TCM Prescription: Four Shen Pulse Recovery Decoction



Prescription Description
Prescription IDTCMF2370
Pinyin NameSi Shen Fu Mai Tang
Chinese Name四参复脉汤
English NameFour Shen Pulse Recovery Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH705 Trichosanthes kirilowii 瓜蒌 TCMH705 ITSAO4359-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 18.4386
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, MIF, PTGS1, PTGS2 15.459
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, MIF, PTGS1, PTGS2 15.0591
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FUT7, GBA2, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 14.7568
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 13.9219
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 13.5593
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 13.5176
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, MIF, PTGS1, PTGS2 12.6766
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 12.6518
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 12.5855
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, MIF, PPARA, PTGS1, PTGS2 12.3698
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5161
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 10.8786
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 10.7865
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 10.6821
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6357
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 10.3145
[BP] GO:0032787 None AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, MIF, PPARA, PTGS1, PTGS2 10.1003
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 10.0807
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 9.93133
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR 9.91835
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 9.77318
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 9.13943
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 9.1301
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TRPV1 8.79477
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 8.3039
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.23615
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.20088
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 8.10343
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.06818
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 8.0501
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TERT, TRPV1 7.78971
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 7.70891
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 7.5899
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 7.5846
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TRPV1 7.49251
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, MIF, PIK3CB, PTGS2, SRC, TNKS, TNKS2, TRPV1 7.30887
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.17829
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 7.17829
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.04843
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 6.99111
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 6.98329
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 6.86483
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 6.70664
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.60116
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.58817
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 6.58041
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC, TERT 6.55664
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 6.41018
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.24002
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 6.16832
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TRPV1, TYR 6.05982
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.03373
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.02004
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.93021
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6, CYP3A4 5.89577
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MIF, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1 5.58545
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF, PTGS1, PTGS2 5.573
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KCNH2, KDR, NR3C1, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 5.573
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.57213
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.57213
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 5.48327
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 5.36439
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 5.32458
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, TYR 5.3226
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.3226
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 5.29008
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TNKS2, TYR 5.29008
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.18577
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.07942
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, HCAR2, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.0465
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AKR1C3, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.0077
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 4.93347
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.917
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 4.90589
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.88581
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.87726
[BP] GO:0006693 None AKR1C3, CES2, MIF, PTGS1, PTGS2 4.81792
[BP] GO:0006692 None AKR1C3, CES2, MIF, PTGS1, PTGS2 4.81792
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.7949
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 4.77557
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AKR1C3, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.76662
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.76662
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.75293
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 4.74155
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.64823
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.61186
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 4.61186
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, MIF, PTGS1, PTGS2 4.61186
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.58198
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.58198
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 4.53105
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.51741
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC, TERT 4.51741
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, MIF, SRC, TNKS, TNKS2, TRPV1 4.51435
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.47918
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 4.4377
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30082
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 4.28319
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.28319
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 4.28025
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, MIF, PTGS1, PTGS2 4.27874
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.24408
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 4.22218
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 4.22218
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 4.17426
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, TYR 4.16822
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.13767
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.08857
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.07697
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, SRC, TERT, TRPV1 3.94627
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 3.87787
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2, TERT 3.83523
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, MIF, PTGS1, PTGS2 3.77357
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.6734
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AKR1C3, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 3.65607
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SLC6A4, SRC, TRPV1, TYR 3.52729
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4 3.49752
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, HCAR2, KCNH2, MIF, MMP12, PTGS2, SLC6A4, SRC, TERT, TRPV1 3.44892
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.44594
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.44278
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.38899
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.38567
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.37662
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.37662
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.37662
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.37662
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.37662
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.33057
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 3.32426
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.32426
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.32269
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, MET, PIK3CA, PIK3CB, SRC 3.31566
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 3.3079
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.29337
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.29337
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.29337
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.23113
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC6A4, SRC, TERT, TNKS2, TRPV1, XDH 3.2103
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.20757
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.19676
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.19567
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF, PIK3CB 3.1651
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9, TRPV1 3.15266
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.14523
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.11741
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.11698
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, KCNH2, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 3.11698
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.11332
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, SLC6A4, SRC 3.06005
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, HSD11B2, PTGS2, SLC6A4, SRC, TRPV1, TYR 3.03613
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.03613
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC, TNKS 3.02773
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.02402
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 3.0052
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4 3.0052
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 3.00214
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.00214
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB, TRPV1 2.99905
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.99027
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 2.93148
[BP] GO:0019371 None AKR1C3, PTGS1, PTGS2 2.90139
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.87367
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.84871
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.84871
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.81746
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 2.81746
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.80773
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.79837
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.79837
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.77517
[BP] GO:0016488 None AKR1B10, AKR1C3 2.77517
[BP] GO:0016487 None AKR1B10, AKR1C3 2.77517
[BP] GO:0016107 None AKR1B10, AKR1C3 2.77517
[BP] GO:0009115 None AOX1, XDH 2.77517
[BP] GO:0006714 None AKR1B10, AKR1C3 2.77517
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.77517
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.77517
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.77517
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CYP1A1, PTGS2, SLC6A4, TRPV1, TYR 2.77331
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC, TERT, TRPV1 2.77331
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, GBA2, PIK3CB, SRC, XDH 2.76725
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT, TRPV1, TYR 2.75442
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, SRC, TYR 2.74173
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.74173
[BP] GO:0071396 cellular response to lipid AKR1C3, AXL, CDK6, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC 2.74173
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HSD11B2, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 2.7391
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.73691
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.73691
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.73691
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.68422
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.67345
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.67167
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 2.67167
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.65111
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.6493
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.64467
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.64467
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.63079
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.62711
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.61103
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.60455
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, KCNH2, MMP9, PTGS2 2.60003
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SLC6A4, SRC, TRPV1 2.60003
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 2.57959
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.57935
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.57935
[BP] GO:0006633 None ALOX12, ALOX15, MIF, PTGS1, PTGS2 2.57935
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.57935
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.56938
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MIF, MMP12, SLC6A4, SRC, TRPV1 2.55474
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, MIF, PTGS1, PTGS2 2.49964
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.49964
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49964
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.44868
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTGS2, SLC6A4, SRC 2.43035
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.42609
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PTGS2, TERT 2.41454
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.40612
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.4025
[BP] GO:0046110 None AOX1, XDH 2.4025
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4025
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.4025
[BP] GO:0016095 None AKR1B10, AKR1C3 2.4025
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.38965
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.38884
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.3766
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.37109
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, KDR, MIF, PIK3CB, PTPN1, SRC, XDH 2.36033
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.32245
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.32245
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.30934
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.29879
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.27841
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.2694
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, XDH 2.2694
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.26251
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, PTGS2, TRPV1, XDH 2.23462
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.22289
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MIF, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1 2.19646
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.1914
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, MMP9, TERT 2.18877
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, MIF, PTPN1, SRC 2.18829
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.18829
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.18004
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, TRPV1, XDH 2.17973
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, MIF, PIK3CB, PTPN1, SRC 2.17822
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PTGS2, TERT 2.16626
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AKR1C3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.15976
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNH2, PPARA, SLC6A2, SLC6A4, TRPV1 2.15976
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MET, MIF, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TERT, TNKS, XDH 2.15976
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.15976
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.15976
[BP] GO:0070213 None TNKS, TNKS2 2.15976
[BP] GO:0006145 None AOX1, XDH 2.15976
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15976
[BP] GO:0090344 None CDK6, MIF, TERT 2.15976
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.15976
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15976
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.15976
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TRPV1, XDH 2.15676
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, PTGS2 2.13861
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.13861
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.13556
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC, TRPV1 2.12998
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.11309
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.11309
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11309
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.10823
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.10153
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, HCAR2, MET, PIK3CA, PPARA 2.10153
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.10008
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, MIF, PIK3CB, PTPN1, SRC 2.0938
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, MIF, PTGS1, PTGS2 2.07476
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.06739
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, MIF, PTGS1, PTGS2 2.06739
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.06739
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, FLT3, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.04718
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SRC 2.04569
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.04327
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.03555
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, BCL2, CDC25B, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.02592
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, PTGS2, SLC6A4 2.02592
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.02592
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SRC, TERT, TNKS, TNKS2, TRPV1 2.0059
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.00489
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, MIF, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TNKS2, TRPV1, XDH 2.00489
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KCNH2, KDR, MIF, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 4.28247
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 4.27753
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 3.70361
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR 2.88945
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.05659
[CC] GO:0005783 None ADORA1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, KDR, PTGS2, PTPN1, XDH 2.01489
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TRPV1, TYR 2.0059
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 22.3536
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.6371
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 16.0843
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 13.7099
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 12.5835
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, XDH 11.1819
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 10.6821
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6107
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TRPV1, TYR, XDH 10.4007
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 10.115
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 10.0866
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC, TNKS 9.85775
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, TYR 9.83097
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 9.83097
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 9.46045
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.38736
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.63803
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4 8.17532
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 8.12929
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4 7.43793
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 7.41507
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.81659
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.80451
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.77436
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 5.29748
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TRPV1 5.2189
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.90589
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.90589
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.75293
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.61186
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.9531
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.76704
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MIF, MMP9, NQO2, PTGS2, SLC6A4, TERT, TRPV1, TYR, XDH 3.38567
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.3219
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.28185
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.21855
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.14523
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.11741
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.11741
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.0052
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.90139
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 2.79837
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.77517
[MF] GO:0045550 None AKR1B10, AKR1C3 2.77517
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.77517
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.77517
[MF] GO:0003845 None HSD11B1, HSD11B2 2.77517
[MF] GO:0008389 None CYP2A13, CYP2A6 2.77517
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.74594
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.72648
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.71931
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.6573
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, F3, KCNH2, MET, MIF, NR3C1, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TNKS2 2.64467
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.61948
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NQO2, NR3C1 2.59575
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.49368
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.42609
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.42609
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.4025
[MF] GO:0047718 None AKR1B10, AKR1C3 2.4025
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.4025
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.4025
[MF] GO:0005330 None SLC6A2, SLC6A4 2.4025
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.4025
[MF] GO:0047374 None CES1, CES2 2.4025
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.33768
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.24864
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.24655
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.22252
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15976
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.15976
[MF] GO:0032795 None ADORA1, ADRA2A 2.15976
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.15976
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 2.13861
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.11597
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 2.10153


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.6556
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.634
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 11.5865
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1C3, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 8.5962
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 8.7366
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.8083
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, ALOX12, PTGS2, CYP2C19, PTGS1 6.8716
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1, SLC6A4 6.4403
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.6451
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.7331
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.6396
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.1416
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP3A4, CYP2C19 5.3092
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.4816
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.4816
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.364
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.9014
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.1047
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.9087
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0951
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.2728
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.7812
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.056
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.5651
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.8074
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 2.9961
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.1765
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.1534
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.7176
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.3485
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.7176
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.1155
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.856
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8821
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.3333
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB, ADRA2A 2.6453
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.7176
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8986
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5989
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.079
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.4356
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.528
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.3727
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4408
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.446
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3727
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.3727
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3362
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.1874
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3727
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.188
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.1501
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0053
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1, ADRA2A 1.8775
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8265
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6916
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.6757
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.8814
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.0742
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1918
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3943
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.563
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.821
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5309
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4304
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.3362
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2233
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.4728
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8213
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.1841
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4728
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4332
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3668
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.186
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3781
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1841
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2696
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2814
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2906
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.0443
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3419
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1692
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.691
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 0.8921
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8739
Axon guidance_Homo sapiens_hsa04360 MET 0.3754
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3831
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6755
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.6834
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8256
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8514
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8428
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.8116
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4478
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4478
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8851
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0546
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4478
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4573
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0624
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0092
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4567
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9897
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0124
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9996
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4697
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4706
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0235
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9996
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4724
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4724
Gap junction_Homo sapiens_hsa04540 SRC 0.4724
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4715
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7865
Peroxisome_Homo sapiens_hsa04146 XDH 0.4841
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4989
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5217
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5198
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5342
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2254
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5363
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2675
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5553
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2427
Shigellosis_Homo sapiens_hsa05131 SRC 0.5553
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2427
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5553
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5758
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2675
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3582
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4332
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3668
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6353
Malaria_Homo sapiens_hsa05144 MET 0.6474
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6568
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4823
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6519
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6568
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5297
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8213
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8091
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6916
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7794
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8254
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8514
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.815
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8431
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0086
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1416
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9996
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9876
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0546
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3668


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)