TCM Prescription: Decoction of Rehmanniae



Prescription Description
Prescription IDTCMF2560
Pinyin NameDi Huang Yin Zi
Chinese Name地黄引子
English NameDecoction of Rehmanniae
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH237 Acorus calamus 菖蒲 TCMH237 ITSAI4402-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, KDR, MET, PPARA, SLC1A1, SRC, TRPV1, XDH 8.80056
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.04456
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1B1, DRD3, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TRPV1, XDH 6.23897
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1B1, DRD3, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 6.23897
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HMGCR, HSD11B1, MET, PPARA, TRPV1 5.73334
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.44863
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CYP1B1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 5.39539
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD3, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PTPN1, SRC, XDH 5.39539
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD3, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PTPN1, SRC, XDH 5.39539
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CYP1B1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 5.20107
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, DRD3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TRPV1 5.20107
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8 5.20107
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD3, GRIK5, GRM1, GRM3, GRM5, GRM8 5.20107
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.20107
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.20107
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.18711
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD3, F10, GRIK5, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TRPV1 5.09683
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, PPARA, SLC1A1, TRPV1 5.09683
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD3, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 5.09683
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1B1, DRD3, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IGF1R, KDR, MMP2, NR3C1, PPARA, RORC, SRC, TRPV1 5.09683
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD3, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 5.00915
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.98994
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, BCL2, CYP1B1, DRD3, FABP3, GRIK5, GRM5, HMGCR, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1 4.97029
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, BCL2, CYP19A1, CYP1B1, DRD3, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TRPV1 4.9471
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F10, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 4.89608
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CYP1B1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 4.80475
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, FABP3, FUT7, HMGCR, PIM1, PPARA, XDH 4.7454
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.68302
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.67153
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TRPV1 4.64403
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.63769
[BP] GO:0007193 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 4.60873
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, RORC, SRC, TRPV1 4.59457
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.59457
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD3, KDR, SRC, TRPV1 4.48514
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4845
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CYP1B1, DRD3, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.47314
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1B1, DRD3, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1 4.43357
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, BCL2, CDC25B, CYP1B1, DRD3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 4.43357
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, DRD3, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 4.37976
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CYP19A1, CYP1B1, CYP3A4, DRD3, HMGCR 4.35948
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 4.29106
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, PPARA, SLC1A1, TRPV1 4.27258
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD3, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP9, PTPN1, SRC, XDH 4.20807
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 4.08439
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1B1, FABP4, KDR, MMP9, SRC 3.99124
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.9373
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD3, F10, IGF1R, KDR, MET, MMP9, SRC 3.90735
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD3, HMGCR, KDR, SRC, TRPV1 3.90735
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 3.84301
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.83348
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, SRC 3.74285
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.72258
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.72258
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.66886
[BP] GO:0042391 None ADORA1, BCL2, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.59929
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.59929
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HMGCR, MET, PPARA 3.59921
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.55964
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, SRC 3.52381
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PTPN1, RORC, SRC, TRPV1 3.52381
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.50723
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD3, F10, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PTPN1, SRC, XDH 3.50723
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CYP1B1, DRD3, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.49534
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CYP1B1, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1 3.39917
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.39463
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.31796
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, DRD3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1 3.24751
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DRD3, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 3.24478
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CYP1B1, DRD3, FABP3, HMGCR, KDR, NR3C1, SRC, TRPV1 3.21912
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, MET, MMP9, SRC 3.21912
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, DRD3, GRIK5, GRM5, HMGCR, MMP9, PPARA, PTPN1, SRC, TRPV1 3.18573
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 3.17946
[BP] GO:0007188 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 3.1441
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DRD3, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 3.13591
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, HMGCR, HSD11B1 3.11314
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR 3.06197
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, DRD3, FABP3, FLT3, HMGCR, PPARA, RORC, SRC 3.03526
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 3.02319
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.95703
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.90356
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 2.8955
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.8955
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 2.8955
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.8955
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.8955
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.8955
[BP] GO:0009719 response to endogenous stimulus AKR1B1, BCL2, CA2, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 2.87105
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.87105
[BP] GO:0007187 None ADORA1, DRD3, GRM1, GRM3, GRM5, GRM8 2.82305
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, SRC, TRPV1 2.81244
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1B1, CYP3A4, HSD11B1 2.80905
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, DRD3, GRM1, HMGCR, MMP2, PPARA, SRC, TRPV1 2.80905
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.80355
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.80241
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.80241
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.80241
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CYP1B1, DRD3, HMGCR, KDR, SRC 2.80241
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1B1 2.79343
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.78379
[BP] GO:0007268 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.75419
[BP] GO:0098916 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.75419
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.7535
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD3, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 2.75053
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, SRC 2.71408
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CYP1B1, DRD3, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TRPV1 2.71408
[BP] GO:0099536 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.70932
[BP] GO:0099537 None DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.70932
[BP] GO:0007154 None ADORA1, AXL, BCL2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TRPV1 2.70008
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CDC25B, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TRPV1, XDH 2.66608
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.66608
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, FLT3, GRM1, HMGCR, IGF1R, KDR, PTPN1, SRC, XDH 2.64995
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 2.64995
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CYP1B1, DRD3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 2.64669
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.64275
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.64275
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, HMGCR, HSD11B1, XDH 2.60789
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, F10, MET, SRC, XDH 2.5856
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, F10, IGF1R, KDR, MET, MMP9, SRC 2.5856
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1 2.57104
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1 2.57104
[BP] GO:0099566 None GRM1, GRM5 2.57104
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57104
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CYP19A1, DRD3, HMGCR, IGF1R, MET, MMP9, PPARA, PTPN1, SRC, XDH 2.55849
[BP] GO:0045936 None DRD3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.54639
[BP] GO:0010563 None DRD3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.5432
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, F10, IGF1R, KDR, MET, MMP9, SRC 2.50402
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD3, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1 2.49123
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.43831
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, F10, IGF1R, KDR, MET, MMP9, SRC 2.43484
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CYP1B1, DRD3, HMGCR, KDR, MET, MMP9, PIM1, SLC1A1, SRC, TRPV1 2.43219
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.39863
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.38065
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, PPARA, SRC, TRPV1 2.38065
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.38003
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DRD3, F10, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTPN1, SRC, XDH 2.3663
[BP] GO:1900543 None DRD3, GRM3, GRM8, PPARA 2.36155
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TRPV1 2.34704
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, F10, IGF1R, KDR, MET, MMP9, SRC 2.34704
[BP] GO:0045980 None DRD3, GRM3, GRM8, PPARA 2.34459
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.30767
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.26579
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD3, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TRPV1 2.26428
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, XDH 2.25696
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, DRD3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PTPN1, SRC, XDH 2.25454
[BP] GO:0009725 response to hormone AKR1B1, BCL2, CA2, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 2.25454
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1B1, CYP3A4, HMGCR, HSD11B1 2.24772
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 2.24772
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, GRIK5, SLC1A1, TRPV1 2.22982
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.21931
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD3, FABP3, GRM1, GRM5, TRPV1 2.21702
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.19424
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, RORC 2.18235
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.16877
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5 2.16877
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.15646
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.1538
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.1538
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.12334
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.08342
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD3, HMGCR, PPARA 2.04315
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, PTPN1, SRC 2.03687
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, HSD11B1 2.03507
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, DRD3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 2.03436
[BP] GO:0030522 intracellular receptor signaling pathway NR3C1, PIM1, PPARA, RORC, SRC 2.0193
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CDC25B, CYP19A1, CYP1B1, DRD3, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 2.01648
[BP] GO:0048511 rhythmic process AXL, BCL2, DRD3, PPARA, RORC, SRC 2.01269
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00634
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD3, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 4.35948
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, DRD3, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TRPV1 4.24615
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 4.24615
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, DRD3, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SRC, TRPV1 3.96802
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.74285
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.65175
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 3.41536
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 3.3077
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TRPV1 3.04535
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA12, CA14, CA2, CA4, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TRPV1 2.73124
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.70305
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.70305
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00634
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.26688
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, XDH 8.17485
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.17485
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 5.73334
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 5.20107
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.18711
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 5.09683
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TRPV1, XDH 4.91739
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 4.74953
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.63311
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 4.47314
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, TRPV1 4.47314
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CYP19A1, CYP1B1, CYP3A4, F10, FLT3, FUT7, HMGCR, HSD11B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, XDH 4.27819
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, XDH 4.14641
[MF] GO:0030594 None DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 3.87991
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.74285
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, MMP1, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC 3.57253
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, DRD3, F10, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, TRPV1, XDH 3.53876
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.31796
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, HMGCR, HSD11B1, XDH 3.24751
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.8955
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.85489
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.84678
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.81307
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, FABP3, FABP4, NR3C1, PPARA, RORC, TRPV1 2.80612
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, F10, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, TRPV1, XDH 2.64995
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.64275
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.64275
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.57104
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.57104
[MF] GO:0099583 None GRM1, GRM5 2.57104
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1B1, CYP3A4, DRD3, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 2.49019
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.4866
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, XDH 2.4386
[MF] GO:0070330 aromatase activity CYP19A1, CYP1B1, CYP3A4 2.43648
[MF] GO:0004971 None GRIA2, GRIA4 2.32479
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1B1, CYP3A4 2.30767
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.30767
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.28617
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.26428
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.23108
[MF] GO:0019902 phosphatase binding BCL2, HMGCR, MET, PPARA, PTPN1 2.13641
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.12334
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00634


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, NR3C1, DRD3, GRM1, GRIA4 9.611
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.611
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.719
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9488
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1B1, CYP19A1, IGF1R 3.6964
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.5837
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.0982
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, CYP1B1, CYP3A4, CYP19A1 3.5837
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.2726
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3416
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.9176
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.9045
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.9045
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.8353
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, FUT7, AKR1B10, ALOX5, ALOX15, AKR1B1, ALOX12, HMGCR, CYP3A4, CYP19A1, XDH 2.6985
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.4318
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4318
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.4261
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.37
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1817
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 2.0939
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1B1, CYP3A4 2.2856
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.2996
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.0334
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.0334
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 2.0195
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 2.1086
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1B1, CYP3A4 2.1786
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8254
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12 1.9359
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.8765
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD3, GRIA4 1.8254
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.7097
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, IGF1R 1.5246
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.3243
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1967
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5758
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5337
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.3005
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.2457
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5711
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2903
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.4919
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.2633
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1751
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4919
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.2132
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.461
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.1825
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5519
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.392
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9401
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.1404
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 1.0598
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.108
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1404
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4883
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9165
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1 0.8841
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.6674
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.6442
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8841
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7097
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9646
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.8063
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3181
Epstein-Barr virus infection_Homo sapiens_hsa05169 BCL2 0.3827
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3706
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3813
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3945
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4292
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4188
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP3A4 1.9792
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4777
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4016
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4777
Platelet activation_Homo sapiens_hsa04611 SRC 0.5029
Tight junction_Homo sapiens_hsa04530 SRC 0.4777
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4652
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4617
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4493
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4764
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5031
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5274
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4849
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5029
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5051
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5029
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1014
Axon guidance_Homo sapiens_hsa04360 MET 0.498
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5743
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5782
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5556
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5709
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5743
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5743
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5743
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5743
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5743
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5709
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2 0.5709
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5709
Peroxisome_Homo sapiens_hsa04146 XDH 0.5782
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6149
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6089
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6354
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5743
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.588
Glioma_Homo sapiens_hsa05214 IGF1R 0.6354
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8604
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6211
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6354
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6354
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6343
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP3A4 0.6218
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9359
Retinol metabolism_Homo sapiens_hsa00830 CYP3A4 0.6354
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6354
Shigellosis_Homo sapiens_hsa05131 SRC 0.6354
Malaria_Homo sapiens_hsa05144 MET 0.7118
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1B1 0.7894
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8841
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.927
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8854
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9176
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9846
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.4919


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)