, MAP2K1, MET, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 7.00951
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 6.83981
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PRKCD, PTGES, RELA, SRC 6.73238
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, PRKCD, PRKCE, RELA, SRC 6.62248
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 6.62248
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, PRKCG, RELA, RORC, SRC, TNKS2, TYR 6.58451
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 6.54849
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC, TYR 6.51267
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 6.51267
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HSD17B3, HTR1A, MAOA, TYR 6.50548
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.47411
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, RELA, SIGMAR1, SRC, XDH 6.47411
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.47411
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.47411
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.47411
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, RELA, SIGMAR1, SRC, XDH 6.47411
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, MAP2K1, MMP9, PIM1, PPARA, RELA, RORC, SIGMAR1, SRC, TYR 6.47411
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 6.4628
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 6.39138
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, F2, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, PRKCD, PRKCE, RORC, SRC 6.34938
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, PRKCA, PRKCE, PTPN1, SRC, XDH 6.25328
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 6.17442
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 6.11819
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 6.09055
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 6.03968
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 5.98023
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 5.97979
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 5.97979
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, RELA, SIGMAR1, SRC, XDH 5.97819
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 5.91287
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.8732
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 5.87217
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 5.84411
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F2, F3, HCAR2, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCE, RELA, SRC 5.82978
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, PRKCD, PRKCE, SRC 5.82978
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2, PRKCE 5.778
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 5.7113
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.70028
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, RELA, SRC, TNKS2, XDH 5.68128
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, MET, PRKCB, PRKCE, SRC 5.55228
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, FABP3, FABP4, HTR2A, HTR2B, MET, PRKCB, PRKCE 5.5376
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, FABP3, HTR2A, HTR2B, PRKCB, PRKCE 5.5376
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.5376
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, XDH 5.5376
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.52235
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.52235
[BP] GO:0007187 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.52235
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 5.51679
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, RELA, SRC 5.51588
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.51175
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 5.48002
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, F2, HCAR2, HTR1A, HTR2A, HTR2B, KCNA3, MAP2K1, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 5.45873
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, RELA, SRC 5.41889
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, MET, MMP9, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, XDH 5.41413
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 5.37338
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F2, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.35779
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, F2, HTR1A, HTR2A, KCNA3, MMP9, PRKCD, PRKCE 5.35453
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, PRKCE, SRC, TNKS, TNKS2 5.33507
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.33507
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC 5.31627
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 5.31138
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNA3, PPARA, PRKCB, PRKCE 5.3056
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.18417
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, MMP2, PPARA, PRKCB, PRKCE, RELA, SRC, TYR 5.18417
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.18417
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, XDH 5.17531
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 5.17531
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PRKCB, PRKCD, PRKCE, RELA, RORC, SRC 5.17531
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.1544
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 5.11727
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PRKCD, SRC 5.10744
[BP] GO:0030168 platelet activation AXL, F2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.10155
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 5.10155
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 5.08325
[BP] GO:0007188 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.08325
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 4.99777
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.97861
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.96379
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PRKCB, PRKCD, PRKCE, RELA, RORC, SRC 4.96007
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, XDH 4.93792
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, PRKCB, PRKCD, PRKCE, RELA, RORC, SRC 4.91468
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, MAP2K1, PRKCA, PRKCB, PRKCD, TNKS 4.9137
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 4.90975
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, RELA, SRC, XDH 4.8949
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 4.88776
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, RELA, SRC 4.88151
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, RELA, SRC, TYR 4.87888
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TNKS 4.87028
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.87028
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA, PRKCG, RORC, SRC 4.85755
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, PRKCE 4.83825
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGES 4.82626
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, F2, HCAR2, TNKS, TNKS2 4.8053
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.79821
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, XDH 4.78845
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TNKS, XDH 4.76416
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, KDR, MAP2K1, MET, PPARA, PRKCA, PRKCD, PRKCG, RELA 4.72032
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 4.70573
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, MAP2K1, PRKCA, PRKCB, PRKCD, TNKS 4.70573
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES 4.70461
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 4.66454
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 4.65767
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, FUT7, GBA2, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, TNKS, TNKS2, TYR, XDH 4.65487
[BP] GO:0007200 None ADRA1A, CHRM2, DRD1, DRD2, ESR1, HTR2A, HTR2B 4.65487
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 4.65471
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, PRKCE 4.65471
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, PRKCE 4.65471
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, MAOA 4.65002
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.65002
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA, PRKCB, PRKCD 4.64884
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 4.61919
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.57502
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DRD2, ESR1, F2, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, XDH 4.55051
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 4.52911
[BP] GO:0035265 organ growth ADRA1A, AR, BCL2, CYP19A1, ESR1 4.5041
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, RELA, SRC, TYR 4.48602
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 4.47339
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7, PRKCE 4.44871
[BP] GO:0043278 None DRD2, DRD3, PRKCE, PRKCG, RELA 4.37439
[BP] GO:0014072 None DRD2, DRD3, PRKCE, PRKCG, RELA 4.37439
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, MAP2K1, PRKCA, SRC 4.36638
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.36638
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36638
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SRC 4.35101
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 4.3478
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 4.3021
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 4.24417
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SRC 4.24417
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.23247
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, PRKCE 4.23247
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 4.17001
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, MAP2K1, PRKCA, PTPN1, SRC 4.15147
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.13856
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, PPARA, PRKCD, RELA, RORC, SRC, TNKS, TNKS2 4.13856
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, RELA, SRC 4.12678
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 4.10871
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, RELA, SRC 4.10543
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, PRKCD, RELA, SRC 4.10543
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3, PRKCE 4.09878
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, PRKCD, PRKCE, RELA, SRC 4.055
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PRKCD, PTPN1, RELA, SRC, XDH 4.02734
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.01376
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, F2, HTR2A, HTR2B, PRKCE 3.98346
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PRKCD, SRC 3.95903
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SRC 3.94259
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.91977
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, ESRRB, HCAR2, HTR2A, HTR2B, KDR, MAP3K7, MET, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA 3.91799
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, AR, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, IGF1R, MET, MMP9, PPARA, PRKCB, PRKCD, PTPN1, RELA, SRC, XDH 3.90977
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, PRKCE 3.82879
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD, PRKCE, RELA 3.8202
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, PRKCD, RELA, SRC 3.79481
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 3.79478
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.79347
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.79347
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.73693
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.73693
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTPN1, RELA, SRC, XDH 3.73693
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNA3, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 3.73144
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.7223
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTPN1, RELA, SRC, XDH 3.72144
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, PRKCD, PRKCE, SRC, TNKS, TNKS2 3.71971
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, CHRM2, DRD1, DRD2, DRD3, ESR1, F2, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 3.71969
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 3.70239
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MAP2K1, MET, PIM1, PRKCD, SRC, TYR 3.67286
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PRKCD, PRKCE, PTPN1, SRC, TNKS, XDH 3.66487
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, F2, HTR2A, HTR2B, PRKCE 3.63024
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PPARA, PTGES 3.62965
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, PRKCD, SRC 3.61108
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B, PRKCE 3.61033
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.58086
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, PRKCD, SRC 3.56437
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.5623
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, RELA, SRC 3.54166
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PRKCB, PRKCD, PRKCE, PTPN1, RELA, RORC, SRC 3.5054
[BP] GO:0060359 None DRD1, DRD2, DRD3, PRKCE, PRKCG, RELA 3.50177
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MAP2K1, MET, PPARA, PRKCD, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 3.4696
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC, TNKS 3.46196
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 3.45866
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, PRKCB, PRKCE 3.45544
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, PRKCA, PRKCE 3.44491
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42691
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD, PRKCE 3.42637
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, HTR2A, MMP9, PRKCE 3.41156
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC 3.40823
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CA3, CYP1B1, MMP9, PRKCD, RELA, SRC 3.37971
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SRC, TNKS 3.37971
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B, PRKCE 3.37971
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC, TNKS 3.37971
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.36792
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.36288
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.36288
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F2, F3, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TNKS, TNKS2 3.35772
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 3.34265
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.34265
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.31594
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, DRD2, DRD3, F2, HCAR2, HTR2B, PRKCA, PRKCD, PRKCE, PTPN1, SRC 3.31594
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SRC 3.3108
[BP] GO:0008217 None ADORA1, ADRA1A, AR, DRD2, DRD3, HSD11B2, PPARA 3.28073
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PRKCG, RORC 3.27142
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MAP2K1, MET, PPARA, PRKCD, RELA, RORC, SRC, TNKS, TNKS2 3.27142
[BP] GO:0072347 None DRD2, DRD3, PRKCE, PRKCG, RELA 3.26233
[BP] GO:0034762 None APP, BCL2, CA2, CACNA1C, DRD1, DRD2, DRD3, F2, KCNA3, MMP9, PRKCE 3.26233
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, ESR1, ESRRA, F2, HCAR2, MAP3K7, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC 3.23837
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 3.23735
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.21311
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, F2, HTR2A, HTR2B, PRKCE 3.20953
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.19446
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, RELA, SRC 3.15735
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, FABP4, HTR2B, IGF1R, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.13457
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD, RELA 3.13147
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC 3.11275
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC 3.11275
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 3.10796
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.10518
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, F2, HCAR2, HTR2B, PRKCD, PRKCE, SRC 3.09071
[BP] GO:0046627 None PRKCB, PRKCD, PTPN1, RELA 3.08762
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.0805
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, XDH 3.05655
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F2, HSD11B2, HTR1A, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, SRC 3.04918
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.04499
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.03593
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, PRKCD, PRKCE, PTPN1, SRC 3.01381
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CYP1A1, HTR2A, MAP2K1, PRKCD, RELA 3.01381
[BP] GO:0007154 None ADORA1, ADRA1A, AR, AXL, BCL2, CACNA1C, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, PRKCG 3.0136
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 3.0136
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, PRKCB, RELA 2.98109
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CACNA1C, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 2.96656
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.963
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.963
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 2.963
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, RORC 2.9474
[BP] GO:1900077 None PRKCB, PRKCD, PTPN1, RELA 2.9433
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.9433
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, PRKCE, SRC 2.93788
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.93788
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, SRC 2.93538
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.88918
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, PRKCA, PRKCE, SRC 2.88551
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F2, F3, MET, PRKCA, PRKCD, PRKCE, XDH 2.88551
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, F2, FABP4, MAP3K7, MMP2, PPARA, PRKCD, PRKCE, PTPN1, RELA, SRC 2.87923
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.87485
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGES 2.87479
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC 2.87081
[BP] GO:0035408 None PRKCA, PRKCB 2.86369
[BP] GO:0009115 None AOX1, XDH 2.86369
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.86308
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, PRKCE, RELA, SRC 2.86064
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGES, RELA, SRC 2.85752
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, F2, PPARA 2.8474
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.82737
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.82073
[BP] GO:0023052 None ADORA1, ADRA1A, AR, CACNA1C, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, PRKCG 2.80578
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CSNK2A1, DRD2, DRD3, F2, HCAR2, HTR2B, PRKCA, PRKCD, PRKCE, PTPN1, SRC 2.80271
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, SRC 2.79201
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CDK6, CYP1B1, DRD2, FABP3, MAP2K1, PTGES, XDH 2.77715
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.77069
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.77069
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.76328
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.7413
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.73767
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC 2.72129
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, DRD2, DRD3, F2, HCAR2, HTR2B, PRKCA, PRKCD, PRKCE, PTPN1, SRC 2.69649
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.67786
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.67786
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.67786
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, HCAR2, HTR2B, MET, PPARA, PRKCG, RELA 2.67666
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PTPN1, SRC 2.66725
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP2, MMP9, SRC, XDH 2.65822
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PRKCD, RELA, SRC 2.65173
[BP] GO:0007267 None ADORA1, ADRA1A, AR, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, PRKCG 2.62795
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PRKCD, RELA, SRC 2.61588
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, PRKCA, PRKCE, SRC 2.60695
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.60495
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.59373
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, F2, FLT3, FUT7, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC 2.58866
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.5836
[BP] GO:0010959 None ADORA1, BCL2, CACNA1C, DRD1, DRD2, DRD3, F2, HTR2A, PRKCE 2.56527
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, ESR1, FLT3, PRKCE, RELA, RORC, SRC 2.55694
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA, PRKCE, PRKCG 2.54972
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 2.52457
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, KDR, MAP2K1, PIM1, PPARA, PRKCA, PRKCB, RELA, RORC, SRC, TNKS2, XDH 2.52319
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.52037
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F2, PPARA, PRKCD 2.52037
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.52037
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.52037
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.52037
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.52037
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD2, DRD3, HCAR2, HTR2B, PRKCA, PRKCE, SRC 2.50853
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, XDH 2.48655
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, PRKCE 2.48361
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, PRKCE 2.48361
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 2.47421
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, ESR1, F2, F3, FLT3, FUT7, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, TNKS, TNKS2 2.47103
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, RELA, TYR 2.46588
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PRKCD, PRKCE 2.45859
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.4585
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 2.4585
[BP] GO:0046110 None AOX1, XDH 2.4585
[BP] GO:0060160 None DRD2, DRD3 2.4585
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4585
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.45751
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.45751
[BP] GO:1904062 None APP, CACNA1C, DRD1, DRD2, DRD3, F2, MMP9, PRKCE 2.45605
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, PRKCA, PRKCE, SRC 2.45199
[BP] GO:0009410 None DRD1, DRD2, DRD3, PRKCE, PRKCG, RELA 2.44449
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, IGF1R, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.44008
[BP] GO:0060341 regulation of cellular localization APP, AR, BCL2, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, F2, MAP2K1, PRKCD, PRKCE, PTPN1, SRC 2.42965
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.42965
[BP] GO:0043279 None DRD2, DRD3, PRKCE, PRKCG, RELA 2.42753
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.42753
[BP] GO:0007268 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG 2.41283
[BP] GO:0098916 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG 2.41283
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.39713
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.39297
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.39297
[BP] GO:0051223 None ACHE, APP, CACNA1C, DRD2, DRD3, F2, HCAR2, HTR2B, PRKCA, PRKCD, PRKCE, PTPN1, SRC 2.3738
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, ESR1, F2, FLT3, FUT7, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2 2.37015
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, ESR1, F2, FLT3, FUT7, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2 2.37015
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, HTR2B, PRKCE, SRC 2.37015
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.36867
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNA3, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.36651
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HTR2B, KDR, MAP2K1, MET, MMP2, MMP9, PRKCD, RORC, SRC 2.36488
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HTR2A, KDR, MAP2K1, PIM1, PRKCA, PRKCB, RELA, SRC 2.36286
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, F2, FABP3, HTR2A, HTR2B, KCNA3, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SRC, TNKS, XDH 2.36043
[BP] GO:0099536 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG 2.35597
[BP] GO:0099537 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PRKCG 2.35597
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, KDR, MAP2K1, MET, PPARA, RELA, RORC, SRC, TNKS, TNKS2 2.35597
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, ESR1, F2, FLT3, FUT7, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2 2.33536
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.33536
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.33536
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, ESR1, FLT3, IGF1R, MMP2, PRKCD, PRKCE, RELA, SRC 2.33536
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, DRD3, F2, HSD11B2, HTR2A, PRKCD, PTGES, RELA, SRC, TYR 2.33536
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MMP1, MMP9, PRKCD, SRC 2.3335
[BP] GO:0051100 negative regulation of binding AURKB, CYP2D6, MET, PPARA, PRKCD, TNKS 2.32943
[BP] GO:0010522 None BCL2, CACNA1C, DRD1, F2, PRKCE 2.32006
[BP] GO:0010676 None ESRRB, PPARA, PRKCE, SRC 2.28243
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MAP2K1, MMP1, MMP9, PRKCD, SRC 2.27983
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.27403
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2, FABP3, HTR2A, HTR2B, KCNA3, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.26536
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.26308
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.25653
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.25653
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.25024
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CDK6, DRD2, DRD3, ESRRA, ESRRB, F2, HTR2A, KDR, MAP2K1, PPARA, PRKCA, PRKCB, RELA, RORC, XDH 2.23261
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, PRKCG 2.22841
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA, PRKCA 2.22609
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.21819
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 2.21819
[BP] GO:0070213 None TNKS, TNKS2 2.21409
[BP] GO:0006145 None AOX1, XDH 2.21409
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21409
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.20729
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.20729
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PRKCD, PTPN1, SRC 2.1975
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, AR, BCL2, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP9, PRKCB, PRKCD, PTPN1, RELA, SRC, XDH 2.19214
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1685
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.1685
[BP] GO:1903034 regulation of response to wounding F2, F3, MAP2K1, PRKCA, PRKCD, PRKCE 2.16542
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA, PRKCA 2.16336
[BP] GO:0006816 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B, PRKCB, PRKCE 2.16336
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 2.15662
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, PRKCE 2.15583
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.15583
[BP] GO:0032409 None APP, BCL2, DRD2, DRD3, MMP9, PRKCD, PRKCE 2.15583
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.15192
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, MAP3K7, PRKCB, RELA 2.14657
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PRKCD, SRC 2.14427
[BP] GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling APP, ESR1, HTR2B, MAP3K7, PRKCB, PRKCE, RELA 2.13735
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, F2, PPARA, PRKCD 2.13417
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, F2, HCAR2, HTR2B, PRKCD, PRKCE, SRC 2.13043
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.12342
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12342
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.10952
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.10952
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.10952
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, CACNA1C, CHRM2, DRD2, DRD3, HCAR2, HTR2A, PRKCA 2.10909
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, F2, FABP3, HTR2A, HTR2B, KCNA3, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SIGMAR1, SRC, TNKS, XDH 2.10909
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HTR2A, PPARA, PRKCE, RORC, SRC 2.10093
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 2.09336
[BP] GO:0050708 None ACHE, CACNA1C, DRD2, DRD3, HCAR2, HTR2B, PRKCA, PRKCE, SRC 2.09148
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.08628
[BP] GO:0045088 regulation of innate immune response DRD2, ESR1, MAP3K7, MMP2, PRKCD, PRKCE, PTPN1, RELA, SRC 2.08557
[BP] GO:0034765 None APP, CACNA1C, DRD1, DRD2, DRD3, F2, KCNA3, MMP9, PRKCE 2.07912
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.07912
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.07892
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07892
[BP] GO:0040007 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, SRC, TNKS2 2.06005
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.04378
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA 2.03972
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, HTR2B, PRKCE, SRC 2.03972
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.03947
[BP] GO:0021853 None DRD1, DRD2 2.03853
[BP] GO:0043696 None CDK6, ESRRB 2.03853
[BP] GO:0043697 None CDK6, ESRRB 2.03853
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.03853
[BP] GO:0010641 None F3, SRC 2.03853
[BP] GO:0090325 None DRD2, DRD3 2.03853
[BP] GO:1904936 None DRD1, DRD2 2.03853
[BP] GO:0042321 None ADORA1, DRD2 2.03853
[BP] GO:0010513 None HTR2A, HTR2B 2.03853
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, PRKCD 2.03773
[BP] GO:0045685 None APP, DRD3, F2, RELA 2.02248
[BP] GO:0051172 None APP, AR, AURKB, CSNK2A1, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, FABP4, IGF1R, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.01456
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNA3, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SIGMAR1, SRC, TNKS, TNKS2, TYR 6.47411
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, GBA2, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNA3, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 5.65364
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR5A, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 4.88776
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HSD17B3, HTR5A, KDR, MAP2K1, PRKCA, PRKCD, PRKCE, PTPN1, SIGMAR1, XDH 4.36638
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, CHRM2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 3.99186
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, F2, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1, SIGMAR1 3.7111
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.36288
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, SIGMAR1 3.31594
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNA3, KDR, MAOA, MET, PRKCG, PTGES, PTPN1, SIGMAR1, SRC, TYR 3.26731
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CHRM2, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 3.22811
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM2, DRD1, DRD2, DRD3, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNA3, KDR, MET, PRKCG, SIGMAR1, SRC 3.10233
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, HTR2A, HTR5A, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SHBG, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.69406
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, PRKCA, PRKCD, PRKCE, PRKCG, PTGES, SRC, TNKS2, TYR 2.5182
[CC] GO:0043226 organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, HTR2A, HTR5A, HTR6, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SHBG, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.24299
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TNKS, TYR, XDH 18.9126
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.6469
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 14.5383
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 11.8211
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5115
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TNKS 10.2665
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1468
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 9.98016
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 8.59629
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, PPARA, PRKCE, RORC, SIGMAR1 8.50824
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SIGMAR1, SRC 8.42677
[MF] GO:0008227 None ADRA1A, CHRM2, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.41888
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.8675
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CDK6, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 7.8675
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.5377
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, RORC, SIGMAR1 7.51088
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.33813
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 7.14306
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F2, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 6.97373
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC, SHBG 6.97373
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.75423
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.5184
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.5184
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.51267
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.51267
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.47411
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.47411
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.47411
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.11819
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.11819
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.98023
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.72752
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.67132
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.62528
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.52235
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 4.99956
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.88151
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.71494
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.70461
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.69202
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.68108
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.57502
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 4.47252
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 4.44886
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 4.44886
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.36638
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B2, HSD17B1, PTGES, SRC, XDH 4.32036
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.26169
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.2598
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, SHBG 4.17641
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.13856
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, PRKCD, SRC 3.6909
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.39625
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, MAP2K1, MAP3K7, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.14561
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.10349
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CHRM2, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.00345
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.963
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.86369
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.86369
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86369
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86369
[MF] GO:0008389 None CYP2A13, CYP2A6 2.86369
[MF] GO:0035403 None PRKCA, PRKCB 2.86369
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, RORC, SHBG, SRC, XDH 2.84623
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.77069
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.67021
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.5326
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.5182
[MF] GO:0004699 None PRKCD, PRKCE 2.4585
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.45751
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.27403
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, F2, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, RELA, SRC, XDH 2.21819
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21409
[MF] GO:0005497 None AR, SHBG 2.21409
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNA3, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SHBG, SIGMAR1, SRC, TNKS, TNKS2, TYR, XDH 2.19214
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.13647
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.03853
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, RELA, SRC 2.01456


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.6238
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, MAP2K1, PRKCB, MAOA, HTR2B, HTR1A, PRKCA, CACNA1C, HTR2A, HTR5A, HTR6, HTR7, CYP2D6, ALOX5 15.5664
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, HTR6, HTR7, PRKCB, HTR2B, PRKCA, CACNA1C, HTR2A, DRD1, HTR5A, ADRA1A 8.8483
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 9.4675
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR2B, HTR1A, HTR2A, F2, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 8.8483
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, F3, RELA 7.613
Gap junction_Homo sapiens_hsa04540 PRKCG, MAP2K1, PRKCB, SRC, HTR2B, PRKCA, HTR2A, DRD1, DRD2 8.0877
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, MAP2K1, PRKCB, SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, IGF1R 7.3561
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, MAP2K1, PRKCB, FLT3, MMP1, MMP2, PRKCA, MMP9, RELA, IGF1R, AR, CDK6, BCL2, MET 7.2475
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, MAP2K1, ADORA1, HTR1A, CACNA1C, DRD1, DRD2, PPARA, RELA 7.4013
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 7.4417
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.3015
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, MAP2K1, CDK6, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, CDC25B 6.8099
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, SRC, PRKCE, PRKCD, HTR2B, PRKCA, HTR2A 6.6868
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, MAP2K1, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, RELA 7.2131
Hepatitis B_Homo sapiens_hsa05161 PRKCG, MAP2K1, CDK6, PRKCB, SRC, BCL2, PRKCA, MMP9, RELA 6.5547
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, MAP2K1, PRKCB, BCL2, PRKCA, CACNA1C 6.3143
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, MAP2K1, PRKCB, PRKCE, PRKCD, PRKCA, CACNA1C, ADRA1A 6.0742
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, MAOA, PRKCA, CACNA1C, DRD1, DRD2, DRD3 5.8758
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, PRKCB, SRC, MMP2, PRKCD, PRKCA, CACNA1C 5.7399
Focal adhesion_Homo sapiens_hsa04510 PRKCG, MAP2K1, PRKCB, SRC, KDR, BCL2, PRKCA, MET, IGF1R 5.5223
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, PRKCD, MMP9, ESR1, ESR2 5.5277
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, MAP2K1, PRKCB, SRC, KDR, PRKCA, DRD2, MET, IGF1R 5.4143
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, HSD17B3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.3551
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.0101
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, MAP2K1, PRKCB, SRC, KDR, PRKCA 5.5277
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, MAP2K1, PRKCB, BCL2, PRKCA, RELA, IGF1R 5.4462
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, MAP2K1, HTR7, PRKCB, KDR, PRKCA, MET, RELA, IGF1R 5.2093
Glioma_Homo sapiens_hsa05214 PRKCG, MAP2K1, CDK6, PRKCB, PRKCA, IGF1R 5.4161
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, MAOA, PRKCA, CACNA1C, DRD1 5.3694
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.7153
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.1832
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, MAP2K1, PRKCB, PRKCE, PRKCD, PRKCA 4.6371
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, PRKCE, PRKCD, PPARA, RELA 4.2731
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, CDK6, KDR, BCL2, PRKCA, MET, RELA, IGF1R 3.9427
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, MAP2K1, PRKCB, PRKCA, CACNA1C, MAP3K7, RELA, CDC25B 4.0074
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, MAP2K1, PRKCB, SRC, PRKCA, ESR1 4.1082
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, MAP2K1, CDK6, PRKCB, PRKCA 4.5287
Long-term depression_Homo sapiens_hsa04730 PRKCG, MAP2K1, PRKCB, PRKCA, IGF1R 4.3913
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 4.0552
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, MAP2K1, PRKCB, PRKCA, CACNA1C 4.2091
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA, CACNA1C 3.8453
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, MAP2K1, PRKCB, SRC, PRKCA, CACNA1C 3.5141
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, MAP2K1, PRKCB, SRC, PRKCA 3.7049
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1 4.125
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.6751
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, PRKCE, ADORA1, CACNA1C, ADRA1A 3.3974
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA, CACNA1C 3.6899
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA, DRD1 3.6375
Melanogenesis_Homo sapiens_hsa04916 PRKCG, MAP2K1, PRKCB, PRKCA, TYR 3.4831
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.1756
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2042
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, MAP3K7, RELA 3.6091
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA, MAP3K7 2.8321
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, MMP2, PRKCA, MMP9 3.1677
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.4388
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PRKCB, SRC, PRKCD, RELA 2.3774
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA, CACNA1C 2.5804
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, MAP2K1, PRKCB, PRKCA 2.5058
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA, RELA 2.5098
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.3865
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.9508
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA, CACNA1C 2.5058
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 3.0128
HTLV-I infection_Homo sapiens_hsa05166 RELA 0.1561
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA, ADRA1A 2.6801
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA, CACNA1C 2.7488
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA, CACNA1C 2.3409
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.5696
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PRKCD, BCL2, RELA 2.2708
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 2.1012
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.2918
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, MAP2K1, PRKCB, PRKCA 2.1075
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2515
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2607
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA, CACNA1C, ADRA1A 2.0052
Influenza A_Homo sapiens_hsa05164 MAP2K1, PRKCB, PRKCA, RELA 1.7703
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.7421
Axon guidance_Homo sapiens_hsa04360 MET 0.3453
Platelet activation_Homo sapiens_hsa04611 SRC 0.356
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.5943
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0534
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, SRC, F2 1.5154
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1464
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.3535
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.292
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4065
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.3409
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4141
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7948
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4327
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6609
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.3369
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.403
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7612
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4493
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 1.0114
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4498
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.7948
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4748
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.7275
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2491
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, ADRA1A, IGF1R 1.4697
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.108
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4493
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8176
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.1385
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.7731
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.7948
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PRKCA 0.7545
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.7086
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6297
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4554
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4493
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.6476
Peroxisome_Homo sapiens_hsa04146 XDH 0.4656
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 1.7086
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4656
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4829
Pertussis_Homo sapiens_hsa05133 RELA 0.4946
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.636
Bile secretion_Homo sapiens_hsa04976 CA2 0.5095
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.8368
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4969
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PRKCB, PRKCA 3.9069
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.0088
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PRKCB, RELA 2.0204
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5174
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 2.0204
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2, RELA 3.5807
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 2.1075
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C 1.0937
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5429
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.1006
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5429
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, MAP3K7, RELA 2.0204
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.2106
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.0397
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1315
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.0875
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.1251
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PRKCA 1.2249
Legionellosis_Homo sapiens_hsa05134 RELA 0.5948
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2091
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5948
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6112
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2091
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2449
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2548
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.616
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.616
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGES 2.1754
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2498
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6182
Malaria_Homo sapiens_hsa05144 MET 0.6232
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3389
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.2498
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.2764
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6286
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.6482
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3324
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3085
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.634
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCE, PRKCD, CACNA1C 2.4505
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6889
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7364
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4748
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.8041
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7948
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8058
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7737
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7948
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.8041
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7948
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8147
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.783
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7841
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8058
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7421
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6564
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8413
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.978
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.957
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0493
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3389
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2341


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)