TCM Prescription: Da Yuan Decoction



Prescription Description
Prescription IDTCMF2861
Pinyin NameDa Yuan Yin
Chinese Name达原饮
English NameDa Yuan Decoction
Function Description瘟疫初起先憎寒而后发热, 日后但热而无憎寒也, 脉不浮不沉而数, 昼夜发热, 日晡益甚, 头疼身痛
IndicationsFever
Disease ICD-11 Category MG26 [Fever of other or unknown origin, 其他或不明原因的发热 ];
Human Tissues Associated with IndicationLung, blood
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH217 Amomum tsaoko crevost et lemarie 草果仁 TCMH217 GQ118666
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1865 Paeonia obovata 芍药 TCMH1865 GBVX7902-15
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOB, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.64138
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, PPARA, SMAD3, SRC, TEK, TYR 8.02036
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 7.78891
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, MAOB, PPARA, SRC, TEK, TYR 7.38838
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MAOB, SRC, TYR 7.29506
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.06975
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.96717
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.96538
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, PPARA, SMAD3, SRC, TEK, TYR 6.87402
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.67486
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.54046
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.39725
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.31196
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.3011
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, INSR, MAOB, PPARA, SRC, TEK 6.26143
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.16003
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HSPA1A, PDE5A, PPARA, TBXAS1, TYR, XDH 6.11091
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 5.93575
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, HSD11B2, MAOB, SRC, TEK, TYR 5.76912
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7 5.73807
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.68273
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 5.64729
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, IGF1R, INSR, MAOB, PPARA, SMAD3, SRC, TEK 5.6371
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TBXAS1, TYR, XDH 5.40624
[BP] GO:0080134 regulation of response to stress ABCB1, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.24941
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, PPARA, PTPN1, SMAD3, SRC, TEK 5.22788
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, INSR, KDR, MAOB, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.21802
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.21802
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.20388
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PDE5A, SMAD3, SRC, TEK, XDH 5.20388
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.09201
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, GPR35, HSPA1A, INSR, KDR, MET, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.06671
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, EGFR, F10, F3, GPR35, HSPA1A, INSR, KDR, MET, PDE5A, PTPN1, SRC, TEK, XDH 4.97227
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, MAOB, MET, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, TYR 4.97033
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.83848
[BP] GO:0040012 regulation of locomotion BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.73667
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MAOB, SRC 4.64834
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.54346
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.53045
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTPN1, SRC, TEK, XDH 4.48848
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.44881
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, GPR35, HSPA1A, INSR, KDR, MET, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.4369
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PPARA, TBXAS1 4.34925
[BP] GO:0042493 response to drug ABCB1, AKR1B1, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, MAOB, SRC 4.23597
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.23597
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALPL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, MET, PDE5A, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 4.08742
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.00767
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 4.00767
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.89613
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.88831
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.78739
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.76837
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, CNR1, EGFR, HCAR2, KDR, SRC, TNKS, TNKS2 3.76357
[BP] GO:2000145 regulation of cell motility BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.75296
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 3.75296
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 3.7428
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.70001
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.69173
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F10, F3, INSR, MET, SRC, TEK 3.64454
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.5963
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, KDR, MAOB, SRC 3.58376
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.54692
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.53851
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51779
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.51779
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 3.51669
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA6, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR 3.51218
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 3.51218
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, MAOB, TYR 3.51218
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.49623
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 3.48483
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.48483
[BP] GO:0010941 regulation of cell death AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, HCAR2, HSPA1A, IGF1R, KDR, MET, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.48483
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 3.48364
[BP] GO:0051270 regulation of cellular component movement BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.46718
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAOB 3.46718
[BP] GO:0030334 regulation of cell migration BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.42867
[BP] GO:0008283 cell proliferation ABCB1, ACHE, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, MET, SRC, TEK, TYR 3.40311
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, KDR, MET, PPARA, PTPRS, SMAD3, TEK 3.37728
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.37564
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 3.36089
[BP] GO:0043067 regulation of programmed cell death AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, HCAR2, HSPA1A, IGF1R, KDR, MET, PTPN1, SMAD3, SRC, TEK, XDH 3.35813
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK 3.32521
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.30627
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.29196
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.25648
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.24157
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.22911
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MAOB, MET, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.22568
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, IGF1R, INSR, KDR, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.2124
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MAOB, MET, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.2124
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.2124
[BP] GO:0051239 regulation of multicellular organismal process BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, PDE5A, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 3.20481
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.20401
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, IGF1R, INSR, KDR, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.1783
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2 3.15697
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.13183
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13183
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.13183
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, IGF1R, INSR, KDR, SRC, TEK 3.11972
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.11836
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, PTPN1, PTPRS, SMAD3, SRC, XDH 3.10514
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, PTPN1, PTPRS, SMAD3, SRC, XDH 3.09399
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.07565
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.05867
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 3.00201
[BP] GO:0010638 positive regulation of organelle organization ALOX15, BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 2.97973
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, HSPA1A, IGF1R, INSR, KDR, SMAD3, SRC 2.96297
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 2.95998
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, F3, IGF1R, INSR, KDR, TEK 2.93562
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.92142
[BP] GO:0042981 regulation of apoptotic process AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, HCAR2, HSPA1A, IGF1R, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.9008
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.88472
[BP] GO:0065009 regulation of molecular function ABCB1, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.88126
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MAOB, PPARA, PTPN1, SMAD3, SRC 2.88126
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, HSD11B2, MAOB, SRC 2.86458
[BP] GO:0002682 regulation of immune system process ALOX15, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, PDE5A, PTPN1, PTPRS, SMAD3, SRC 2.83125
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.83125
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.81497
[BP] GO:0009894 regulation of catabolic process BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.81195
[BP] GO:0009115 None AOX1, XDH 2.81091
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, IGF1R, INSR, KDR, SMAD3, SRC 2.80386
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, EGFR, HCAR2, TNKS, TNKS2 2.80386
[BP] GO:0007165 signal transduction AKR1B1, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.80386
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MAOB 2.77953
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.7544
[BP] GO:0006468 protein phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 2.72628
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, HSD11B2, MAOB, SRC 2.7248
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.7248
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, FABP3, PPARA 2.72096
[BP] GO:0050790 regulation of catalytic activity BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, INSR, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.71375
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.68813
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.68813
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.68132
[BP] GO:0060548 negative regulation of cell death AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PPARA, PTPN1, SMAD3, SRC, TEK 2.68092
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, INSR, KDR, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.67713
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, INSR, KDR, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.67713
[BP] GO:0009893 positive regulation of metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.67196
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.66099
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.65011
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.64122
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.62088
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.58703
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.56206
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK 2.56206
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.49258
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DUSP3, EGFR, IGF1R, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 2.48396
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.4838
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.48201
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.48201
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.46953
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, EGFR, HCAR2, MET, PPARA, SMAD3 2.46557
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.45423
[BP] GO:0044092 negative regulation of molecular function CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PPARA, PTPN1, SRC, TNKS 2.4492
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.44763
[BP] GO:0003006 developmental process involved in reproduction ALPL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.44763
[BP] GO:0046110 None AOX1, XDH 2.44763
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44763
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 2.44763
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.44763
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.44763
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.44763
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, TBXAS1 2.44763
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.44188
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, IGF1R, INSR, KDR, PDE5A, PPARA, PTPN1, SRC, TEK, XDH 2.44188
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.42636
[BP] GO:0050793 regulation of developmental process BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, INSR, KDR, NUAK1, PDE5A, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 2.40363
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.38981
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.3725
[BP] GO:0042592 homeostatic process AKR1B1, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3, SRC 2.36772
[BP] GO:0032496 response to lipopolysaccharide ALPL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, SRC 2.36772
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, TEK 2.36715
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, SMAD3 2.35287
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, PPARA, SMAD3, TEK 2.35287
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.33239
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.33014
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, HSPA1A, IGF1R, INSR, KDR, MET, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.31677
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.28111
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, EGFR, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 2.27295
[BP] GO:0044093 positive regulation of molecular function ABCB1, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, HSPA1A, INSR, MET, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.27086
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.25906
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, PTPN1, SRC, XDH 2.23948
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.23433
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23433
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.23433
[BP] GO:0002237 response to molecule of bacterial origin ALPL, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, SRC 2.22164
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, PTPRS, XDH 2.2202
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.21962
[BP] GO:0070213 None TNKS, TNKS2 2.21962
[BP] GO:0006145 None AOX1, XDH 2.21962
[BP] GO:0038171 None CNR1, CNR2 2.21962
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21962
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, SRC, TYR 2.21829
[BP] GO:0002683 negative regulation of immune system process ALOX15, CDK6, CNR1, CNR2, CYP19A1, DUSP3, PDE5A, PTPRS 2.21516
[BP] GO:0051894 None KDR, SMAD3, TEK 2.20202
[BP] GO:0007346 regulation of mitotic cell cycle BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, SMAD3, TNKS 2.18778
[BP] GO:0050927 None F3, KDR, SMAD3 2.15267
[BP] GO:0043207 response to external biotic stimulus ALPL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, SMAD3, SRC 2.14275
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.14275
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, HSPA1A, INSR, KDR, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.14275
[BP] GO:0051054 positive regulation of DNA metabolic process EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.13548
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 2.11806
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.11646
[BP] GO:0050926 None F3, KDR, SMAD3 2.1138
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1138
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.06859
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.06859
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOB, PDE5A, SRC, XDH 2.06252
[BP] GO:0009991 response to extracellular stimulus ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, SRC, TYR 2.0604
[BP] GO:2000241 regulation of reproductive process CNR1, ESR1, INSR, PDE5A, SRC 2.05912
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.05144
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, HSD11B2, MAOB 2.05144
[BP] GO:0043696 None CDK6, ESRRB 2.05144
[BP] GO:0043697 None CDK6, ESRRB 2.05144
[BP] GO:0010641 None F3, SRC 2.05144
[BP] GO:0007598 None F10, F3 2.05144
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.04101
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, EGFR, ESRRB, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 2.03749
[BP] GO:0016310 phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 2.02093
[BP] GO:0009607 response to biotic stimulus ALPL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MAOB, SMAD3, SRC 2.01907
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, SMAD3, TEK, XDH 2.00022
[CC] GO:0044425 membrane part ABCB1, ACHE, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, PTPN1, PTPRS, SRC, TBXAS1, TEK, TYR 3.04168
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FUT7, GBA2, GPR35, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR 2.60003
[CC] GO:0031233 None CA4, F10, F3 2.3827
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALOX15, ALPL, CA12, CA14, CA2, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, F3, GBA2, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PTPN1, PTPRS, SMAD3, SRC, TEK 2.34494
[CC] GO:0031226 intrinsic component of plasma membrane CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, TEK 2.07364
[CC] GO:0098590 plasma membrane region ABCB1, CA2, CA4, CHRM1, CHRM2, CHRM4, CNR1, EGFR, INSR, MET, SRC, TEK 2.06272
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PTPN1, PTPRS, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 9.7722
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 9.64138
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, SMAD3, TBXAS1, TNKS, TYR, XDH 8.70768
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PPARA, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 7.51097
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, TBXAS1, TYR, XDH 6.48253
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 6.16003
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.10884
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 5.35564
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.51889
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.50068
[MF] GO:0038023 signaling receptor activity CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 4.39858
[MF] GO:0008144 drug binding ABCB1, ACHE, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, SRC, TEK 4.23597
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.21448
[MF] GO:0060089 molecular transducer activity CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 4.10091
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.00138
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.89613
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.80796
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, SMAD3, TNKS 3.80058
[MF] GO:0004871 signal transducer activity CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 3.7428
[MF] GO:0004872 receptor activity CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 3.73643
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, MAOB, SRC, TBXAS1, XDH 3.72867
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.72867
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.72867
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.64454
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57612
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.43187
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.43035
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.41892
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.37837
[MF] GO:0008289 lipid binding ALOX15, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.29009
[MF] GO:0004713 protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.288
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.288
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7 3.24938
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.24237
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.10514
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PTPRS, SRC, TEK, TUBB3, XDH 3.07565
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.94749
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.83125
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81091
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81091
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.7248
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.71752
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.68813
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 2.67293
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.62461
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.48201
[MF] GO:0004949 None CNR1, CNR2 2.44763
[MF] GO:0036094 small molecule binding ABCB1, AOX1, CDK6, CSNK2A1, EGFR, FABP3, FABP4, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, SRC, TEK, TUBB3, XDH 2.43165
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, CDK6, CSNK2A1, EGFR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, SRC, TEK, TUBB3, XDH 2.31267
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, CDK6, CSNK2A1, EGFR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, SRC, TEK, TUBB3, XDH 2.31172
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 2.2944
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21962
[MF] GO:0004672 protein kinase activity CDK6, CSNK2A1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.21516
[MF] GO:0099600 transmembrane receptor activity CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 2.21516
[MF] GO:0004888 transmembrane signaling receptor activity CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 2.21516
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.15533
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05144
[MF] GO:0043559 insulin binding IGF1R, INSR 2.05144


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA14 11.0563
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.9385
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9846
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2369
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, ALOX15, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.7172
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 5.3826
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, INSR, KDR, TEK, MET, EGFR, IGF1R 5.0645
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.3611
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.1483
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.5754
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.5864
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 3.4509
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.9446
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.5754
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.3064
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.3064
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, CYP1B1, MET, EGFR, CDC25B 3.3064
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0944
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.1269
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CNR2, GPR35, CNR1, CHRM4 2.6824
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 2.3351
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2103
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2 2.1574
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, BCL2, MET, EGFR, IGF1R 2.0724
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.1574
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1574
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15, TBXAS1 2.166
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.1574
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.8245
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1574
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1522
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1119
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PPARA 1.7962
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1 2.1522
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8979
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, F3 1.787
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.9003
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1522
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7149
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5099
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.5071
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.594
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4651
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1, EGFR 1.2557
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.1621
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 KDR, MET, EGFR 0.9442
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0468
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.0861
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.2216
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1152
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0733
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX15 0.9551
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3228
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MET, EGFR 1.2693
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9245
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.3772
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1178
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3772
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1753
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9442
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0754
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.87
Toxoplasmosis_Homo sapiens_hsa05145 BCL2, HSPA1A 0.9442
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8529
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9176
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8422
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8395
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3174
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8529
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.172
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8216
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2369
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.803
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3423
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.803
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.768
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2395
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR, PDE5A 0.7721
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.7479
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MET, IGF1R 0.7406
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7442
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3324
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6834
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3399
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3443
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3319
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3832
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3905
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3832
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4064
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4185
Axon guidance_Homo sapiens_hsa04360 MET 0.431
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4447
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4447
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4391
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4286
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4973
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4973
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4899
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4973
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4973
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5002
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4996
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.6178
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.594
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4973
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.517
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5186
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5325
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5177
Peroxisome_Homo sapiens_hsa04146 XDH 0.5336
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5702
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5586
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.588
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5901
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.5979
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7908
Shigellosis_Homo sapiens_hsa05131 SRC 0.6022
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6022
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6262
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7981
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6566
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6712
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6759
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6566
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7562
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6751
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6834
Malaria_Homo sapiens_hsa05144 MET 0.6832
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.6832
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6834
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.679
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6834
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9634
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6834
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6834
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6934
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7645
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7277
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8339
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8008
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8139
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8395
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8339
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8529
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9465
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9442
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0168
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0944
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2837


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)