TCM Prescription: Lung Clearing Decoction



Prescription Description
Prescription IDTCMF2468
Pinyin NameQing Fei Huo Gan Li Lao Tang
Chinese Name
English NameLung Clearing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2160 Herba artemisiae 万年蒿 TCMH2160
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH212 Iphigenia indica 草贝母 TCMH212 GBVY1310-14, GBVC2253-11
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2551 Polygonatum odoratum 玉竹 TCMH2551 ITSAM921-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH2252 Agrimonia pilosa var. japonica 仙鹤草 TCMH2252
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PDE5A, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 13.3988
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PDE5A, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 13.3988
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B3, HSPA1A, INSR, KDR, MAOA, MAOB, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.8489
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PDE5A, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.8489
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.8326
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.7113
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, PDE5A, RELA, SRC, TEK, XDH 10.4179
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, RELA, SRC, TEK, XDH 9.12528
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MMP12, NUAK1, PDE5A, PIM1, PTGES, RELA, SMAD3, SRC, TEK, XDH 8.47541
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PDE5A, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.1305
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.74788
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MET, MMP12, PPARA, SMAD3, SRC, TEK 7.7215
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MAOB, PTGES, RELA, SRC 7.67932
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, PPARA, PTGES, RELA, RORC, SMAD3, SRC, TEK 7.53745
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.53745
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.53745
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B3, INSR, KDR, MAP2K1, PPARA, PTPRS, RELA, SMAD3, SRC, TEK 7.1573
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PPARA, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.13937
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.07632
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B3, MET, PPARA, PTGES 7.07632
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSD17B3, HSPA1A, PDE5A, PIM1, PPARA, PTGES, XDH 6.68266
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 6.49399
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PPARA, PTPRS, RELA, SMAD3, SRC, TEK, XDH 6.46744
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 6.46744
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, PPARA, PTGES, RELA, RORC, SMAD3, SRC, TEK 6.38304
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MAP2K1, MET, PIM1, PPARA, RELA, SMAD3, SRC, TEK, XDH 6.36483
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.35109
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, EGFR, FLT3, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, XDH 6.33527
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, XDH 6.32588
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, MAOB, PTGES, RELA, RORC, SRC, TEK 6.26766
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MAP2K1, MET, PIM1, RELA, SMAD3, SRC, TEK, XDH 6.24203
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.23598
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MAOB, PPARA, RELA, SMAD3, SRC, TEK 6.14265
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.06464
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, IGF1R, INSR, MAOB, PPARA, PTGES, RELA, RORC, SRC, TEK 6.00218
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, MAOB, PPARA, RELA, SRC, TEK 5.97234
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, PTPRS, SRC, TEK, TNKS, XDH 5.74472
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TNKS 5.6625
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.6625
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MAP2K1, PIM1, RELA, SMAD3, SRC, TEK, XDH 5.63544
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, RELA, SMAD3, SRC, TEK 5.58353
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, MAOB, PTGES, RELA, RORC, SRC 5.50625
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, PTPRS, SRC, TEK, TNKS, XDH 5.40932
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B3, INSR, KDR, MAOB, MAP2K1, MET, PIM1, PPARA, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS2 5.38962
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B3, INSR, KDR, MAOB, MAP2K1, PIM1, PPARA, PTPRS, RELA, RORC, SMAD3, SRC, TEK 5.37378
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MAOB, MAP2K1, MET, MMP12, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.34941
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIM1, RELA, SMAD3, SRC, TEK 5.33512
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MAOB, MAP2K1, MET, MMP12, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.24553
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CACNA1C, CYP1B1, EGFR, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PIM1, PTPRS, RELA, SMAD3, SRC, TEK, TNKS2, XDH 5.22816
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 5.18379
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 5.17692
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 5.14135
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 5.06455
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 5.04148
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, CSNK2A1, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.04148
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, PPARA, RELA, SMAD3, SRC, TEK, TNKS, XDH 5.01178
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.99729
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, EGFR, F3, HCAR2, HSPA1A, KDR, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PIM1, RELA, SMAD3, SRC, TEK 4.86798
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.86798
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 4.8667
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.72529
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK, XDH 4.71905
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PIM1, RELA, SMAD3, SRC, TEK 4.68025
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK, XDH 4.67588
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, CSNK2A1, EGFR, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.64131
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MMP12, NUAK1, PPARA, PTGES, RELA, RORC, SMAD3, SRC, TEK 4.61289
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, SRC, TEK, TNKS 4.56109
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.56109
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, MAOB, RELA, SRC 4.54347
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.49016
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PDE5A, SRC 4.45604
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, RELA, RORC, SMAD3, SRC 4.44277
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.38638
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTPRS, RELA, SMAD3, TEK 4.37262
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.34147
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MAOB, MAP2K1, MMP12, PPARA, SMAD3, SRC 4.30266
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, RELA, RORC, SMAD3, SRC 4.27053
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.25572
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX15, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP4, IGF1R, INSR, MET, MMP12, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS2 4.23212
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, RELA, RORC, SMAD3, SRC 4.21503
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, CSNK2A1, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, PDE5A, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.1551
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.15279
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, EGFR, FABP3, FLT3, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SMAD3, SRC, TEK, XDH 4.13316
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, EGFR, FABP3, FLT3, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SMAD3, SRC, TEK, XDH 4.13316
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, EGFR, HCAR2, KDR, SRC, TNKS, TNKS2 4.1294
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGES 4.12177
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, EGFR, F3, FLT3, HSPA1A, INSR, MAP2K1, MAP3K7, MET, PDE5A, RELA, SMAD3, SRC, TEK, TNKS, XDH 4.12177
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MAP2K1, MAP3K7, NUAK1, PDE5A, SMAD3, SRC, TEK, TNKS, XDH 4.08238
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.0546
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.0423
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, PDE5A, RELA, SRC, TEK, XDH 4.03501
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES 4.0285
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, CSNK2A1, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, PDE5A, RELA, SMAD3, SRC, TEK, XDH 3.96731
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B3 3.89174
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, TNKS 3.89174
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 3.87897
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, SMAD3, SRC, TEK, TNKS, TNKS2 3.84838
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.83021
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MAOB, PTGES 3.8047
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 3.8047
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PDE5A, PPARA, SRC, TEK, XDH 3.79631
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.79097
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.74561
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, PPARA, PTGES, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 3.72898
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.72898
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, CYP1A1, EGFR, FLT3, MAP2K1, MET, PIM1, SRC, TEK 3.71401
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, RELA, SMAD3 3.71296
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MAP3K7, MMP12, PPARA, PTPRS, RELA, SMAD3, SRC, TEK 3.68174
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, XDH 3.66581
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B3 3.66278
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B3 3.65477
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, RELA, SRC 3.65477
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 3.60003
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.59408
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, EGFR, FLT3, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, XDH 3.57958
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.55488
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, RELA, SRC, TEK 3.5529
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.5529
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, MAP2K1, MAP3K7, PDE5A, SRC 3.48109
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B3 3.46649
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, HSPA1A, MAP2K1, PDE5A, PTGES, SMAD3, XDH 3.45062
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC, TEK 3.42954
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MAP3K7, MET, RELA, SMAD3, SRC, TEK, TNKS, TNKS2 3.42862
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.42199
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, EGFR, FLT3, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, XDH 3.3981
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PDE5A, SRC, TEK 3.39556
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, MAP2K1, SRC, TEK 3.39556
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, RELA, SRC 3.36082
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, MAP2K1, SRC, TEK 3.32486
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, PPARA, PTPRS, RELA, SMAD3, SRC, TEK, XDH 3.30868
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, MAOB, RELA, SRC 3.29068
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.29068
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29068
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.26182
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 3.25326
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, EGFR, F3, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, RELA, TEK 3.23633
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.23112
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, CA2, CYP1B1, EGFR, F3, INSR, KDR, MAP2K1, NUAK1, PDE5A, PIM1, PPARA, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS2, XDH 3.22477
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PDE5A, SRC 3.22091
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.20675
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B3, MAOA, MAOB, XDH 3.19545
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.1908
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SMAD3, SRC, TEK, XDH 3.18018
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.15452
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 3.13263
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, CSNK2A1, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, PDE5A, RELA, SMAD3, SRC, TEK, XDH 3.13255
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 3.1241
[BP] GO:0048545 response to steroid hormone AR, CA2, EGFR, FLT3, MAOB, RELA, SRC 3.0872
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, NUAK1, PTPRS, XDH 3.08027
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, HSD17B3, MAOA, MAOB 3.07137
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAOA, MAOB 3.07137
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MAP2K1, MAP3K7, PDE5A, SRC 3.04338
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, TNKS 3.02799
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 3.01607
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.98799
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, EGFR, F3, FLT3, HSPA1A, INSR, MAP2K1, MAP3K7, PDE5A, SMAD3, SRC, TEK, TNKS, XDH 2.98712
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, KDR, MAP3K7, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK 2.97864
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.97126
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, CA2, CYP1B1, F3, INSR, KDR, MAP2K1, PDE5A, PIM1, RELA, SMAD3, SRC, TEK 2.96383
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP3K7, MET, SMAD3, SRC, TEK 2.95482
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.94966
[BP] GO:0050678 None AR, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.91888
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC 2.91848
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.91848
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, EGFR, FLT3, INSR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, TNKS 2.90386
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPRS, RELA, SMAD3, SRC, XDH 2.89742
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, FABP3, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TNKS, TNKS2 2.89727
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPRS, RELA, SMAD3, SRC, XDH 2.88751
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.82864
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MAOA, MAOB, MMP12, PDE5A, SRC, XDH 2.82575
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, RELA, SRC 2.82018
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TNKS, TNKS2 2.79554
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, PPARA, RELA, SMAD3, SRC, TEK 2.758
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, MAP2K1, MAP3K7, PDE5A, SRC 2.758
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 2.758
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.74017
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, SRC, TNKS 2.73632
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOA, MAOB, SMAD3 2.73632
[BP] GO:0019538 protein metabolic process ACHE, APP, AR, AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PPARA, PTPRS, RELA, SMAD3, SRC, TEK, TNKS, TNKS2 2.73263
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.73263
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.73263
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.73263
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.73263
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.73059
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.71926
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 2.71752
[BP] GO:0006464 cellular protein modification process APP, AR, AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.70334
[BP] GO:0036211 protein modification process APP, AR, AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.70334
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.69903
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, RELA, SRC 2.69903
[BP] GO:0050679 None AR, EGFR, F3, KDR, MMP12, TEK 2.68681
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1 2.68087
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MET, PPARA, RELA, SMAD3 2.67981
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, HCAR2, HSPA1A, MAP3K7, MMP12, PDE5A, PTPRS, RELA, SMAD3, SRC 2.67981
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES 2.67079
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, CSNK2A1, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, NUAK1, PDE5A, RELA, SMAD3, SRC, TEK, XDH 2.65853
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, HSPA1A, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TNKS, TNKS2 2.64457
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.64194
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.62845
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.62632
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B3, INSR, MAP2K1, SRC 2.62285
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, EGFR, FLT3, INSR, KDR, MAP2K1, MAP3K7, PDE5A, SRC, TEK, XDH 2.61695
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, XDH 2.61405
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.61405
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.61163
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.61163
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, EGFR, IGF1R, INSR, RELA, RORC, SRC 2.60813
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAP2K1, MAP3K7, NUAK1, PPARA, PTGES, RELA, SMAD3, SRC, TEK 2.58549
[BP] GO:0033590 None EGFR, RELA 2.58256
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58256
[BP] GO:0002520 None CACNA1C, SMAD3 2.58256
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, RELA, SRC, TEK 2.58117
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, MAOB, PTGES, RELA, SRC 2.57557
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.57109
[BP] GO:2000243 None AR, INSR, PDE5A, SRC 2.56541
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.56057
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MAP3K7, MET, PPARA, RELA, SMAD3 2.55003
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.53974
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.53876
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, RELA, SRC 2.53876
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, HSPA1A, MAP3K7, PIM1, RELA 2.53876
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, RELA, SMAD3, TEK 2.53876
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.53816
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, FABP3, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, RELA, RORC, SMAD3, SRC, TNKS, TNKS2 2.51357
[BP] GO:0042135 None ACHE, MAOA, MAOB 2.48419
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.48419
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.47039
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.46047
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.45011
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B3 2.45011
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.45011
[BP] GO:0040008 regulation of growth APP, AR, CSNK2A1, EGFR, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 2.45011
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, KDR, MAOB, RELA, SRC 2.45011
[BP] GO:0002237 response to molecule of bacterial origin AXL, CYP1A1, CYP1A2, MAOB, PTGES, RELA, SRC 2.4305
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.42628
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CYP19A1, DUSP3, MMP12, PDE5A, PTPRS 2.42435
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.42284
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38007
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.37785
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, IGF1R, INSR, RELA, SRC 2.36158
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC 2.36158
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.34867
[BP] GO:0070213 None TNKS, TNKS2 2.34867
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.34867
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34867
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, RELA, SRC, TEK 2.34484
[BP] GO:0051894 None KDR, SMAD3, TEK 2.34484
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.34484
[BP] GO:0033674 positive regulation of kinase activity ADORA1, EGFR, FLT3, INSR, MAP2K1, MAP3K7, PDE5A, SRC, TEK 2.32299
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, EGFR, FLT3, IGF1R, INSR, RELA, SMAD3, SRC 2.32063
[BP] GO:0050927 None F3, KDR, SMAD3 2.29695
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B3, PTGES 2.29695
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, CA2, CA9, CACNA1C, CYP1B1, EGFR, INSR, MET, RELA, SMAD3, SRC, TEK 2.2916
[BP] GO:0050926 None F3, KDR, SMAD3 2.25202
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.25202
[BP] GO:1903393 None KDR, SMAD3, TEK 2.25202
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, PTGES, RELA, SRC 2.24377
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3, SRC, TNKS 2.23813
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.21686
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, CA2, CYP1B1, EGFR, F3, INSR, KDR, MAP2K1, PIM1, PTPRS, RELA, SMAD3, SRC, TEK, XDH 2.21686
[BP] GO:0032868 None FABP3, INSR, PPARA, RELA, SRC 2.21579
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.21253
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.21253
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CACNA1C, CYP1B1, EGFR, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, RELA, SRC, TEK 2.21253
[BP] GO:0051092 positive regulation of NF-kappaB transcription factor activity APP, AR, HSPA1A, MAP3K7, RELA 2.20642
[BP] GO:0043412 macromolecule modification APP, AR, AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.18881
[BP] GO:0071383 None AR, EGFR, FLT3, SRC 2.18086
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MET, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.16861
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.16861
[BP] GO:0010641 None F3, SRC 2.16861
[BP] GO:0007598 None F10, F3 2.16861
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, HSPA1A, MAOA, MAOB, PDE5A, XDH 2.14994
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.14613
[BP] GO:1901575 None ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MAOA, MAOB, PDE5A, XDH 2.14281
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.13531
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.12914
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4 2.11219
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.10988
[BP] GO:0051098 regulation of binding APP, AURKB, MET, PPARA, SMAD3, SRC, TNKS 2.10726
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09927
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05733
[BP] GO:1901655 None AKR1B1, AR, EGFR, SRC 2.05125
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.03308
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.03308
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, MET, SMAD3, SRC 2.02257
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.02182
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, FLT3, RELA, RORC, SRC 2.02114
[BP] GO:1990535 None APP, INSR 2.02114
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.02114
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, F10, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPRS, SMAD3, SRC, TEK 3.70315
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.55488
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B3, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.32518
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, DUSP3, EGFR, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SRC, TEK 3.17549
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.58117
[CC] GO:0031233 None CA4, F10, F3 2.53876
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, TEK 2.36499
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, CA4, EGFR, F3, MET, TEK 2.34867
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGES, PTPRS, RELA, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, XDH 12.0687
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSD17B1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MAOA, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PTGES, PTPRS, SRC, TEK, TNKS, TNKS2, TUBB3, XDH 10.9586
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4179
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP12, PIM1, PPARA, RORC, SMAD3, TNKS, XDH 7.79814
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.54089
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, PTGES, PTPRS, RELA, SRC, TEK, TUBB3, XDH 7.48187
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.84832
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MET, SRC, TEK 6.59516
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.46744
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, PPARA, SRC, TEK 6.0316
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 6.00736
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.68515
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, SHBG 5.37378
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 5.10168
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3, XDH 4.7824
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 4.67588
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3, XDH 4.12177
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3, XDH 4.12177
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B3, MAOA, MAOB, XDH 3.98549
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, PTPRS, SRC, TEK, TUBB3 3.91845
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.9058
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.8047
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.8047
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, PPARA, RORC, SMAD3, TEK 3.67765
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63897
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.4792
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.40915
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, RELA, SMAD3, SRC 3.40271
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, MAP2K1, MAP3K7, SMAD3 3.399
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.35214
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3 3.26471
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.24104
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3 3.23633
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3 3.23112
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK 3.22005
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 3.14411
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, MAP3K7, MMP12, NUAK1, PDE5A, PIM1, PPARA, RORC, SMAD3, TNKS, TNKS2, XDH 3.02799
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, RELA, SMAD3, SRC 3.02799
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, MMP12, PPARA, RORC, SMAD3, TNKS 2.94966
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, F10, F3, FABP3, FABP4, HSD17B1, PPARA, RORC, SHBG 2.94918
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, NUAK1, PIM1, SRC, TEK, TUBB3 2.89602
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.85112
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, MAP3K7, MMP12, NUAK1, PDE5A, PIM1, PPARA, RORC, SMAD3, TNKS, TNKS2, XDH 2.81686
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, MAOB, PTGES, SRC, XDH 2.646
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.62632
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.61776
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PIM1, PTPRS, SRC, TEK 2.5324
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.49417
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.34919
[MF] GO:0051425 None APP, INSR 2.34867
[MF] GO:0005497 None AR, SHBG 2.34867
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.33295
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD17B1, HSD17B3, XDH 2.25202
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.22656
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16861
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MAP2K1, MAP3K7, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, RELA, RORC, SHBG, SMAD3, SRC, TEK, TUBB3, XDH 2.15229
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.1364
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02114
[MF] GO:0008131 None MAOA, MAOB 2.02114


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1401
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.942
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.1641
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOB, MAOA, ALOX5, ALOX15, CACNA1C 5.6702
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 5.9234
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, MAOA, CYP1A2, CYP1A1, CYP1B1 5.3325
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 5.1019
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 4.9187
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, INSR, TEK, EGFR, RELA, IGF1R 4.7752
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, INSR, KDR, TEK, MET, EGFR, RELA, IGF1R 3.7467
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, EGFR, RELA, IGF1R 3.8058
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, HSPA1A 3.6895
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, INSR, ADORA1, PDE5A, CACNA1C 3.6895
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.678
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, MAOA, ALOX15, HSD17B3, AKR1B1, CYP19A1, FUT7, ALOX5, HSD17B1, CYP1A2, CYP1A1, XDH, PTGES 3.5474
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, SMAD3, FLT3, MET, EGFR, RELA, IGF1R 3.4622
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.4409
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, KDR, MET, EGFR, IGF1R 3.4409
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, MET, EGFR, IGF1R 3.4409
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.4676
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, EGFR, RELA 3.3584
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, INSR, EGFR, IGF1R 3.3584
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGES 3.4409
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET, EGFR 3.3584
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, EGFR, IGF1R 3.3018
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.3584
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIM1, F3, RELA 2.8236
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, CACNA1C, EGFR 2.9594
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.271
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, ABCB1, PIM1, CYP1B1, MET, EGFR 2.769
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, EGFR, HSPA1A 2.8324
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, TUBB3, EGFR 3.0012
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1052
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA, HSPA1A 2.6055
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.5896
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA, HSPA1A 2.4082
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, SRC, RELA 2.3449
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 2.2734
Glioma_Homo sapiens_hsa05214 MAP2K1, EGFR, IGF1R 2.3466
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.3961
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4829
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3466
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, RELA, IGF1R 2.0915
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA, HSPA1A 1.965
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, MAOA, CACNA1C 2.3277
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 2.2736
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC, RELA 2.3466
Cocaine addiction_Homo sapiens_hsa05030 MAOB, MAOA, RELA 2.6187
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, EGFR 2.8236
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, RELA 2.2734
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC, EGFR 2.0876
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, RELA, IGF1R 2.0148
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, MAOA, CYP1A2 2.3182
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.8972
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 1.8614
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.9133
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA, RELA 1.87
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MAP3K7, RELA 1.8658
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 2.0148
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.3182
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6436
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.76
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, MAP3K7, IGF1R 1.76
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.6979
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, MAOA, CACNA1C 1.7192
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR, RELA 1.6949
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, IGF1R 1.6405
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.6405
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, INSR, EGFR 1.6295
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA, RELA 1.5902
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA, HSPA1A 1.4636
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOB, MAOA 1.4535
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.4296
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3824
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC, EGFR 1.2969
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 1.0512
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4085
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4023
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4085
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.4169
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.4263
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, RELA 0.6031
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4461
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8239
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.9598
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4461
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1, INSR 0.9618
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9618
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.7395
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C, EGFR 0.8182
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.8228
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4684
Platelet activation_Homo sapiens_hsa04611 SRC 0.4716
Axon guidance_Homo sapiens_hsa04360 MET 0.4624
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8542
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 1.0618
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 1.0669
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4932
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 1.0618
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, IGF1R 1.1996
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, RELA 1.161
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5349
Melanogenesis_Homo sapiens_hsa04916 MAP2K1 0.5349
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 1.1799
Amoebiasis_Homo sapiens_hsa05146 RELA 0.5349
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5439
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5354
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5415
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5403
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5415
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5349
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5493
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5507
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5507
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5581
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5564
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5507
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5563
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5563
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5507
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5583
Peroxisome_Homo sapiens_hsa04146 XDH 0.5581
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.5563
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5581
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5698
Pertussis_Homo sapiens_hsa05133 RELA 0.5787
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5717
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5807
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2808
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.6041
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5807
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3649
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.4142
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.4296
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.4605
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6245
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.4636
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.5047
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.4142
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.4605
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3589
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3 1.4828
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4636
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.4296
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.4263
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.4636
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6535
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, EGFR 1.5514
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, EGFR 1.5972
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.542
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.5611
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.678
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, CACNA1C 1.6405
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB, MAOA 1.6245
Malaria_Homo sapiens_hsa05144 MET 0.721
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7399
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7545
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.8542
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.8002
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 2.0148
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB, MAOA 1.76
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.965
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, MAOA 1.8542
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8867
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8801
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.87
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8608
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8228
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.107
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9248
Histidine metabolism_Homo sapiens_hsa00340 MAOB, MAOA 2.0876
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8801
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9129
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MAOA 2.319
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2171


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)