TCM Prescription: Rehmannia Bolus for Improving Eyesight



Prescription Description
Prescription IDTCMF2473
Pinyin NameMing Mu Di Huang Wan
Chinese Name明目地黄丸
English NameRehmannia Bolus for Improving Eyesight
Function Description男女肝肾两亏, 风邪外乘, 热气上攻, 畏日羞明, 瞳神散大, 视物不清, 迎风流泪, 内生翳障, 及时眼之后, 久不还元, 一切目疾
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLiver
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH73 Tribulus terrestris 白蒺藜 TCMH73 ITSAJ4258-14
TCMH1937 Concha haliotidis 石决明 TCMH1937
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 11.7283
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0638
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1847
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, KDR, MAOA, MET, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 9.02727
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 8.36825
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 7.60976
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 7.59841
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FDPS, FUT7, GLO1, HMGCR, NISCH, PIM1, PPARA, XDH 6.68674
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.54249
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.54249
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.47166
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.47166
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 6.47166
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH 6.46958
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH 6.46958
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.45615
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.32825
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, HSD11B1, HSD17B1, MET, PPARA 6.32825
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 6.18076
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 6.07471
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.0532
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.96179
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 5.87626
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.62206
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, F10, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.49155
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FDPS, HMGCR, HSD11B1, HSD17B1 5.45729
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.34198
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HCAR2, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.31749
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, FABP3, GRIK5, GRM5, HMGCR, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A3, SRC 5.31749
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 5.20322
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MAOA, MET, MMP1, MMP2, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 5.10528
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.06027
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTPN1, SRC, TNKS, TNKS2, XDH 5.06027
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3 5.0372
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3 5.0372
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, F10, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PTPN1, SRC, TNKS, TNKS2, XDH 4.94872
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.90876
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FDPS, FLT3, HCAR2, HMGCR, PPARA, RORC, SRC 4.88024
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.72819
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CDK6, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HMGCR, KDR, SLC6A2, SLC6A3, SRC 4.67941
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 4.67146
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, MAOA, SLC6A3 4.63385
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, FABP3, FABP4, FDPS, FUT7, HMGCR, MET, PPARA 4.56025
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, DRD2, DRD3, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2 4.5495
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.52042
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A3, SRC 4.51925
[BP] GO:0042417 None DRD2, DRD3, DRD4, MAOA, SLC6A3 4.51468
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, HMGCR, KDR, SLC6A3, SRC 4.47277
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, MAOA, SLC1A1, SLC6A2, SLC6A3 4.47277
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FLT3, HASPIN, IGF1R, KDR, MET, SRC, TNKS, TOP2A 4.44917
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.41438
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK2, F10, GRIK5, GRM5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PPARA, PTPN1, SRC 4.39677
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FDPS, HMGCR, MAOA, SLC6A3 4.36217
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD17B1, MAOA, PHF8, XDH 4.34976
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.3493
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8 4.34896
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, RORC, TOP2A 4.32835
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 4.31799
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2, NISCH 4.27977
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.26324
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.17845
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.17845
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FDPS, FLT3, HASPIN, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 4.15561
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD2, DRD3, DRD4, MAOA, SLC6A3 4.13879
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, PPARA, RORC, SRC, TOP2A 4.12708
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.10801
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD17B1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 4.07148
[BP] GO:0051937 None CHRM5, NISCH, SLC6A2, SLC6A3 4.07148
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.95218
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 3.93611
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A3, SRC 3.92067
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 3.90798
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FDPS, FLT3, HASPIN, HMGCR, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.8308
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 3.76885
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CDK6, CHRM1, CYP19A1, CYP1B1, DRD2, DRD3, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC 3.76549
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5 3.76549
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.74596
[BP] GO:0018958 None AKR1B1, DRD2, DRD3, DRD4, MAOA, SLC6A3 3.7401
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DYRK1A, DYRK1B, DYRK3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, KDR, MET, MMP2, MMP9, PHF8, PIM1, PPARA, RORC, SLC6A3, SRC, TNKS2, TOP2A 3.7401
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 3.67596
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, F10, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.65193
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.64598
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FLT3, FUT7, GLO1, HASPIN, HMGCR, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.64598
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.64598
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.60575
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.58895
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.54664
[BP] GO:0015844 None CHRM5, NISCH, SLC6A2, SLC6A3 3.54664
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.52865
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, F10, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A3, SRC, TNKS2 3.52198
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRM5 3.52141
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.50563
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.50563
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, RORC, SLC6A3, SRC 3.49476
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.48386
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.47052
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.42342
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.42342
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.42292
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.42292
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 3.32756
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.31392
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.31392
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK2, DYRK3, FABP3, FABP4, GLO1, GRM3, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 3.28282
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.24594
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.24594
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DYRK2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 3.23854
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.23854
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, DRD3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.23854
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.23854
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.21694
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.18806
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, HCAR2, TNKS, TNKS2 3.16159
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.0737
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD2, DRD3, DRD4, FABP3, MMP12, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, TNKS 3.0737
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, DYRK2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 3.06371
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.97762
[BP] GO:0007195 None DRD2, DRD3, DRD4 2.97247
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.97247
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.97247
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC 2.96409
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, XDH 2.93865
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, CHRM5, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.93865
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 2.93858
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HCAR2, HMGCR, HSD11B1, HSD17B1 2.9285
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 2.9285
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK3, FABP3, FABP4, GLO1, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.9208
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.88511
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DYRK1A, DYRK3, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.87353
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, HASPIN, MMP12, MMP9, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 2.87263
[BP] GO:0034776 None DRD2, DRD3, DRD4 2.86398
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.85913
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 2.84393
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD2, DRD3, DRD4, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC 2.83696
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 2.81788
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1 2.81788
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, DRD2, DRD4, F10, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 2.81683
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS, HMGCR 2.7754
[BP] GO:0015872 None CHRM5, SLC6A2, SLC6A3 2.76711
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HMGCR, HSD11B1, HSD17B1 2.76482
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 2.76482
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.725
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC 2.71848
[BP] GO:0046717 None CHRM5, DRD2, DRD3, DRD4, SLC1A1 2.70458
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, SLC6A3, SRC, XDH 2.7028
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FABP3, GRIA2, GRIA4, GRIK5, MMP12, MMP9, NISCH, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, XDH 2.68639
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.68548
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.68172
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC 2.66463
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, NISCH, SRC 2.65057
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F10, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.60551
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.59032
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD2, DRD3, KDR, SRC 2.54409
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.54025
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, DRD4, MMP9, NISCH, SLC1A1, SLC6A3, XDH 2.54025
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.53182
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, MET, SRC, XDH 2.51592
[BP] GO:0032845 None ADORA1, DRD2, HMGCR, SRC, TNKS, TNKS2 2.49056
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA 2.48376
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, DRD2, DRD3, DRD4, DYRK2, HCAR2, HMGCR, MMP12, PTPN1, SRC 2.46516
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.44871
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.43612
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.43455
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.42842
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SLC6A3, SRC 2.42705
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PTPN1, XDH 2.42545
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.39295
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.37356
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.36788
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.36788
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F10, MET, SLC6A3, XDH 2.35744
[BP] GO:0099566 None GRM1, GRM5 2.33704
[BP] GO:0051944 None DRD2, DRD4 2.33704
[BP] GO:0060160 None DRD2, DRD3 2.33704
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.33704
[BP] GO:0051586 None DRD2, DRD4 2.33704
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK2, F10, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SRC, TOP2A 2.32338
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, DRD4, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.29095
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.28499
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.27441
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.24764
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRM1, HCAR2, SLC1A1 2.24764
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.24764
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FABP4, FDPS, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.24015
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.20791
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.20791
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CHRM1, CYP19A1, DRD2, DRD3, DRD4, DYRK2, GRIK5, GRM5, HCAR2, HMGCR, MMP12, MMP9, PPARA, PTPN1, SRC 2.20422
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 2.19471
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.18984
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.18984
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.17507
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.15582
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC, TNKS 2.14633
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 2.13941
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.1361
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.13538
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.12166
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.12166
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.12022
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DRD4, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.12022
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CLK1, CYP1A1, FLT3, MET, PIM1, SRC 2.11733
[BP] GO:0070213 None TNKS, TNKS2 2.09369
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.09369
[BP] GO:0015874 None NISCH, SLC6A2 2.09369
[BP] GO:0051582 None DRD2, DRD4 2.09369
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.09369
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.0807
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.06676
[BP] GO:0034502 protein localization to chromosome AURKB, HASPIN, TNKS, TNKS2 2.06543
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.06543
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 2.04698
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DRD4, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.04698
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.04698
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.04698
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.04698
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.04698
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.04698
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, MAOA, SLC6A3 2.04378
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.04378
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, DRD4, HCAR2, HMGCR, MMP12, SRC 2.04179
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.02921
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1 2.02921
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.02921
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.02451
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, NISCH 2.02301
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.01964
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.01026
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.01026
[BP] GO:0008299 None CYP1A1, FDPS, HMGCR 2.01026
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.01026
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, DRD4, GRIK5, HCAR2, HMGCR, MMP12, SRC 2.00426
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RORC, SRC 2.0014
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 5.6251
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 5.56453
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 5.10236
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.92623
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3 4.72819
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, F10, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SRC 3.82439
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD2, DRD3, DRD4, F10, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, NISCH, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC 3.76885
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 3.69685
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.50563
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.50563
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3 3.33496
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.0737
[CC] GO:0098793 None ADORA1, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC6A3 3.06581
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, F10, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, IGF1R, KDR, MAOA, MET, MMP2, NISCH, PHF8, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2 2.85452
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.75615
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SLC6A2, SLC6A3, SRC 2.54025
[CC] GO:0098794 None ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRM3 2.38111
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.15582
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.16
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, TNKS, XDH 11.7283
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FABP3, FABP4, FDPS, FLT3, GLO1, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, TOP2A, XDH 11.7283
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FDPS, FLT3, FUT7, GLO1, HASPIN, HMGCR, HSD11B1, HSD17B1, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, XDH 11.7283
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3075
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1847
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 10.1383
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD2, DRD3, DRD4, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PPARA, SLC6A3, SRC, TOP2A 8.74079
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.60976
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.60976
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, DRD3, DRD4, DYRK2, DYRK3, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TOP2A, XDH 7.10559
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.54249
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PTPN1, RORC, TNKS 6.18076
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.1613
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 6.05352
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.0532
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 5.52784
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 5.45729
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 5.45729
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD17B1, MAOA, PHF8, XDH 5.39645
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 5.26439
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 5.20322
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.06448
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PHF8, XDH 5.0372
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, F10, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, TNKS, TNKS2, TOP2A, XDH 4.92623
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.9014
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 4.53965
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 4.3763
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.30469
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 3.94629
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD2, DRD3, DRD4, SLC6A3 3.87623
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.76885
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.66661
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.64598
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.62354
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, XDH 3.52865
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.50563
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.33725
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.24594
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.23854
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PHF8 3.23854
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 3.20626
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.0737
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.01928
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1 2.87269
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.84393
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SLC6A3, SRC 2.76711
[MF] GO:0004952 None DRD2, DRD3, DRD4 2.76711
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8, HCAR2 2.74936
[MF] GO:0008389 None CYP2A13, CYP2A6 2.72542
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.68641
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.66463
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIM1 2.66463
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A3, SRC 2.55226
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FLT3, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC 2.54025
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, SRC, XDH 2.457
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.41123
[MF] GO:0005330 None SLC6A2, SLC6A3 2.33704
[MF] GO:0099583 None GRM1, GRM5 2.33704
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, SLC1A1, SRC, TOP2A, XDH 2.26384
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.24764
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.24764
[MF] GO:0004971 None GRIA2, GRIA4 2.09369
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.02921


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.6819
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 11.8027
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.105
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.105
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 5.8854
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.8921
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.5575
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.7945
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, DRD2, PPARA, GRIA4 4.6538
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD2, SLC6A3 4.6538
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.7997
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.0583
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.0583
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, MAOA, AKR1B1, HMGCR, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, XDH 2.9348
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.6245
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6133
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 2.87
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, SLC6A3, GRIA4 2.8788
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.1356
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.3178
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.87
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.3044
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1 2.4907
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, CDC25B 2.0973
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.0109
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.0053
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, MET, IGF1R 1.8948
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.8948
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0053
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9169
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 1.9208
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.8807
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6014
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2 1.8948
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.4734
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.1582
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.1582
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD2, SLC6A3 1.0178
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.8254
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.1582
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.8306
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.8817
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0833
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8465
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.117
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.856
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 0.9458
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1537
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0178
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.0674
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7932
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7258
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.8551
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5 0.7794
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9867
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0639
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1349
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7409
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7293
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7469
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.0376
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7293
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.702
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.6972
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.1126
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.6855
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6885
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6002
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.4968
HTLV-I infection_Homo sapiens_hsa05166 FDPS 0.1832
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1832
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2413
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2511
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2571
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2654
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2653
Influenza A_Homo sapiens_hsa05164 FDPS 0.2654
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2571
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.2917
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.2906
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.2994
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.2917
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3157
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3159
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3157
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3269
Platelet activation_Homo sapiens_hsa04611 SRC 0.3459
Axon guidance_Homo sapiens_hsa04360 MET 0.3387
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3459
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.353
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.37
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.353
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.3892
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4114
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3925
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.3996
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.3963
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4114
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4114
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4114
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4114
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.407
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4069
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4113
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.4114
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4114
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4114
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4072
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4114
Peroxisome_Homo sapiens_hsa04146 XDH 0.4114
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4403
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4114
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4412
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4152
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4475
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.461
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.461
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.461
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4486
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.461
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.461
Shigellosis_Homo sapiens_hsa05131 SRC 0.461
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9248
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.595
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.4968
Legionellosis_Homo sapiens_hsa05134 CLK1 0.4968
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4734
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5188
Malaria_Homo sapiens_hsa05144 MET 0.5248
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5217
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5516
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6002
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7989
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6002
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA 0.6386
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6774
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6574
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.6885
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7049
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6855
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS, HMGCR 1.8251
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7009
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7261
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8254


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)