Prescription Description
| Prescription ID | TCMF2567 |
| Pinyin Name | Bu Shen Yi Nao Pian |
| Chinese Name | 补肾益脑片 |
| English Name | Bushen Yinao Tablets |
| Function Description | 心悸, 不寐, 健忘, 遗精, 耳聋, 耳鸣 |
| Indications | Involuntary ejaculation disorder, Tinnitus disorder, Forgetfulness disorder, Insomnia disorder, Amnesia |
| Disease ICD-11 Category |
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1)
]; SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; MB21.1 [Amnesia, 健忘症 ]; |
| Human Tissues Associated with Indication | Heart, Brain |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1349 | Cervus elaphus | 鹿茸 | TCMH1349 | ABMC060-05 |
| TCMH877 | Radix ginseng rubra | 红参 | TCMH877 | GBVE1679-11 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH943 | Rhizoma dioscoreae | 淮山药 | TCMH943 | |
| TCMH1966 | Rehmannia glutinosa | 熟地黄 | TCMH1966 | ITSAH4578-14 |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
| TCMH193 | Psoralea corylifolia | 补骨脂 | TCMH193 | |
| TCMH1588 | Achyranthes bidentata | 牛膝 | TCMH1588 | ITSAJ4612-14 |
| TCMH1186 | Lycium chinense | 枸杞子 | TCMH1186 | ITSAO4545-14 |
| TCMH2343 | Scrophularia ningpoensis | 玄参 | TCMH2343 | ITSAO4295-14 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
| TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
| TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
| TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
| TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
| TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
| TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
| TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
| TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
| TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
| TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
| TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
| TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
| TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
| TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
| TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
| TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
| TCMT332 | AOC3 | Amine oxidase, copper containing | Oxidoreductase | Q16853 |
| TCMT38 | DRD2 | Dopamine D2 receptor | GPCR | P14416 |
| TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
| TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
| TCMT619 | HSP90AA1 | Heat shock protein HSP 90-alpha | Unclassified | P07900 |
| TCMT624 | HSP90AB1 | Heat shock protein HSP 90-beta | Unclassified | P08238 |
| TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
| TCMT634 | SLC6A2 | Norepinephrine transporter | Transporter | P23975 |
| TCMT635 | SLC6A3 | Dopamine transporter | Transporter | Q01959 |
| TCMT648 | DRD4 | Dopamine D4 receptor | GPCR | P21917 |
| TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
| TCMT651 | DRD3 | Dopamine D3 receptor | GPCR | P35462 |
| TCMT653 | GRM1 | Metabotropic glutamate receptor 1 | GPCR | Q13255 |
| TCMT654 | GRM5 | Metabotropic glutamate receptor 5 | GPCR | P41594 |
| TCMT655 | GRM2 | Metabotropic glutamate receptor 2 | GPCR | Q14416 |
| TCMT656 | GRM3 | Metabotropic glutamate receptor 3 | GPCR | Q14832 |
| TCMT657 | GRM4 | Metabotropic glutamate receptor 4 | GPCR | Q14833 |
| TCMT660 | GRM8 | Metabotropic glutamate receptor 8 | GPCR | O00222 |
| TCMT664 | SLC1A1 | Excitatory amino acid transporter 3 | Transporter | P43005 |
| TCMT67 | PPARG | Peroxisome proliferator-activated receptor gamma | Nuclear receptor | P37231 |
| TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
| TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
| TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
| TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
| TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1207 | Legionella pneumophila |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
| TCMT1212 | Verticillium dahliae |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
| TCMT1218 | Staphylococcus aureus |
| TCMT1221 | Human herpesvirus 4 |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1231 | Human herpesvirus 1 strain KOS |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1245 | Phytophthora cactorum |
| TCMT1246 | Escherichia coli |
| TCMT1247 | Human herpesvirus 1 |
| TCMT1248 | Hepatitis C virus |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1286 | Bacillus cereus |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1321 | Staphylococcus hominis |
| TCMT1343 | Staphylococcus simulans |
| TCMT1344 | Staphylococcus sciuri |
| TCMT1346 | Helicobacter pylori |
| TCMT1349 | Helicobacter pylori SS1 |
| TCMT1361 | Neisseria meningitidis |
| TCMT1370 | Prevotella melaninogenica |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1390 | Human herpesvirus 2 strain G |
| TCMT1408 | Colletotrichum gloeosporioides |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1439 | Mycobacterium smegmatis |
| TCMT1442 | Leishmania donovani |
| TCMT1444 | Fusarium oxysporum |
| TCMT1448 | Enterobacter aerogenes |
| TCMT1449 | Influenza A virus |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1464 | Hepatitis B virus |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0007193 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 | 13.6357 |
| [BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 | 10.7524 |
| [BP] GO:0007188 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 | 10.2275 |
| [BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1 | 10.1283 |
| [BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9 | 9.75745 |
| [BP] GO:0007187 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 | 9.61329 |
| [BP] GO:0007268 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 8.69311 |
| [BP] GO:0098916 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 8.69311 |
| [BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1 | 8.69311 |
| [BP] GO:0099536 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 8.62968 |
| [BP] GO:0099537 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 8.62968 |
| [BP] GO:0006811 | None | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3 | 8.55583 |
| [BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSP90AA1, HSP90AB1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, XDH | 7.88393 |
| [BP] GO:0007215 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 7.40581 |
| [BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 7.40512 |
| [BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 7.40512 |
| [BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.06259 |
| [BP] GO:0001505 | regulation of neurotransmitter levels | ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, HSP90AA1, HSP90AB1, SLC1A1, SLC6A2, SLC6A3 | 7.02068 |
| [BP] GO:0007267 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 6.97302 |
| [BP] GO:0007197 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.68585 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, FABP3, FABP4, FUT7, HSD17B1, PPARA, PPARG | 6.57917 |
| [BP] GO:0023052 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 | 6.41362 |
| [BP] GO:0007207 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.28649 |
| [BP] GO:0007154 | None | ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, SLC1A1, SLC6A2 | 6.0913 |
| [BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.79005 |
| [BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, PPARA, PPARG, XDH | 5.77443 |
| [BP] GO:0007200 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD2, ESR1, GRM5 | 5.61392 |
| [BP] GO:0007196 | None | GRM1, GRM3, GRM5, GRM8 | 5.48696 |
| [BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, ESR1, FABP3, GRIK5, GRM5, HSP90AB1, MMP2, MMP9, PPARA, PPARG, SLC6A3 | 5.47149 |
| [BP] GO:0051966 | regulation of synaptic transmission, glutamatergic | ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 | 5.17826 |
| [BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD17B1 | 4.91582 |
| [BP] GO:0015908 | None | DRD2, DRD3, DRD4, FABP3, PPARA, PPARG | 4.86439 |
| [BP] GO:0097164 | None | ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 | 4.77782 |
| [BP] GO:0010033 | response to organic substance | AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM5, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, SLC6A3 | 4.74753 |
| [BP] GO:1900543 | None | DRD2, DRD3, DRD4, GRM3, GRM8, PPARA | 4.74125 |
| [BP] GO:0071702 | None | ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, HSP90AA1, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3 | 4.72808 |
| [BP] GO:0045980 | None | DRD2, DRD3, DRD4, GRM3, GRM8, PPARA | 4.7246 |
| [BP] GO:0006810 | None | ACHE, ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, XDH | 4.7246 |
| [BP] GO:0007216 | None | GRM1, GRM3, GRM5, GRM8 | 4.71255 |
| [BP] GO:0007186 | G-protein coupled receptor signaling pathway | ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG | 4.71255 |
| [BP] GO:0060078 | None | ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5 | 4.57592 |
| [BP] GO:0042221 | response to chemical | AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM5, HSP90AA1, HSP90AB1, MMP2, MMP9, PPARA, PPARG, SLC6A2, SLC6A3 | 4.55524 |
| [BP] GO:0014070 | response to organic cyclic compound | CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, HSP90AB1, PPARG, SLC6A3 | 4.53684 |
| [BP] GO:0051234 | None | ACHE, ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, XDH | 4.49475 |
| [BP] GO:0007213 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.49475 |
| [BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, PPARG | 4.41576 |
| [BP] GO:0006584 | None | AKR1B1, DRD2, DRD3, DRD4, SLC6A3 | 4.39371 |
| [BP] GO:0009712 | None | AKR1B1, DRD2, DRD3, DRD4, SLC6A3 | 4.39371 |
| [BP] GO:0030818 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 4.35235 |
| [BP] GO:0030803 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 4.26991 |
| [BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD2, DRD3, DRD4, SLC6A3 | 4.20656 |
| [BP] GO:0030815 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 4.19135 |
| [BP] GO:1900372 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 4.15644 |
| [BP] GO:0030809 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 4.15644 |
| [BP] GO:0051179 | None | ACHE, ADORA1, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A3, XDH | 4.15644 |
| [BP] GO:0048878 | chemical homeostasis | AKR1B1, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, PPARG | 4.15554 |
| [BP] GO:0030800 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 4.1363 |
| [BP] GO:0042752 | None | ADORA1, DRD2, DRD3, DRD4, PPARA, PPARG | 4.09084 |
| [BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, FABP3, FABP4, FUT7, PPARA, PPARG | 4.07909 |
| [BP] GO:0015909 | None | DRD2, DRD3, DRD4, FABP3, PPARG | 4.04024 |
| [BP] GO:0019369 | arachidonic acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.00794 |
| [BP] GO:0095500 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.9628 |
| [BP] GO:1903831 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.9628 |
| [BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 | 3.88084 |
| [BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, SLC1A1, SLC6A3, XDH | 3.87961 |
| [BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.81152 |
| [BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.81152 |
| [BP] GO:0007165 | signal transduction | ADORA1, ADORA3, AKR1B1, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, MMP2, MMP9, PPARA, PPARG, PTPN1 | 3.77889 |
| [BP] GO:0042493 | response to drug | AKR1B1, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HSP90AB1, PPARG, SLC6A2, SLC6A3 | 3.77264 |
| [BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 | 3.74914 |
| [BP] GO:0046903 | None | CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, HSP90AA1, HSP90AB1, MMP9, SLC1A1, SLC6A3, XDH | 3.74535 |
| [BP] GO:0007271 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.72628 |
| [BP] GO:0042417 | None | DRD2, DRD3, DRD4, SLC6A3 | 3.66405 |
| [BP] GO:0051940 | None | DRD2, DRD3, DRD4 | 3.65078 |
| [BP] GO:0051584 | None | DRD2, DRD3, DRD4 | 3.65078 |
| [BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD17B1 | 3.57134 |
| [BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, MMP1, MMP2, MMP9, SLC6A3, XDH | 3.51808 |
| [BP] GO:0042220 | None | DRD2, DRD3, HSP90AB1, SLC6A3 | 3.51641 |
| [BP] GO:0044057 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRM1, HCAR2, SLC1A1 | 3.51302 |
| [BP] GO:0006631 | fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG | 3.5098 |
| [BP] GO:0007194 | None | DRD2, DRD3, DRD4, GRM3 | 3.47466 |
| [BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7, DRD2 | 3.47466 |
| [BP] GO:0015718 | None | DRD2, DRD3, DRD4, FABP3, PPARA, PPARG | 3.47466 |
| [BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, SLC6A3 | 3.41284 |
| [BP] GO:0031280 | None | DRD2, DRD3, DRD4, GRM3 | 3.38823 |
| [BP] GO:0007195 | None | DRD2, DRD3, DRD4 | 3.38823 |
| [BP] GO:2001225 | regulation of chloride transport | CA2, CA7, GRM5 | 3.38823 |
| [BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.38823 |
| [BP] GO:0046717 | None | CHRM5, DRD2, DRD3, DRD4, SLC1A1 | 3.38557 |
| [BP] GO:0018958 | None | AKR1B1, DRD2, DRD3, DRD4, SLC6A3 | 3.36085 |
| [BP] GO:0051350 | None | DRD2, DRD3, DRD4, GRM3 | 3.30098 |
| [BP] GO:0034776 | None | DRD2, DRD3, DRD4 | 3.26452 |
| [BP] GO:0009410 | None | DRD2, DRD3, DRD4, HSP90AB1, PPARG, SLC6A3 | 3.26175 |
| [BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSP90AB1, MMP9, PPARA, PTPN1, XDH | 3.23131 |
| [BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, GRM1, GRM3, GRM5, GRM8, HSP90AB1, MMP9, PPARA, PTPN1, XDH | 3.19009 |
| [BP] GO:0015872 | None | CHRM5, SLC6A2, SLC6A3 | 3.16136 |
| [BP] GO:0060359 | None | DRD2, DRD3, DRD4, HSP90AB1, SLC6A3 | 3.13742 |
| [BP] GO:0010035 | response to inorganic substance | AKR1B1, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, MMP9, SLC6A3 | 3.09602 |
| [BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, MMP9, PPARG, PTPN1, XDH | 3.09602 |
| [BP] GO:0043279 | None | DRD2, DRD3, HSP90AB1, PPARG, SLC6A3 | 3.07704 |
| [BP] GO:0045776 | None | ADORA1, DRD2, DRD3, PPARA | 3.07437 |
| [BP] GO:0060134 | None | DRD2, DRD3, SLC6A3 | 3.07376 |
| [BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, XDH | 3.02683 |
| [BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, MMP9, PPARG, PTPN1, XDH | 3.02448 |
| [BP] GO:0051580 | None | DRD2, DRD3, DRD4 | 2.98609 |
| [BP] GO:0045761 | None | DRD2, DRD3, DRD4, GRM3 | 2.97971 |
| [BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CHRM5, CYP1A1, DRD3, FABP3, HCAR2, PPARA, PPARG | 2.97828 |
| [BP] GO:0010243 | response to organonitrogen compound | AKR1B1, DRD2, DRD3, DRD4, FABP3, GRM5, HSP90AB1, MMP2, PPARA, PPARG, SLC6A3 | 2.97828 |
| [BP] GO:0033559 | unsaturated fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.97828 |
| [BP] GO:0030817 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 2.95902 |
| [BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, GRM1, HCAR2, HSP90AB1, MMP9, PTPN1, XDH | 2.94643 |
| [BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, GRM1, HCAR2, HSP90AB1, MMP9, PTPN1, XDH | 2.92615 |
| [BP] GO:0051049 | regulation of transport | ACHE, ADORA1, CA2, CA7, CHRM1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PPARA, PPARG, PTPN1 | 2.92615 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.92615 |
| [BP] GO:0051937 | None | CHRM5, SLC6A2, SLC6A3 | 2.92072 |
| [BP] GO:0046942 | None | DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1 | 2.87762 |
| [BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 | 2.86961 |
| [BP] GO:0006690 | icosanoid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.85826 |
| [BP] GO:0007626 | None | DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 | 2.85826 |
| [BP] GO:0032225 | None | DRD2, DRD3, DRD4 | 2.84836 |
| [BP] GO:0015849 | None | DRD2, DRD3, DRD4, FABP3, PPARA, PPARG, SLC1A1 | 2.81197 |
| [BP] GO:0032102 | negative regulation of response to external stimulus | ADORA1, CYP19A1, DRD2, DRD3, PPARA, PPARG, SLC6A3 | 2.7941 |
| [BP] GO:0001504 | None | SLC1A1, SLC6A2, SLC6A3 | 2.77198 |
| [BP] GO:0048511 | rhythmic process | CSNK2A1, DRD2, DRD3, DRD4, ESR1, PPARA, PPARG | 2.74893 |
| [BP] GO:1903522 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, SLC1A1 | 2.7414 |
| [BP] GO:0009987 | cellular process | ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, SLC1A1, SLC6A2, SLC6A3, XDH | 2.72548 |
| [BP] GO:0050801 | ion homeostasis | CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, GRM1, GRM5 | 2.71589 |
| [BP] GO:1901698 | response to nitrogen compound | AKR1B1, DRD2, DRD3, DRD4, FABP3, GRM5, HSP90AB1, MMP2, PPARA, PPARG, SLC6A3 | 2.71589 |
| [BP] GO:0009636 | response to toxic substance | AKR1B1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HSP90AA1, SLC6A3 | 2.71513 |
| [BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1 | 2.69401 |
| [BP] GO:0044092 | negative regulation of molecular function | ADORA3, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM3, MMP9, PPARA, PPARG, PTPN1 | 2.68644 |
| [BP] GO:0030814 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 2.66316 |
| [BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PPARA, PPARG, PTPN1 | 2.66316 |
| [BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, CA2, CYP1A1, DRD2, DRD3, GRM1, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG | 2.6536 |
| [BP] GO:0045187 | None | ADORA1, DRD2, DRD3 | 2.6536 |
| [BP] GO:0072347 | None | DRD2, DRD3, HSP90AB1, SLC6A3 | 2.64991 |
| [BP] GO:0030802 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 2.62779 |
| [BP] GO:0099566 | None | GRM1, GRM5 | 2.61716 |
| [BP] GO:0051944 | None | DRD2, DRD4 | 2.61716 |
| [BP] GO:0060160 | None | DRD2, DRD3 | 2.61716 |
| [BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.61716 |
| [BP] GO:0051586 | None | DRD2, DRD4 | 2.61716 |
| [BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, CA2, CA7, DRD2, DRD4 | 2.61716 |
| [BP] GO:0048148 | None | DRD2, DRD3, DRD4 | 2.61716 |
| [BP] GO:0035813 | None | ADORA1, DRD2, DRD3 | 2.61716 |
| [BP] GO:0031279 | None | DRD2, DRD3, DRD4, GRM3 | 2.56772 |
| [BP] GO:0015844 | None | CHRM5, SLC6A2, SLC6A3 | 2.55902 |
| [BP] GO:0042749 | None | ADORA1, DRD2, DRD3 | 2.55902 |
| [BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MMP2, MMP9, PPARA, PPARG, PTPN1, SLC6A2, SLC6A3 | 2.55697 |
| [BP] GO:0051339 | None | DRD2, DRD3, DRD4, GRM3 | 2.54753 |
| [BP] GO:0010038 | response to metal ion | CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 | 2.50364 |
| [BP] GO:1900371 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 2.49946 |
| [BP] GO:0030808 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 2.48529 |
| [BP] GO:0022600 | None | CHRM1, CHRM3, CHRM5, DRD3 | 2.47763 |
| [BP] GO:0006940 | None | ADORA1, CHRM1, CHRM2, CHRM3 | 2.47763 |
| [BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, FABP3, MMP2, MMP9, PPARG, XDH | 2.46474 |
| [BP] GO:1903963 | None | DRD2, DRD3, DRD4 | 2.46123 |
| [BP] GO:0044062 | None | ADORA1, DRD2, DRD3 | 2.46123 |
| [BP] GO:0050482 | None | DRD2, DRD3, DRD4 | 2.46123 |
| [BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.46123 |
| [BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, PPARG, XDH | 2.45678 |
| [BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, MMP9, PPARG, PTPN1, XDH | 2.42845 |
| [BP] GO:0045936 | None | DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, PPARA, PTPN1, XDH | 2.42308 |
| [BP] GO:0010563 | None | DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, PPARA, PTPN1, XDH | 2.41922 |
| [BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1 | 2.41692 |
| [BP] GO:0035902 | response to immobilization stress | CYP1A1, CYP1A2, PPARG | 2.41692 |
| [BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.41692 |
| [BP] GO:0060079 | None | ADORA1, GRIA2, GRIA4, GRIK5 | 2.40099 |
| [BP] GO:0007589 | None | CHRM1, CHRM3, SLC6A3, XDH | 2.38421 |
| [BP] GO:1905323 | None | HSP90AA1, HSP90AB1 | 2.38421 |
| [BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.38421 |
| [BP] GO:0051582 | None | DRD2, DRD4 | 2.38421 |
| [BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.38421 |
| [BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM1, GRM5, GRM8, MMP1, MMP2, MMP9, PPARA, SLC6A2, SLC6A3 | 2.36962 |
| [BP] GO:0043271 | negative regulation of ion transport | ADORA1, DRD2, DRD3, DRD4, MMP9 | 2.36555 |
| [BP] GO:0043269 | regulation of ion transport | ADORA1, CA2, CA7, CHRM1, DRD2, DRD3, DRD4, GRM5, MMP9 | 2.36351 |
| [BP] GO:0030799 | None | DRD2, DRD3, DRD4, GRM3, GRM8 | 2.35434 |
| [BP] GO:1900542 | None | DRD2, DRD3, DRD4, GRM3, GRM8, PPARA | 2.35152 |
| [BP] GO:0035235 | None | GRIA2, GRIA4, GRIK5 | 2.34119 |
| [BP] GO:0032309 | None | DRD2, DRD3, DRD4 | 2.34119 |
| [BP] GO:0001975 | None | DRD2, DRD3, DRD4 | 2.34119 |
| [BP] GO:0032787 | None | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG | 2.30597 |
| [BP] GO:0032413 | None | DRD2, DRD3, DRD4, MMP9 | 2.29387 |
| [BP] GO:0006140 | None | DRD2, DRD3, DRD4, GRM3, GRM8, PPARA | 2.29387 |
| [BP] GO:0032409 | None | DRD2, DRD3, DRD4, GRM5, MMP9, PPARG | 2.28879 |
| [BP] GO:0015893 | None | CA2, CHRM5, SLC1A1, SLC6A2, SLC6A3 | 2.28879 |
| [BP] GO:0051952 | None | ADORA1, DRD2, DRD3, DRD4 | 2.27848 |
| [BP] GO:0008217 | None | ADORA1, DRD2, DRD3, PPARA, PPARG | 2.27814 |
| [BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, DRD2, ESR1, FABP4, HSP90AB1, MMP2, PPARA, PPARG, PTPN1 | 2.26506 |
| [BP] GO:0046320 | None | FABP3, PPARA, PPARG | 2.26224 |
| [BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, CA1, CSNK2A1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MMP2, MMP9, PTPN1 | 2.26168 |
| [BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, CA2, CHRM1, CYP19A1, DRD2, DRD3, DRD4, HCAR2, HSP90AB1, PPARG | 2.23481 |
| [BP] GO:0071715 | None | DRD2, DRD3, DRD4 | 2.22206 |
| [BP] GO:1901571 | None | DRD2, DRD3, DRD4 | 2.22206 |
| [BP] GO:0098771 | inorganic ion homeostasis | CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRM1, GRM5 | 2.21801 |
| [BP] GO:1901568 | fatty acid derivative metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 2.21527 |
| [BP] GO:0046541 | None | CHRM1, CHRM3 | 2.21527 |
| [BP] GO:0090325 | None | DRD2, DRD3 | 2.21527 |
| [BP] GO:0032800 | receptor biosynthetic process | ACHE, PPARG | 2.21527 |
| [BP] GO:0042321 | None | ADORA1, DRD2 | 2.21527 |
| [BP] GO:0010891 | None | PPARA, PPARG | 2.21527 |
| [BP] GO:1901575 | None | ACHE, ADORA1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, SLC6A3, XDH | 2.17867 |
| [BP] GO:0044070 | regulation of anion transport | ADORA1, CA2, CA7, GRM5 | 2.17867 |
| [BP] GO:0090087 | None | ACHE, ADORA1, CA2, CHRM1, DRD2, DRD3, DRD4, HCAR2, HSP90AB1, PTPN1 | 2.17867 |
| [BP] GO:0055082 | cellular chemical homeostasis | CA2, CA7, DRD2, DRD3, DRD4, ESR1, GRIK5, GRM1, GRM5 | 2.17867 |
| [BP] GO:0009719 | response to endogenous stimulus | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, GRM5, MMP2, PPARA, PPARG | 2.17834 |
| [BP] GO:0032410 | None | DRD2, DRD3, DRD4, MMP9 | 2.16311 |
| [BP] GO:1904063 | None | DRD2, DRD3, DRD4, MMP9 | 2.16311 |
| [BP] GO:0010039 | response to iron ion | CYP1A1, DRD2, SLC6A3 | 2.15841 |
| [BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, PPARA, PPARG | 2.15735 |
| [BP] GO:0045860 | positive regulation of protein kinase activity | ADORA1, CDC25B, DRD2, DRD4, GRM1, GRM5, HSP90AB1, PTPN1 | 2.14576 |
| [BP] GO:0098657 | import into cell | ACHE, ADORA1, DRD2, DRD3, HSP90AA1, SLC1A1, SLC6A2, SLC6A3 | 2.13555 |
| [BP] GO:0098801 | None | ADORA1, DRD2, DRD3 | 2.12393 |
| [BP] GO:0030336 | None | ADORA1, ADORA3, CYP19A1, CYP1B1, DRD2, PPARG | 2.11785 |
| [BP] GO:0006869 | None | DRD2, DRD3, DRD4, FABP3, PPARA, PPARG | 2.10142 |
| [BP] GO:0051338 | regulation of transferase activity | ADORA1, CDC25B, DRD2, DRD4, FABP4, GRM1, GRM5, HSP90AA1, HSP90AB1, PPARG, PTPN1 | 2.07955 |
| [BP] GO:0010887 | None | PPARA, PPARG | 2.07955 |
| [BP] GO:0010871 | None | PPARA, PPARG | 2.07955 |
| [BP] GO:0032415 | None | DRD3, DRD4 | 2.07955 |
| [BP] GO:0051934 | None | SLC6A2, SLC6A3 | 2.07955 |
| [BP] GO:0021984 | None | DRD2, SLC6A3 | 2.07955 |
| [BP] GO:0090494 | None | SLC6A2, SLC6A3 | 2.07955 |
| [BP] GO:0090493 | None | SLC6A2, SLC6A3 | 2.07955 |
| [BP] GO:0051583 | None | SLC6A2, SLC6A3 | 2.07955 |
| [BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, DRD2, PPARA, PPARG | 2.05885 |
| [BP] GO:0051588 | None | DRD2, DRD3, DRD4, GRIK5 | 2.05876 |
| [BP] GO:0051347 | positive regulation of transferase activity | ADORA1, CDC25B, DRD2, DRD4, GRM1, GRM5, HSP90AA1, HSP90AB1, PTPN1 | 2.05876 |
| [BP] GO:0050878 | regulation of body fluid levels | ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, SLC6A3, XDH | 2.03478 |
| [BP] GO:2000146 | None | ADORA1, ADORA3, CYP19A1, CYP1B1, DRD2, PPARG | 2.01414 |
| [CC] GO:0044456 | None | ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3 | 7.28899 |
| [CC] GO:0098590 | plasma membrane region | ADORA1, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, SLC1A1 | 7.06259 |
| [CC] GO:0097060 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 6.54587 |
| [CC] GO:0043005 | None | ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3 | 4.89275 |
| [CC] GO:0045211 | None | CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 | 4.39371 |
| [CC] GO:0005887 | integral component of plasma membrane | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRM1, GRM3, GRM5, GRM8, SLC1A1, SLC6A2, SLC6A3 | 4.25908 |
| [CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, CA12, CA14, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD2, DRD3, DRD4, ESR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, MMP2, PTPN1, SLC1A1, SLC6A2, SLC6A3 | 4.10671 |
| [CC] GO:0044459 | plasma membrane part | ADORA1, ADORA3, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, SLC1A1, SLC6A2, SLC6A3 | 4.09319 |
| [CC] GO:0031226 | intrinsic component of plasma membrane | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRM1, GRM3, GRM5, GRM8, SLC1A1, SLC6A2, SLC6A3 | 4.06731 |
| [CC] GO:0098793 | None | ADORA1, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 | 4.00794 |
| [CC] GO:0042734 | None | GRIK5, GRM1, GRM3, GRM5, GRM8 | 3.75466 |
| [CC] GO:0042995 | cell projection | ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3 | 3.74081 |
| [CC] GO:0014069 | None | ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5 | 3.58555 |
| [CC] GO:0099572 | None | ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5 | 3.58555 |
| [CC] GO:0120025 | None | ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3 | 3.38823 |
| [CC] GO:0098794 | None | ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRM3 | 3.17265 |
| [CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, CA12, CA14, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, ESR1, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, PTPN1, SLC1A1, SLC6A2, SLC6A3 | 3.13742 |
| [CC] GO:0097458 | None | ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A2, SLC6A3 | 3.09602 |
| [CC] GO:0044463 | None | ADORA1, AKR1B1, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1 | 3.06487 |
| [CC] GO:0120038 | None | ADORA1, AKR1B1, CA9, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1 | 3.06487 |
| [CC] GO:0043679 | None | CHRM1, CHRM2, CHRM3, DRD2 | 2.69401 |
| [CC] GO:0043197 | None | ADORA1, DRD2, GRIA2, GRIA4, GRM3 | 2.64124 |
| [CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, CA12, CA14, CA2, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, ESR1, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, MMP2, PTPN1, SLC1A1, SLC6A2, SLC6A3 | 2.63179 |
| [CC] GO:0044309 | None | ADORA1, DRD2, GRIA2, GRIA4, GRM3 | 2.61716 |
| [CC] GO:0030425 | None | CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIK5, GRM1 | 2.41044 |
| [CC] GO:0044306 | None | CHRM1, CHRM2, CHRM3, DRD2 | 2.38421 |
| [CC] GO:0045202 | None | ACHE, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2 | 2.15735 |
| [MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 | 15.1776 |
| [MF] GO:0030594 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 | 11.837 |
| [MF] GO:0046914 | transition metal ion binding | CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, XDH | 10.7524 |
| [MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 | 10.014 |
| [MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 | 8.87537 |
| [MF] GO:0008066 | None | GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 | 8.80289 |
| [MF] GO:0038023 | signaling receptor activity | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG | 7.28899 |
| [MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.11232 |
| [MF] GO:0016907 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 6.68585 |
| [MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1 | 6.47575 |
| [MF] GO:0004872 | receptor activity | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG | 6.47575 |
| [MF] GO:0060089 | molecular transducer activity | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG | 6.26032 |
| [MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9 | 5.89965 |
| [MF] GO:0004871 | signal transducer activity | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, ESR1, ESR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARA, PPARG | 5.78241 |
| [MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 5.61392 |
| [MF] GO:0043169 | cation binding | ACHE, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, ESR1, ESR2, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, SLC1A1, SLC6A2, SLC6A3, XDH | 5.60935 |
| [MF] GO:0099600 | transmembrane receptor activity | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG | 5.60935 |
| [MF] GO:0004888 | transmembrane signaling receptor activity | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG | 5.60935 |
| [MF] GO:0004930 | None | ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG | 5.25532 |
| [MF] GO:0043167 | ion binding | ACHE, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, ESR1, ESR2, FABP3, FABP4, HSD17B1, HSP90AA1, HSP90AB1, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, SLC1A1, SLC6A2, SLC6A3, XDH | 5.18752 |
| [MF] GO:0035240 | None | DRD2, DRD3, DRD4, SLC6A3 | 4.80237 |
| [MF] GO:0070405 | ammonium ion binding | ACHE, CHRM3, DRD2, DRD3, DRD4, SLC6A3 | 4.70949 |
| [MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 4.31177 |
| [MF] GO:0015464 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 4.31177 |
| [MF] GO:1901338 | None | DRD2, DRD3, DRD4, SLC6A3 | 4.15644 |
| [MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.1472 |
| [MF] GO:0005506 | iron ion binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH | 4.09319 |
| [MF] GO:0008227 | None | CHRM1, CHRM2, CHRM3, CHRM5, DRD2 | 3.90196 |
| [MF] GO:0008144 | drug binding | ACHE, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD2, DRD3, DRD4, HSP90AA1, HSP90AB1, PPARA, PPARG, SLC6A3 | 3.82539 |
| [MF] GO:0030235 | nitric-oxide synthase regulator activity | ESR1, HSP90AA1, HSP90AB1 | 3.81152 |
| [MF] GO:0001591 | None | DRD2, DRD3, DRD4 | 3.65078 |
| [MF] GO:0004629 | None | ADORA1, CHRM1, CHRM3, CHRM5 | 3.56494 |
| [MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.52861 |
| [MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6 | 3.38823 |
| [MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.38823 |
| [MF] GO:0099528 | None | CHRM1, CHRM2, CHRM3, CHRM5 | 3.21697 |
| [MF] GO:0004952 | None | DRD2, DRD3, DRD4 | 3.16136 |
| [MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 3.13742 |
| [MF] GO:0046872 | metal ion binding | CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, MMP1, MMP2, MMP9, PPARA, PPARG, PTPN1, SLC1A1, SLC6A2, SLC6A3, XDH | 3.05772 |
| [MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.98121 |
| [MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.98121 |
| [MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, PPARA, PPARG | 2.86302 |
| [MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, PPARA, PPARG | 2.86302 |
| [MF] GO:0004970 | None | GRIA2, GRIA4, GRIK5 | 2.6536 |
| [MF] GO:0005234 | None | GRIA2, GRIA4, GRIK5 | 2.6536 |
| [MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, PPARA, PPARG | 2.61716 |
| [MF] GO:0005330 | None | SLC6A2, SLC6A3 | 2.61716 |
| [MF] GO:0099583 | None | GRM1, GRM5 | 2.61716 |
| [MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, CA1, CA12, CA14, CA2, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FUT7, HSD17B1, HSP90AA1, MMP1, MMP2, MMP9, PTPN1, XDH | 2.58245 |
| [MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, XDH | 2.47763 |
| [MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.38421 |
| [MF] GO:0004971 | None | GRIA2, GRIA4 | 2.38421 |
| [MF] GO:0005504 | None | FABP3, FABP4, PPARG | 2.29592 |
| [MF] GO:0004435 | None | CHRM1, CHRM3, CHRM5 | 2.29592 |
| [MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, XDH | 2.28893 |
| [MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.21527 |
| [MF] GO:0005329 | None | SLC6A2, SLC6A3 | 2.07955 |
| [MF] GO:0050543 | None | FABP3, PPARG | 2.07955 |
| [MF] GO:0004064 | arylesterase activity | CA1, CA2 | 2.07955 |
| [MF] GO:0008081 | None | ADORA1, CHRM1, CHRM3, CHRM5 | 2.04227 |
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 | 14.9674 |
| Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA7, CA6, CA9, CA14 | 16.971 |
| Glutamatergic synapse_Homo sapiens_hsa04724 | GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 | 7.5539 |
| Estrogen signaling pathway_Homo sapiens_hsa04915 | HSP90AA1, HSP90AB1, MMP2, MMP9, ESR1, GRM1, ESR2 | 6.6148 |
| cAMP signaling pathway_Homo sapiens_hsa04024 | CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD2, PPARA, GRIA4 | 5.8703 |
| Dopaminergic synapse_Homo sapiens_hsa04728 | GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 | 4.8022 |
| Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 5.1207 |
| Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 4.7737 |
| PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARG, PPARA | 4.8022 |
| Calcium signaling pathway_Homo sapiens_hsa04020 | CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 | 4.123 |
| Cholinergic synapse_Homo sapiens_hsa04725 | CHRM2, ACHE, CHRM3, CHRM1, CHRM5 | 4.053 |
| Chemical carcinogenesis_Homo sapiens_hsa05204 | CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 4.5638 |
| Ovarian steroidogenesis_Homo sapiens_hsa04913 | HSD17B1, CYP1A1, CYP1B1, CYP19A1 | 4.1199 |
| Cocaine addiction_Homo sapiens_hsa05030 | GRM3, GRIA2, DRD2, SLC6A3 | 4.123 |
| Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | GRIA2, GRM5, GRM1, GRIA4 | 2.9776 |
| Pathways in cancer_Homo sapiens_hsa05200 | HSP90AA1, HSP90AB1, MMP1, MMP2, PPARG, MMP9 | 2.4458 |
| Phospholipase D signaling pathway_Homo sapiens_hsa04072 | GRM3, GRM5, GRM8, GRM1 | 2.4628 |
| Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.9776 |
| Bladder cancer_Homo sapiens_hsa05219 | MMP1, MMP2, MMP9 | 2.9702 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, SLC6A3, GRIA4 | 2.4458 |
| Long-term potentiation_Homo sapiens_hsa04720 | GRIA2, GRM5, GRM1 | 2.4458 |
| Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1 | 2.4458 |
| Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | CHRM2, CHRM3, CHRM1, CHRM5 | 1.9666 |
| Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | HSP90AA1, HSP90AB1, CDC25B | 2.0064 |
| Gap junction_Homo sapiens_hsa04540 | GRM5, DRD2, GRM1 | 2.122 |
| Metabolic pathways_Homo sapiens_hsa01100 | CYP2A6, FUT7, AKR1B10, HSD17B1, CYP1A2, CYP1A1, AKR1B1, CYP19A1, XDH | 1.6972 |
| PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | CHRM2, HSP90AA1, HSP90AB1, CHRM1 | 1.4168 |
| Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.4903 |
| Proteoglycans in cancer_Homo sapiens_hsa05205 | MMP2, MMP9, ESR1 | 1.3637 |
| Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, ADORA1 | 1.5058 |
| Prolactin signaling pathway_Homo sapiens_hsa04917 | ESR1, ESR2 | 1.3706 |
| Long-term depression_Homo sapiens_hsa04730 | GRIA2, GRM1 | 1.4862 |
| Gastric acid secretion_Homo sapiens_hsa04971 | CHRM3, CA2 | 1.3699 |
| Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.488 |
| Prostate cancer_Homo sapiens_hsa05215 | HSP90AA1, HSP90AB1 | 1.2603 |
| Taste transduction_Homo sapiens_hsa04742 | CHRM3, GRM1 | 1.307 |
| Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2 | 1.3943 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1 | 1.3699 |
| NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | HSP90AA1, HSP90AB1 | 1.5042 |
| Circadian entrainment_Homo sapiens_hsa04713 | GRIA2, GRIA4 | 1.2183 |
| MicroRNAs in cancer_Homo sapiens_hsa05206 | CYP1B1, MMP9, CDC25B | 1.0279 |
| Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PPARA | 1.1264 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSP90AA1, HSP90AB1 | 1.358 |
| Pancreatic secretion_Homo sapiens_hsa04972 | CHRM3, CA2 | 1.2183 |
| Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, ADORA1 | 1.0685 |
| Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 1.0729 |
| Nicotine addiction_Homo sapiens_hsa05033 | GRIA2, GRIA4 | 1.7479 |
| Parkinson's disease_Homo sapiens_hsa05012 | DRD2, SLC6A3 | 0.9555 |
| Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.6576 |
| cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, ADORA1 | 0.8801 |
| Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | HSP90AA1, HSP90AB1 | 0.8784 |
| Alcoholism_Homo sapiens_hsa05034 | DRD2, SLC6A3 | 0.8533 |
| Huntington's disease_Homo sapiens_hsa05016 | GRM5, PPARG | 0.8091 |
| Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | PPARG, MMP9 | 0.8533 |
| Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 1.9481 |
| Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.8228 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2 | 0.5267 |
| Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.9083 |
| Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.539 |
| MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2952 |
| GnRH signaling pathway_Homo sapiens_hsa04912 | MMP2 | 0.539 |
| TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.4999 |
| Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1 | 0.3594 |
| Insulin secretion_Homo sapiens_hsa04911 | CHRM3 | 0.539 |
| Rap1 signaling pathway_Homo sapiens_hsa04015 | DRD2 | 0.3498 |
| Salivary secretion_Homo sapiens_hsa04970 | CHRM3 | 0.539 |
| Osteoclast differentiation_Homo sapiens_hsa04380 | PPARG | 0.4609 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PPARG | 0.4713 |
| Measles_Homo sapiens_hsa05162 | CSNK2A1 | 0.4597 |
| FoxO signaling pathway_Homo sapiens_hsa04068 | GRM1 | 0.4609 |
| Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3962 |
| Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | ESR1 | 0.4793 |
| Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3839 |
| Hepatitis B_Homo sapiens_hsa05161 | MMP9 | 0.4516 |
| Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5267 |
| Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.4609 |
| Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PPARG | 0.539 |
| Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.539 |
| Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.4444 |
| Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1 | 0.4597 |
| Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.539 |
| Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.4713 |
| Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4568 |
| Tight junction_Homo sapiens_hsa04530 | CSNK2A1 | 0.4597 |
| Peroxisome_Homo sapiens_hsa04146 | XDH | 0.539 |
| NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1 | 0.539 |
| Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.539 |
| Protein digestion and absorption_Homo sapiens_hsa04974 | SLC1A1 | 0.539 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5867 |
| Bile secretion_Homo sapiens_hsa04976 | CA2 | 0.5867 |
| Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6149 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | GRIA2 | 0.6994 |
| Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.7258 |
| Thyroid cancer_Homo sapiens_hsa05216 | PPARG | 0.8801 |
| Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.8801 |
| Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.8693 |
| Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8969 |
| Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2 | 0.9404 |
| Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.8891 |
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples