TCM Prescription: Detoxification Decoction



Prescription Description
Prescription IDTCMF2451
Pinyin NameJie Du Nei Xiao Tang
Chinese Name解毒内消汤
English NameDetoxification Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2596 Fritillaria verticillata 浙贝母 TCMH2596
TCMH923 Radix trichosanthis 花粉 TCMH923
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH72 Bletilla striata 白芨 TCMH72 ITSAJ4380-14
TCMH293 Manis pentadactyla 穿山甲 TCMH293 GBMA15413-17
TCMH2567 Spina gleditsiae 皂刺 TCMH2567
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH740 Rhizoma curcumae 广西莪术 TCMH740
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, SRC, TERT 7.51316
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.25408
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, TYR, XDH 6.95254
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MAOB, MMP2, MMP9, NR3C1, SRC, TYR 6.46702
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT, TOP2A, XDH 6.16237
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.16237
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, PDE5A, PIM1, TYR, XDH 6.16237
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET 6.09593
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2 6.03259
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, NR3C1, SRC, TYR 5.9116
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PDE5A, PGR, PIM1, SRC, TERT, XDH 5.84985
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT, TOP2A, XDH 5.84788
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PDE5A, SRC, TERT, XDH 5.84148
[BP] GO:0042221 response to chemical AKR1B1, APEX1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, NR3C1, SRC, TERT, TYR 5.84148
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PDE5A, SRC, TERT, XDH 5.84148
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIM1, SRC, TERT, TOP2A, XDH 5.68472
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, MAOB, NR3C1, SRC, TYR 5.68472
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, MAOB, NR3C1, SRC, TYR 5.66267
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, XDH 5.66039
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.5928
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MAOB, MET, SRC, TERT, XDH 5.51864
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PGR, PIM1, SRC, TERT, TOP2A, TYR 5.45902
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 5.21778
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, TYR, XDH 5.20317
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, XDH 5.04503
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MAOB, MMP2, NR3C1, SRC 5.03497
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1, HSD17B2 4.87698
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT 4.82698
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, MAOB, TYR, XDH 4.67214
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT 4.35772
[BP] GO:0009725 response to hormone AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, MAOB, NR3C1, SRC 4.35772
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TERT 4.32803
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, SRC, TERT 4.04536
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.79561
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.79561
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, MAOB, NR3C1, SRC 3.78869
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.75223
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.75223
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.6976
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.67495
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD11B1, HSD17B1, HSD17B2 3.63209
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.57325
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, XDH 3.56706
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PDE5A, SRC, TERT, XDH 3.55763
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TERT, TOP2A 3.53789
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, SRC, TERT 3.53789
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, SRC, TERT, TOP2A, XDH 3.49868
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.49749
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.49595
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, TYR, XDH 3.42605
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, TYR, XDH 3.41924
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, SRC, TYR 3.39725
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, TERT 3.32176
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, SRC 3.28817
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP12, MMP2, MMP9, NR3C1, SRC, TERT, TOP2A, TYR 3.25365
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23302
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.19987
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.19073
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, MAOB, NR3C1, SRC 3.19073
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, IGF1R, MMP2, MMP9, NR3C1, SRC 3.10467
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, SRC, TERT, XDH 3.0879
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, AR, CYP1A1, CYP1B1, FLT3, NR3C1, SRC 3.08376
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, SRC, TERT, XDH 3.01167
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PDE5A, SRC, TERT, XDH 2.95993
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.92851
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PGR, PIM1, SRC, TYR 2.87979
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, FLT3, KDR, MET, PDE5A, SRC, XDH 2.86832
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.86268
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.85543
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC, TERT 2.84124
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, SRC 2.75085
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, SRC, XDH 2.73401
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, MAOB, SRC 2.73401
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.73401
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.72152
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.70752
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, MAOB, TYR 2.65946
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.65143
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.63768
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 2.56616
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.55014
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.54923
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, SRC, TERT 2.54051
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.54051
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, SRC, TYR 2.47028
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.44964
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.44577
[BP] GO:0060748 None AR, PGR 2.43555
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43555
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, MAOB, NR3C1, SRC 2.41619
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41529
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, SRC 2.41403
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, HCAR2, KDR, MET, MMP12, MMP9, PDE5A, PIM1, SRC, TERT 2.37114
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.36929
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.36677
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, MMP9, SRC 2.32246
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOB, PDE5A, XDH 2.32246
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31733
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET 2.30794
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.29067
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.27263
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, XDH 2.22088
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.21046
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.2047
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.2047
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2047
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.20285
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, MET, PIM1, SRC, TYR 2.2008
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.16363
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, PDE5A, SRC, XDH 2.15878
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.13282
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.11561
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, XDH 2.09364
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, FLT3, IGF1R, MMP2, NR3C1, SRC 2.08752
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.08752
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.08752
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.0619
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.04971
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.03413
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, FLT3, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PGR, SRC, TERT, TOP2A, XDH 2.01107
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, SRC 2.01107
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, PDE5A, TERT, XDH 2.01107
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.00795
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.00795
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, KDR, MAOB, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, TYR, XDH 2.79555
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP2, NR3C2, PGR, PIM1, SRC, TERT, TYR 1.83159
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.7072
[CC] GO:0097386 None AKR1B1, APP 1.20338
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SRC, TERT 1.15704
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, TYR, XDH 12.4348
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4603
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, SRC, TERT, TOP2A, TYR, XDH 9.63962
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, SRC, TERT, TOP2A, TYR, XDH 9.32008
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.25408
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.64864
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.9116
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, TERT, TOP2A, TYR, XDH 5.9116
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR 5.87959
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, MAOB, TYR, XDH 5.66039
[MF] GO:0046872 metal ion binding ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, TERT, TOP2A, TYR, XDH 5.61995
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.79561
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.64755
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63904
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 3.35987
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.24693
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 3.11856
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR 3.10467
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.03181
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.92851
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.86832
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.78346
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.72152
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.54923
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR 2.49185
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.43555
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.43555
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.31373
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, MAOB, SRC, XDH 2.28778
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, SRC 2.22754
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.20285
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, FLT3, IGF1R, KDR, MAOB, MET, MMP9, PGR, TERT, TOP2A, TYR, XDH 2.16005
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.15878
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.13282
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.08752


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.0672
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.6847
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.3887
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 4.1277
Metabolic pathways_Homo sapiens_hsa01100 MAOB, AKR1B1, TYR, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 3.8377
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1277
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7418
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 3.2431
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.3538
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.3538
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2431
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9382
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0647
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.9087
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.2208
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9087
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, ALOX5 1.8035
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7426
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.7605
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.5505
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.4535
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4535
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4535
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2414
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4257
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9435
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8156
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4393
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.7605
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.376
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3646
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1442
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.376
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.2142
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3867
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1211
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2072
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.158
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1 1.0821
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2 1.376
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2991
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.9136
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8035
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7605
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9205
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0463
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.05
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9496
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.828
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1 0.7597
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5575
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3206
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3881
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3766
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5256
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.387
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4488
Platelet activation_Homo sapiens_hsa04611 SRC 0.504
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4103
Alcoholism_Homo sapiens_hsa05034 MAOB 0.4174
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4174
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5256
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5575
Measles_Homo sapiens_hsa05162 CSNK2A1 0.486
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4787
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4488
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4312
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5541
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5447
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5571
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4787
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5119
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5511
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5575
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4899
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5025
Gap junction_Homo sapiens_hsa04540 SRC 0.5575
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4103
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5575
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5575
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5575
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4968
Axon guidance_Homo sapiens_hsa04360 MET 0.4981
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5119
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6002
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5571
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5571
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.595
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6171
Peroxisome_Homo sapiens_hsa04146 XDH 0.5575
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5571
Glioma_Homo sapiens_hsa05214 IGF1R 0.6171
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6176
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6171
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6171
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6171
Bile secretion_Homo sapiens_hsa04976 CA2 0.6002
Shigellosis_Homo sapiens_hsa05131 SRC 0.6171
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6171
Malaria_Homo sapiens_hsa05144 MET 0.6866
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.6866
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6849
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6985
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.7491
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7491
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7491
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8179
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.83
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7994
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8595
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8517
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8847
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9952
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2372


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)