TCM Prescription: Bolus of Dendrobii for Poor Vision



Prescription Description
Prescription IDTCMF2627
Pinyin NameShi Hu Ye Guang Wan
Chinese Name石斛夜光丸
English NameBolus of Dendrobii for Poor Vision
Function Description内障, 视物不清, 云翳攀睛, 瞳仁返背, 慢性目疾
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLiver
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH219 Semen cassiae 草决明 TCMH219 GENG109-13
TCMH73 Tribulus terrestris 白蒺藜 TCMH73 ITSAJ4258-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1698 Semen celosiae 青葙子 TCMH1698
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 11.5865
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, KDR, MAOA, MET, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 9.49754
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 8.68879
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.95115
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 7.95115
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH 7.86368
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH 7.86368
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.91019
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.91019
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.87971
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.87971
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.83618
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.78181
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SLC6A3, SRC, TYR 6.5656
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.5092
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 6.31035
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.10533
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 5.91068
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 5.91068
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 5.84295
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, PPARA, SLC6A3, SRC, TYR 5.79769
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.75816
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.59978
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTPN1, SRC, TNKS, TNKS2, XDH 5.58818
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.4767
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 5.47565
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTPN1, SRC, TNKS, TNKS2, XDH 5.47565
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.46863
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3 5.21249
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3 5.21249
[BP] GO:0042221 response to chemical AKR1B1, APEX1, APP, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SLC6A2, SLC6A3, SRC, TYR 5.20414
[BP] GO:0018958 None AKR1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3, TYR 5.08426
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 5.08154
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.01008
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, MAOA, SLC6A3 4.8848
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DYRK1A, DYRK1B, DYRK3, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIM1, PPARA, SLC6A3, SRC, TNKS2, TOP2A, TYR 4.83278
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.83278
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.83278
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 4.7734
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, MAOA, SLC1A1, SLC6A2, SLC6A3 4.7734
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, FUT7, GLO1, HASPIN, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.7549
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.74282
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AXL, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK2, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PPARA, PTPN1, SRC 4.7283
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3, TYR 4.72756
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.70007
[BP] GO:0042417 None DRD2, DRD3, DRD4, MAOA, SLC6A3 4.68396
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, NISCH, PIM1, PPARA, TYR, XDH 4.67115
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, SLC6A3, SRC, TYR 4.537
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 4.53033
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.51911
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CDK6, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, KDR, SLC6A2, SLC6A3, SRC 4.48187
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2, NISCH 4.43072
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DYRK2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 4.43072
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC6A2, SLC6A3, SRC, TNKS2, TYR 4.43072
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 4.417
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 4.40965
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.40654
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 4.34026
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.33616
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.33131
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.33131
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.33131
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, SRC, TNKS, TOP2A 4.33131
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CDK6, CHRM1, CYP19A1, CYP1B1, DRD2, DRD3, IGF1R, KDR, MET, MMP9, NISCH, SRC 4.24984
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, DRD2, DRD3, HCAR2, KDR, SRC, TNKS, TNKS2 4.2214
[BP] GO:0051937 None CHRM5, NISCH, SLC6A2, SLC6A3 4.21956
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, DYRK2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 4.19625
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.15504
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.12282
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.11293
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.11095
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 4.10211
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, KDR, SLC6A3, SRC 4.0821
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.07494
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, APP, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.04911
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 4.03353
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 4.00763
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5 3.99574
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.99574
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 3.90904
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 3.86244
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 3.86074
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 3.84696
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3 3.82152
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FLT3, GRM1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.81348
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, FLT3, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.78912
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.78548
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.75544
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRM5 3.73439
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.71533
[BP] GO:0015844 None CHRM5, NISCH, SLC6A2, SLC6A3 3.70587
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.67973
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.67973
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.6449
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, PPARA, SRC, TOP2A 3.6227
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, MAOA, PHF8, TYR, XDH 3.6227
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK3, FABP3, FABP4, GLO1, GRM3, GRM8, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 3.60513
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.57609
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.57609
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.57143
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.52422
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, MMP9, NISCH, SLC1A1, SLC6A3, XDH 3.52422
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51591
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, TOP2A 3.49506
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, HCAR2, TNKS, TNKS2 3.41767
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.38723
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CDK6, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, NISCH, SRC 3.38272
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.37412
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.37412
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.36541
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.33793
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.28729
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.28729
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.19536
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.14802
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.12711
[BP] GO:0007626 None APP, DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 3.11786
[BP] GO:0040014 regulation of multicellular organism growth APP, DRD2, DRD3, SLC6A3, TNKS2 3.11719
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.11719
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.09671
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.09671
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.09671
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, DRD3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.08232
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.08066
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 3.0781
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD2, DRD4 3.05293
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.05293
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CDK6, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, NISCH, SRC 3.04802
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CLK1, CYP1A1, FLT3, MET, PIM1, SRC, TYR 3.04802
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, NISCH, SRC 3.04063
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 2.99142
[BP] GO:0034776 None DRD2, DRD3, DRD4 2.98538
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, SRC 2.90243
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 2.90139
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, SLC6A2, SLC6A3, SRC, TOP2A, TYR 2.88381
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A3 2.87729
[BP] GO:0046717 None CHRM5, DRD2, DRD3, DRD4, SLC1A1 2.87377
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.87377
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.86614
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.8518
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, DRD3, DRD4, DYRK2, HCAR2, MMP12, PTPN1, SRC 2.83813
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.82825
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.81908
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DYRK1A, DYRK1B, FLT3, HSD17B2, KDR, MMP9, PHF8, PIM1, PPARA, SLC6A3, SRC, TYR 2.81212
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.79218
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.79218
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, SLC6A3, SRC, XDH 2.79133
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD2, DRD3, KDR, SRC 2.78077
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, FLT3, GRM1, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.7565
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.75131
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, HASPIN, MMP12, MMP9, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 2.73832
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, MET, PPARA 2.73809
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.7268
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CHRM1, CYP19A1, DRD2, DRD3, DRD4, DYRK2, GRIK5, GRM5, HCAR2, MMP12, MMP9, PPARA, PTPN1, SRC 2.72471
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.71058
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.71058
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, SRC, TYR 2.69991
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, DRD4, FLT3, GRM1, KDR, MET, PTPN1, SRC, XDH 2.69433
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.69433
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC 2.6637
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.653
[BP] GO:0042391 None ADORA1, APP, DRD4, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.64078
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, XDH 2.63011
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HCAR2, HSD17B1, HSD17B2 2.6043
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, DRD4, FLT3, GRM1, KDR, PTPN1, SRC, XDH 2.59254
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.59254
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.59254
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.56787
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DYRK1A, DYRK3, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.55968
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.55811
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRM1, HCAR2, SLC1A1 2.55269
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC 2.54663
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, PTPN1, SRC, TNKS 2.54199
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 2.53646
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 2.52158
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.49281
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.49281
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.48457
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.46487
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SRC 2.42851
[BP] GO:0099566 None GRM1, GRM5 2.42851
[BP] GO:0051944 None DRD2, DRD4 2.42851
[BP] GO:0060160 None DRD2, DRD3 2.42851
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.42851
[BP] GO:0051586 None DRD2, DRD4 2.42851
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, PTPN1, SRC 2.38461
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DYRK2, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, SRC, TOP2A 2.37173
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.37173
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.36951
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.36794
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.36794
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, XDH 2.3626
[BP] GO:0019538 protein metabolic process ACHE, APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.35108
[BP] GO:0044267 cellular protein metabolic process APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.34869
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.3447
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, MMP12, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, TNKS 2.3447
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AXL, CDK6, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, SRC 2.33725
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.33679
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.32456
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.32456
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, PPARA, SRC 2.32377
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.31638
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC, TNKS 2.30557
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.29439
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.27102
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.27102
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.26877
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, NISCH 2.24816
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.2367
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD2, DRD4, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.2367
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CHRM1, CYP19A1, DRD2, DRD3, DRD4, HCAR2, MMP12, SRC 2.22964
[BP] GO:0034502 protein localization to chromosome AURKB, HASPIN, TNKS, TNKS2 2.22545
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.22545
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, FABP4, FLT3, GRM1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, XDH 2.21163
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.20767
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.20113
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.20074
[BP] GO:0070213 None TNKS, TNKS2 2.20074
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.20074
[BP] GO:0015874 None NISCH, SLC6A2 2.20074
[BP] GO:0051582 None DRD2, DRD4 2.20074
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20074
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.18922
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.18922
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.18922
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3 2.18922
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.18922
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.18922
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.18922
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.18922
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, SRC 2.18922
[BP] GO:0006464 cellular protein modification process APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.18922
[BP] GO:0036211 protein modification process APP, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.18922
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.18851
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.18384
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.18106
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, DRD4, FLT3, GRM1, IGF1R, KDR, PTPN1, SRC, XDH 2.17734
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.17734
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.17489
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, IGF1R, PTPN1, SRC 2.17456
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.16038
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.15951
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, NISCH 2.15078
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1501
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.1501
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, SRC 2.13661
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.13661
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, MMP12, SRC 2.1231
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CHRM1, DRD2, DRD3, DRD4, GRM5, MMP9 2.11677
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.11677
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.11677
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.11677
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, SLC1A1 2.11608
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD2, DRD3, GRM1, MMP2, PPARA, SRC, TYR 2.11421
[BP] GO:0048169 None APP, DRD2, GRM5 2.10985
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DRD2, DYRK1A, DYRK3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 2.07796
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.07717
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.06414
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.06414
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.06414
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.05304
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.04213
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.04203
[BP] GO:0046541 None CHRM1, CHRM3 2.04062
[BP] GO:0090325 None DRD2, DRD3 2.04062
[BP] GO:0042321 None ADORA1, DRD2 2.04062
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.03702
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.03702
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, NISCH 2.03692
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.03692
[BP] GO:0030808 None DRD2, DRD3, DRD4, GRM3, GRM8 2.03612
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.03263
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.03263
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, SRC 2.02559
[BP] GO:0007589 None CHRM1, CHRM3, SLC6A3, XDH 2.02559
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CDK6, CYP19A1, DRD2, DRD3, DYRK1A, DYRK3, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A3, SRC, XDH 2.02559
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, MET, SLC6A3, XDH 2.02559
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, DRD2, DRD3, GRM1, GRM5, GRM8, SLC6A3, TYR 2.02056
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.01782
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.01782
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, PTPN1, SRC 2.01357
[BP] GO:0098657 import into cell ACHE, ADORA1, APP, AXL, DRD2, DRD3, SLC1A1, SLC6A2, SLC6A3 2.00213
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, MET, SRC, XDH 2.00172
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 6.87971
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 6.24858
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 5.94886
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 5.6678
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.24552
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD2, DRD3, DRD4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, NISCH, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 4.87203
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 4.7734
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC 4.63303
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 4.23844
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.77277
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.77277
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.77277
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MAOA, MET, MMP2, NISCH, PHF8, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TYR 3.65338
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.60513
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.53399
[CC] GO:0098794 None ADORA1, APP, DRD2, DRD4, GRIA2, GRIA4, GRM3 3.5207
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.26174
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.09671
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.0698
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A2, SLC6A3, SRC 2.69796
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.38568
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, SRC 2.38568
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.32377
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 2.29255
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.02559
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 9.92646
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.46707
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 9.32078
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.20608
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.19744
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PPARA, SLC6A3, SRC, TOP2A 8.95499
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.86368
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.87971
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.3768
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.10533
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 6.09799
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.09799
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 6.09799
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.94886
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 5.74338
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 5.67305
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK2, DYRK3, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TOP2A, TYR, XDH 5.38322
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 5.29938
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.25161
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.85828
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 4.83278
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA 4.68396
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, MAOA, PHF8, TYR, XDH 4.52481
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.43072
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 4.43072
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD2, DRD3, DRD4, SLC6A3 4.10211
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PTPN1, TNKS 4.06323
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.93726
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.77277
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 3.6602
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57609
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.40622
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, XDH 3.38723
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.38723
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.37412
[MF] GO:0046872 metal ion binding ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, DYRK3, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TOP2A, TYR, XDH 3.36723
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.26174
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SLC6A3, SRC 3.18792
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.16647
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2 3.13914
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIM1 2.9598
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A3, SRC 2.9253
[MF] GO:0004952 None DRD2, DRD3, DRD4 2.87729
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.82899
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.82825
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.81212
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC 2.7268
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.59254
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.59254
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, PIM1, SLC1A1, SRC, TOP2A, XDH 2.55398
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, TYR 2.55398
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.52158
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.46396
[MF] GO:0005330 None SLC6A2, SLC6A3 2.42851
[MF] GO:0099583 None GRM1, GRM5 2.42851
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.37173
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.37173
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.3674
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.34105
[MF] GO:0043168 anion binding APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, NISCH, PIM1, SLC1A1, SRC, TOP2A, XDH 2.26577
[MF] GO:0004971 None GRIA2, GRIA4 2.20074
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.17489
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.05415
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.03263


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 12.1648
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9855
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.4938
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.4277
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.657
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.8969
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD2, PPARA, GRIA4 4.7981
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD2, SLC6A3 4.7212
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8771
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.183
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.6763
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.183
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6745
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 2.9622
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, SLC6A3, GRIA4 2.9622
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 2.8965
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9454
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.3788
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 2.4058
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.4563
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.4437
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.6297
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.7249
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, CDC25B 2.3124
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.1963
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.1854
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, MET, IGF1R 2.0702
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0213
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1288
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9767
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0396
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.714
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.5754
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2649
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5 1.5206
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.243
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD2, SLC6A3 1.1126
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9161
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2242
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1586
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1832
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2195
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9112
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9559
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9201
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.93
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0204
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7967
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1428
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0959
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8661
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.201
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9289
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1393
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0618
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8069
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.1586
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7481
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.813
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7557
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.1791
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7951
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.1358
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.7373
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7442
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6436
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5396
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2085
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2696
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2799
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2863
Purine metabolism_Homo sapiens_hsa00230 XDH 0.295
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2947
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2862
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3222
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3061
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3301
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3222
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3469
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3472
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3469
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3584
Platelet activation_Homo sapiens_hsa04611 SRC 0.3752
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3752
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3752
Axon guidance_Homo sapiens_hsa04360 MET 0.3706
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3816
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3989
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4724
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4368
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3816
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4185
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4218
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4368
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4218
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4252
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4368
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4368
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4368
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4326
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4368
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4366
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4325
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4368
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4368
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4326
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4368
Peroxisome_Homo sapiens_hsa04146 XDH 0.4368
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6467
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4689
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4368
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4697
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4713
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.5516
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4847
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4847
Bile secretion_Homo sapiens_hsa04976 CA2 0.4706
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4847
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4724
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4847
Shigellosis_Homo sapiens_hsa05131 SRC 0.4847
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5246
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.604
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5391
Legionellosis_Homo sapiens_hsa05134 CLK1 0.5267
Malaria_Homo sapiens_hsa05144 MET 0.5521
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5464
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5491
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.5719
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8492
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6227
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6227
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7044
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6844
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7263
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7481
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7442
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7632
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8684
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9454


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)