TCM Prescription: Shen Tong Zhu Yu Decoction



Prescription Description
Prescription IDTCMF2881
Pinyin NameShen Tong Zhu Yu Tang
Chinese Name身痛逐瘀汤
English NameShen Tong Zhu Yu Decoction
Function Description凡肩痛, 臂痛, 腰痛, 腿痛, 或周身疼痛, 总名曰痹症明知受风寒, 用温热发散药不愈; 明知有湿热, 用利湿降火药无功久而肌肉消瘦, 议论阴亏, 随用滋阴药又不效至此便云:病在皮脉, 易于为功; 病在筋骨, 实难见效因不思风寒湿热入皮肤, 何处作痛入于气管, 痛必流走; 入于血管, 痛不移处如论虚弱, 是因病而致虚, 非因虚而致病古方颇多, 如古方治之不效, 用身痛逐瘀汤
IndicationsLumbago disorder
Disease ICD-11 Category SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
Human Tissues Associated with IndicationSkeletaMuscle
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1300 Faeces trogopterori 灵脂 TCMH1300
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH456 Rhizoma dioscoreae nipponicae 地龙 TCMH456
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5525
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6794
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.34028
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 9.34028
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, PIM1, PPARA, TYR, XDH 8.51537
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.14113
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, SLC1A1, SRC, TNKS, TNKS2, XDH 7.8578
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 7.23536
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.64463
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 6.46489
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 6.3652
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.09852
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.03428
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.89165
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.81693
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 5.73675
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.60447
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 5.28399
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.26579
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.21625
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.97387
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.76775
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.74828
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, MET, PPARA 4.74828
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC 4.63551
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 4.56545
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.50899
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 4.49737
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.47081
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.47081
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.47081
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.42756
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 4.41348
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.34188
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.34188
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.32106
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.25842
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.25842
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.24993
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.1995
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TNKS, TNKS2, XDH 4.19207
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 4.14211
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.14211
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.12901
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR 4.12158
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 4.00685
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 3.70408
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SRC 3.68395
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 3.66984
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.61885
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, SRC, TNKS, TNKS2 3.60882
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, SRC 3.59185
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA 3.58404
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 3.57269
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 3.51195
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 3.51195
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.43207
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.43207
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.43207
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.28583
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.16451
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SRC, XDH 3.05618
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GRM1, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.03076
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 3.0223
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.96375
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.96375
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.95844
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.92817
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.91984
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.89158
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.86164
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.85717
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, SRC 2.85717
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.83921
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F3, FLT3, GRM1, KDR, MET, PTPN1, SRC, XDH 2.83921
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.82402
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.82402
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, TYR 2.76118
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 2.72911
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 2.71475
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.71404
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.67049
[BP] GO:0009115 None AOX1, XDH 2.66971
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.66804
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 2.65812
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.63955
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GRM1, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.62907
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.5973
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.58754
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, SRC, TYR 2.53029
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 2.52892
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.4316
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.42922
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 2.41605
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.40928
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, TYR 2.38075
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.36492
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.36492
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.36154
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.35898
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.35898
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.33245
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, TYR 2.32137
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.30915
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.28228
[BP] GO:0099566 None GRM1, GRM5 2.28228
[BP] GO:0046110 None AOX1, XDH 2.28228
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.28228
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.28067
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.28067
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.2633
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.25532
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.25532
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.25525
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.25096
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.22951
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.22951
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.1709
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.16348
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, SRC 2.15524
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.15524
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.14272
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.14272
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.11637
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.11165
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1112
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TYR, XDH 2.1066
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.08885
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.08885
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC 2.08391
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.07963
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.07265
[BP] GO:0070213 None TNKS, TNKS2 2.07265
[BP] GO:0006145 None AOX1, XDH 2.07265
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.07265
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.05131
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.04794
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.03392
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, SRC 2.01942
[BP] GO:0042391 None ADORA1, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.019
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.00863
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.00831
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.00701
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.19206
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TYR 3.12774
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 2.83287
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 2.56095
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TYR 2.32074
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.07265
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.07265
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.07265
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2 2.00653
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.9574
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 16.3686
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6794
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.36715
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 9.34028
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.08277
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SRC, TNKS, TNKS2, TYR, XDH 7.35413
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 7.26646
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 7.13806
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 6.53243
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.42552
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.03947
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.96633
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 5.31434
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TNKS, TNKS2, TYR, XDH 5.2953
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.01246
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, TNKS, TNKS2, TYR, XDH 5.01005
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 4.97361
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.6352
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 4.56545
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.12901
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 4.00763
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.93873
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.76764
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.72933
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.72347
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.62049
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.62049
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, SRC, XDH 3.55933
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.47271
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.28583
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.23502
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.19206
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.12774
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.0223
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.89082
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 2.88378
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 2.88378
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.77292
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.66971
[MF] GO:0003845 None HSD11B1, HSD11B2 2.66971
[MF] GO:0008389 None CYP2A13, CYP2A6 2.66971
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.53617
[MF] GO:0099583 None GRM1, GRM5 2.28228
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.2633
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.2633
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.25532
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.24395
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.22951
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.07265
[MF] GO:0004971 None GRIA2, GRIA4 2.07265
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 2.00653


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.4851
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.8049
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7474
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7838
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.7838
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.5662
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.5057
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 5.1473
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.7773
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.1249
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.137
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.2092
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9285
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.2034
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9172
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.5342
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2034
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.5342
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1266
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, PPARA, GRIA4 2.3761
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.3669
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.0667
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0722
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1419
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.1191
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0722
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0315
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0288
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0519
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8225
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.6269
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.6308
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.8225
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4066
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5462
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2991
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0059
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.04
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0298
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3151
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9996
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0102
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3096
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9296
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2453
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2804
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0597
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9129
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.937
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9743
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2368
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0199
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1298
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2368
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15 0.9292
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9136
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9136
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9136
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8356
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2991
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8465
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8639
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2326
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8877
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8251
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8199
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.6849
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7228
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6861
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.624
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4066
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3829
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6232
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2305
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2771
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.305
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3118
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3244
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3341
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4394
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3117
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3678
Apoptosis_Homo sapiens_hsa04210 BCL2 0.38
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3527
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3644
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.38
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3784
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3907
Platelet activation_Homo sapiens_hsa04611 SRC 0.4082
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4093
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4082
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4082
Axon guidance_Homo sapiens_hsa04360 MET 0.4033
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4366
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5462
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4639
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4638
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4806
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4676
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.472
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7111
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4717
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4876
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4716
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4802
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4806
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4806
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4806
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4806
Peroxisome_Homo sapiens_hsa04146 XDH 0.4876
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4806
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.52
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4981
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5188
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7275
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6269
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5277
Bile secretion_Homo sapiens_hsa04976 CA2 0.5264
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1585
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5418
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5418
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5418
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.529
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5418
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5441
Shigellosis_Homo sapiens_hsa05131 SRC 0.5418
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6682
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.614
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5795
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8871
Malaria_Homo sapiens_hsa05144 MET 0.6232
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6256
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.624
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6256
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6861
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7647
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.787
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8199
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8114
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9136
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9863
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2514


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)