TCM Prescription: Lusika Pills



Prescription Description
Prescription IDTCMF2565
Pinyin NameLu Si Ka Wan
Chinese Name鹭鸶咯丸
English NameLusika Pills
Function Description咳嗽, 百日咳
IndicationsUpper respiratory infection(uri)
Disease ICD-11 Category CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2047 Fructus perillae 苏子 TCMH2047
TCMH79 Sinapis alba 白芥子 TCMH79 ITSAD4265-14
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH706 Trichosanthes kirilowii 瓜蒌皮 TCMH706 ITSAO4359-14
TCMH1870 Belamcanda chinensis 射干 TCMH1870
TCMH1678 Indigo naturalis 青黛 TCMH1678
TCMH626 Concha meretricis seu cyclinae 蛤壳 TCMH626
TCMH923 Radix trichosanthis 花粉 TCMH923
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 13.2559
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 11.9695
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TYR 11.1094
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FDPS, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.2874
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SRC, TYR 9.89138
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TERT, TYR 9.36293
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 9.36293
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, TERT, XDH 9.36293
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, HMGCR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.3109
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, HMGCR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.29281
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.80064
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.6785
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.65672
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.57379
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.51734
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.46694
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, FABP3, FABP4, FDPS, FUT7, GBA2, HMGCR, KIT, MET, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 8.41464
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FDPS, FUT7, GBA2, GLO1, HMGCR, IDO1, MIF, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 8.29626
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, PTGS2, RORC, SRC, TYR 8.2711
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HMGCR, IDO1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.21056
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, HMGCR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.16421
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.81635
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, KIT, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SRC, TERT, TNKS2, TOP2A, TYR 7.81336
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 7.78691
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 7.7297
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TERT 7.67944
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, HMGCR, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.61847
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, KIT, MMP2, PTGS2, SRC 7.56955
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 7.52649
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 7.3741
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 7.3741
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SRC 7.34704
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, IDO1, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.27352
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 7.08147
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.99572
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.86561
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC, TERT 6.79574
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, HMGCR, KDR, MIF, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.79572
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 6.78582
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TYR 6.77264
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.77264
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.77264
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TYR 6.75049
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC, TERT 6.6821
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.65009
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.60227
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.58853
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, KIT, MIF, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 6.55666
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.44833
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, IDO1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 6.44833
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, PIM1, SRC 6.35138
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.32285
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.26836
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, TNKS2 6.21818
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.1878
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC, TERT 6.1878
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.06468
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.05092
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.94536
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB, SRC, TERT 5.88937
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PTGS2, SRC 5.83967
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.83636
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.83636
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.83022
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.82415
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.82415
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TNKS2, TYR 5.81561
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.78141
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.71528
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 5.69015
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC, TERT 5.69015
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, SRC, TYR 5.65151
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.60307
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.57636
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.55169
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2 5.53974
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.53511
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.53263
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, GRIK5, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SRC, TERT 5.531
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FDPS, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 5.44176
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2 5.32332
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 5.23992
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, KIT, MET, PIK3CA, PIK3CB, SRC 5.23992
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.23992
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS 5.23558
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.21761
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, KIT, MET, MIF, PIK3CB, PIM1, SRC, TYR 5.19188
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 5.18496
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.15043
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 5.13609
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, KIT, MIF, PIK3CB, PTPN1, SRC 5.11721
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.08464
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FDPS, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 5.07184
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.06051
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 5.06051
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.06051
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 5.04218
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, GRM1, HMGCR, KDR, KIT, MIF, PIK3CB, PTPN1, SRC, XDH 4.95118
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 4.89871
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.86902
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.86842
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS, HMGCR 4.79844
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 4.77429
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, GRM1, HMGCR, IDO1, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC1A1, SRC, TERT, TNKS2, XDH 4.76984
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.65404
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.64386
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.61968
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.61628
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, KDR, PTGS2, SRC 4.59223
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.54579
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 4.52394
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, KIT, MET, MIF, MMP2, MMP9, PTGS2, RORC, SRC, TERT, TOP2A 4.51828
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 4.50583
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, GRM1, GRM5, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 4.46902
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2 4.35741
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, KIT, MIF, PIK3CB, PTPN1, SRC 4.35741
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.34271
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, GBA2, HMGCR, TYR 4.32368
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30598
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DYRK1A, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MET, MIF, MMP12, MMP2, PTGS2, PTPN1, SRC, TERT, XDH 4.28828
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.28828
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 4.28138
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, MMP9, PTGS1, PTGS2, SRC 4.26797
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSD11B2, KIT, MMP2, PTGS2, SRC, TERT, TYR 4.23229
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 4.19189
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 4.19189
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2 4.19189
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.18744
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS 4.16317
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.14075
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, RORC, SRC, TOP2A 4.12315
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIK3CA, PIM1, PTGS2, RORC, SRC, TYR 4.10896
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.10241
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.08674
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 4.08674
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, KDR, KIT, MIF, PIK3CB, PTPN1, SRC, XDH 4.07776
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1, RORC 4.00348
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HMGCR, IDO1, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SLC1A1, SRC, TERT 3.99664
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PIK3CA, PIK3CB 3.96033
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.93764
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, KIT, MIF, PTPN1, SRC 3.9368
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.93387
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.92975
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.86542
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.86277
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.8492
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.83137
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.81902
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MIF, PTGS1, PTGS2 3.76192
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 3.70351
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.70068
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, MIF 3.68993
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.68898
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 3.67555
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, EGFR, ERBB2, ESR1, FLT3, GRM5, IGF1R, KIT, MMP2, PTGS2, SRC 3.64215
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HMGCR, IGF1R, KIT, MIF, PIK3CB, PTPN1, SRC 3.56788
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.56788
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, HMGCR, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.45381
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.44284
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.44239
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.42726
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.41983
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, MIF, SRC, TNKS, TNKS2 3.40843
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, KIT, MIF, PIK3CB, PTPN1, SRC 3.4029
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.37748
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS, HMGCR, IDO1, MIF, PTGS1, PTGS2 3.36842
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.36842
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.35127
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC 3.31657
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.30152
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.3008
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.29782
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, HMGCR, KIT, PTGS2, RORC, SRC 3.29524
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GRIK5, GRM5, HMGCR, MIF, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SRC, TERT 3.2923
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 3.28166
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 3.28166
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.2582
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.23163
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.22511
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.2083
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PTGS2, SRC, TYR 3.18038
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PTGS1, PTGS2 3.17628
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 3.16118
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, PIK3CB, PTGS2, TNKS, TNKS2 3.14081
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP2A 3.14081
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSD11B2, IDO1, KIT, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A 3.14028
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.12894
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.09546
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, MIF, PTGS2, TERT 3.08234
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05187
[BP] GO:0046834 lipid phosphorylation EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 3.03219
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.03093
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, IGF1R, PIK3CA, PIK3CB 3.0303
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, IGF1R, MMP2, PTGS2, SRC 3.02263
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 2.97698
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, PIK3CA, TNKS2 2.96999
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.96322
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, KIT, MIF, PTPN1, SRC 2.96322
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.94628
[BP] GO:0030258 lipid modification CYP1A1, CYP3A4, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 2.94119
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, RORC, SRC 2.9399
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.9399
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.9399
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.92982
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 2.90995
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 2.90829
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PTGS2, SRC, TYR 2.86087
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.86087
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.85394
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.84573
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, SLC1A1 2.84453
[BP] GO:0009968 negative regulation of signal transduction BCL2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, XDH 2.83376
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.82651
[BP] GO:0009115 None AOX1, XDH 2.81468
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT 2.77655
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GRM5, IGF1R, MMP2, PTGS2, SRC 2.76888
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGS1, PTGS2 2.76669
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.75865
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.751
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.74392
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74392
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.74392
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.74392
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, IDO1 2.74348
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, MIF, MMP12, PTGS2, SRC, TERT 2.74348
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HMGCR, IDO1, KDR, KIT, MIF, PIK3CA, PIM1, PTGS2, RORC, SRC, TERT, TNKS2, XDH 2.74034
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.73515
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.71326
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, RORC, SRC 2.71326
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT 2.70571
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 2.70557
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, HSD11B2, IGF1R, PTGS2, SRC 2.70557
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.7007
[BP] GO:0038128 None EGFR, ERBB2, PIK3CA, SRC 2.7007
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.69592
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MIF, PIM1, PTGS1, PTGS2, TYR 2.69204
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MIF, MMP12, MMP9, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.66438
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66214
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, EGFR, ERBB2, HMGCR, KDR, MIF, PTPN1, SRC 2.64121
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DYRK1A, EGFR, HMGCR, IGF1R, MET, MIF, PTGS2, PTPN1, TERT, XDH 2.63214
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF, PIK3CB 2.62664
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.62664
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.62621
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.60393
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, IDO1, KDR, MET, MIF, PTGS2 2.59508
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.58315
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.58315
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.58268
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.58268
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, EGFR, PIM1, TERT, TNKS, TOP2A 2.58268
[BP] GO:0030154 cell differentiation ADRB1, ALPL, AXL, BCL2, CBR1, CDK6, CYP1A1, ERBB2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, KIT, MMP2, MMP9, PTGS2, RORC, TOP2A 2.58039
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.57394
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.57021
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, EGFR, ERBB2, GRM5, IGF1R, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.56963
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, ERBB2, ESR1, ESRRA, IDO1, KIT, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.56718
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.56718
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.5545
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HMGCR, KIT, PTGS2, TYR 2.5496
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, EGFR, MIF, SRC, TERT 2.54227
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GRM1, GRM5, PIK3CB 2.53523
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 2.5215
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.52094
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.52094
[BP] GO:0070920 None EGFR, ESR1, TERT 2.52094
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MIF, MMP12, PTGS2 2.52094
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, SRC, TNKS, TNKS2 2.50191
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TERT 2.49983
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.45888
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.4452
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.43544
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.43544
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, MIF, PIM1, PTGS2, SRC, TERT, TNKS, TOP2A 2.43544
[BP] GO:0099566 None GRM1, GRM5 2.43544
[BP] GO:0046110 None AOX1, XDH 2.43544
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43544
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AURKB, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.40653
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.38261
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, EGFR, ERBB2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SRC 2.38261
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, HMGCR, PTGS2, SRC 2.36569
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, ERBB2, FABP3, IDO1, PTGS2, TERT, XDH 2.36129
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.35261
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.32437
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31967
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MIF, PIM1, PTGS1, PTGS2, TYR 2.3058
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.30501
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, GRM1, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.30141
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.29753
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, GRM5, MIF, MMP9, PTGS2 2.28681
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, MIF, TERT, TNKS 2.28504
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.2805
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, FDPS, HMGCR, TYR 2.27956
[BP] GO:0006644 phospholipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, FDPS, KIT, MET, PIK3CA, PIK3CB 2.27082
[BP] GO:0048146 positive regulation of fibroblast proliferation CDK6, EGFR, ESR1, MIF 2.26658
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.26658
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, KIT, MIF, MMP9, PIK3CA, PIK3CB, RORC, SRC 2.26658
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.25724
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, IDO1, MIF, PIM1, PTGS1, PTGS2, TYR 2.24278
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.24278
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.24278
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, RORC, SRC 2.21932
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.21123
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.21123
[BP] GO:0009889 regulation of biosynthetic process ADORA3, ADRB1, APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FDPS, GLO1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, KIT, MET, MMP12, PIM1, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.19351
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.19044
[BP] GO:0070213 None TNKS, TNKS2 2.18846
[BP] GO:0006145 None AOX1, XDH 2.18846
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18846
[BP] GO:1901342 regulation of vasculature development CYP1B1, ERBB2, F3, KDR, KIT, PTGS2, TERT, XDH 2.17666
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.16635
[BP] GO:0090344 None CDK6, MIF, TERT 2.16635
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.16635
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.16635
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.15752
[BP] GO:0003008 None ADORA1, ADRB1, AKR1B1, APP, BCL2, CYP1B1, EGFR, GRM1, GRM5, GRM8, HMGCR, HSD11B2, KIT, PIK3CA, PTGS2, SRC, TYR 2.14975
[BP] GO:0007154 None ADORA1, ADRB1, AXL, BCL2, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1 2.14634
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 2.14361
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.13499
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GRM1, GRM5, PIK3CB 2.12304
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.1219
[BP] GO:2001251 None DNMT1, SRC, TNKS, TNKS2, TOP2A 2.12069
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.11965
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11965
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, KIT, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 2.11332
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.0986
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT, TNKS 2.09161
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2 2.09079
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.07657
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.07657
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.07657
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.07421
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07421
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB 2.07421
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, SLC1A1 2.07364
[BP] GO:1901987 None APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, EGFR, TERT 2.07364
[BP] GO:0007187 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.04873
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.04824
[BP] GO:0050900 leukocyte migration FUT7, KIT, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.03647
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.0272
[BP] GO:0048169 None APP, GRM5, KIT 2.0272
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, MET, PIK3CA 2.01885
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF 2.01885
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CACNA1C, CSNK2A1, EGFR, ERBB2, HMGCR, MIF, MMP12, PTGS2, PTPN1, SRC, TERT 2.01784
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.01784
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.01784
[BP] GO:0043696 None CDK6, ESRRB 2.01784
[BP] GO:0043697 None CDK6, ESRRB 2.01784
[BP] GO:0010641 None F3, SRC 2.01784
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.01784
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.01264
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ERBB2, ESR1, ESR2, GRIK5, IGF1R, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.00671
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.00582
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, ESR1, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB 2.00183
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.00183
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.00041
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.00041
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.00041
[BP] GO:0006693 None MIF, PTGS1, PTGS2 2.00041
[BP] GO:0006692 None MIF, PTGS1, PTGS2 2.00041
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, IDO1, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.5074
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SRC, TERT 4.49436
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TERT, TNKS, TNKS2, TYR 4.44167
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, NQO2, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.44156
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, PTGS2, SLC1A1, SRC 4.35817
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, KIT, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.82418
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, PTGS2, SLC1A1, SRC 3.50428
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 3.41983
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 3.36842
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.12092
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 2.9399
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.66124
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5, SRC 2.66124
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.41231
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.40384
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, GRIK5, HMGCR, KDR, PTGS2, PTPN1, XDH 2.33291
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, BACE1, CA4, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 2.31903
[CC] GO:0043235 receptor complex APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R 2.24278
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, MET, MIF 2.08496
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.01885
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.01837
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.00183
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, F3, FDPS, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 13.8628
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PTPN1, RORC, TNKS, TYR, XDH 13.0068
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, GLO1, HMGCR, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.9695
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.36293
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 8.91995
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.75413
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.95322
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 6.79572
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PTPN1, RORC, TNKS 6.77264
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FDPS, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.77264
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.66917
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.26836
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET 6.11131
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B2, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, SRC, XDH 5.94536
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.85028
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.84306
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, RORC 5.83636
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS1, PTGS2, SRC 5.80227
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, SRC 5.67556
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS1, PTGS2, SRC 5.55854
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CDK6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, RORC 5.32332
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP9, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 5.2152
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR, KIT 5.06051
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.02812
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, RORC 5.00734
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.95118
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A 4.79104
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.77429
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.63478
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 4.50583
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET, RORC 4.31491
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 4.27776
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TOP2A, XDH 4.23229
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TYR 4.19189
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 4.17731
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 4.14075
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.1074
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 4.08674
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, KIT, MET, PIK3CA, PIK3CB 3.92694
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.84765
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.71139
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 3.60231
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 3.58856
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, KIT, MET 3.58856
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, RORC 3.55208
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, RORC 3.55208
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, XDH 3.42478
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, XDH 3.42308
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.36842
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.24086
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, RORC 3.2083
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.18254
[MF] GO:0019899 enzyme binding ADRB1, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, KIT, MET, MIF, PTGS2, PTPN1, SRC, TNKS2, TOP2A 3.17267
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.13573
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.9399
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 2.90829
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TOP2A, XDH 2.908
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.81468
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81468
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81468
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, ADRB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.76506
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FDPS, FLT3, HMGCR, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.59817
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRB1, AOX1, AXL, BCL2, EGFR, ERBB2, FLT3, HMGCR, KIT, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 2.57588
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, NQO2 2.5701
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.53375
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, RORC 2.50189
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.43544
[MF] GO:0099583 None GRM1, GRM5 2.43544
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.31967
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.31967
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP2A 2.30102
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 2.25702
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP2A 2.19351
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18846
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.18846
[MF] GO:0004971 None GRIA2, GRIA4 2.18846
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.18846
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP2A 2.16861
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.16367
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.15051
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.01784
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01784
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FDPS, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.00716
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.00041


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.5965
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.5369
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.1136
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2 7.7467
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, KIT, ERBB2, BCL2, MET 7.4293
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PTGS2, MMP9, EGFR, CDC25B, CDK6, PIK3CA, ERBB2, BCL2, PIM1, CYP1B1, MET 7.7467
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, ERBB2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.4293
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, DNMT1, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 7.4293
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.4293
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, ADRB1, PIK3CB, PTGS2, PTGS1 7.0965
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, ERBB2, PIK3CB, MET, EGFR 6.5807
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.348
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.474
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, KIT, GRM8, PIK3CB, GRM1, EGFR 5.5935
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, ERBB2, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.5776
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, ADRB1, GRM1, GRIA4 5.4414
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.0676
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.1922
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KIT, KDR, PIK3CB, MET, EGFR, IGF1R 4.5072
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 4.678
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.1436
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.4503
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, PTGS2, GRM1, GRIA4 4.4503
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, ERBB2, PIK3CB, EGFR 4.4631
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.0124
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 4.4173
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.4503
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.1425
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 4.2422
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, PIK3CA, ADORA1, ADRB1, CACNA1C, PIK3CB, GRIA4 3.8545
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3635
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, ERBB2, PIK3CB, EGFR 4.2242
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0526
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.6904
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, EGFR, IGF1R 3.5524
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 3.522
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, ERBB2, PIK3CB, EGFR 3.7058
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.7174
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, ADRB1, CACNA1C, PIK3CB 3.4107
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, CACNA1C, PIK3CB 3.2803
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R 3.2684
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 3.2684
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.6942
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, CACNA1C, PTGS2, PTGS1 3.2722
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.1715
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, GRM1, EGFR, IGF1R 3.0063
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6959
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, ADRB1, CACNA1C, PIK3CB 2.8173
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, ERBB2, PIK3CB, EGFR 3.4646
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5741
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4021
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.6874
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2646
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.1563
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9024
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3108
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.3108
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3108
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.1715
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.2256
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.2454
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 3.0424
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.1319
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.8791
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.0999
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7809
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6445
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2437
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2531
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2649
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2743
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.6323
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.5789
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3248
Axon guidance_Homo sapiens_hsa04360 MET 0.358
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.366
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.3716
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB 1.6394
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, TERT, PIK3CB 1.361
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.7455
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7802
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4049
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.7147
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5462
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.7726
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7828
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4088
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, EGFR 1.4503
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.8639
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.4765
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6582
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.2272
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB 1.1946
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4464
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1274
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4451
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.0428
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB 0.755
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1576
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4589
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8038
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4603
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.815
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4603
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.828
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2187
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8598
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4603
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4603
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1319
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4702
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 2.1194
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.1844
Peroxisome_Homo sapiens_hsa04146 XDH 0.476
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4795
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.1576
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9686
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.476
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9788
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4877
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.9952
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4859
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9952
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9788
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5043
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0035
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0396
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.107
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5043
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.1006
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5043
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.071
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.1006
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.071
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0574
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5219
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.1087
Shigellosis_Homo sapiens_hsa05131 SRC 0.5414
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5414
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1976
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.4508
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2419
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2156
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3379
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.6934
Malaria_Homo sapiens_hsa05144 MET 0.644
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6544
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3474
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6492
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6544
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6686
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6627
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4449
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.469
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.8173
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5258
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7033
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7537
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5122
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8309
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6098
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7937
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7713
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7926
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8114
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8398
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8162
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8038
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7635
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.679
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8309
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0034
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9923
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9788
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 2.0362
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0563
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3629
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1715


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)