TCM Prescription: Xiao Er Jie Biao Granules



Prescription Description
Prescription IDTCMF282
Pinyin NameXiao Er Jie Biao Ke Li 
Chinese Name小儿解表颗粒
English NameXiao Er Jie Biao Granules
Function Description感冒
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH1142 Schizonepetae spica 荆芥穗 TCMH1142
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH1716 Calculus bovis artificiosus 人工牛黄 TCMH1716
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, KIT, MET, PPARA 10.2469
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.98279
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TYR 8.88921
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 8.73714
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, PPARA, RORC, SRC, TYR 8.70018
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GLO1, HMGCR, PIM1, PPARA, TYR, XDH 8.69146
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, APEX1, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TERT, TYR 8.67355
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.4004
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HMGCR, HSD17B1, HSD17B2 8.3785
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.03123
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 7.82635
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC 7.62265
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 7.50994
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, PPARA, PTPRS, RORC, SRC, TERT, TNKS2, TOP2A, TYR 7.45517
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, RORC, SRC, TYR 7.44821
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT 7.31641
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, XDH 6.96873
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.96258
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.92084
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, HSD17B2, TYR, XDH 6.91167
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 6.91167
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH 6.86328
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.84474
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.58977
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, AR, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, RORC, SRC, TYR 6.58973
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HMGCR, KIT, MET, PPARA 6.43861
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.37026
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, SRC, TERT, XDH 6.36083
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.31612
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.31284
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.29753
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.07734
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.06626
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.92841
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.92047
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.86771
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.86375
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 5.80219
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.76
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 5.64238
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, KIT, MMP2, NR3C1, PPARA, SRC 5.60052
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 5.57893
[BP] GO:0009725 response to hormone AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, KIT, NR3C1, PPARA, SRC 5.50853
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.47152
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.23562
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.20934
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, KIT, PPARA, PTPRS, SRC, TYR 5.17717
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, RORC, SRC, TERT 5.07307
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.06303
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.9571
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.9571
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.92986
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.88281
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CNR1, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.84916
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.77453
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.74538
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.68231
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.62371
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 4.62371
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.623
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, RORC, SRC 4.36542
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TYR 4.33547
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AXL, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HMGCR, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR 4.3312
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD17B1, HSD17B2 4.28458
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.21771
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, NR3C1, SRC 4.2118
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 4.2118
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.19284
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.11898
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TERT 4.04749
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC 4.01826
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.00229
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC, TERT, TOP2A 3.97231
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 3.96991
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CNR1, CNR2, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.95118
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HMGCR, KIT, PPARA, RORC, SRC 3.90959
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, CNR1, CNR2, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.85167
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.84393
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, KIT, PGR, PPARA, RORC, SRC, TOP2A 3.84138
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.83828
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.78533
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.74822
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA 3.74001
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.57994
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, FLT3, HMGCR, KDR, KIT, MET, PTPN1, SRC, XDH 3.57523
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.57259
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.57259
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.57259
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.57259
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.56459
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 3.49917
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT 3.4749
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, TYR 3.46086
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, PPARA, PTPRS, RORC, SRC, TYR 3.46086
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CBR1, CDC25B, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, KIT, MET, MMP2, MMP9, PGR, PTPRS, RORC, SRC, TERT, TOP2A 3.46086
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.44073
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.43655
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC 3.42248
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.40711
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.39118
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.38459
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, CNR1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.3455
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.32316
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 3.30812
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.2925
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 3.26869
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.26857
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, KIT, MMP2, MMP9, PGR, SRC, TOP2A 3.20609
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.17906
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.15785
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.13916
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.12989
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12989
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.12325
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 3.0992
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 3.08486
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.07468
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.05353
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, CDC25B, ESRRB, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.05353
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.03205
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CNR1, HMGCR, KDR, SRC, TNKS, TNKS2 3.03205
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.02055
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.98962
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.96488
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AR, AURKB, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.95618
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.9521
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, ESRRB, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.93604
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, CNR2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.92944
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.91778
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, CNR2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.91761
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.915
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.89249
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.8792
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 2.86692
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, KIT 2.84743
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, KIT 2.84743
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.82992
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.82495
[BP] GO:0009115 None AOX1, XDH 2.82495
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.80704
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.7826
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.7718
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.7718
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.7522
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.7321
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.72833
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.72833
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 2.71685
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, HMGCR, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, XDH 2.70319
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 2.68351
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.67431
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTPRS 2.67041
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.66237
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC 2.65292
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 2.63771
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.62065
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60034
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 2.59696
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, ESR1, KIT, PGR, SRC 2.59311
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, HMGCR, TYR 2.58962
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 2.57713
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.55718
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.5497
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.54378
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, SRC 2.53603
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.53579
[BP] GO:0045893 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.52769
[BP] GO:1903508 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.52769
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT, TNKS 2.52769
[BP] GO:1902680 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.52769
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.51199
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.51199
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, FABP4, FLT3, HMGCR, IGF1R, KIT, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.49163
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.49163
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, ESR1, FLT3, FUT7, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.48613
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HMGCR, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.47632
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.45118
[BP] GO:0060748 None AR, PGR 2.44999
[BP] GO:0046110 None AOX1, XDH 2.44999
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44999
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.44476
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 2.43789
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, CNR1, CSNK2A1, ESR1, ESR2, IGF1R, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A 2.43615
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.43015
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.43014
[BP] GO:0006357 None APP, AR, AURKB, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MET, MMP12, NR3C1, PGR, PPARA, RORC, TERT, TNKS, TOP2A 2.42713
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.41842
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.41805
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.38663
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.36992
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, HMGCR, KIT, MMP2, PPARA, SRC, TERT, TYR 2.35984
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.35499
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, SRC 2.34832
[BP] GO:0051254 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.32798
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.2892
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, IGF1R, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.27531
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.26389
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.25732
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.25732
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, SRC 2.24993
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.2425
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.24041
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.22751
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, PIM1 2.22216
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21124
[BP] GO:0070213 None TNKS, TNKS2 2.21124
[BP] GO:0006145 None AOX1, XDH 2.21124
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.21124
[BP] GO:0038171 None CNR1, CNR2 2.21124
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21124
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CNR1, CNR2, CYP19A1, ESR1, ESRRA, KIT, MMP12, MMP2, PTPN1, PTPRS, SRC 2.20522
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.19809
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CNR1, CYP1B1, ESRRB, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIM1, SRC, TERT 2.19025
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.19025
[BP] GO:0006355 regulation of transcription, DNA-templated ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.18255
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17721
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.16859
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.15707
[BP] GO:1903506 regulation of nucleic acid-templated transcription ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.1488
[BP] GO:2001141 regulation of RNA biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.13618
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.13198
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, MMP12, PTPRS 2.12247
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, CDC25B, ESR1, ESR2, FLT3, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.08859
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.08624
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.08624
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIM1, PTPRS, SRC, TERT, TNKS2, XDH 2.08391
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.06556
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.06278
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.05984
[BP] GO:0010556 regulation of macromolecule biosynthetic process ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.05655
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.04677
[BP] GO:0045944 None APP, AR, ESR1, ESRRA, ESRRB, MET, MMP12, NR3C1, PGR, PPARA, TERT, TNKS, TOP2A 2.04437
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AOX1, APEX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, FUT7, GLO1, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.0368
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.0368
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.02846
[BP] GO:0045934 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TNKS, TNKS2 2.01444
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.01254
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.01254
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.01254
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.01241
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.37812
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FLT3, FUT7, GLO1, HMGCR, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TYR 2.46507
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 1.9767
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.90884
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA9, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 1.8656
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 23.4681
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 15.4957
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS 10.7082
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 10.7082
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 10.4552
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC 10.4552
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.4552
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.1288
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1288
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.38797
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, HSD17B2, TYR, XDH 8.19878
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.1593
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.1593
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.0113
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.96287
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.85545
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.3321
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 6.1833
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.14146
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.38384
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.2319
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.22334
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 5.06303
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.0194
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.94583
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.68231
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.6448
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, SRC, XDH 4.50563
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.50127
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.19284
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP2A 4.11898
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.09021
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.00229
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 3.59473
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.26004
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.24823
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.20246
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TUBB3, XDH 3.0945
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.94339
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TUBB3, XDH 2.85115
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PGR, TERT, TOP2A, TYR, XDH 2.85115
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82495
[MF] GO:0008389 None CYP2A13, CYP2A6 2.82495
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 2.80704
[MF] GO:0019899 enzyme binding APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, ESR1, ESR2, ESRRB, HMGCR, KIT, MET, NR3C1, PGR, PPARA, PTPN1, SRC, TNKS2, TOP2A 2.76048
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.69489
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.62474
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.44999
[MF] GO:0004949 None CNR1, CNR2 2.44999
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.41805
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.36992
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21124
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21124
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21124
[MF] GO:0043565 None APEX1, AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, NR3C2, PGR, PPARA, RORC, TERT 2.20907
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.19714
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.09517
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.08609
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.0368
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0368


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.994
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6232
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.3302
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.739
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.4785
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, HMGCR, TYR, CYP3A4, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 4.8871
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0976
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.3303
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1018
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, KIT, MMP9, MET, IGF1R 3.2311
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.643
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9076
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.902
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KIT, KDR, MET, IGF1R 3.1537
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.1537
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1537
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 3.13
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, MMP9, MET, CDC25B 2.4755
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0124
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.2393
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1, NR3C1 1.9024
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0124
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.1525
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.0737
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4755
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8204
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.7102
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.6859
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.5727
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0491
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.6202
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5322
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3671
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0856
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, MET, IGF1R 1.0918
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.248
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9462
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.297
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1547
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.02
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0111
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.9462
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1798
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0918
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.0202
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8955
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2648
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0202
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8505
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8505
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8453
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8283
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7491
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7557
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7575
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7178
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6906
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.5974
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7102
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2274
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2274
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2833
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2733
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2825
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3116
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3034
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6202
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3116
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3461
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3226
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3658
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3034
Platelet activation_Homo sapiens_hsa04611 SRC 0.3832
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.359
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3695
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3388
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.3581
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3623
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3434
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4083
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3695
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4362
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3816
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4083
Axon guidance_Homo sapiens_hsa04360 MET 0.3774
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4295
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4267
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3907
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4317
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4347
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4362
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4362
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4362
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4295
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4347
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4347
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4362
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4347
Peroxisome_Homo sapiens_hsa04146 XDH 0.4465
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4851
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5197
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5013
Glioma_Homo sapiens_hsa05214 IGF1R 0.5197
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5188
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5242
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5197
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5197
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6824
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6202
Shigellosis_Homo sapiens_hsa05131 SRC 0.5197
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5528
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8948
Malaria_Homo sapiens_hsa05144 MET 0.5931
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5974
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5957
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.6498
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6131
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6457
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7185
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7055
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7328
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7557
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7256
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7491
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8058
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2208


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)