TCM Prescription: Liver Soothing and Stagnation Desolving Decoction



Prescription Description
Prescription IDTCMF2555
Pinyin NameShu Gan San Jie Tang
Chinese Name疏肝散结汤
English NameLiver Soothing and Stagnation Desolving Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2161 Vaccaria segetalis 王不留行 TCMH2161
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH1348 Liquidambar formosana 路路通 TCMH1348 ITSAM899-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1297 Punta Toro virus
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6428
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.766
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.32657
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, RELA, SRC, TERT 8.85082
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 8.53314
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HSD17B3, PIM1, PPARA, PTGES, TYR, XDH 8.26625
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 8.22924
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.91704
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.90228
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CYP1B1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, TOP2A, XDH 7.24265
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CYP1B1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT, TOP2A, XDH 7.17433
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TYR 7.08661
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTGES, RELA, RORC, SRC, TERT, TOP1, TYR 6.88518
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B2, HSD17B3, KDR, KIT, MAOA, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH 6.25519
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, PTGES, RELA, RORC, SRC, TYR 6.24913
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, HSD17B2, HSD17B3, KIT, MET, PPARA, PTGES 6.00535
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 5.94226
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CYP1B1, DNMT1, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MMP2, MMP9, PIM1, PTGES, RELA, SRC, TERT, XDH 5.8906
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CYP1B1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SRC, TERT, TOP2A, XDH 5.84408
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.80848
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.62243
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.62243
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, TERT, TNKS2, TOP2A, TYR 5.49941
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PTGES, RELA, RORC, SRC, TYR 5.44376
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FLT3, PTGES, RELA, RORC, SRC, TYR 5.41353
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT 5.39908
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RELA, RORC, SRC, TERT 5.29828
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CYP1A1, CYP1A2, CYP1B1, DNMT1, F10, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TOP1, TOP2A, TYR 5.27689
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.26032
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.23159
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CYP1A2, DNMT1, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, RELA, SRC 5.23159
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT 5.22426
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PTPN1, RELA, RORC, SRC, TERT, TOP2A 5.15841
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.12713
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DYRK1A, F10, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.11817
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.08179
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, DYRK1A, F10, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.02152
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B2, HSD17B3 5.01343
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.96796
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.91731
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PPARA, RELA, SRC, TYR 4.85998
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS, TOP1 4.85998
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.84348
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 4.77544
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RELA, RORC, SRC 4.72305
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 4.63388
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CYP1B1, DYRK1A, F10, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, XDH 4.62097
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.5599
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP1, TOP2A 4.51432
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FABP4, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.48857
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CYP1A2, FABP3, FLT3, KIT, PPARA, RELA, SRC 4.47793
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 4.47072
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.45941
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, RELA, SRC 4.38211
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 4.38211
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.25284
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 4.15298
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, TERT 4.14794
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, F10, F3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PPARA, PTPN1, SRC, TERT 4.13799
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.12677
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SRC, TERT 3.95533
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, F10, F3, FABP4, HSD17B2, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RELA, RORC, SRC, TNKS2, TOP1, TYR 3.93006
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.86207
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.81376
[BP] GO:0046777 protein autophosphorylation AURKB, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.81341
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 3.802
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, FLT3, KIT, MAP2K1, MET, PIM1, SRC, TYR 3.79057
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS, TOP1 3.77899
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B2, HSD17B3, MAOA, TYR, XDH 3.75991
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.70971
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.70971
[BP] GO:0048511 rhythmic process AXL, BCL2, DYRK1A, KIT, PPARA, RORC, SRC, TOP1, TOP2A 3.6624
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.60113
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MMP9, PIM1, PPARA, RELA, RORC, SRC, TYR 3.58994
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTPN1, SRC, TNKS, TOP1, XDH 3.58994
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, HCAR2, KDR, SRC, TNKS, TNKS2 3.57868
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DYRK1A, F10, F3, FLT3, FUT7, GLO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.56171
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.54756
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES 3.54438
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.48184
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 3.47443
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.47443
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.47443
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES 3.43887
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGES 3.43678
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, RELA, SRC 3.39575
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.3623
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.32482
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, FABP3, KDR, RELA, SRC, TOP1 3.32418
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTPN1, SRC, TNKS, TOP1, XDH 3.32226
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HSD17B3, MAOA, TYR 3.30475
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 3.30338
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2, HSD17B3 3.28181
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.268
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, BCL2, CDC25B, F3, FLT3, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, XDH 3.26343
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, DNMT1, IGF1R, MMP2, MMP9, RELA, RORC, SRC 3.23891
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DNMT1, DYRK1A, FABP3, FABP4, GLO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.20762
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, RELA, TERT 3.20762
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 3.19598
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DYRK1A, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PTPN1, RELA, SRC, TERT, XDH 3.15316
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DNMT1, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.13553
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.12234
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.12234
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.07582
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 3.07582
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.07045
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B2, HSD17B3 3.07045
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.06717
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, FLT3, RORC, SRC 3.06422
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 3.06281
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.05639
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05639
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.01262
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, HSD17B2, HSD17B3, KIT, MAP2K1, MMP2, MMP9, SRC, TOP2A 3.01262
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, RORC, SRC 2.9661
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, RELA, SRC 2.9661
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.94199
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.94057
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, F3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SRC, TERT 2.93319
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, F3, FABP3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.93228
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.86985
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.86985
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DNMT1, DYRK1A, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.86422
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, PTGES 2.86422
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.80485
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 2.80086
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 2.80085
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, KIT, MET, SRC, XDH 2.7687
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTPN1, RELA, SRC, TERT 2.7687
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.764
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.74049
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.7206
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, KIT, MMP2, PPARA, RELA, SRC, TERT, TYR 2.71306
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 2.71306
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, DYRK1A, F10, F3, FLT3, FUT7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TNKS, TNKS2, TOP1, TOP2A 2.69078
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, RELA, SRC 2.69078
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B2, HSD17B3 2.68442
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 2.67858
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.62905
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SRC, TYR 2.60708
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, KIT, MET, SRC 2.59706
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.58332
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MAP2K1, RELA, TERT 2.56173
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CYP1B1, DYRK1A, F10, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.54095
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, SRC, XDH 2.532
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.53156
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DYRK1A, F10, F3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PPARA, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.52489
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, MAP2K1, PIM1, TERT, TNKS, TOP2A 2.48992
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, FLT3, MET, SRC, TERT 2.48614
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.4423
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.43525
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.42499
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 2.42219
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PTPN1, SRC 2.41472
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TYR 2.40413
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.40413
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, PTPN1, RELA, SRC, TERT, TOP2A 2.38588
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, DNMT1, FLT3, IGF1R, KIT, MMP2, RELA, SRC 2.37145
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.36212
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.34921
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, RELA, SRC 2.33508
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, IGF1R, MMP2, PPARA, RELA, SRC, TYR 2.33364
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.33146
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.32696
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.3154
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.30254
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTPN1, SRC, XDH 2.29642
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, FABP3, MAP2K1, PTGES, TERT, XDH 2.28215
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.25859
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.24937
[BP] GO:2001251 None DNMT1, SRC, TNKS, TNKS2, TOP2A 2.23684
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.23393
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, SRC, TNKS, TOP1 2.2133
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.20958
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, DYRK1A, F10, FLT3, FUT7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP1, TOP2A 2.20913
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CYP1B1, F3, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SRC, TERT, TNKS2, XDH 2.19681
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.19602
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, PTGES, TYR 2.18474
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.18044
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.17591
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.15983
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.15983
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.15983
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, F3, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2 2.15654
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B2, HSD17B3 2.13727
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 2.13519
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA, SRC 2.12125
[BP] GO:0070213 None TNKS, TNKS2 2.12125
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12125
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12097
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, BCL2, DNMT1, DYRK1A, FABP4, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, PPARA, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.11294
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, KIT, MAP3K7, PIM1, RELA 2.08823
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CHRM2, CYP1B1, DNMT1, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 2.08365
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.07941
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.07941
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.07897
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07897
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.06092
[BP] GO:0006081 None AKR1B10, CYP1B1, GLO1, RELA 2.06092
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, IGF1R, MMP2, RELA, SRC 2.05272
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CYP1B1, F3, FABP4, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PTPN1, RELA, SRC, TERT, TNKS, XDH 2.02357
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.02293
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.01839
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, IGF1R, MET, MMP9, PTPN1, RELA, SRC, XDH 2.00337
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.30475
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, F3, FLT3, FUT7, GLO1, HCAR2, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 3.13282
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PTGES, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.7687
[CC] GO:0009330 None TOP1, TOP2A 2.74701
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.56132
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, F10, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SRC, TERT 2.31341
[CC] GO:0031233 None CA4, F10, F3 2.25859
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, HSD17B2, HSD17B3, PTGES, PTPN1 2.2133
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, PPARA, PTPN1, RELA, RORC, SHBG, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.05435
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.8247
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 14.7887
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, F3, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTGES, PTPN1, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 14.2196
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 12.5897
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9639
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.766
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.26625
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, F10, GLO1, KIT, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.88428
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, F10, GLO1, KIT, MAP3K7, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 7.52158
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, GLO1, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 7.17433
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.40702
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.07417
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 5.03785
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP1, TOP2A 4.96796
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B2, HSD17B3, MAOA, TYR, XDH 4.72821
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.6897
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.47793
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.40923
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.92525
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.92525
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.79966
[MF] GO:0004672 protein kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.79313
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.75618
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.47443
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.07962
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.9661
[MF] GO:0016301 kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 2.75554
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74701
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TERT, TOP1 2.68442
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, SRC, XDH 2.17591
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, DYRK1A, F10, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TOP1 2.12616
[MF] GO:0005497 None AR, SHBG 2.12125
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, DYRK1A, F10, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGES, RELA, SRC, TOP1, TOP2A, XDH 2.07941


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.2667
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 5.7077
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, RELA, IGF1R 5.2041
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 5.4874
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.9404
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.5923
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, KIT, PIM1, RELA 4.4165
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, HSD17B3, AKR1B1, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 4.0123
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, IGF1R 3.9905
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 4.0123
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.0123
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MAP3K7, MET, IGF1R 4.0123
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, KIT, KDR, BCL2, MET, RELA, IGF1R 3.5532
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.7595
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.5442
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, BCL2, CACNA1C 3.3743
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 3.8752
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.8554
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, CACNA1C 3.3743
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 3.1918
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KIT, KDR, MET, IGF1R 3.135
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 3.2525
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KIT, KDR, MET, RELA, IGF1R 2.9867
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, BCL2, MMP9, RELA 2.9602
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, KIT, MET 3.1487
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.7196
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9 2.5953
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.135
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.586
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.4651
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.5591
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.3641
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.0325
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0177
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 1.919
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.1692
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.0325
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.0579
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.0325
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9101
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.102
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2 2.0516
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.7151
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.7001
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, MAP3K7, RELA 1.7592
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6568
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.6708
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.6404
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.5424
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.5213
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.4003
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.4523
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3747
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.2965
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.2747
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2498
Epstein-Barr virus infection_Homo sapiens_hsa05169 BCL2, MAP3K7, RELA 1.1555
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.2251
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, SRC 1.1219
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1 0.8874
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3191
Purine metabolism_Homo sapiens_hsa00230 XDH 0.331
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3412
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.87
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.9055
Measles_Homo sapiens_hsa05162 MAP3K7, RELA 0.8617
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2901
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.934
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 0.934
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.87
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.8499
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.8844
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, IGF1R 0.8453
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.2747
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9259
Tight junction_Homo sapiens_hsa04530 SRC 0.4001
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.8312
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, KIT 0.8438
Wnt signaling pathway_Homo sapiens_hsa04310 MAP3K7 0.3956
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2747
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.2765
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8248
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.1335
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4075
HTLV-I infection_Homo sapiens_hsa05166 TERT, RELA 0.5502
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2965
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8024
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.7406
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CACNA1C 0.7347
Herpes simplex infection_Homo sapiens_hsa05168 MAP3K7, RELA 0.7192
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7352
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.0911
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.6688
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3116
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.2375
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.2747
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4314
Axon guidance_Homo sapiens_hsa04360 MET 0.4257
Platelet activation_Homo sapiens_hsa04611 SRC 0.4345
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.2375
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.2747
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1335
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, RELA 1.1335
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2747
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4556
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2498
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.1335
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1335
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2683
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.2747
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.2765
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1948
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.2375
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4857
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4936
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4936
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2747
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4936
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5018
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4938
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4996
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4985
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2438
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1897
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4996
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4074
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4936
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.507
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2498
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5082
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5082
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5268
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5194
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5209
Peroxisome_Homo sapiens_hsa04146 XDH 0.5268
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5271
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5268
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5384
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5502
Pertussis_Homo sapiens_hsa05133 RELA 0.5502
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4523
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5502
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5754
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7151
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5957
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5957
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6404
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.6415
Legionellosis_Homo sapiens_hsa05134 RELA 0.6453
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6643
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6832
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6688
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6702
Malaria_Homo sapiens_hsa05144 MET 0.6749
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6264
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6796
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7077
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7022
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.919
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7352
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.776
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7352
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8312
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8453
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.815
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7964
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8312
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8489
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8248
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8453
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.87
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9755
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0532


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)