TCM Prescription: Jiang Ling Zhu Decoction



Prescription Description
Prescription IDTCMF2815
Pinyin NameJiang Ling Zhu Tang
Chinese Name甘姜苓术汤
English NameJiang Ling Zhu Decoction
Function Description肾著之病, 其人身体重, 腰中冷, 如坐水中, 形如水状, 反不渴, 小便自利, 饮食如故, 病属下焦身劳汗出, 衣里冷湿, 久久得之, 腰以下冷痛, 腹重如带五千钱, 甘姜苓术汤主之
IndicationsKidney stagnation disorder
Disease ICD-11 Category SB00 [Kidney stagnation disorder (TM1), 肾著 (TM1) ];
Human Tissues Associated with Indication
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT601 F2 Thrombin Unclassified P00734
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.2957
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5112
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 10.4738
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 9.20174
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 8.15954
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, SRC, TEK 8.0645
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 8.04199
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.9766
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.81426
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.81345
[BP] GO:0010647 positive regulation of cell communication AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.78536
[BP] GO:0023056 positive regulation of signaling AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.76877
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 7.65775
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HSPA1A, PPARA, TYR, XDH 7.4928
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 7.4928
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.2838
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 7.09262
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 6.9344
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.89443
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.85804
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.73847
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, SRC, TEK, TYR 6.73847
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.12968
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.69903
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.5968
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.42953
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.40626
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, BCL2, CYP1B1, EGFR, F2, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 4.99808
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 4.88999
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.88763
[BP] GO:0080134 regulation of response to stress CDK6, CYP19A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.87944
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.85685
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK, XDH 4.85429
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.80141
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, IGF1R, INSR, KDR, MMP12, TEK 4.78568
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 4.6994
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.66374
[BP] GO:0048583 regulation of response to stimulus AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.59971
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.47904
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.43351
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39424
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK, TNKS, XDH 4.39424
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK 4.3353
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.14821
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, BCL2, CA2, CA3, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR 4.14039
[BP] GO:0009966 regulation of signal transduction AKR1B1, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.13337
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.11296
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK, TNKS, XDH 4.11296
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.02664
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.02664
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.97556
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.92104
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.8734
[BP] GO:0006468 protein phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 3.80997
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.77168
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.72979
[BP] GO:0031325 positive regulation of cellular metabolic process BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.71506
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.70736
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.70736
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, F2, INSR, SMAD3, XDH 3.70488
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.70341
[BP] GO:0010604 positive regulation of macromolecule metabolic process BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.70341
[BP] GO:0009893 positive regulation of metabolic process BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.70341
[BP] GO:2000145 regulation of cell motility BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.7002
[BP] GO:0010941 regulation of cell death AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, MET, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.67534
[BP] GO:0032879 regulation of localization ACHE, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F2, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 3.67534
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.61951
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, SMAD3, SRC 3.59871
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 3.59871
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, EGFR, F2, PPARA, SMAD3 3.5985
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.55874
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.5433
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, EGFR, F2, KDR, SRC, TNKS, TNKS2 3.5148
[BP] GO:0043067 regulation of programmed cell death AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, MET, PTPN1, SMAD3, SRC, TEK, XDH 3.49207
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA3, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, SRC 3.46396
[BP] GO:0042592 homeostatic process AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.44634
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.43596
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, SRC, TEK 3.41459
[BP] GO:0040012 regulation of locomotion BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.4138
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.40592
[BP] GO:0051270 regulation of cellular component movement BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.40592
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 3.40001
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 3.40001
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.3794
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, SMAD3, SRC 3.3794
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.31082
[BP] GO:0030334 regulation of cell migration BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.30492
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.27467
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.27467
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, F2, F3, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 3.25302
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.24774
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 3.23929
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, F3, INSR, MET, SRC, TEK, XDH 3.23929
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.20594
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, CDC25B, EGFR, ESRRB, F2, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.20594
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.20318
[BP] GO:0060548 negative regulation of cell death AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PPARA, PTPN1, SMAD3, SRC, TEK 3.17748
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC 3.15742
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 3.15547
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 3.14237
[BP] GO:0065009 regulation of molecular function BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.13956
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PPARA 3.13027
[BP] GO:0016310 phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 3.01641
[BP] GO:0042325 regulation of phosphorylation BCL2, CDC25B, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, IGF1R, INSR, KDR, PPARA, PTPN1, SRC, TEK, XDH 3.01483
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 3.01483
[BP] GO:0042981 regulation of apoptotic process AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.01483
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F3, INSR, MET, SRC, TEK 3.0087
[BP] GO:0050790 regulation of catalytic activity BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.00758
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.96618
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.95437
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, SMAD3, XDH 2.94494
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.93065
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.93065
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.90563
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.89496
[BP] GO:0009115 None AOX1, XDH 2.89064
[BP] GO:0044093 positive regulation of molecular function BCL2, CDC25B, EGFR, ESR1, ESR2, F2, F3, FLT3, HSPA1A, INSR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.88841
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.88841
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK 2.88841
[BP] GO:0018193 peptidyl-amino acid modification BCL2, CSNK2A1, EGFR, F2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 2.87624
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.86851
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.85393
[BP] GO:0003006 developmental process involved in reproduction ALPL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.8482
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.8482
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.8482
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.79826
[BP] GO:0031348 negative regulation of defense response CYP19A1, F2, MMP12, PPARA, SMAD3, TEK 2.79619
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SMAD3, SRC 2.7705
[BP] GO:0010638 positive regulation of organelle organization BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 2.76896
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.75991
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.75624
[BP] GO:0043085 positive regulation of catalytic activity BCL2, CDC25B, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.75624
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.75624
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.74062
[BP] GO:0009891 positive regulation of biosynthetic process EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.74062
[BP] GO:0051247 positive regulation of protein metabolic process BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.72574
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.71436
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 2.69793
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.68118
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.67189
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.67189
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F2, F3, FABP4, KDR, MET, SMAD3 2.63938
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, SMAD3, TEK 2.63805
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.62631
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.62272
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.62272
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.6214
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.62043
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, PTPN1, SRC, XDH 2.60683
[BP] GO:0008283 cell proliferation ACHE, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, SRC, TEK, TYR 2.59521
[BP] GO:0007346 regulation of mitotic cell cycle BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, SMAD3, TNKS 2.57079
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.57079
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, F2, PPARA, SMAD3, TEK 2.56662
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CA3, CYP1A1, CYP1B1, KDR, SRC 2.55283
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.55267
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.55267
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A 2.55267
[BP] GO:0046110 None AOX1, XDH 2.54362
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54362
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, GPR35, SMAD3 2.53526
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.53526
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.51779
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.51199
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.48543
[BP] GO:0042327 positive regulation of phosphorylation BCL2, CDC25B, EGFR, ESRRB, F2, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.48509
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2 2.47174
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.46937
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.46622
[BP] GO:0032270 positive regulation of cellular protein metabolic process BCL2, CDC25B, EGFR, ESR1, F2, F3, FLT3, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.46425
[BP] GO:0009628 response to abiotic stimulus AKR1B1, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, PPARA, SMAD3, SRC, TEK, TYR 2.43574
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.43256
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, F2, KDR, SRC 2.43103
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.43103
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.4208
[BP] GO:0043549 regulation of kinase activity CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.41353
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PTPN1, SMAD3, SRC, XDH 2.4098
[BP] GO:0007166 cell surface receptor signaling pathway BCL2, CA1, CSNK2A1, EGFR, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.4098
[BP] GO:0051338 regulation of transferase activity CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK, TNKS 2.40335
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PTPN1, SMAD3, SRC, TEK 2.39747
[BP] GO:0051054 positive regulation of DNA metabolic process EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.39234
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38051
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.37732
[BP] GO:0001932 regulation of protein phosphorylation BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.37726
[BP] GO:0031399 regulation of protein modification process BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SRC, TEK, XDH 2.36938
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.36938
[BP] GO:0051239 regulation of multicellular organismal process BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, TNKS2, XDH 2.35852
[BP] GO:0043408 regulation of MAPK cascade DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.34208
[BP] GO:0051894 None KDR, SMAD3, TEK 2.34208
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.34208
[BP] GO:0006464 cellular protein modification process ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.34048
[BP] GO:0036211 protein modification process ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.34048
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.33105
[BP] GO:0070213 None TNKS, TNKS2 2.32725
[BP] GO:0006145 None AOX1, XDH 2.32725
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32725
[BP] GO:0050927 None F3, KDR, SMAD3 2.30361
[BP] GO:0050793 regulation of developmental process BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F2, F3, INSR, KDR, NUAK1, PPARA, SMAD3, SRC, TEK, TNKS2, XDH 2.29343
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, EGFR, F2, TNKS, TNKS2 2.29276
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.2813
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2 2.2813
[BP] GO:0050926 None F3, KDR, SMAD3 2.26343
[BP] GO:1903393 None KDR, SMAD3, TEK 2.26343
[BP] GO:0032268 regulation of cellular protein metabolic process BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.26042
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.25966
[BP] GO:0009892 negative regulation of metabolic process BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH 2.25355
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.23816
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP12, SRC, XDH 2.23102
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.22334
[BP] GO:0006979 response to oxidative stress AKR1B1, BCL2, CA3, CYP1B1, EGFR, HSPA1A, SRC 2.21926
[BP] GO:0009894 regulation of catabolic process BCL2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.19821
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, SRC 2.15993
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.15881
[BP] GO:0019538 protein metabolic process ACHE, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F2, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.15072
[BP] GO:0019222 regulation of metabolic process ACHE, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.15004
[BP] GO:0043696 None CDK6, ESRRB 2.15004
[BP] GO:0043697 None CDK6, ESRRB 2.15004
[BP] GO:0010641 None F3, SRC 2.15004
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.12828
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.10966
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.10966
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.10966
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, F2, FABP3, FLT3, PPARA, SRC, TEK 2.09303
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.09266
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 2.08954
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.08241
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.08241
[BP] GO:1901890 None KDR, SMAD3, TEK 2.08031
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.05174
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, GPR35, SMAD3 2.05039
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.05039
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.02656
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.01853
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.01164
[BP] GO:0046113 None AOX1, XDH 2.01164
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, EGFR, ESR2, F2, HSPA1A, INSR, SMAD3, TNKS2 2.00732
[BP] GO:0043410 positive regulation of MAPK cascade EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.00083
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.31628
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.11909
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.08817
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01164
[CC] GO:0016323 basolateral plasma membrane CA2, CA4, CA9, EGFR, TEK 1.81233
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.7161
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 13.5112
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5112
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0097
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, SRC, TEK, TNKS, TNKS2, TYR, XDH 12.0097
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 10.4738
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PTPN1, SMAD3, TNKS 8.63045
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 8.01232
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.33732
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.6241
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.397
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP12, NUAK1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TYR, XDH 4.82639
[MF] GO:0004713 protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.55384
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP12, NUAK1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TYR, XDH 4.48328
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.14875
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.11311
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.95341
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.95341
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73824
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.6398
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59871
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.54428
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.47249
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.44634
[MF] GO:0008144 drug binding ACHE, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, SRC, TEK 3.43554
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.37885
[MF] GO:0004672 protein kinase activity CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 3.22324
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.21473
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.11772
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.03532
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.02905
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.90534
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.89064
[MF] GO:0003845 None HSD11B1, HSD11B2 2.89064
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.88841
[MF] GO:0038023 signaling receptor activity EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.88542
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.87624
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.87624
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.86851
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, SRC, XDH 2.78017
[MF] GO:0060089 molecular transducer activity CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.76896
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.66876
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.65522
[MF] GO:0004871 signal transducer activity EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 2.49653
[MF] GO:0004872 receptor activity EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.41286
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.40101
[MF] GO:0016301 kinase activity CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.3921
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.37838
[MF] GO:0019899 enzyme binding BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, MET, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS2 2.37291
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32725
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.29276
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.15004
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15004
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.09836
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.08031
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01164
[MF] GO:0043546 None AOX1, XDH 2.01164


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.1217
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.4433
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4275
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.7392
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1565
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.9237
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.8573
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9237
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8573
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.8573
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.5479
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.8147
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.5479
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.3087
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.3045
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, BCL2, MET, EGFR, IGF1R 2.9751
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2852
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, MET, EGFR, CDC25B 2.8239
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.1387
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4007
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2 2.3056
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.3056
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3056
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.3033
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3007
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3056
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2558
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, F3 1.8768
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2978
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 2.0192
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2946
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8213
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6749
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6371
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.7018
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.6371
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.6
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.377
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.2781
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 1.2361
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.4679
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.3097
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4151
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.4679
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0676
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.2133
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1915
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1529
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1793
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4104
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2153
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2716
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0326
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3438
Toxoplasmosis_Homo sapiens_hsa05145 BCL2, HSPA1A 1.0326
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4337
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.001
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.2113
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9586
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.181
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9367
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9263
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8914
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.2689
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9215
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9367
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8847
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8847
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8554
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.73
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8222
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6749
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.7018
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2761
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, F2 0.6036
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3804
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3703
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3761
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.3528
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3804
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3699
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.3915
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4182
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4263
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4425
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4547
Platelet activation_Homo sapiens_hsa04611 SRC 0.4786
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8554
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4806
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4806
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4786
Axon guidance_Homo sapiens_hsa04360 MET 0.4704
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5336
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7602
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5336
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5262
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.534
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5336
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5384
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5381
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.555
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5561
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5561
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5661
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5555
Peroxisome_Homo sapiens_hsa04146 XDH 0.5667
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6033
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8213
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5918
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7476
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6128
Bile secretion_Homo sapiens_hsa04976 CA2 0.6114
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6276
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6142
Shigellosis_Homo sapiens_hsa05131 SRC 0.6293
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6293
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6525
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3 0.6686
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6784
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6966
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.045
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6998
Malaria_Homo sapiens_hsa05144 MET 0.7115
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7153
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7153
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7153
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7153
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7153
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8159
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8847
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8554
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8739
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8739
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8871
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8847
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.001
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.076
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1726
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3438


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)