TCM Prescription: Pus Discharging Powder and Decoction



Prescription Description
Prescription IDTCMF2773
Pinyin NamePai Nong San Ji Tang
Chinese Name排脓散及汤
English NamePus Discharging Powder and Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCurrent Kampo Medicine
Reference Book/linkISSN 1559-033X
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1865 Paeonia obovata 芍药 TCMH1865 GBVX7902-15
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: Current Kampo Medicine

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MET, MTNR1B, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 11.1833
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, PTGES, SMAD3, SRC, TEK, TRPV1, TYR 10.7175
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 10.0851
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 10.0717
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, POLB, PPARA, PTGES, SRC, TEK, TRPV1, TYR 9.52064
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 8.69811
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, PTGES, SMAD3, SRC, TEK, TRPV1, TYR 8.29091
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.24358
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.12937
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGES, SRC, TYR 8.02037
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 7.78201
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, SRC, TEK, TRPV1 7.77665
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HMGCR, HSPA1A, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 7.77665
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.40661
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.38587
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.35799
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGES, SRC, TEK, TRPV1, TYR 7.22101
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SMAD3, SRC, TEK, TRPV1 6.84746
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 6.66836
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.33524
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.08655
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.07635
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, XDH 6.07635
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.98653
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, TNKS, XDH 5.98653
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK, XDH 5.94875
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.90936
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.88483
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.87993
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.76635
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, TNKS, XDH 5.64022
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA, PTGES, TBXAS1 5.49901
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.45696
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 5.41072
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, PTGES, SRC 5.35776
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, IGF1R, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.35776
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 5.35776
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 5.348
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, PIM1, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.27515
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, NUAK1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TRPV1, TYR 5.13194
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.0562
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.01829
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 5.00313
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MTNR1B 4.97632
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 4.93674
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 4.9232
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.86897
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, MTNR1B, POLA1, POLB, SMAD3, SRC, TRPV1 4.84303
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, IGF1R, KDR, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 4.83811
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, KDR, POLB, SRC, TRPV1 4.8296
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.72989
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MET, PIM1, PTPN1, SMAD3, SRC, TEK 4.70639
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 4.6855
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.67192
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.65431
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.60647
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.56153
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, EGFR, HMGCR, KDR, SRC, TNKS, TNKS2, TRPV1 4.46521
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.46497
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, POLA1, POLB, PTPN1, SMAD3, SRC, TRPV1 4.31817
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.31817
[BP] GO:0032879 regulation of localization ACHE, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 4.31817
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, SMAD3, SRC, TRPV1 4.31714
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, SMAD3, SRC, TRPV1 4.2377
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, MAOA, TYR 4.17506
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MET, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 4.14821
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.14821
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, PIM1, PTPN1, SMAD3, SRC, TEK 4.10287
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.10287
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.09195
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.08063
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 4.01146
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSD11B2, HSPA1A, POLB, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 3.99271
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.95711
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.95711
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, PIM1, TEK 3.95711
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, NUAK1, PIM1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.94991
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 3.93252
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 3.93252
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.91954
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES 3.89548
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.85467
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.85162
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, SRC 3.79866
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.76246
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.758
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, MTNR1B, SMAD3, TRPV1 3.67434
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, TBXAS1 3.67162
[BP] GO:2000145 regulation of cell motility BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.65326
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.63762
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.6326
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 3.59916
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 3.57761
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 3.57761
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.57438
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 3.56023
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.56023
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC 3.54259
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 3.50524
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.50341
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 3.40321
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 3.39596
[BP] GO:0040012 regulation of locomotion BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.3249
[BP] GO:0080134 regulation of response to stress CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.31889
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.31684
[BP] GO:0051270 regulation of cellular component movement BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.31684
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SRC, TRPV1, TYR 3.30952
[BP] GO:0030334 regulation of cell migration BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.29194
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.26692
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, TRPV1 3.25999
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS 3.25618
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.24808
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.20139
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.1409
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13883
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.09507
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR 3.09007
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.07269
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 3.06463
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.00509
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.98628
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, SRC, TRPV1 2.98628
[BP] GO:0065009 regulation of molecular function AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 2.97625
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, PTGES, TBXAS1 2.97423
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.92385
[BP] GO:0007165 signal transduction AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, NUAK1, PIM1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 2.9173
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.9173
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, POLB, PPARA, SMAD3, SRC, TEK 2.90203
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.83949
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 2.83949
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81589
[BP] GO:0009115 None AOX1, XDH 2.81472
[BP] GO:0032845 None BCL2, HMGCR, SRC, TNKS, TNKS2, TRPV1 2.79269
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC 2.7759
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.77566
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.77566
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, EGFR, FLT3, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 2.77144
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SRC, TRPV1, TYR 2.76317
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, PIM1, PPARA, PTPN1, SRC, TNKS 2.7585
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 2.74016
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.74016
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, PTPN1, SRC, XDH 2.73908
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TRPV1, TYR 2.72381
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.71026
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.70359
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.68657
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAOA 2.67591
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, PTGES 2.67379
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, PPARA, PTPN1, SRC, TEK, XDH 2.6702
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.66004
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.66004
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.66004
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.66004
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59611
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HMGCR, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.56649
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.56605
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.56196
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.56175
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.53639
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.52504
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC 2.51112
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.50575
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.50575
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 2.50156
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.50156
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.50156
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.50156
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.50156
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.48287
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.46647
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TRPV1, TYR 2.46468
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.4511
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.4511
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOA, SMAD3, TRPV1 2.44788
[BP] GO:0046110 None AOX1, XDH 2.44551
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44551
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, SRC, TRPV1 2.44551
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, SRC 2.43613
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.43117
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 2.42919
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.42673
[BP] GO:0050790 regulation of catalytic activity AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.42399
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.42341
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.42341
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.42242
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.41612
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.41505
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.41505
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.40378
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.40378
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, PTPN1, SMAD3, SRC, XDH 2.39295
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, PTPN1, SMAD3, SRC, XDH 2.37922
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, EGFR, ESRRB, FLT3, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 2.37041
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.36343
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.36343
[BP] GO:0051239 regulation of multicellular organismal process AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PIM1, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 2.35386
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.34431
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.34431
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.34352
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.34352
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.33493
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32137
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MTNR1A, PPARA, SMAD3, SRC, TNKS, TNKS2, TRPV1 2.32017
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, TEK 2.32017
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.29832
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC, TEK, TNKS 2.28134
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, SRC, TEK, TRPV1 2.27794
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TNKS 2.27794
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.27597
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.27497
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.27497
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, TRPV1, TYR 2.25188
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.24104
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22405
[BP] GO:0070213 None TNKS, TNKS2 2.22405
[BP] GO:0006145 None AOX1, XDH 2.22405
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22405
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HMGCR, KDR, SRC, TEK 2.21506
[BP] GO:0051049 regulation of transport ACHE, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HMGCR, HSPA1A, INSR, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TRPV1 2.20073
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.19472
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.19019
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, MTNR1A, SRC 2.18468
[BP] GO:0051894 None KDR, SMAD3, TEK 2.18468
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18468
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.15311
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HMGCR, HSPA1A, KDR, MET, PIM1, SMAD3, SRC, TEK, TRPV1 2.14552
[BP] GO:0050927 None F3, KDR, SMAD3 2.13622
[BP] GO:0043412 macromolecule modification ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.13581
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.11354
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, KDR, SRC, TRPV1 2.10614
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.10381
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MTNR1A, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2 2.10328
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.09858
[BP] GO:0050926 None F3, KDR, SMAD3 2.09858
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.09858
[BP] GO:1903393 None KDR, SMAD3, TEK 2.09858
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, PPARA, SMAD3, TEK 2.09582
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.09052
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.08086
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, EGFR, HMGCR, HSD11B2, PTGES, SMAD3, SRC, TRPV1, TYR 2.05812
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.05812
[BP] GO:0044093 positive regulation of molecular function AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.05812
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.05812
[BP] GO:0032872 regulation of stress-activated MAPK cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.05812
[BP] GO:0043696 None CDK6, ESRRB 2.05812
[BP] GO:0043697 None CDK6, ESRRB 2.05812
[BP] GO:0010641 None F3, SRC 2.05812
[BP] GO:0007598 None F10, F3 2.05812
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.04875
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.04058
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.04058
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 2.02807
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, SMAD3, TRPV1 2.02278
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.02216
[BP] GO:0043085 positive regulation of catalytic activity AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.01469
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.0092
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2 2.0092
[CC] GO:0016020 membrane ACHE, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR 3.04148
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, TBXAS1 2.83979
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, NQO2, PIM1, POLA1, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.6819
[CC] GO:0044425 membrane part ACHE, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPN1, SRC, TBXAS1, TEK, TRPV1, TYR 2.66004
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, TBXAS1 2.62557
[CC] GO:0031233 None CA4, F10, F3 2.37041
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, NQO2, NUAK1, PIM1, POLA1, POLB, PTGES, PTPN1, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 12.3423
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.9304
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, NQO2, PIM1, PPARA, PTPN1, SMAD3, TBXAS1, TNKS, TYR, XDH 11.9304
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 11.2718
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, POLB 8.02037
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 7.97978
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.64214
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.28645
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.48712
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.01268
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, NQO2, POLA1, PTGES, SRC, TBXAS1, XDH 5.98653
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 5.72493
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 5.5142
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, SMAD3, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.28179
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.13543
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, POLB 5.08924
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2 5.04874
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, NQO2, PPARA, PTPN1, SMAD3, TNKS 5.04056
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, SMAD3, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.01312
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.65431
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, TRPV1 4.48934
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.20706
[MF] GO:0038023 signaling receptor activity AXL, CHRM2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 4.17346
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PTGES, SRC, TEK, TRPV1, XDH 4.08063
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 3.95711
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, POLA1, SRC, TEK, TRPV1, XDH 3.89966
[MF] GO:0060089 molecular transducer activity AXL, CDK6, CHRM2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 3.89966
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.86789
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, POLA1, SRC, TEK, TRPV1, XDH 3.86789
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, POLA1, SRC, TEK, TRPV1, XDH 3.86789
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.86221
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.77082
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.77082
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.65939
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63534
[MF] GO:0004872 receptor activity AXL, CHRM2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 3.55015
[MF] GO:0004871 signal transducer activity AXL, CHRM2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, SMAD3, TEK, TRPV1 3.54506
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.49697
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.47464
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.46067
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.44483
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.40321
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.40321
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.29604
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.27047
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HMGCR, HSPA1A, MET, POLA1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS2 3.1409
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.04124
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.87902
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81472
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81472
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.67883
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.66004
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.66004
[MF] GO:0008502 None MTNR1A, MTNR1B 2.44551
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, PIM1, PPARA, PTPN1, SMAD3, SRC 2.37697
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, NQO2, SMAD3, TRPV1, TYR, XDH 2.34431
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.31242
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.26327
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22405
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.21651
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TRPV1 2.19019
[MF] GO:0097159 organic cyclic compound binding AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MTNR1A, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, SMAD3, SRC, TBXAS1, TEK, TRPV1, XDH 2.15311
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.10328
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, PPARA, PTPN1, SMAD3, SRC 2.05812
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05812
[MF] GO:0043559 insulin binding IGF1R, INSR 2.05812
[MF] GO:0099600 transmembrane receptor activity AXL, CHRM2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 2.03233
[MF] GO:0004888 transmembrane signaling receptor activity AXL, CHRM2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 2.03233
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.02938


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.2646
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.2611
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.8941
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, HMGCR, TYR, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 7.6351
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.1427
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.1565
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.2019
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.762
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.3657
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.3264
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.3284
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.0859
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.0859
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGES 3.0859
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MET, EGFR, CDC25B 3.0859
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.9355
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.9714
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, BCL2, MET, EGFR, IGF1R 2.5011
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9714
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1, F3 2.5164
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.8216
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1062
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2 2.0701
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.0701
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0701
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.0701
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, MTNR1A, GPR35, MTNR1B, TRPV1 1.9045
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0701
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0701
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.7402
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0701
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0301
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8055
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1 2.0701
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6029
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.0701
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6048
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, ALOX15 1.6029
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.5599
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4313
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.5289
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.4313
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.392
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.5289
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.3961
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3165
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.2022
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.1082
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 1.0985
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.0767
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.1865
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0856
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.0684
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.0392
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0392
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8979
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.3363
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3363
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0547
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1401
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0885
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8435
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.0522
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2967
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8259
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9179
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0827
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3296
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8259
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8239
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0572
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1366
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8239
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7983
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7423
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.202
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7744
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2907
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7194
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, EGFR 0.716
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.317
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.716
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3244
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3286
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3165
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3165
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.3407
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, PPARA 0.6674
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3662
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3743
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3899
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5532
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4018
Axon guidance_Homo sapiens_hsa04360 MET 0.4142
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4278
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4278
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4223
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.4118
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.5289
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4694
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4769
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4769
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4769
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.5599
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4692
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4865
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4859
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5032
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5049
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5049
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5156
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.504
Peroxisome_Homo sapiens_hsa04146 XDH 0.5167
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7106
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5415
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5532
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5675
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5795
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5696
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7284
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5772
Shigellosis_Homo sapiens_hsa05131 SRC 0.5819
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5819
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6057
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6666
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6029
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6362
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6546
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6586
Malaria_Homo sapiens_hsa05144 MET 0.6668
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6668
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6674
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6625
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6674
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9045
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6674
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6674
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6674
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7452
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.716
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8239
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7817
DNA replication_Homo sapiens_hsa03030 POLA1 0.7423
Base excision repair_Homo sapiens_hsa03410 POLB 0.765
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8239
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8239
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8398
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8658
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9531
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9714
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9344
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0296
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2793


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)