TCM Prescription: Three Ginseng and Two White Colon Disease Decoction



Prescription Description
Prescription IDTCMF2362
Pinyin NameSan Shen Er Bai Tang
Chinese Name三参二白汤
English NameThree Ginseng and Two White Colon Disease Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH2252 Agrimonia pilosa var. japonica 仙鹤草 TCMH2252
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH73 Tribulus terrestris 白蒺藜 TCMH73 ITSAJ4258-14
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH448 Fructus kochiae 地肤子 TCMH448
TCMH462 Sanguisorba officinalis 地榆 TCMH462 GENG545-14, GBVT2403-13
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 11.871
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.0497
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.0497
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 11.0494
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KCNH2, KDR, MAOA, MET, MIF, NISCH, PPARA, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 11.0048
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 10.8589
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NISCH, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.2897
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NISCH, NUAK1, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 10.1078
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 10.0841
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 9.45263
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 9.37543
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.33213
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, CDC25B, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK, TERT 9.26036
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC, TEK 9.26036
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, NISCH, SMAD3, SRC, TEK, TERT 9.22479
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SLC6A4, SMAD3, SRC, TEK, TYR 9.0735
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TEK, TYR 8.94005
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, APEX1, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DYRK2, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 8.89732
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 8.77678
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.73311
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.70071
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM4, DRD2, DRD3, HTR1A, HTR5A, HTR7 8.65933
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.62327
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HTR5A, RORC, SLC6A4, SRC, TEK, TYR 8.53759
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 8.53575
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AXL, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 8.53575
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, INSR, PPARA, SLC6A4, SRC, TEK 8.48827
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, IGF1R, INSR, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK 8.48827
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, ALPL, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CES1, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, DYRK1B, DYRK3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SIGMAR1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 8.42758
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 8.18997
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.18997
[BP] GO:0007200 None ADRA1A, ADRA2A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, ESR1, HTR2A, HTR2B 8.18997
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, TBXAS1 8.18997
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 8.18997
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, NISCH, SMAD3, SRC, TEK, TERT 8.14005
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC, TEK 8.02854
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 8.02854
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 8.02854
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AXL, CHRM1, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TYR 7.79758
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, MIF, TBXAS1 7.77139
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 7.76139
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 7.73281
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, NISCH, SMAD3, SRC, TEK, TERT 7.67331
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 7.66958
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 7.64593
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AURKB, AXL, CA2, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DYRK2, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KCNH2, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 7.63839
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, HTR2B, MIF, NISCH, PIM1, PPARA, TBXAS1, TYR, XDH 7.62209
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, MIF, TBXAS1 7.52915
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 7.45096
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.36828
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 7.15959
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, HSD17B1, HSD17B2 7.12308
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.09655
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MIF, MMP9, NISCH, SMAD3, SRC, TEK, TERT 7.06148
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.03662
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.8262
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AXL, CA1, CA2, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HASPIN, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK 6.77676
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.68335
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 6.59321
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MIF, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.57336
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.53767
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.52959
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, INSR, KCNH2, MET, SMAD3, SRC, TERT 6.52394
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, DYRK1A, EGFR, ESR1, HTR7, PPARA, RORC, SLC6A4, SRC, TOP2A 6.47861
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 6.46724
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.45583
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.45583
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.37567
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, RORC, SLC6A4, SRC, TYR 6.37126
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 6.35451
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, AKR1C3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.32478
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, MIF, PPARA, TBXAS1 6.30698
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, DRD3, DYRK2, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, KCNH2, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC, TERT 6.27943
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KCNH2, KDR, SLC6A2, SLC6A4, SRC 6.2466
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, AKR1C3, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, RORC, SRC, TEK 6.23044
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.2158
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 6.20789
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, AKR1C3, AURKB, CDC25B, DRD1, DRD2, DRD3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.19953
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A 6.15103
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.14557
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, MAOA, SLC6A2, SLC6A4, SMAD3 6.05575
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, MIF, TBXAS1 6.0431
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.0082
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.00431
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOA 5.96381
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 5.96019
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 5.94788
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, KCNH2, MIF, MMP12, SLC6A4, SMAD3, SRC, TERT 5.90379
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA, TBXAS1 5.89949
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC, TERT 5.8869
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SMAD3, SRC, TERT 5.87359
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, CYP19A1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.87103
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FLT3, HASPIN, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 5.8574
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TBXAS1 5.8543
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2, NISCH 5.7822
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1C3, CA2, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 5.77088
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, MIF, SRC 5.75848
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.6237
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, CDC25B, CHRM1, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HASPIN, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.54299
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 5.54124
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.48893
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 5.47338
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DRD2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.4058
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, KCNH2, MET, SMAD3 5.38012
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 5.37312
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A, NISCH, SLC6A4 5.37271
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A, NISCH, SLC6A4 5.37271
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, DUSP3, DYRK1A, DYRK3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 5.31528
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, MIF, SLC6A4, SRC, TERT 5.31407
[BP] GO:0030335 positive regulation of cell migration ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.31407
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MIF, MMP2, MMP9, NUAK1, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A 5.20275
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.19679
[BP] GO:2000147 positive regulation of cell motility ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.1338
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.13244
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AKR1C3, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.13244
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 5.11373
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.08908
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 5.08908
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DYRK2, EGFR, HASPIN, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KCNH2, KDR, MET, MIF, NISCH, NUAK1, PTPN1, SRC, TEK 5.08908
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 5.08908
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.0688
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.02913
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.02913
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 5.02913
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 5.02167
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.01867
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 5.00363
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, ALPL, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, HTR5A, INSR, KDR, MMP9, PIM1, PPARA, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 4.98682
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SLC6A4, SRC 4.97385
[BP] GO:0032787 None AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PPARA, TBXAS1 4.94948
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, RORC 4.94558
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.93348
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA2, CHRM1, CHRM2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KCNH2, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 4.91005
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, MIF, PTPN1, SRC, TEK 4.89439
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC 4.88289
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 4.87368
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.86982
[BP] GO:0040017 positive regulation of locomotion ADRA2A, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TERT 4.86982
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM4, CLK1, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, MIF, PIM1, SRC, TEK, TYR 4.85794
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 4.85287
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.83122
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, RORC, SLC6A4, SRC 4.75469
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 4.67062
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, DRD2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 4.57397
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM1, CHRM2, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, KCNH2, SMAD3 4.57397
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, CA2, CA7, CHRM1, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A, KCNH2, MIF, MMP9, SLC6A4 4.51825
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT 4.51825
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.47576
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.45394
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 4.44952
[BP] GO:0007623 circadian rhythm DRD2, DRD3, DYRK1A, EGFR, HTR7, PPARA, RORC, SLC6A4 4.41516
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.4044
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SLC6A4, SMAD3, SRC 4.4044
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MIF, MMP12, SLC6A4, SRC 4.39839
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.31795
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, DRD2, DRD3, GPR35, HTR2A, KCNH2, MMP9 4.30993
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.30112
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, EGFR, HTR2A, HTR2B, KDR, MIF, SRC, TEK 4.24953
[BP] GO:0010907 None DYRK2, ESRRB, INSR, PPARA, SRC 4.24953
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.24953
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.22382
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TBXAS1 4.20655
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC 4.15209
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, SLC6A4 4.1458
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.1458
[BP] GO:0051937 None DRD1, NISCH, SLC6A2, SLC6A4 4.1458
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1C3, APEX1, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.14417
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.13289
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.12126
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 4.12126
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.1144
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.07743
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 4.07038
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, KCNH2, SMAD3 4.05814
[BP] GO:0032225 None DRD1, DRD2, DRD3, SLC6A4 4.03999
[BP] GO:0045913 None DYRK2, ESRRB, HTR2A, INSR, PPARA, SRC 4.00787
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.976
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.96899
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MIF, MMP12, SLC6A4, SRC 3.9654
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, SMAD3, TEK 3.9182
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.89569
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM1, CHRM2, DRD2, EGFR, HTR2A, KCNH2 3.8929
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 3.88022
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 3.88022
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, KCNH2, SLC6A2, TEK 3.85529
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SMAD3, SRC, TEK, TERT 3.81869
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 3.80888
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 3.80888
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.78228
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, CHRM1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 3.75742
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A 3.75574
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, CHRM1, DRD2, DRD3, DYRK2, EGFR, HCAR2, HTR2B, MIF, MMP12, PTPN1, SMAD3, SRC 3.73874
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.73236
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.73236
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 3.73236
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 3.73236
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 3.71933
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, SLC6A2, TEK 3.71474
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.71396
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.71396
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.71132
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1C3, APEX1, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.70743
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.70161
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.69922
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A4, SRC, TEK, TYR 3.69922
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 3.68845
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.68826
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.65902
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.65712
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.65712
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC, TEK 3.65024
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.65019
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MIF, MMP12, SLC6A4, SRC 3.64123
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, KCNH2, SMAD3 3.62193
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1C3, CHRM1, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, HTR7, INSR, KCNH2, SLC6A4, SRC, TEK, TYR 3.62193
[BP] GO:0015844 None DRD1, NISCH, SLC6A2, SLC6A4 3.61729
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.61729
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.58229
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.58229
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.58229
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.57168
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.56661
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.55988
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.54939
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 3.53303
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.52295
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SLC6A4, SRC 3.52247
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.50556
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, TBXAS1, TYR 3.49377
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1C3, APEX1, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.48987
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, AURKB, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MIF, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.47842
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC 3.4653
[BP] GO:0007154 None ADORA1, ADRA1A, AKR1C3, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, SLC6A2, TEK 3.43746
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40307
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.40307
[BP] GO:0010676 None DYRK2, ESRRB, INSR, PPARA, SRC 3.38942
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.37996
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.35874
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APEX1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SLC6A4, SMAD3, SRC 3.35272
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.34711
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.34711
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.34711
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.34711
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.34711
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC, TEK 3.34682
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 3.33688
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC 3.33644
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.31384
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC 3.31329
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 3.30974
[BP] GO:0032845 None ADORA1, ADRA2A, DRD2, HTR2A, HTR2B, MIF, SRC 3.30974
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 3.28143
[BP] GO:0050890 None ADORA1, CHRM1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, SLC6A4 3.27119
[BP] GO:0010906 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 3.27057
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9, TERT 3.25703
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC 3.25544
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AKR1C3, APEX1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.2506
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, MIF, PTPN1, SRC, TEK 3.23747
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 3.22739
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A 3.22739
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, NISCH, PPARA, SMAD3 3.22739
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, MIF, PTPN1, SRC 3.22707
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.20336
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.20336
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 3.20336
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, MIF, PPARA, SMAD3, TEK 3.20171
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.18825
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, GPR35, KCNH2, MMP9 3.18825
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, SLC6A4, SRC 3.18411
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.17559
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KCNH2, KDR, SRC 3.17483
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17483
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17483
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17483
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.17483
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.17483
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.17483
[BP] GO:0019229 None ADRA1A, ADRA2A, CHRM1, EGFR, HTR2A 3.14252
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, KCNH2, SMAD3 3.11096
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 3.11082
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.07724
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC 3.07267
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.07267
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SLC6A4, SMAD3, SRC, TERT, TOP2A 3.0713
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, TBXAS1, TYR 3.03997
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.02394
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.02394
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.02394
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2 3.02152
[BP] GO:0006940 None ADORA1, ADRA1A, ADRA2A, CHRM1, CHRM2 2.99096
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, AXL, CDC25B, CES1, CYP1A1, DRD1, DRD2, DYRK3, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, MET, MIF, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.98822
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 2.9724
[BP] GO:0050730 None ADORA1, ADRA2A, EGFR, FLT3, HTR2A, MIF, PTPN1, SRC 2.95899
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.95899
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, TBXAS1, TYR 2.95899
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.95899
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.92342
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 2.91992
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC 2.91247
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.90584
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.8985
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, EGFR, HSPA1A, HTR1A, MIF, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A 2.89386
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, CDC25B, DRD2, DYRK1A, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.89315
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1 2.88164
[BP] GO:0043270 None ADORA1, ADRA2A, CHRM1, DRD1, DRD2, KCNH2, MIF, SLC6A4 2.88107
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, HTR2A, MIF, PTPN1, SRC 2.8729
[BP] GO:0016488 None AKR1B10, AKR1C3 2.86959
[BP] GO:0016487 None AKR1B10, AKR1C3 2.86959
[BP] GO:0016107 None AKR1B10, AKR1C3 2.86959
[BP] GO:0009115 None AOX1, XDH 2.86959
[BP] GO:0006714 None AKR1B10, AKR1C3 2.86959
[BP] GO:0006109 regulation of carbohydrate metabolic process DYRK2, ESRRB, HTR2A, INSR, PPARA, RORC, SRC 2.86587
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.8619
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.85569
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.84832
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.84423
[BP] GO:1901796 None AURKB, CSNK2A1, DYRK1A, DYRK2, DYRK3, MIF, NUAK1 2.842
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CHRM1, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUT7, HASPIN, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.842
[BP] GO:0010038 response to metal ion AKR1C3, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, TERT 2.81964
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 2.81623
[BP] GO:0051223 None ACHE, ADRA2A, CHRM1, DRD2, DRD3, DYRK2, EGFR, HCAR2, HTR2B, MIF, MMP12, PTPN1, SMAD3, SRC 2.81039
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, PPARA, SMAD3 2.80124
[BP] GO:0010675 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.79648
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CDC25B, CHRM1, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.79616
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CDC25B, CHRM1, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.79616
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.79542
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.78659
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.77128
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.77128
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.77128
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.76942
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, SLC6A4 2.74821
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.74618
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CDC25B, CHRM1, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.72966
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.7204
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CES1, CYP19A1, HSD17B1, HSD17B2 2.71327
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.70279
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.68643
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, CHRM1, CSNK2A1, DRD2, DRD3, DYRK2, EGFR, HCAR2, HTR2B, MIF, MMP12, PTPN1, SMAD3, SRC, TERT 2.68561
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.68476
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.68476
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.68476
[BP] GO:0043518 None DYRK1A, DYRK3, MIF 2.68476
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.67984
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, AURKB, AXL, CDC25B, CHRM1, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GLO1, HASPIN, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 2.66159
[BP] GO:0050708 None ACHE, ADRA2A, DRD2, DRD3, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC 2.64255
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 2.62853
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 2.62853
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.62347
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.61892
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.6122
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.60936
[BP] GO:0070201 None ACHE, ADRA2A, CHRM1, DRD2, DRD3, DYRK2, EGFR, HCAR2, HTR2B, MIF, MMP12, PTPN1, SMAD3, SRC 2.60252
[BP] GO:0045725 None DYRK2, ESRRB, INSR 2.60252
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.60252
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ADRA2A, APEX1, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.60252
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.58014
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.58014
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, GPR35, MMP9 2.56321
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.56116
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.54116
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, PPARA, SLC6A2, SLC6A4 2.54116
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, CDC25B, CHRM1, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, HTR2B, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A 2.52752
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.52752
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.52752
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.52752
[BP] GO:0070920 None EGFR, ESR1, TERT 2.52752
[BP] GO:0070875 None DYRK2, ESRRB, INSR 2.52752
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, TERT 2.52714
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.52714
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, APEX1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.51532
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.5047
[BP] GO:0046110 None AOX1, XDH 2.47473
[BP] GO:0060160 None DRD2, DRD3 2.47473
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47473
[BP] GO:0016095 None AKR1B10, AKR1C3 2.47473
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.47253
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, HTR1A, MAOA, SLC6A4 2.4654
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 2.46015
[BP] GO:0055065 metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, HTR2A, HTR2B, KCNH2, SMAD3 2.46015
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.46015
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.4566
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.44903
[BP] GO:0080135 regulation of cellular response to stress DUSP3, DYRK1A, DYRK3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTPN1, TERT, XDH 2.43019
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.42985
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, SLC6A4 2.42985
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, SMAD3, XDH 2.42985
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.42274
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 2.39773
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.39773
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.39773
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.39773
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.39484
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.39296
[BP] GO:2000351 None AKR1C3, KDR, TEK, TERT 2.3593
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, SLC6A4, SRC, TOP2A 2.35727
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.33087
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.33087
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.33073
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.33027
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.33027
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.3222
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, AKR1C3, DRD2 2.31269
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.29225
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.27057
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.27057
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.27001
[BP] GO:0051222 positive regulation of protein transport ACHE, CHRM1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, SMAD3, SRC 2.25984
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.2459
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.22932
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.22352
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, SLC6A4, SRC 2.21945
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, DRD2, HSPA1A, HTR2B, MIF, MMP12, SMAD3, SRC 2.21945
[BP] GO:0006145 None AOX1, XDH 2.21945
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.21945
[BP] GO:0015874 None NISCH, SLC6A2 2.21945
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21945
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.21853
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.21853
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.21853
[BP] GO:0007568 aging ADRA1A, APEX1, AURKB, CYP1A1, HTR2A, MIF, TERT 2.21713
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.21438
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, GPR35, HTR2A, HTR2B, SMAD3 2.20081
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.19154
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.19154
[BP] GO:0007611 None DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, SLC6A4 2.17532
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, DRD2, DRD3, DYRK2, GPR35, HSPA1A, HTR2A, KCNH2, MMP9 2.16918
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.16663
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.16663
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.16663
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.16663
[BP] GO:0007613 None DRD1, DRD2, HTR2A, INSR, SLC6A4 2.15794
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.14671
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.14027
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.14005
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, CYP1B1, EGFR, INSR, SMAD3, XDH 2.11741
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.1156
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.1156
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.1156
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1156
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.1156
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.10952
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TERT 2.08985
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.08985
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.08483
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, MIF, TERT 2.07562
[BP] GO:0051894 None KDR, SMAD3, TEK 2.06712
[BP] GO:0071875 None ADRA1A, ADRA2A, DRD2 2.06712
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.06712
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, CHRM1, DRD2, EGFR, HCAR2, HTR2B, MIF, MMP12, SMAD3, SRC 2.05865
[BP] GO:0050678 None EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 2.05543
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B 2.05539
[BP] GO:0050679 None EGFR, F3, HTR2B, KDR, MMP12, TEK 2.05055
[BP] GO:0050715 None DRD2, HTR2B, MIF, MMP12, SRC 2.04608
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.04316
[BP] GO:0021853 None DRD1, DRD2 2.04001
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.04001
[BP] GO:0010641 None F3, SRC 2.04001
[BP] GO:0090325 None DRD2, DRD3 2.04001
[BP] GO:0007598 None F10, F3 2.04001
[BP] GO:1904936 None DRD1, DRD2 2.04001
[BP] GO:0042321 None ADORA1, DRD2 2.04001
[BP] GO:0010513 None HTR2A, HTR2B 2.04001
[BP] GO:0050927 None F3, KDR, SMAD3 2.02714
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2C19, CYP2D6, MAOA 2.02188
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.02188
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ADRA2A, AKR1C3, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, FABP3, HASPIN, HSPA1A, HTR2A, HTR2B, KCNH2, MIF, MMP12, MMP9, NISCH, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, XDH 2.01824
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, EGFR, IGF1R, INSR, MMP2, SLC6A4, SRC 2.00761
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.00729
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA4, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC6A2, SLC6A4, TEK 8.43523
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC6A2, SLC6A4, TEK 6.86466
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, MMP2, NISCH, PIM1, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 6.12816
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, SIGMAR1, SLC6A2, SLC6A4, SRC, TEK 6.05701
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, DRD2, EGFR, HTR2A, INSR, MET, SIGMAR1, SRC, TEK 3.95934
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MMP2, NISCH, PIM1, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TYR 3.65712
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MAOA, MET, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TBXAS1, TEK, TYR 3.17054
[CC] GO:0045121 membrane raft ADRA1A, EGFR, HTR2A, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 3.06122
[CC] GO:0098857 membrane microdomain ADRA1A, EGFR, HTR2A, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 3.03997
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 2.95975
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.71283
[CC] GO:0098589 membrane region ADRA1A, EGFR, HTR2A, INSR, KDR, SLC6A2, SLC6A4, SRC, TEK 2.52714
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA2, CA4, CES1, CES2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSPA1A, HTR2A, HTR5A, IGF1R, INSR, KDR, MAOA, MIF, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.46015
[CC] GO:0031233 None CA4, F10, F3 2.27057
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOA, MET, SIGMAR1, SLC6A2, SLC6A4, TBXAS1, TEK, TYR 2.16663
[CC] GO:0005783 None ADORA1, APEX1, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, HSPA1A, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.08683
[CC] GO:0043226 organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA2, CA4, CA9, CES1, CES2, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSPA1A, HTR2A, HTR5A, HTR6, IGF1R, INSR, KDR, MAOA, MIF, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.02164
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 13.5282
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 12.5224
[MF] GO:0008227 None ADRA1A, ADRA2A, CHRM1, CHRM2, CHRM4, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 12.3789
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1, TEK 12.3299
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SLC6A4, SRC, TEK, TOP2A 11.8744
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1, TEK 11.0497
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 10.8589
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1, TEK 10.8403
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1, SMAD3, TEK 10.8096
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.72182
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.64627
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 9.57641
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.46495
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, SLC6A4 8.78763
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TOP2A, TYR, XDH 8.78763
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 8.53575
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 8.53575
[MF] GO:0004672 protein kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 7.76387
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.71562
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TBXAS1, TYR 6.59321
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.52959
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.52959
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 6.52959
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.45583
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.45583
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.17339
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.01883
[MF] GO:0016301 kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK 5.99861
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TBXAS1, XDH 5.9398
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.81412
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.8037
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 5.75848
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 5.67738
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 5.62851
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIM1, SRC, TEK, TERT 5.59048
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.23328
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.11596
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TBXAS1, TYR 5.02913
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.98567
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.97385
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.78088
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.78088
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.74307
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TOP2A, TYR, XDH 4.64984
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.63437
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC, TBXAS1 4.59787
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.47167
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC, TBXAS1 4.37509
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.33403
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.96899
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, APEX1, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, XDH 3.91571
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FLT3, HASPIN, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 3.79652
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.69919
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.68826
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MIF, MMP9, NISCH, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.63189
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.50677
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD17B1, HSD17B2, XDH 3.4464
[MF] GO:0005524 ATP binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.27119
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.20336
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.1508
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.11096
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, NUAK1, PIM1 3.06721
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6 2.88163
[MF] GO:0045550 None AKR1B10, AKR1C3 2.86959
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86959
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.8619
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD17B1, SRC, TBXAS1, XDH 2.85439
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, NISCH, PPARA, RORC 2.83417
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.77128
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.75797
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NISCH, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.69747
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, XDH 2.60252
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.52752
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.52714
[MF] GO:0047718 None AKR1B10, AKR1C3 2.47473
[MF] GO:0005330 None SLC6A2, SLC6A4 2.47473
[MF] GO:0047374 None CES1, CES2 2.47473
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.44924
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.44903
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.39773
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 2.39402
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.27057
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21945
[MF] GO:0032795 None ADORA1, ADRA2A 2.21945
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.10952
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04001
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04001
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.03011
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.00356


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, GPR35, CHRM4, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, ADRA2A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 11.6353
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 10.0413
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A, CYP2C19, SLC6A4 9.6832
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.2052
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.1646
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 6.5092
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 6.5618
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, CHRM1, ADORA1, HTR1A, DRD1, DRD2, PPARA 5.1118
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.1118
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.1809
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7169
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.0899
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.7036
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2, EGFR 4.3059
Metabolic pathways_Homo sapiens_hsa01100 MAOA, AKR1C3, AKR1B1, TYR, CYP2C19, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 3.7357
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, AOX1, CYP2C19 3.7357
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.0502
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 2.7926
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.7846
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 2.4313
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, AKR1C3, CYP2C19 2.7926
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 3.6966
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A, ADRA2A 2.1642
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.1404
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 2.5884
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.6637
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.0324
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP2C19 2.4313
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.1237
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 1.9041
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 1.9041
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 1.8564
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2, DRD3 1.8592
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.8564
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 1.9539
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8564
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.1404
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.0937
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.7867
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.8374
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.4934
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7796
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5357
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.4742
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.8564
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8294
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.3667
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.2273
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.0843
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.09
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1061
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.052
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 0.9314
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8088
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.869
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.6809
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.6944
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 0.8582
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.6944
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.6944
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.6876
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8345
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8533
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6461
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2041
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.6796
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6499
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8557
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2255
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2334
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2389
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9314
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6424
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6413
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2331
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2334
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2254
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6424
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1061
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6413
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6123
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.636
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2647
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6012
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.052
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.2716
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.4794
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.0821
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6012
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.299
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9314
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.0465
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.3952
Legionellosis_Homo sapiens_hsa05134 CLK1, HSPA1A 1.1214
Axon guidance_Homo sapiens_hsa04360 MET 0.3128
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.0411
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3199
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3249
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.09
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3502
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3658
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.052
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3725
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3725
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3725
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3807
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3803
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.3848
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3952
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3952
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4011
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.3952
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4003
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3952
Peroxisome_Homo sapiens_hsa04146 XDH 0.4011
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4332
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.421
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4318
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4414
Bile secretion_Homo sapiens_hsa04976 CA2 0.4399
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4594
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4634
Shigellosis_Homo sapiens_hsa05131 SRC 0.4614
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4794
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.4716
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.4985
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.523
Malaria_Homo sapiens_hsa05144 MET 0.5381
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5342
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.542
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5421
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5468
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.542
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6012
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.5662
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5102
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.437
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6289
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6012
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6012
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.678
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6461
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6413
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6538
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7542
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6796
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6499
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 1.9041
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.678
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.6944
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.869
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.7926
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1214


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)