TCM Prescription: Hou Pu Ma Huang Decoction



Prescription Description
Prescription IDTCMF2817
Pinyin NameHou Pu Ma Huang Tang
Chinese Name厚朴麻黄汤
English NameHou Pu Ma Huang Decoction
Function Description咳而脉浮者, 厚朴麻黄汤主之
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH2322 Prunus armeniaca 杏仁 TCMH2322 ITSAJ4486-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2300 Triticum aestivum 小麦 TCMH2300 ITSAO4010-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1451 Sclerotinia
TCMT1452 Rhizopus microsporus var. chinensis
TCMT1453 Penicillium crustosum
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.4718
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5112
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA, TRPV1 10.3229
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, MIF, PIM1, PPARA, TYR, XDH 9.83411
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F2, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, SRC, TRPV1, XDH 9.22868
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, NR3C1, PPARA, SRC, TRPV1, TYR 8.34072
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 7.59375
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 7.59375
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, SRC, TYR 7.53965
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, NR3C1, PPARA, SRC, TRPV1, TYR 7.21917
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 6.9269
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 6.74237
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, TYR, XDH 6.52246
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, NR3C1, PPARA, SRC, TRPV1, TYR 6.52246
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 6.34785
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.09137
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, CNR1, EGFR, F2, HCAR2, KDR, MIF, SRC, TRPV1 6.08295
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, NR3C1, SRC, TRPV1, TYR 5.78943
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.73142
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, PIM1, PPARA, SRC, TRPV1, XDH 5.5734
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F2, FLT3, HCAR2, KDR, MET, MIF, MMP12, SRC, XDH 5.55198
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F2, FLT3, HCAR2, KDR, MET, MIF, MMP12, SRC, XDH 5.53909
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.53909
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 5.48485
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.48485
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, XDH 5.48485
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, PIM1, SRC, TRPV1, XDH 5.43654
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, F2, FABP3, FABP4, FLT3, MET, SRC, TRPV1 5.43654
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, SRC, XDH 5.19827
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, FABP3, FABP4, MET, MIF, PPARA 5.19827
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 5.18844
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, IGF1R, NR3C1, PPARA, SRC, TRPV1 5.10151
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, SRC, XDH 5.10151
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 5.01384
[BP] GO:0042493 response to drug AKR1B1, AXL, CA3, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC, TRPV1 5.01384
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F2, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, PIM1, SRC, XDH 5.01384
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.00154
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.86447
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F2, HCAR2, IGF1R, KDR, MET, MIF, MMP12, PPARA, SRC, TRPV1 4.86447
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, IGF1R, KDR, MIF, PIM1, SRC, TRPV1, XDH 4.85386
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, XDH 4.77972
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, SRC 4.77266
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA3, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP12, NR3C1, PPARA, SRC, TRPV1, TYR 4.7609
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, KDR, MET, MIF, MMP12, PPARA 4.72907
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, ERBB2, F2, PPARA 4.71615
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, XDH 4.69836
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MIF 4.66032
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, NR3C1, PIM1, PPARA, SRC, TYR, XDH 4.62954
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.62399
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.57618
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 4.51111
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 4.4688
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, ERBB2, F2, FLT3, KDR, MET, MIF, SRC, XDH 4.44457
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, F2, KDR, SRC, TRPV1 4.28044
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CNR1, CNR2, CYP19A1, EGFR, ERBB2, ESR1, ESR2, F2, IGF1R, MET, MIF, MMP12, PPARA, SRC, XDH 4.28044
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 4.21774
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, HSD11B1, HSD17B2, KDR, MET, MIF, PIM1, PPARA, SRC, TYR 4.18397
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, XDH 4.00719
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 4.00554
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 3.97537
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 3.96637
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD11B1, HSD17B2, KDR, PIM1, PPARA, SRC, TYR 3.94566
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, ALOX5, AXL, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F2, FABP4, HSD17B2, IGF1R, MET, MMP12, PIM1, PPARA, SRC, TRPV1, TYR 3.9293
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.92247
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, F2, FABP3, FABP4, MET, TRPV1 3.88149
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 3.87755
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, IGF1R, KDR, MET, MIF, PIM1, PPARA, SRC 3.85226
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 3.82887
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.78202
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, F2, FLT3, IGF1R, KDR, MET, MIF, SRC, XDH 3.7676
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, ALOX12, AXL, CA2, CACNA1C, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, HCAR2, KDR, MET, MIF, MMP12, PIM1, SRC, TRPV1, XDH 3.72253
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, F2, FABP3, FLT3, HCAR2, PPARA, SRC 3.57302
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, F2, FLT3, KDR, MET, MIF, MMP12, SRC, XDH 3.54633
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, IGF1R, KDR, MET, MIF, PIM1, SRC 3.53424
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, ALOX12, MET, TRPV1 3.52838
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ALOX12, AXL, CA2, CNR1, CYP1B1, EGFR, ESRRB, F2, HCAR2, KDR, MET, MIF, MMP12, PIM1, SRC, TRPV1 3.48433
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CSNK2A1, EGFR, ERBB2, ESR1, F2, FLT3, IGF1R, KDR, MIF, MMP12, PIM1 3.46268
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 3.42594
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC, TRPV1 3.42594
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, SRC 3.42594
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.39422
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, SRC, TRPV1 3.39422
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA 3.39076
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F2, FABP4, FLT3, KDR, MET, MIF, MMP12, SRC, XDH 3.3044
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CA3, CNR1, CNR2, CYP1A1, CYP1B1, KDR, SRC 3.2759
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25873
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, ERBB2, MIF, MMP12 3.24805
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, SRC, TRPV1 3.22855
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALDH2, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 3.19663
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, IGF1R, MET, MIF, MMP12, PPARA, SRC, XDH 3.14314
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, CNR1, EGFR, ERBB2, F2, HCAR2, MIF, MMP12, SRC 3.13387
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, EGFR, ERBB2, F2, HCAR2, MIF, MMP12, SRC, TRPV1 3.13182
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF 3.12389
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, F2, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, PPARA, SRC, XDH 3.10553
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, PPARA, TRPV1 3.09738
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CACNA1C, CNR1, CYP19A1, EGFR, ERBB2, F2, HCAR2, MIF, MMP12, PPARA, SRC, TRPV1 3.09738
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, F2, HCAR2 3.09738
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, SRC 3.09738
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, SRC, TRPV1 3.0859
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, AURKB, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PPARA, SRC, TRPV1, XDH 3.06688
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.95128
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, IGF1R, KDR, MIF, PIM1, SRC 2.94808
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, EGFR, HCAR2, MIF, MMP12, SRC 2.94104
[BP] GO:0045776 None ADORA1, ADRB1, CNR1, PPARA 2.94104
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.89935
[BP] GO:0009115 None AOX1, XDH 2.89195
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.89195
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.89195
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.89195
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.89195
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.89195
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.88886
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, SRC, TRPV1 2.87318
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC, TRPV1 2.85554
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PPARA, SRC, TRPV1, XDH 2.84852
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, AURKB, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PPARA, SRC, TRPV1, XDH 2.82675
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MIF, MMP12, SRC 2.82602
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, SRC 2.8226
[BP] GO:0050866 negative regulation of cell activation ALOX12, AXL, CNR1, CNR2, ERBB2, F2 2.7984
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.7984
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 2.7984
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AXL, CA1, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, NR3C1, PIM1, PPARA, SRC, TRPV1 2.79357
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, F2, MMP12, PPARA 2.79357
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 2.78891
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.74963
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.74614
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.74614
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, IGF1R, PPARA, SRC, TRPV1, TYR 2.74614
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.71508
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.70449
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, MET, MIF, SRC 2.6955
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.67142
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.65979
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.65673
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, KDR, MIF, SRC, XDH 2.6487
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, KDR, MIF, SRC, XDH 2.6487
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CNR1, CNR2, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PPARA, SRC, TRPV1, XDH 2.63951
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F2, FABP4, MMP12, PPARA, SRC 2.63938
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, F2, MIF, PPARA 2.63938
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F2, FABP4, KDR, MET, MIF 2.63938
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, ERBB2, FLT3, KDR, MIF, SRC, XDH 2.63533
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, F2, PPARA 2.55083
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.53274
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET 2.53274
[BP] GO:0046110 None AOX1, XDH 2.53274
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53274
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, IGF1R, PPARA, SRC, TRPV1, TYR 2.5027
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR 2.46439
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR 2.46439
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC 2.4621
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CNR1, CNR2, CYP19A1, ERBB2, ESR1, ESRRA, F2, HCAR2, MIF, MMP12, SRC 2.45684
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45684
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, SRC 2.44924
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, PIM1, PPARA, SRC 2.44924
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.44924
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, PPARA, SRC, XDH 2.42234
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.42234
[BP] GO:0050708 None ACHE, CACNA1C, CNR1, EGFR, HCAR2, MIF, MMP12, SRC 2.41809
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.41072
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.41072
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC, XDH 2.39152
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, PPARA, SRC, XDH 2.3903
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, TYR 2.36335
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.36103
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, F2, MIF, TRPV1 2.35561
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, NR3C1, SRC, TRPV1 2.33152
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, MIF 2.33152
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PPARA, SRC, TRPV1 2.32053
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, EGFR, ERBB2, FLT3, IGF1R, KDR, MIF, SRC, XDH 2.31575
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31575
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, ERBB2, F2, FLT3, IGF1R, KDR, MET, SRC 2.30357
[BP] GO:0006145 None AOX1, XDH 2.30357
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.30357
[BP] GO:0038171 None CNR1, CNR2 2.30357
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30357
[BP] GO:0050793 regulation of developmental process ADRB1, ALOX12, AXL, CA2, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, KDR, MIF, PIM1, PPARA, SRC, TRPV1, XDH 2.26916
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.23334
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F2, FABP4, FLT3, IGF1R, MET, MIF, PIM1, PPARA, SRC, TRPV1, XDH 2.2134
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, MIF, SRC 2.20676
[BP] GO:0009056 catabolic process ACHE, ADORA1, ALDH2, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MMP12, SRC, XDH 2.19974
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, EGFR, ESR1, F2, FABP3, MIF, MMP12, PPARA, SRC, TRPV1, XDH 2.19391
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.19391
[BP] GO:0050714 None ACHE, EGFR, HCAR2, MIF, MMP12, SRC 2.19217
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, F2, MIF, PPARA, SRC, TRPV1 2.16612
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.15734
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.15734
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.15734
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4 2.15032
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, EGFR, F2, FABP3, MIF, MMP12, PPARA, SRC, TRPV1, XDH 2.14827
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA 2.14204
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.14204
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, SRC 2.13609
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, AURKB, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, XDH 2.13518
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, ERBB2, MET 2.13518
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.13518
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.13518
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, NR3C1, SRC 2.13518
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, MIF 2.13518
[BP] GO:0051222 positive regulation of protein transport ACHE, EGFR, ERBB2, F2, HCAR2, MIF, MMP12, SRC 2.1328
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CNR2, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, SRC, XDH 2.13169
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC 2.12966
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, ERBB2, KDR, NR3C1, SRC, TRPV1 2.12966
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC 2.12611
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.12611
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CNR2, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, SRC, XDH 2.12611
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.12253
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, MIF 2.10857
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.1065
[BP] GO:0051223 None ACHE, CACNA1C, CNR1, EGFR, ERBB2, F2, HCAR2, MIF, MMP12, SRC 2.09237
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, SRC 2.09229
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, TYR, XDH 2.08753
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, TYR 2.08299
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF 2.07779
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.07779
[BP] GO:0001659 None ADORA1, ADRB1, TRPV1 2.07572
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.07572
[BP] GO:0030307 positive regulation of cell growth ALOX12, CSNK2A1, EGFR, ERBB2, F2 2.06847
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, EGFR, ERBB2, ESRRB, F2, FABP4, FLT3, IGF1R, KDR, MIF, PPARA, SRC, XDH 2.06108
[BP] GO:0045927 positive regulation of growth ALOX12, CSNK2A1, EGFR, ERBB2, F2, PIM1 2.06108
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 2.057
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, TYR 2.03171
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC 2.01604
[BP] GO:0010907 None ESRRB, PPARA, SRC 2.01604
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.01604
[BP] GO:0046113 None AOX1, XDH 2.01604
[BP] GO:0032229 None ADORA1, CNR2 2.01604
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.01604
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.01604
[BP] GO:0009895 negative regulation of catabolic process ADORA1, CNR1, EGFR, HCAR2, MET, PPARA 2.01009
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2 2.01009
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, MIF, SRC 2.00256
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.6384
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, EGFR, ERBB2, ESR1, F2, FLT3, HCAR2, IGF1R, KDR, MET, PIM1, SRC, TRPV1 2.57081
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, ESR2, F2, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, KDR, MIF, NR3C1, PIM1, SRC, TRPV1, TYR, XDH 2.46242
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, ALOX15, AXL, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, EGFR, ERBB2, F2, FLT3, IGF1R, KDR, MET, SRC, TRPV1 2.26916
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, F2, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, PIM1, SRC, TRPV1, TYR 1.63905
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.7161
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PIM1, PPARA, TYR, XDH 16.7451
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5112
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9977
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NR3C1, PIM1, PPARA, SRC, TRPV1, TYR, XDH 10.3647
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.91541
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, F2, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP12, PIM1, SRC, TYR, XDH 7.71024
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 7.26431
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PPARA 6.83283
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 6.74237
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, MMP12, NR3C1, PIM1, PPARA, TRPV1, TYR, XDH 6.6287
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.6154
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.29312
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, MMP12, NR3C1, PIM1, PPARA, TRPV1, TYR, XDH 6.27117
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 5.9402
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 5.73142
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.64893
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.48485
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1 5.48485
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 5.38962
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 5.36378
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.25291
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 5.06029
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 4.69753
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.69753
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.21774
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.04398
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.04398
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.00554
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.73319
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 3.49711
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.39422
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.39422
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.36899
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.23414
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.23396
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.20794
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, NR3C1 3.05462
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.96306
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89195
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.89195
[MF] GO:0016903 None AKR1B1, ALDH2, AOX1, XDH 2.88886
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 2.71829
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CNR1, CNR2, EGFR, ERBB2, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 2.71829
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.64808
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.53274
[MF] GO:0004949 None CNR1, CNR2 2.53274
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.53274
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.53274
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, PIM1, PPARA, SRC 2.47239
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.37053
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30357
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.30357
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.30357
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TRPV1, XDH 2.29587
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.23334
[MF] GO:0042802 identical protein binding ACHE, AOX1, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, TRPV1, TYR, XDH 2.21306
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.19398
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.19398
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13518
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.13518
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.13518
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, PPARA, SRC 2.05957
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.04304
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01604
[MF] GO:0043546 None AOX1, XDH 2.01604


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.1154
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.4371
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.2964
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 5.5923
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.5297
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 4.4755
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, ERBB2, KDR, MET, ESR1, EGFR, IGF1R 4.4658
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1, ADRB1, TRPV1, NR3C1, F2 4.519
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.4583
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.2534
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.4812
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, EGFR, IGF1R 3.4126
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.3676
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 3.0705
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.3874
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2 2.8389
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, ADRB1, CACNA1C, PPARA 2.7305
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12, CACNA1C 2.6975
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.4527
Bladder cancer_Homo sapiens_hsa05219 SRC, ERBB2, EGFR 2.7937
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.9543
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1401
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.1958
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.3416
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, PIM1, CYP1B1, MET, EGFR 2.1301
Calcium signaling pathway_Homo sapiens_hsa04020 ERBB2, ADRB1, CACNA1C, EGFR 2.1037
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2732
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.319
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2524
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2496
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.2732
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2732
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.0801
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 2.0761
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.8356
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.9801
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, CACNA1C, EGFR 2.0601
Pathways in cancer_Homo sapiens_hsa05200 FLT3, ERBB2, MET, EGFR, IGF1R 1.7196
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 2.0782
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.93
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.631
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.4959
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, EGFR, IGF1R 1.3692
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3956
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 1.2447
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 1.0415
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C 1.1091
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3956
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0004
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.934
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.994
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.934
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4346
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.4798
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8962
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1941
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C 0.8771
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2051
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9062
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.5235
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4738
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.394
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.8511
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.288
Glycerolipid metabolism_Homo sapiens_hsa00561 ALDH2, AKR1B1 1.4538
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR 0.5849
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3572
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.5812
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3481
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3465
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3806
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3704
Tuberculosis_Homo sapiens_hsa05152 SRC 0.38
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.37
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.393
Hepatitis B_Homo sapiens_hsa05161 SRC 0.4349
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4263
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4379
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.4364
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4499
Platelet activation_Homo sapiens_hsa04611 SRC 0.4729
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4729
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4729
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4991
Axon guidance_Homo sapiens_hsa04360 MET 0.4676
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4861
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6073
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1 0.5237
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4655
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5237
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4744
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.477
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5237
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5246
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5253
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5246
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5237
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5403
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5237
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5299
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5246
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5246
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5245
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5299
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5403
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5299
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5354
Peroxisome_Homo sapiens_hsa04146 XDH 0.5403
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5592
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5432
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.5426
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5403
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5722
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5849
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5849
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5849
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5592
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.5849
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5957
Shigellosis_Homo sapiens_hsa05131 SRC 0.5849
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5849
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.648
Malaria_Homo sapiens_hsa05144 MET 0.6621
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.659
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6653
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6688
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 ALDH2, AKR1B1 1.7849
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6904
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0801
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.724
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8268
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8539
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8108
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.8184
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8353
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8539
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8539
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8798
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.994
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1401
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3692


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)