TCM Prescription: Tian Dan Tong Luo Tablet



Prescription Description
Prescription IDTCMF254
Pinyin NameTian Dan Tong Luo Pian 
Chinese Name天丹通络片
English NameTian Dan Tong Luo Tablet
Function Description中风中经络, 风痰淤血痹阻脉络证, 症见半身不遂, 偏身麻木, 口眼歪斜, 语言蹇塞; 脑梗死急性期
IndicationsNumbness disorder, Wind-phlegm pattern, Stroke
Disease ICD-11 Category SC62 [Numbness disorder (TM1), 麻木 (TM1) ];
SF15 [Wind-phlegm pattern (TM1), 风痰证 (TM1) ];
8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationBrain
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH2238 Siegesbeckiae herba 豨莶草 TCMH2238 GQ434487
TCMH2013 Hirudo medicinalis 水蛭 TCMH2013 GBAN0017-06
TCMH938 Sophora japonica 槐花 TCMH938 ITSAN2377-14
TCMH1716 Calculus bovis artificiosus 人工牛黄 TCMH1716
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 9.24365
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B1, HSD17B2, KCNH2, KDR, MET, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, XDH 8.00377
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTAFR, RORC, SLC6A4, SRC, TYR 8.00377
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, PPARA, PTAFR, RORC, SLC6A4, SRC, TYR 7.99953
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, HMGCR, PIM1, PPARA, PTAFR, TYR, XDH 7.14566
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 7.03918
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, HMGCR, HSD17B1, HSD17B2 7.03918
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FABP3, FABP4, HMGCR, HSD17B1, HSD17B2, MET, PPARA 7.03918
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.65763
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.65763
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TOP2A, XDH 6.59896
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, PTAFR, RORC, SLC6A4, SRC, TERT 6.34778
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTAFR, RORC, SLC6A4, SRC, TYR 5.71699
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.71699
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTAFR, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR 5.71699
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, SLC6A4, SRC, TERT, XDH 5.71699
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, XDH 5.71699
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A 5.71699
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 5.58775
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, SLC6A4, SRC 5.58775
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SRC, TYR 5.55022
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 5.48583
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, PTAFR, SLC6A4, SRC 5.4831
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.05923
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, PTAFR, RORC, SLC6A4, SRC 5.03817
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GRIK5, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 5.03281
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, PTAFR, RORC, SLC6A4, SRC, TYR 5.00527
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.99034
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.91565
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.91565
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.71784
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.67605
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.67605
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TERT 4.59771
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.58188
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 4.56457
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.56457
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 4.51742
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 4.51742
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.48753
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.48064
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.47039
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, KCNH2, MET, SRC, TERT 4.42326
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 4.41456
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.41194
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.40883
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.37785
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, RORC 4.36592
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, HMGCR, MET, PPARA 4.35767
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.30309
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, KCNH2, KDR, PTAFR, SLC6A2, SLC6A4, SRC 4.25534
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 4.23102
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.19478
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 4.19478
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.16656
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, PTAFR, RORC, SLC6A4, SRC 4.16656
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 4.16656
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, TERT 4.16656
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 4.16396
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, TERT 4.1301
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.06193
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 4.03358
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 3.95363
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 3.9491
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, GLO1, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TOP2A, TYR 3.93744
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.86533
[BP] GO:0032787 None ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, PPARA 3.77671
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.75621
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 3.72266
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 3.72266
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.62166
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.61799
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 3.61799
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CES1, CYP1A1, CYP1B1, HMGCR, KDR, SLC6A4, SRC 3.60501
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.60132
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.59467
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HMGCR, HSD17B1, HSD17B2 3.5755
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.56656
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CES1, CYP19A1, HMGCR, PTAFR, TYR 3.53483
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, HMGCR, PTAFR, TYR 3.51853
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.48539
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.47092
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.46987
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.45879
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.43084
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.40955
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.40032
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PTAFR, PTPN1, SRC, TERT, XDH 3.40032
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.37606
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.33116
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, HMGCR, KCNH2, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TERT 3.29747
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, CYP1A1, CYP1B1, ESR1, FLT3, PTAFR, RORC, SLC6A4, SRC 3.25118
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.16162
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.14707
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, PPARA, RORC, SRC 3.14707
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HMGCR 3.11989
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HMGCR, HSD17B1, HSD17B2 3.10308
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.08513
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 3.07615
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, TERT 3.07615
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KCNH2, KDR, PTAFR, SRC 3.04921
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 3.03284
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 3.02869
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, PIM1, PPARA, TYR 2.99041
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.97964
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTAFR, SLC6A4, SRC, TERT, TYR 2.96973
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4 2.96973
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SRC 2.94357
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.90662
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 2.86559
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.85574
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.84911
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.83632
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, SLC6A4, SRC, TYR 2.83256
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.83256
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81703
[BP] GO:0009115 None AOX1, XDH 2.79506
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.72149
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 2.70959
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.70856
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, SLC6A4, SRC 2.69856
[BP] GO:0003018 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4, SRC 2.67877
[BP] GO:0007188 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 2.66851
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.65919
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, KCNH2, MET 2.62347
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.61633
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.61627
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2 2.61486
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, PIM1, PPARA, TYR 2.61416
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, XDH 2.60933
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, ESR1, FLT3, GRM5, IGF1R, MMP2, PTAFR, SLC6A4, SRC 2.58227
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.5799
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.56666
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, SLC6A4, SRC, TYR 2.56064
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, PIM1, PPARA, TYR 2.54786
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC 2.54214
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.52816
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.51332
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.50438
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.49098
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, PTPN1, SRC 2.46306
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.45128
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.44828
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.44828
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, GRM1, HMGCR, IGF1R, KDR, PTPN1, SRC, XDH 2.42074
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19 2.41744
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.41744
[BP] GO:0099566 None GRM1, GRM5 2.41744
[BP] GO:0046110 None AOX1, XDH 2.41744
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41744
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.40946
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.4045
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.4001
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.37386
[BP] GO:0007187 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 2.37386
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.35306
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.34053
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.30381
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.2671
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.25653
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.24672
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.24054
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.24054
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.23813
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.23813
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.23493
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.22887
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.22887
[BP] GO:0010675 None ESRRB, PPARA, PTAFR, RORC, SRC 2.22349
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, GRM5, IGF1R, MMP2, PTAFR, SLC6A4, SRC 2.21605
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.21114
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20734
[BP] GO:0007268 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.20734
[BP] GO:0098916 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.20734
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 2.20497
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MMP9, PTAFR, PTPN1, SRC, TERT, XDH 2.20497
[BP] GO:0097746 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.20473
[BP] GO:0035296 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.20473
[BP] GO:0042391 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 2.20473
[BP] GO:0006145 None AOX1, XDH 2.20473
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.20473
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20473
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GRM1, HMGCR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PTAFR, SLC1A1, SLC6A4, SRC, TERT, XDH 2.17848
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.17848
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17848
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.17848
[BP] GO:0003013 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4, SRC 2.17848
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.17848
[BP] GO:0099536 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.17818
[BP] GO:0099537 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.17818
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.16881
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KCNH2, KDR, MET, PIM1, PTAFR, PTPN1, SRC, XDH 2.13169
[BP] GO:0045913 None ESRRB, PPARA, PTAFR, SRC 2.12412
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.10927
[BP] GO:0050880 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.10927
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.10422
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.09918
[BP] GO:0035150 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.09866
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 2.07549
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, KCNH2, MMP12, PTAFR, SLC6A4, SRC, TERT 2.0638
[BP] GO:1900543 None ADRA2A, GRM3, GRM8, PPARA 2.0638
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, GRM5, IGF1R, MMP2, PTAFR, SLC6A4, SRC 2.04625
[BP] GO:0045980 None ADRA2A, GRM3, GRM8, PPARA 2.04487
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 2.04428
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, GRIK5, HMGCR, MMP12, PTAFR, SLC6A4, SRC 2.04428
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 2.04164
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT 2.04041
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.0352
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.03244
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT, XDH 2.02962
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, XDH 2.02767
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.02767
[BP] GO:0061097 None ADORA1, ADRA2A, GRM5, PTPN1 2.01555
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT 4.27547
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 3.65322
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA2, CA4, CA9, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC 3.55369
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4 3.48231
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.37606
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, SLC6A2, SLC6A4 3.14707
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC 2.52816
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TYR 2.47625
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.23493
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.22072
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.22072
[CC] GO:0043005 None ADORA1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A4, SRC 2.15426
[CC] GO:0005783 None ADORA1, APEX1, CA4, CES1, CES2, CYP19A1, FLT3, GRIK5, HMGCR, KDR, PTPN1, XDH 2.14219
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.2348
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.52316
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 8.41792
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.99953
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, PTAFR, RORC 6.83419
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.63412
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 6.63412
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TYR, XDH 6.63412
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TOP2A, TYR, XDH 6.24947
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.11306
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, PTAFR, RORC 6.03936
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TOP2A, TYR, XDH 5.92406
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, PTAFR, RORC 5.80831
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HMGCR, HSD17B1, HSD17B2, TYR, XDH 5.71699
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH 5.58775
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PPARA, PTAFR, RORC 5.44769
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.11458
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.05923
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.05923
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.65366
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 4.24337
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD17B1, HSD17B2, XDH 3.9491
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.94433
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.93744
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.90172
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 3.6732
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.61799
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, TERT, TOP2A, TYR, XDH 3.48539
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.45879
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.37606
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, PTAFR, RORC 3.26139
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR 3.14707
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR 3.14707
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 3.07615
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, HMGCR, HSD17B1, SRC, XDH 3.03445
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.93653
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, SRC 2.92095
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.79506
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, TYR 2.67877
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.67877
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC, TOP2A 2.67532
[MF] GO:0005330 None SLC6A2, SLC6A4 2.41744
[MF] GO:0099583 None GRM1, GRM5 2.41744
[MF] GO:0047374 None CES1, CES2 2.41744
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.40946
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.40601
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.40601
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.4001
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.39643
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.35306
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.24057
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20473
[MF] GO:0004971 None GRIA2, GRIA4 2.20473
[MF] GO:0032795 None ADORA1, ADRA2A 2.20473
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2 2.17848
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.16881
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, HMGCR, KCNH2, SLC6A4, TERT, TOP2A, TYR, XDH 2.15426
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.14151
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, ESR1, ESR2, ESRRB, GRM5, HMGCR, KCNH2, MET, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TOP2A 2.05565
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.03832


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.067
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6951
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, PTAFR, GRM8, ADORA1, GRM1, ADRA2A, GRIA4 7.076
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.8496
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.9796
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.6633
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0667
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0667
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, HMGCR, TYR, CYP2C19, CYP19A1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 3.8636
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8636
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8636
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0322
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.5178
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 2.8371
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, CYP2C19, SLC6A4 2.3988
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0907
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 1.9846
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1277
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.4178
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, CYP2C19 2.1086
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP2C19 2.9344
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0907
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.018
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0907
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.8633
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP2C19 2.0534
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8633
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0179
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 1.7421
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7375
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.6957
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.8633
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4349
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.2739
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, GRM1 1.2337
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.026
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3221
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2818
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3178
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9957
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9038
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0469
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0117
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2422
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.026
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2422
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9439
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2994
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2293
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9038
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.239
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1617
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9038
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8979
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8564
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8798
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7989
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8465
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8102
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.739
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8199
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2293
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4223
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7617
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2354
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2354
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2929
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2822
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2917
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3186
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3035
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3099
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3185
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5704
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3099
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3616
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3501
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3862
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3787
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3824
Platelet activation_Homo sapiens_hsa04611 SRC 0.407
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3902
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4627
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4311
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.407
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.407
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7421
Axon guidance_Homo sapiens_hsa04360 MET 0.4024
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4311
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4627
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4627
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4131
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4503
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4533
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4627
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4563
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4533
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4627
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4598
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4627
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4627
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4598
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4598
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4627
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4598
Peroxisome_Homo sapiens_hsa04146 XDH 0.4627
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4627
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4955
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6605
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5122
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5311
Glioma_Homo sapiens_hsa05214 IGF1R 0.5311
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.53
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5311
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5311
Shigellosis_Homo sapiens_hsa05131 SRC 0.5311
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8996
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5642
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7126
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6482
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.596
Malaria_Homo sapiens_hsa05144 MET 0.6066
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6124
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6096
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.672
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7395
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7752
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7673
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7989
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9527
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8529
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2519


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)