TCM Prescription: An Nao Niu Huang Tablets



Prescription Description
Prescription IDTCMF2940
Pinyin NameAn Nao Niu Huang Pian
Chinese Name安脑牛黄片
English NameAn Nao Niu Huang Tablets
Function Description神昏, 发热, 痉病
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationHeart, Brain, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1573 Bovis calculus 牛黄 TCMH1573
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH2329 Realgar 雄黄 TCMH2329
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH2605 Margarita 珍珠 TCMH2605
TCMH2316 Magnolia liliflora 辛夷 TCMH2316 GBVT919-13, GBVT884-13
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, MAOB, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 14.2844
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, KDR, KIT, MAOA, MAOB, MET, NR1H4, PPARA, PTAFR, PTGS2, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 13.1617
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DHFR 13.099
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, KIT, MAOB, MMP2, NR1H4, NR3C1, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 13.0395
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, GSK3B, HCAR2, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 12.7099
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, GSK3B, HCAR2, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 12.6987
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2295
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, KIT, MAOB, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TERT, TYR 12.0696
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, FABP3, FDPS, FUT7, HMGCR, HSD17B3, IDO1, NR1H4, PDE5A, PIM1, PPARA, PTAFR, PTGES, PTGS2, TYR, XDH 11.4646
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, DHFR, DRD1, DRD2, FDPS, HMGCR, HSD17B3, MAOA, MAOB, NR1H4, PTAFR, TYR 11.4063
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, THRA, TNKS, TNKS2, XDH 10.5514
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, THRA, TNKS, TNKS2, XDH 10.3622
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, GRM1, GSK3B, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 10.1095
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 9.79723
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 9.66788
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MAOB, MMP9, PTGES, PTGS2, RELA, SRC, TERT 9.66324
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 9.66085
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, FABP3, FLT3, GRM5, GSK3B, IGF1R, KIT, MAOB, MMP2, NR1H4, NR3C1, PPARA, PTAFR, PTGS2, RELA, SRC 9.36689
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD2, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MMP12, MMP2, MMP9, PDE5A, PGR, PIM1, PTAFR, PTGES, PTGS2, RELA, SRC, TERT, XDH 9.29751
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 9.18934
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 9.13038
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, KIT, MET, NR1H4, PPARA, PTGES, PTGS2 8.95352
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, MAOB, NR1H4, NR3C1, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 8.91658
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, FLT3, MAOB, NR3C1, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 8.86893
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, GRM1, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MET, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 8.71237
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 8.65587
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 8.48756
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NR1H4, PDE5A, PTAFR, PTGS2, PTPN1, SRC, XDH 8.38202
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NR1H4, PDE5A, PTAFR, PTGS2, PTPN1, SRC, XDH 8.38202
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR1H4, NR3C1, PTAFR, PTGS2, RELA, RORC, SRC, TERT 8.33758
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, KIT, MMP2, NR1H4, NR3C1, PTAFR, PTGS2, RELA, RORC, SRC 8.20316
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GRIK5, GRM5, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MET, MMP12, MMP9, NR1H4, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, THRA 8.15721
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FDPS, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP2, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 7.95356
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 7.92561
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS, HMGCR, HSD17B1, HSD17B2, HSD17B3, NR1H4 7.78713
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 7.73541
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 7.73541
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, NR1H4, PPARA, SLC1A1 7.70143
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.61559
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, THRA, XDH 7.50257
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, NR1H4, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 7.46113
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT, THRA, XDH 7.41432
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, NR1H4, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 7.39114
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, NR1H4, NR3C1, PGR, PIM1, PPARA, RELA, RORC, SRC, THRA, THRB 7.39114
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, DRD2, FLT3, GRM1, HMGCR, KDR, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, XDH 7.34821
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MAOB, PTGS2, TYR, XDH 7.30406
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NR1H4, NR3C1, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT 7.06936
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, TYR 7.04623
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 7.01939
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, HCAR2, HMGCR, KDR, NR1H4, PTGS2, SRC, TNKS, TNKS2 6.95451
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTAFR, PTGS2, RELA, RORC, SRC, THRA, THRB, TNKS2, TYR 6.94421
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 6.92976
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 6.88732
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DHFR, DRD1, DRD2, DYRK1A, FDPS, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 6.87419
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TERT 6.85528
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, GRIK5, GRM5, GSK3B, HCAR2, HMGCR, MAOB, MAP2K1, MMP12, MMP9, NR1H4, PPARA, PTAFR, PTGS2, PTPN1, SRC, TERT, THRA 6.83514
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 6.83514
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, F3, HCAR2, HMGCR, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SRC, TERT 6.83385
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FDPS, FLT3, HCAR2, HMGCR, KIT, NR1H4, PPARA, PTGS2, RORC, SRC, THRA 6.77724
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, PTGS2 6.70814
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, DAO, DHFR, FDPS, HMGCR, HSD17B3, PTAFR, TYR 6.67099
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, APP, CYP19A1, DHFR, DRD2, DYRK1A, F3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 6.65019
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 6.64611
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, GRM3, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 6.64299
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, NR1H4 6.59431
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 6.59431
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, FABP3, HMGCR, KDR, MAOB, NR3C1, PTAFR, PTGS2, RELA, SRC 6.58456
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MAOB, MMP9, PTGES, PTGS2, TERT 6.57398
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, MAOB, NR3C1, PPARA, PTAFR, PTGS2, RELA, SRC 6.57186
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, GRM3, GRM8, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 6.47877
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 6.46571
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DHFR, DRD1, DRD2, DYRK1A, FDPS, FLT3, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PDE5A, PIM1, PTAFR, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 6.46571
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DNMT1, DRD1, GRIK5, GRM5, GSK3B, IGF1R, MMP2, MMP9, NR1H4, NR3C1, PTAFR, PTGS2, RELA, RORC, SRC 6.43404
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, MAP2K1, MMP9, NR1H4, PIM1, PTGS2, PTPN1, RELA, SRC, TERT, THRA, XDH 6.42894
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 6.38525
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PPARA, PTAFR, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, THRA, TNKS, TNKS2, XDH 6.36636
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTPN1, RELA, RORC, SRC, THRA, THRB, TNKS, TNKS2 6.34376
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, SRC, XDH 6.2817
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, NR1H4, PPARA, SLC1A1 6.21186
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, BCL2, CA2, CACNA1C, CYP1B1, DRD2, F3, GRM1, GSK3B, HCAR2, HMGCR, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, PTAFR, PTGS2, PTPRS, RELA, SLC1A1, SRC, TERT, THRA, THRB, TNKS2, XDH 6.18499
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, BCL2, CDC25B, CSNK2A1, DRD2, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, RELA, TERT 6.04353
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, DRD2, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, XDH 6.02647
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 5.97864
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 5.94255
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DRD1, DRD2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 5.89159
[BP] GO:0018958 None AKR1B1, BCL2, DAO, DRD1, DRD2, MAOA, MAOB, TYR 5.85773
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SRC, XDH 5.838
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.80671
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, DHFR, DRD2, F3, FLT3, GRM1, GRM5, GSK3B, KIT, MAP2K1, MAP3K7, MET, MMP9, PDE5A, PTAFR, PTPN1, RELA, SRC, TERT, TNKS, XDH 5.72669
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, DNMT1, DRD1, DRD2, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 5.65933
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, DNMT1, FABP3, HSD17B2, KDR, MMP2, NR1H4, PTAFR, PTGES, PTGS2, RELA, SRC 5.64339
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 5.64339
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, DNMT1, DRD1, FLT3, GRM5, GSK3B, IGF1R, KIT, MMP2, NR1H4, NR3C1, PTAFR, PTGS2, RELA, SRC 5.61971
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, RELA, SRC, TERT 5.60615
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTGS2, PTPN1, RELA, SRC, XDH 5.60615
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 5.57708
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 5.53574
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DYRK1A, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B2, HSD17B3, KDR, KIT, MAOB, MAP2K1, MET, MMP2, MMP9, PGR, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS2, TYR 5.49605
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, MAOB, NR3C1, PTAFR, PTGS2, RELA, SRC 5.48311
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, KIT, MET, PPARA, PTGES, PTGS2 5.47561
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DRD2, DYRK1A, FABP4, GRM3, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 5.4538
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, MAOB, RELA, SRC 5.4538
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, NR1H4, PTAFR, PTPN1, RELA, SRC, TNKS, TNKS2 5.43992
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, F3, FLT3, GRM1, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, THRA, TNKS, TNKS2, XDH 5.36192
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 5.32896
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, CACNA1C, DRD2, PDE5A, PTAFR, PTGS2, SLC1A1, THRA, THRB 5.32265
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, DRD2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, NR1H4, PDE5A, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, SRC, TERT, TNKS, XDH 5.3165
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 5.22185
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, GRM1, HMGCR, KIT, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC, TERT, THRA, TYR 5.21474
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, DNMT1, DRD1, DRD2, FABP3, FLT3, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 5.20472
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 5.20143
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 5.19458
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, TNKS 5.13981
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, FDPS, HMGCR, HSD17B3, IDO1, PTAFR, PTGES, PTGS2 5.02135
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.98799
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 4.97938
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, CACNA1C, DRD2, GRM1, HCAR2, KIT, PDE5A, PTAFR, PTGS2, SLC1A1, THRA, THRB 4.96162
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 4.95022
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, HSD17B2, HSD17B3, IDO1, KIT, MAP2K1, MMP2, MMP9, PGR, PTAFR, PTGS2, SRC, THRA, THRB 4.91237
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.89251
[BP] GO:0006584 None AKR1B1, DAO, DRD1, DRD2, MAOA, MAOB 4.884
[BP] GO:0009712 None AKR1B1, DAO, DRD1, DRD2, MAOA, MAOB 4.884
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, DRD2, IDO1, MAOA, MAOB 4.88287
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 4.87588
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DYRK1A, FLT3, GSK3B, HSD17B2, HSD17B3, KDR, KIT, MAOB, MAP2K1, MMP9, PGR, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SRC, THRA, TYR 4.87588
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.83437
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 4.78848
[BP] GO:0007188 None ADORA1, ADRA2A, ADRA2C, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 4.77248
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, DRD1, DRD2, DYRK1A, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 4.74837
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PTAFR, PTGS2, RELA, SRC 4.74286
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, GRM1, GRM3, GRM5, GRM8 4.7381
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.7381
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.7381
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AR, BCL2, DRD1, DRD2, DYRK1A, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 4.7381
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.73015
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PPARA, PTPRS, RELA, SRC, THRA, TYR 4.72262
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.71922
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 4.70598
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, BCL2, CDC25B, DHFR, DRD2, F3, FLT3, GRM1, GRM5, GSK3B, KIT, MAP2K1, MAP3K7, PDE5A, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 4.5981
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 4.59533
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, NR1H4, PTGES, PTGS2, RELA, SRC 4.58258
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SRC, TERT 4.54771
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, GSK3B, KIT, PGR, PPARA, RORC, SRC 4.48193
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, FLT3, NR3C1, PTAFR, PTGS2, RORC, SRC 4.46002
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2, NR1H4, PTGS2, TNKS, TNKS2 4.4578
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 4.42749
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD17B1, HSD17B2, HSD17B3 4.42749
[BP] GO:0042417 None DAO, DRD1, DRD2, MAOA, MAOB 4.42208
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 4.41758
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, GRM5, GSK3B, IGF1R, MMP2, NR1H4, PTAFR, PTGS2, RELA, SRC 4.3993
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 4.38733
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, MAOB, NR3C1, PTAFR, RELA, SRC 4.35804
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.35202
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, NR1H4, PTGES, PTGS2, RELA, SRC 4.34003
[BP] GO:0051094 positive regulation of developmental process ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, F3, HMGCR, IDO1, KDR, KIT, MAP2K1, NR1H4, PDE5A, PIM1, PTGS2, RELA, SRC, TERT, THRA 4.32107
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DRD2, FLT3, GRM1, GRM5, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 4.32007
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, AR, BCL2, CYP19A1, DRD1, DRD2, DYRK1A, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 4.30289
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, DRD1, DRD2, MAOA, MAOB 4.29546
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC, TNKS 4.28683
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, GSK3B, HCAR2, MMP12, NR1H4, PTAFR, PTGS2, SRC, TERT 4.28611
[BP] GO:0007187 None ADORA1, ADRA2A, ADRA2C, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 4.28455
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DRD2, FABP4, GRM3, GSK3B, HMGCR, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.2839
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 4.2493
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 4.2456
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 4.23627
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.23627
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, F3, FABP4, HMGCR, IDO1, KDR, MAP2K1, MET, MMP12, NR1H4, PPARA, PTGS2, PTPRS, RELA 4.2345
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.23347
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, GRM5, MAOB, MMP9, PTAFR, PTGS2 4.23124
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, BCL2, CACNA1C, CSNK2A1, DRD1, DRD2, GRIK5, GSK3B, HMGCR, MAP2K1, NR1H4, PTGS2, PTPN1, SRC, TERT, THRA 4.20187
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.1973
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.16687
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, NR1H4, PPARA, SLC1A1 4.14762
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 4.12106
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HMGCR, SRC, TNKS, TNKS2 4.07497
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, DRD1, DRD2, GRIK5, MAOA, MAOB, PTGS2, SLC1A1 4.07491
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 4.05343
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ADRA2C, CDC25B, DRD2, FLT3, GRM1, GRM5, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 4.05343
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, CACNA1C, DRD2, GSK3B, HCAR2, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 4.0522
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD17B1, HSD17B2, HSD17B3, PTGES, PTGS2 4.01074
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, KIT, PTAFR, PTGS2 3.97206
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DRD2, DYRK1A, FABP4, GRM3, GRM8, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 3.96678
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 3.95227
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 3.94001
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 3.93894
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 3.93894
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, AR, BCL2, CACNA1C, CSNK2A1, DRD2, GSK3B, HCAR2, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, TERT, THRA 3.93198
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DHFR, DRD1, DRD2, DYRK1A, F3, FLT3, FUT7, GSK3B, HMGCR, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TYR, XDH 3.89824
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, KDR, SRC 3.89425
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, NR1H4, SRC, TERT 3.87241
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, MAOB, NR3C1, PTAFR, PTGS2, SRC 3.87241
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 3.87241
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR, PTGS2, SRC 3.87241
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 3.86486
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOA, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 3.85536
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, HSD17B3, IDO1 3.85016
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, APP, BCL2, DRD2, GSK3B, HMGCR, MAOB, MMP9, NR1H4, PTGS2, THRA 3.81264
[BP] GO:0006937 None ADORA1, ADRA2A, ADRA2C, CACNA1C, KIT, PDE5A, PTAFR, PTGS2 3.7632
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, NR3C1, PTAFR, PTGS2, RELA, SRC 3.73385
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, HMGCR, KIT, PTGS2, RELA, TYR 3.69628
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, CYP19A1, DRD2, GRIK5, HCAR2, HMGCR, MAOB, MMP12, NR1H4, PTAFR, SRC 3.6956
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, GRM5, PTPN1 3.68828
[BP] GO:0007617 None APP, DRD1, THRA, THRB 3.66219
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NR1H4, SRC, TNKS 3.65107
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, HMGCR, IGF1R, MET, MMP9, NR1H4, PTGS2, PTPN1, RELA, SRC, XDH 3.63585
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 3.61943
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, GRM5, PTPN1 3.61943
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, PTGS2 3.57556
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, GSK3B, MAP2K1, TNKS 3.57556
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS2 3.57556
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, GRM5, KIT, PTPN1, SRC 3.57446
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, GRM5, KIT, PTPN1, SRC 3.56489
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, DRD2, FABP3, IDO1, MAP2K1, PDE5A, PTGES, PTGS2, TERT, XDH 3.56404
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PDE5A, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 3.54671
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, NR1H4, PPARA, PTGS2, SRC 3.54054
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR, PTGS2 3.52039
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR, PTGS2 3.52039
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS, HMGCR 3.49888
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, GSK3B, IDO1, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NR1H4, PPARA, PTAFR, PTGES, PTGS2, PTPN1, RELA, SRC, TERT, THRA 3.49888
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, FABP3, IGF1R, KDR, MAP2K1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 3.4921
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, DRD2, PPARA 3.47304
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, PTAFR 3.47166
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, GRM1, GRM5, HMGCR, IDO1, KIT, PPARA, PTGS2, THRA, THRB 3.46963
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTAFR, PTGS2 3.44565
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 3.44321
[BP] GO:0008542 None APP, DRD1, DRD2, HMGCR, KIT 3.42256
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, BCL2, CACNA1C, DRD2, GSK3B, HCAR2, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 3.40564
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, GSK3B, MAP2K1, TNKS 3.39311
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ADRA2C, DRD2, GRM1, KIT, MAP2K1, MAP3K7, PTPN1, SRC 3.38568
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, CYP19A1, DRD2, GRIK5, HCAR2, HMGCR, MAOB, MMP12, NR1H4, PTAFR, SRC 3.37101
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C, DRD2 3.36938
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR, PTGS2 3.36715
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR, PTGS2 3.34702
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DYRK1A, GSK3B, HMGCR, IGF1R, MAP2K1, MAP3K7, MET, PTGS2, PTPN1, PTPRS, TERT, XDH 3.31548
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 3.31122
[BP] GO:0051172 None ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DRD2, DYRK1A, FABP4, GRM3, GRM8, HMGCR, IGF1R, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 3.30272
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.30254
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.30254
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, NR1H4 3.29664
[BP] GO:0046165 None AKR1B1, CYP3A4, DHFR, FDPS, HMGCR, PTAFR 3.29664
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, HMGCR, KIT, PTGS2 3.29664
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, NR1H4, PPARA, PTGES, PTGS2 3.29561
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.2812
[BP] GO:0003008 None ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, BCL2, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HMGCR, KIT, PDE5A, PTAFR, PTGS2, SRC, THRA, THRB, TYR 3.28053
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, THRA 3.27862
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.26999
[BP] GO:0045932 None ADORA1, ADRA2C, PDE5A, PTGS2 3.24739
[BP] GO:0048169 None APP, DRD2, GRM5, KIT 3.24739
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, MAOB, NR3C1, PTAFR, PTGS2 3.24739
[BP] GO:0007632 None APP, DRD1, DRD2, HMGCR, KIT 3.24602
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 3.24389
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 3.24389
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, DNMT1, DRD2, GSK3B, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.2393
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGES, PTGS2, TYR 3.22165
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, MAOB, MMP9, PTGS2 3.21616
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, FABP4, FDPS, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 3.21616
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, ADRA2C, CACNA1C, CYP19A1, DRD2, HCAR2, HMGCR, NR1H4 3.20164
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, DRD1, DRD2, GRM5, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PTAFR, PTPN1, RELA, SRC 3.19644
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.19638
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, DRD2, DYRK1A, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, XDH 3.18664
[BP] GO:0007154 None ADORA1, ADRA2C, AR, AXL, BCL2, CACNA1C, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PTGS2, SLC1A1 3.17425
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, FABP3, IGF1R, MAP2K1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTAFR, PTGS2, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 3.16959
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 3.16004
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, GSK3B, IGF1R 3.13796
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 3.13163
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 3.12832
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, GRM1, HMGCR, IGF1R, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 3.12832
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, DRD1, HMGCR, PTAFR, PTGS2, SRC 3.12504
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CA3, CYP1B1, MMP9, PTGS2, RELA, SRC 3.12177
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT, TNKS 3.12177
[BP] GO:0045934 None ADRA2A, AR, AURKB, DNMT1, DRD2, DYRK1A, FABP4, GRM3, GRM8, MMP12, NR1H4, NR3C1, PPARA, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 3.12177
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, GRM5, HMGCR, KIT, PTGS2, THRA 3.11154
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, APP, CACNA1C, DRD2, GSK3B, HCAR2, HMGCR, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 3.1114
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, FABP4, IDO1, MAP3K7, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, PTPRS, RELA, SRC 3.08138
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, HSD17B2, HSD17B3, KIT, MAP2K1, PGR, PTGS2, SRC 3.07184
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, DHFR, FDPS, HMGCR, PTAFR 3.06783
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, GSK3B, IGF1R, PPARA, PTGS2, RELA, SRC 3.06783
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.04968
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, FLT3, GRM1, KIT, MAP2K1, MAP3K7, PDE5A, PTPN1, SRC 3.04894
[BP] GO:0019098 None APP, DRD1, THRA, THRB 3.03728
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.03728
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, KIT, PTGS2 3.01431
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.00548
[BP] GO:1904645 response to amyloid-beta APP, GRM5, GSK3B, IGF1R 2.98186
[BP] GO:0034762 None ABCB1, ADRA2A, APP, BCL2, CA2, CACNA1C, DRD1, DRD2, GRM5, MMP9, PTAFR 2.97626
[BP] GO:0001817 regulation of cytokine production ADRA2A, AXL, CYP1B1, DRD2, IDO1, MAP3K7, MMP12, NR1H4, PTAFR, PTGS2, PTPRS, RELA, SRC 2.94677
[BP] GO:0046888 None ADORA1, ADRA2A, ADRA2C, DRD2, HMGCR 2.94052
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, DRD1, DRD2, IGF1R, MAP2K1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.94052
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FDPS 2.91978
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 2.90977
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 2.90778
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 2.90284
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.90284
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.88719
[BP] GO:0019371 None CBR1, PTGES, PTGS2 2.88719
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 2.8844
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, ADRA2C, CACNA1C, DRD2, HCAR2, HMGCR, MMP12, NR1H4, SRC 2.87634
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, DRD2, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PGR, PTGS2, PTPRS, RORC, SRC, TERT, THRA, THRB 2.84754
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, GSK3B, SRC, TNKS 2.84501
[BP] GO:0022898 None ABCB1, ADRA2A, APP, BCL2, DRD2, GRM5, MMP9, PTAFR 2.84042
[BP] GO:0090257 None ADORA1, ADRA2A, ADRA2C, CACNA1C, KIT, PDE5A, PTAFR, PTGS2 2.84042
[BP] GO:0008050 None THRA, THRB 2.80524
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, HMGCR, MAP2K1, PTGS2, RELA, TERT 2.80216
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, DRD1, KIT, PGR, PTGS2, SRC, THRA, THRB 2.79822
[BP] GO:0051930 None ADORA1, ADRA2C, GRM1, PTAFR 2.78918
[BP] GO:0051931 None ADORA1, ADRA2C, GRM1, PTAFR 2.78918
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP3A4, DAO, MAOA, MAOB 2.78724
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9, THRA 2.78724
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CYP1A1, CYP1A2, GSK3B, IDO1, MAOB, MMP12, NR1H4, PTAFR, PTGES, PTGS2, RELA, SRC 2.78152
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.78152
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGES, PTGS2, TYR 2.77888
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DYRK1A, FABP4, GSK3B, HMGCR, IGF1R, KDR, MAP2K1, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 2.77183
[BP] GO:0007611 None APP, DRD1, DRD2, GRM5, HMGCR, KIT, PTGS2, THRA 2.76053
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DRD2, HCAR2, IDO1, KIT, MAP3K7, MMP12, MMP2, NR1H4, PDE5A, PTAFR, PTPN1, PTPRS, RELA, SRC 2.75097
[BP] GO:0008016 None ADORA1, ADORA3, CACNA1C, DRD2, PDE5A, SLC1A1, THRA, THRB 2.7366
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, FLT3, KIT, MAP2K1, MET, PIM1, SRC, TYR 2.7277
[BP] GO:1900543 None ADRA2A, DRD2, GRM3, GRM8, PPARA 2.72381
[BP] GO:0008306 None APP, DRD1, DRD2, HMGCR, KIT 2.72381
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.72016
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, IGF1R, KDR, MAP2K1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTAFR, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.71915
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 2.70178
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, NR1H4, SRC 2.70178
[BP] GO:0045980 None ADRA2A, DRD2, GRM3, GRM8, PPARA 2.70178
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGES, PTGS2, TYR 2.70178
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.68837
[BP] GO:0033604 None ADRA2A, ADRA2C, DRD2 2.68837
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, THRA, TYR 2.6878
[BP] GO:0032409 None ABCB1, ADRA2A, APP, BCL2, DRD2, GRM5, MMP9, PTAFR 2.6878
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, DRD2, IDO1, MAP3K7, MMP12, PTAFR, PTGS2, RELA, SRC 2.67694
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.67116
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS2 2.67116
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, DRD1, DRD2 2.59948
[BP] GO:1903531 None ADORA1, ADRA2A, ADRA2C, DRD2, HMGCR, MAOB, NR1H4 2.58541
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, GSK3B, SRC, TNKS 2.58541
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.5847
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.57639
[BP] GO:0050793 regulation of developmental process ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, F3, GSK3B, HMGCR, IDO1, KDR, KIT, MAP2K1, NR1H4, PDE5A, PIM1, PPARA, PTGS2, PTPRS, RELA, RORC, SRC, TERT, THRA, TNKS2, XDH 2.55795
[BP] GO:0045597 positive regulation of cell differentiation ADRA2C, APP, AR, AXL, BCL2, CA2, DRD2, KDR, KIT, MAP2K1, PDE5A, PTGS2, RELA, TERT, THRA 2.51694
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.50834
[BP] GO:0046173 None AKR1B1, CYP3A4, DHFR, PTAFR 2.5063
[BP] GO:0070542 None FABP3, NR1H4, PTAFR, PTGS2, SRC 2.50499
[BP] GO:0023052 None ADORA1, ADRA2C, AR, CACNA1C, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 2.47454
[BP] GO:0045776 None ADORA1, DRD2, PPARA, PTAFR 2.46874
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, HMGCR, KIT, PTGS2, RELA, TYR 2.45876
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.45876
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, CACNA1C, DRD2, HCAR2, HMGCR, MMP12, NR1H4, SRC 2.4428
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.43537
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.43537
[BP] GO:0045986 None ADORA1, ADRA2C, PTGS2 2.43537
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.43537
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CYP1A1, CYP1A2, IDO1, MAOB, MMP12, NR1H4, PTAFR, PTGES, PTGS2, RELA, SRC 2.43428
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HMGCR, KDR, MAP2K1, SRC 2.42331
[BP] GO:0030818 None ADRA2A, DRD2, GRM3, GRM8 2.40602
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.40602
[BP] GO:0099566 None GRM1, GRM5 2.40602
[BP] GO:0060748 None AR, PGR 2.40602
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40602
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.40602
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.40029
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.38308
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, KIT, NR1H4, PTAFR, PTGES, PTGS2, RELA 2.37387
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.37065
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HMGCR, KDR, MAP2K1, PTPN1, SRC 2.3598
[BP] GO:0030803 None ADRA2A, DRD2, GRM3, GRM8 2.34207
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, DHFR, MAOA, MAOB 2.34137
[BP] GO:0007267 None ADORA1, ADRA2C, AR, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 2.3342
[BP] GO:0030799 None ADRA2A, DRD1, DRD2, GRM3, GRM8, PDE5A 2.33307
[BP] GO:0071396 cellular response to lipid AR, AXL, FLT3, NR1H4, NR3C1, PTAFR, RELA, RORC, SRC 2.33122
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, HMGCR, NR1H4, PPARA, PTPRS 2.31212
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2, XDH 2.30154
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, GSK3B, IGF1R, RELA, SRC 2.30131
[BP] GO:0051048 None ADORA1, ADRA2A, ADRA2C, DRD2, HMGCR, MAOB, NR1H4 2.29025
[BP] GO:0030815 None ADRA2A, DRD2, GRM3, GRM8 2.2787
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, KIT, MET, SRC, XDH 2.26642
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, ADRA2A, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, FABP4, GRM3, GRM5, GRM8, GSK3B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTAFR, PTGS2, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.2564
[BP] GO:2000026 regulation of multicellular organismal development ADRA2C, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, F3, GSK3B, HMGCR, IDO1, KDR, KIT, MAP2K1, NR1H4, PIM1, PTGS2, PTPRS, RELA, SRC, TERT, XDH 2.25185
[BP] GO:1900372 None ADRA2A, DRD2, GRM3, GRM8 2.2491
[BP] GO:0030809 None ADRA2A, DRD2, GRM3, GRM8 2.2491
[BP] GO:0046626 regulation of insulin receptor signaling pathway NR1H4, PTPN1, RELA, SRC 2.2491
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.24745
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP3A4, DAO, IDO1, MAOA, MAOB, PDE5A, XDH 2.24297
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.24297
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOA, MAOB, PDE5A, XDH 2.24268
[BP] GO:0008217 None ADORA1, AR, DRD2, PPARA, PTAFR, PTGS2 2.23791
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.22888
[BP] GO:0030800 None ADRA2A, DRD2, GRM3, GRM8 2.22389
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.21823
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, ADRA2A, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FABP4, GRM3, GRM8, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP12, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTPN1, RELA, RORC, SRC, TERT, THRA, THRB, TNKS, TNKS2 2.21105
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.21105
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.20099
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.20099
[BP] GO:0048168 None APP, DRD2, GRM5, KIT 2.19652
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.18682
[BP] GO:0071880 None ADRA2A, ADRA2C, DRD2 2.18682
[BP] GO:0032412 None ABCB1, ADRA2A, APP, DRD2, GRM5, MMP9, PTAFR 2.15849
[BP] GO:0030817 None ADRA2A, DRD1, DRD2, GRM3, GRM8 2.15849
[BP] GO:0035625 None ADRA2A, ADRA2C 2.15849
[BP] GO:0032811 None ADRA2A, ADRA2C 2.15849
[BP] GO:0070213 None TNKS, TNKS2 2.15849
[BP] GO:1901529 None ABCB1, PTAFR 2.15849
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15849
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.15756
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 2.15218
[BP] GO:0099536 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.14971
[BP] GO:0099537 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.14971
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.14971
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.14886
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, HCAR2, MMP12, NR1H4, PTAFR, SRC 2.14801
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.14433
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.14433
[BP] GO:0042135 None ACHE, MAOA, MAOB 2.14433
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.14433
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, FABP3, GRM1, GRM5, NR1H4 2.12046
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, KIT, MAP3K7, NR1H4, PIM1, RELA 2.10437
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GSK3B, PTGES, PTGS2, RELA, SRC 2.10275
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 2.09743
[BP] GO:0010628 positive regulation of gene expression APP, AR, DNMT1, DRD1, DRD2, GSK3B, KIT, MAP2K1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTAFR, RELA, RORC, SRC, TERT, THRA, THRB, TNKS 2.09436
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.08908
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.08908
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.08108
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 2.08108
[BP] GO:2000243 None AR, PDE5A, PTAFR, SRC 2.07264
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.07264
[BP] GO:0050877 None ADORA1, APP, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HMGCR, KIT, PTGS2, THRA, THRB, TYR 2.0663
[BP] GO:0060627 regulation of vesicle-mediated transport ADRA2A, ALOX15, APP, AXL, DRD2, GRIK5, MAP2K1, PTAFR, PTPN1, SRC 2.06036
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, KIT, MMP12, MMP9, NR1H4, PPARA, PTAFR, SLC1A1, SRC, TERT, TNKS, XDH 2.05262
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, GRM3, GRM8, PDE5A, PPARA 2.04795
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.03912
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, ADRA2C, CACNA1C, DRD1, DRD2, GRM5, KDR 2.03912
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, KIT, MMP12, MMP9, NR1H4, PPARA, PTAFR, SLC1A1, SRC, TERT, THRA, TNKS, TNKS2, XDH 2.03756
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TYR 2.0196
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, DRD2, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP2, NR3C2, PGR, PIM1, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR 4.8698
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTAFR, PTPN1, PTPRS, SLC1A1, SRC, TERT 4.29388
[CC] GO:0044456 None ACHE, ADORA1, ADRA2C, APP, CACNA1C, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, PTPRS, SRC 4.22998
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA2A, CA2, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 4.21121
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PTAFR, PTGS2, PTPRS, SLC1A1, SRC 3.94178
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, BACE1, CA4, DRD1, DRD2, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1 3.89824
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM3, GRM5, GSK3B, HMGCR, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 3.67638
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, DRD2, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, SRC, TERT, THRA, TNKS, TNKS2, TYR, XDH 3.61376
[CC] GO:0043005 None ADORA1, ADRA2C, APP, BACE1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 3.57821
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD17B3, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 3.4534
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.26999
[CC] GO:0014069 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.21272
[CC] GO:0099572 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.21272
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, BACE1, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1 3.21272
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3, GSK3B 3.04742
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.97131
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.71741
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.68623
[CC] GO:0030424 None ADRA2C, APP, BACE1, CA2, DRD2, GRM3, PTPRS, TUBB3 2.51746
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAOB, MET, NR3C2, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TYR 2.40665
[CC] GO:0097458 None ADORA1, ADRA2C, APP, BACE1, CA2, CACNA1C, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IDO1, PTGS2, PTPRS, SRC, TUBB3 2.34207
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, GRIA2, HMGCR, HSD17B2, HSD17B3, NR3C2, PTGES, PTGS2, PTPN1 2.30025
[CC] GO:0120025 None ADORA1, ADRA2C, AKR1B1, APP, BACE1, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 2.23858
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 17.9258
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, THRA, THRB, TNKS, TYR, XDH 16.6319
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 15.9331
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, F3, FDPS, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PTGES, PTGS2, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 11.2847
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2327
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, THRA, THRB, TNKS 10.2997
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 9.79723
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 9.09234
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, FDPS, IDO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 8.33758
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 8.20316
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MAOB, PTGS2, TYR, XDH 8.07015
[MF] GO:0003707 steroid hormone receptor activity AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 8.03205
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 7.92638
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, THRA, THRB 7.63061
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.57688
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, FDPS, IDO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, TERT, THRA, THRB, TNKS, TNKS2, TYR, XDH 7.06936
[MF] GO:0005496 steroid binding AR, CYP3A4, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC, SHBG 6.75583
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.18398
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, NR1H4, PGR, PPARA, RORC, THRA, THRB 5.91627
[MF] GO:0004879 nuclear receptor activity AR, NR1H4, PGR, PPARA, RORC, THRA, THRB 5.91627
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, SHBG, THRA, THRB 5.5975
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HMGCR, HSD17B1, IDO1, MAOB, PTGES, PTGS2, SRC, XDH 5.32896
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.81671
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.57495
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.38733
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PTAFR 4.37371
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, KIT, MET, PTAFR 4.37371
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, F3, FABP3, FABP4, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, SHBG 4.34455
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.31099
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, HSD17B3, XDH 4.2345
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.20101
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DAO, DHFR, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, NR1H4, PDE5A, PIM1, PTAFR, PTGES, PTPRS, RELA, SLC1A1, SRC, TUBB3, XDH 4.16687
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.08074
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 3.84184
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC 3.8042
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 3.78168
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, APP, BCL2, CSNK2A1, DRD2, DYRK1A, FLT3, GRIK5, HMGCR, IGF1R, KDR, KIT, MAOB, MAP3K7, MET, MMP9, PGR, PTGS2, RELA, TERT, TYR, XDH 3.7179
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, HSD17B3 3.61447
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1, DRD2 3.57915
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.55024
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.54138
[MF] GO:0004887 None NR1H4, THRA, THRB 3.43783
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.29664
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.19638
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.17095
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.13796
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.13163
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, NR1H4, PDE5A, PIM1, SLC1A1, SRC, TUBB3, XDH 3.12177
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FDPS, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, MMP12, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RELA, RORC, SHBG, SRC, TERT, THRA, THRB, TUBB3, XDH 3.10975
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2, TYR 2.99857
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 2.90284
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, F3, GRM5, GSK3B, HMGCR, KIT, MET, NR3C1, PGR, PPARA, PTAFR, PTGS2, PTPN1, RELA, SRC, THRB, TNKS2 2.65466
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 2.5546
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, ADRA2C, BCL2, DRD2, FLT3, HMGCR, KIT, MAOB, PTGS2, RELA, TERT, TYR, XDH 2.5063
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTAFR, PTGES, PTGS2, PTPN1, PTPRS, RELA, RORC, SHBG, SLC1A1, SRC, TERT, THRA, THRB, TNKS, TNKS2, TUBB3, TYR, XDH 2.48026
[MF] GO:0016641 None DAO, MAOA, MAOB 2.43537
[MF] GO:0004935 None ADRA2A, ADRA2C, DRD2 2.43537
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, ADRA2C, AR, AXL, BCL2, DAO, DRD2, FLT3, HMGCR, KIT, MAOB, PTGS2, RELA, TERT, TYR, XDH 2.42206
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.40602
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.40602
[MF] GO:0004938 None ADRA2A, ADRA2C 2.40602
[MF] GO:0099583 None GRM1, GRM5 2.40602
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.24297
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.24297
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 2.21111
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SRC, TUBB3, XDH 2.16222
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, KIT, MAOB, MAP2K1, MAP3K7, MET, PDE5A, PIM1, SRC, TUBB3, XDH 2.16028
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.15849
[MF] GO:0004971 None GRIA2, GRIA4 2.15849
[MF] GO:0032795 None ADORA1, ADRA2A 2.15849
[MF] GO:0005497 None AR, SHBG 2.15849
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.15849
[MF] GO:0016638 None DAO, MAOA, MAOB 2.14433
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, THRA 2.14032
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TERT 2.04092
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SRC, THRA 2.02398
[MF] GO:0008134 transcription factor binding AR, BCL2, FLT3, GSK3B, NR1H4, PIM1, PPARA, RELA, SRC, TERT, THRA 2.01033


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.2064
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, THRB, THRA, GRIK5, PTAFR, NR3C1, ADRA2C, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4 11.4645
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.0849
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOB, MAOA, ALOX15, HSD17B3, AKR1B1, HMGCR, PTGS2, CYP3A4, CYP19A1, FUT7, ALOX5, HSD17B1, HSD17B2, XDH, FDPS, CBR1, TYR, DHFR, DAO, AKR1B10, CYP1A2, CYP1A1, ALPL, PTGES, IDO1 7.9355
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 7.7683
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 6.8204
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, MAOA, DRD1, DRD2, RELA 6.8489
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, MAP2K1, FLT3, MMP1, MMP2, PTGS2, MMP9, RELA, IGF1R, AR, KIT, BCL2, MET 5.8122
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, MAP2K1, ADORA1, CACNA1C, DRD1, DRD2, PPARA, RELA, GRIA4 5.9041
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, MAOA, CYP1A2, CYP1A1, CYP1B1, IDO1 5.9813
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOB, MAOA, ALOX5, ALOX15, CACNA1C, PTGS2 5.8122
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GSK3B, MAOB, MAOA, CACNA1C, DRD1, DRD2, GRIA4 5.3851
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, TUBB3, DRD1, DRD2, GRM1 5.3851
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, MAOA, CACNA1C, DRD1, GRIA4 4.8567
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, DNMT1, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.5827
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.6582
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, BCL2, RELA, IGF1R 4.2625
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.6582
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, PTGS2, GRM1, GRIA4 3.9884
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 4.4467
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, KIT, PIM1, RELA 4.0481
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, PDE5A, CACNA1C, ADRA2C, ADRA2A 3.7924
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, IGF1R 3.3194
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGES 3.909
Focal adhesion_Homo sapiens_hsa04510 GSK3B, MAP2K1, SRC, KDR, BCL2, MET, IGF1R 3.3194
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 3.7948
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KIT, KDR, DRD2, MET, IGF1R 3.2442
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, KIT, GRM8, GRM1 3.2594
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.6347
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.0641
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, NR1H4, HMGCR, CYP3A4 3.6763
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, GRM1 3.0916
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, MAP2K1, KIT, KDR, BCL2, MET, RELA, IGF1R 2.8216
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PTGS2, MMP9, MAP3K7, RELA 2.9101
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.2062
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, MAP2K1, THRB, THRA, SRC 2.8216
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 2.7989
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KIT, KDR, MET, RELA, IGF1R 2.4196
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 2.9101
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, BCL2, MMP9, RELA 2.4807
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR, PTGS2 2.9066
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, KIT, MET 2.794
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, SRC, RELA 2.7149
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PGR, CDC25B, IGF1R 2.2668
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.3775
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, CACNA1C, DRD1, GRM1 2.1695
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOB, MAOA, DRD1, DRD2 2.1695
Melanogenesis_Homo sapiens_hsa04916 GSK3B, MAP2K1, KIT, TYR 2.2429
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, MAOA, CYP1A2, CYP3A4 2.7683
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.204
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, MAP3K7, RELA 2.1967
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.1695
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7683
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.1465
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA, RELA 2.168
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2, MAP3K7, RELA 2.0165
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, BCL2, RELA 2.0449
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.0643
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, PGR, IGF1R 2.0198
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, MAP3K7, RELA 1.8962
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.67
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.657
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, PTGS2 1.71
Influenza A_Homo sapiens_hsa05164 FDPS, GSK3B, MAP2K1, RELA 1.601
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, GSK3B, APP, CACNA1C 1.6509
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2064
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2396
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, SRC, RELA 1.5193
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.2635
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2635
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.2978
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.2138
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, MAP3K7, IGF1R 1.3126
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.2573
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.4768
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, GRM1, IGF1R 1.2573
HTLV-I infection_Homo sapiens_hsa05166 FDPS, GSK3B, TERT, RELA 1.1489
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, MAP2K1 1.2138
Platelet activation_Homo sapiens_hsa04611 SRC 0.3268
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, MAP2K1, SRC 1.6617
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, RELA 1.2573
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA, RELA 1.1489
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, IGF1R 1.2068
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1, MAP3K7 1.2068
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.4693
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.4873
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, RELA 1.8438
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.1396
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 1.8598
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.5892
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.5585
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.0797
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2, RELA 1.67
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.3761
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6698
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.6137
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3834
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.3834
Amoebiasis_Homo sapiens_hsa05146 RELA 0.3834
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6813
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.6511
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3918
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.3862
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0245
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3907
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 0.9957
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.3965
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 1.8438
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4053
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 1.8962
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.763
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 0.7445
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4053
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.731
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.7542
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4053
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4053
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4107
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4122
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1, BCL2 1.9944
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 1.9427
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOB, MAOA 2.1695
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4239
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4179
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4319
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4302
Pertussis_Homo sapiens_hsa05133 RELA 0.4433
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4454
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 0.9215
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4454
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.4693
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9423
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9642
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 0.9974
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9642
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4873
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.4873
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 0.9974
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.034
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.0813
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1101
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5287
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.5287
Legionellosis_Homo sapiens_hsa05134 RELA 0.5299
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOB, MAOA 2.4004
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5299
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.1445
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.1487
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.1445
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1101
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5299
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1489
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, MAOA, TYR 2.5439
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1487
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.1487
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.2138
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1 1.2625
Malaria_Homo sapiens_hsa05144 MET 0.5594
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.5575
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2008
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.5643
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2735
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.7683
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5919
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5862
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.633
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3478
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.6698
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6698
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4574
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7261
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7055
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7452
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.657
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7537
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6131
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.53
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7156
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7452
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8438
Histidine metabolism_Homo sapiens_hsa00340 MAOB, MAOA 1.8136
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8511
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MAOA 2.0375
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.8598
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.168
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9066


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)