TCM Prescription: Xiao Er Gan Mao Tea



Prescription Description
Prescription IDTCMF278
Pinyin NameXiao Er Gan Mao Cha 
Chinese Name小儿感冒茶
English NameXiao Er Gan Mao Tea
Function Description感冒
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH110 Cynanchum atratum 白薇 TCMH110
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 8.99165
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, GLO1, HMGCR, IDO1, PIM1, PPARA, PTGS2, TYR, XDH 8.65897
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TYR 8.48656
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, PHF8, PTGS2, TYR, XDH 8.37236
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 7.74145
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 7.49872
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP2, PPARA, PTGS2, RORC, SRC, TYR 7.49872
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA, PTGS2 7.31468
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 7.31468
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, APEX1, AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TYR 7.19522
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 7.19522
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 7.11364
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 7.05018
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP2A, TYR 6.92757
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 6.91985
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 6.66929
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSD17B2, KDR, MET, PPARA, PTGS2, SRC, TNKS, TNKS2, XDH 6.61905
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 6.20777
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC 6.11323
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 6.11267
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.04983
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.03274
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.75665
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.65987
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.65491
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.55769
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.42546
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CDK6, CSNK2A1, CYP1B1, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 5.40291
[BP] GO:0033993 response to lipid AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, PTGS2, RORC, SRC, TYR 5.34715
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, AURKB, AXL, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DHFR, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.3052
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.11403
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2 4.87946
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 4.72089
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PTGS2 4.72014
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.68677
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, HMGCR, KDR, PTGS2, SRC, TNKS, TNKS2 4.53712
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.5287
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.52388
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.50743
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1B1, DHFR, FABP3, HMGCR, KDR, PTGS2, SRC 4.46345
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR 4.45116
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.29565
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.26658
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DHFR, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 4.0248
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2, TYR 4.00567
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.00567
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.00344
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC 3.96274
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.88326
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.84999
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2, TYR 3.80098
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.78029
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.78029
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.78029
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, PTGS2, RORC, SRC, TYR 3.75893
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, PTGS2, RORC, SRC 3.71231
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 3.6908
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PPARA, PTGS2 3.6908
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, PTGS2, RORC, SRC 3.66812
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.66605
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC, TOP2A 3.66605
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC 3.66561
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 3.64062
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.60663
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, PTGS2, SRC 3.56548
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.47657
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HMGCR, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TYR 3.43911
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS2, TYR 3.43424
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 3.43424
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, HSD17B2, KDR, MMP9, PHF8, PIM1, PPARA, PTGS2, RORC, SRC, TYR 3.43424
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.29787
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.29311
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 3.29311
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.28758
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 3.28758
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DHFR, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.2802
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27822
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.20952
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PHF8, PPARA, SRC, TYR 3.1563
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.09746
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.03712
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.0192
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.00089
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.0004
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.99383
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 2.99205
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.9562
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.83359
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.79461
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.79084
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.78607
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, FABP3, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.77172
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.76305
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.74486
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HMGCR, HSD17B1, HSD17B2 2.73831
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, PTGS2, SRC 2.67376
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.67358
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, HMGCR, KDR, MET, PTGS2, PTPN1, SRC, XDH 2.67226
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.67073
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.66862
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, GSK3B, PPARA, RORC, SRC, TOP2A 2.65787
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.65692
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1 2.64739
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.64739
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.64688
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.64688
[BP] GO:0048869 cellular developmental process ACHE, AXL, CBR1, CDC25B, CDK6, CYP1A1, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, RORC, SRC, TOP2A 2.64688
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.64144
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.59865
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DHFR, HMGCR, TYR 2.5556
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.54384
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.53165
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, PTGS2 2.51638
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.50799
[BP] GO:0030154 cell differentiation AXL, CBR1, CDK6, CYP1A1, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, KDR, MMP2, MMP9, PTGS2, RORC, TOP2A 2.49633
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.49276
[BP] GO:0043393 regulation of protein binding AURKB, GSK3B, MET, MMP9, PPARA, SRC 2.48997
[BP] GO:0006807 nitrogen compound metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, APEX1, AURKB, AXL, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.48707
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48553
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.47629
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.47629
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.47461
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.45927
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.45927
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.45927
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.45901
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.45901
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.45563
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.45563
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45563
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.45563
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, DHFR, HMGCR, IDO1, PTGS2 2.44076
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.42792
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.40415
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.38002
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34904
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.31882
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, PTGS2, TNKS, TNKS2 2.31882
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30688
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CDK6, CYP19A1, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.28251
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.28251
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PTGS2, SRC 2.26776
[BP] GO:0051098 regulation of binding AURKB, GSK3B, MET, MMP9, PPARA, SRC, TNKS 2.26776
[BP] GO:0070213 None TNKS, TNKS2 2.26776
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.26776
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26776
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.26608
[BP] GO:0051186 None AKR1B1, AKR1B10, CYP1A1, CYP1A2, DHFR, GLO1, HMGCR, PTGS2 2.25378
[BP] GO:0032845 None ADORA1, HMGCR, SRC, TNKS, TNKS2 2.23182
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.2316
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.2316
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, FLT3, PTGS2, RORC, SRC 2.22615
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GLO1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.21135
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2 2.21117
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.19767
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.19767
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.19767
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.18742
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.13864
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.12457
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 2.12457
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.12344
[BP] GO:0080135 regulation of cellular response to stress CDK6, DHFR, GSK3B, HMGCR, IGF1R, MET, PTGS2, PTPN1, XDH 2.11747
[BP] GO:0051100 negative regulation of binding AURKB, GSK3B, MET, PPARA, TNKS 2.11747
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC 2.10665
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.08944
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, IDO1, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TOP2A 2.08332
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.08189
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.06919
[BP] GO:0010942 positive regulation of cell death CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, TOP2A, XDH 2.06919
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, MMP9, RORC 2.05498
[BP] GO:1902532 negative regulation of intracellular signal transduction HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.05344
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, HMGCR, MMP2, PPARA, PTGS2, SRC, TYR 2.05344
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.05344
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, DHFR, HMGCR, TYR 2.05344
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.0229
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.02177
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.02177
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.02177
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, FABP4, FLT3, GSK3B, HMGCR, IGF1R, PTPN1, SRC, TNKS 2.02177
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.00603
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.09718
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, AXL, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.45563
[CC] GO:0043231 intracellular membrane-bounded organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IGF1R, KDR, MMP12, MMP2, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.32844
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.96405
[CC] GO:0043226 organelle ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, AXL, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 1.86117
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, FUT7, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 15.1272
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 11.1783
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 10.8111
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HMGCR, HSD17B1, HSD17B2, IDO1, PHF8, PTGS2, TYR, XDH 8.65897
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.37097
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.92476
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PTPN1, RORC, TNKS 5.58946
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.27073
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 5.1129
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 5.07105
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTGS2, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 4.71893
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.70506
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.53712
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HMGCR, HSD17B1, IDO1, PTGS2, SRC, XDH 4.49778
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 4.41588
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.38003
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, PTGS2, TYR 4.05744
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, XDH 3.99843
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.8341
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.66812
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.66605
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.60663
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 3.43424
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.27822
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.23587
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AURKB, AXL, CDK6, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 3.06389
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.89258
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.85351
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.78513
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.74922
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.72132
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.67358
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.50926
[MF] GO:0000166 nucleotide binding ABCG2, AURKB, AXL, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.34278
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AURKB, AXL, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.34264
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC 2.27884
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.2316
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.19767
[MF] GO:0043168 anion binding ABCG2, AURKB, AXL, CDK6, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, XDH 2.06112
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05344
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.02721


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.9555
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.618
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.3161
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, DHFR, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, IDO1 5.4837
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, CDK6, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 4.5388
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4214
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1679
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.2665
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.6621
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.7031
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1679
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.3241
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3858
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.7138
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3201
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.3989
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2 2.3201
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.194
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, KDR, MET, IGF1R 1.8761
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0354
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.8595
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.194
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.8595
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.7908
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.636
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.5243
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1 1.5959
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.6792
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1372
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.306
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3783
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.2556
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2925
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3622
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.1372
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.1341
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2916
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0783
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PTGS2 1.1372
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1257
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.306
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0297
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0847
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2007
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.0783
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0274
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1175
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, PTGS2 1.0256
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.0043
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0043
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.806
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9987
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9809
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.9408
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9694
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.9281
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.9252
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.9252
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.8914
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9281
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.87
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6972
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8428
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9638
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.7575
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.7575
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.7975
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.7523
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7828
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6302
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.2972
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2976
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3491
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4042
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3938
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4036
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4042
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.4134
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4313
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4393
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4859
Platelet activation_Homo sapiens_hsa04611 SRC 0.5074
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5095
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4935
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5074
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5314
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5122
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5521
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.556
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5599
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5521
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5645
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5642
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.556
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.573
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5741
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.564
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5733
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5741
Gap junction_Homo sapiens_hsa04540 SRC 0.5741
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5737
Peroxisome_Homo sapiens_hsa04146 XDH 0.5845
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6265
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6265
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.636
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6265
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6253
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6302
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.636
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.636
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6415
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.636
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6302
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6302
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.636
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.636
Shigellosis_Homo sapiens_hsa05131 SRC 0.636
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6643
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6844
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6668
Malaria_Homo sapiens_hsa05144 MET 0.6985
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6953
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7192
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.7321
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7975
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7575
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7975
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8268
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8069
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8428
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.87
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8348
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8604
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9281
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9212
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.157
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.0256


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)