TCM Prescription: Four Son Yellowness Removing Decoction



Prescription Description
Prescription IDTCMF2356
Pinyin NameSi Zi Tui Huang Tang
Chinese Name四子退黄汤
English NameFour Son Yellowness Removing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH1106 Fructus meliae toosendan 金铃子 TCMH1106
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1455 Ranunculus japonicus 茅根 TCMH1455 ITSAF2010-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TERT, TRPV1, XDH 17.5235
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RELA, RORC, SRC, TERT, TRPV1 17.0719
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, FABP3, GSK3B, HSD11B2, HTR1B, HTR5A, IDO1, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PPARD, PRKCB, PRKCD, PRKCE, PTGES, PTGS2, RELA, RORC, SRC, TRPV1 15.7829
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7829
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7829
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HTR1B, HTR5A, IDO1, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RELA, RORC, SRC, TRPV1 15.579
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GSK3B, HTR2B, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, TRPV1, XDH 13.7164
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GSK3B, HTR2B, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, TRPV1, XDH 13.5258
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, XDH 12.6634
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, XDH 12.6306
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, RELA, SRC, XDH 12.3536
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, GSK3B, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, TRPV1, XDH 12.2845
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PRKCE, PRKCG, PTGES, PTGS2, RELA, RORC, SRC, TRPV1 11.8578
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, XDH 11.4458
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1 11.4257
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IDO1, PPARD, PRKCE, PTGES, PTGS2, RELA, RORC, SRC 11.0439
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, GSK3B, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT 11.0439
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, GSK3B, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT 11.0087
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PRKCD, PRKCE, PRKCG, PTGS2, RELA, SRC, TRPV1 10.8817
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, XDH 10.7583
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, ESR1, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PPARA, PRKCD, PRKCE, PTGS2, RELA, SRC, TRPV1 10.6963
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, KDR, KIT, MAP2K1, MMP2, MMP9, PIM1, PPARD, PRKCA, PTGES, PTGS1, PTGS2, RELA, SRC, TERT, XDH 10.6154
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F3, FABP4, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT, XDH 10.5959
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, F3, FABP3, FLT3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 10.2934
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GSK3B, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, RELA, RORC, SRC, TERT, TRPV1 10.2759
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGES, PTGS1, PTGS2, TRPV1 10.2606
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, XDH 10.2219
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GSK3B, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, RELA, RORC, SRC, TRPV1 10.1898
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, PTGS2, RELA, SRC, TERT 10.1796
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PPARA, PRKCD, PRKCE, PTGS2, RELA, SRC, TRPV1 10.1564
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TRPV1 10.0707
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, XDH 10.0682
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 9.72953
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GLO1, GSK3B, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT 9.6314
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR1A, HTR2A, HTR2C, PPARD, PRKCA, PRKCE, SLC22A1 9.47776
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, ESR1, FABP4, FLT3, GSK3B, HTR1B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1 8.77435
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, DYRK1A, FLT3, GSK3B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 8.53289
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B2, HTR1A, HTR2C, IDO1, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, TRPV1 8.44363
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CNR1, CNR2, CYP19A1, DHFR, DYRK1A, ESR1, F3, FABP4, GSK3B, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT, XDH 8.2992
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, FABP3, FABP4, GLO1, GSK3B, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 8.22445
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.21296
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, DNMT1, ESR1, GSK3B, IGF1R, MMP2, MMP9, PIK3CA, PPARD, PRKCB, PRKCD, PRKCE, PTGS2, RELA, RORC, SRC, TRPV1 8.20387
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DHFR, DNMT1, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, RELA, SRC, TRPV1 8.13343
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, DYRK1A, FLT3, GSK3B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 8.03045
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, GSK3B, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 8.03045
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, SRC 8.0178
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, XDH 7.97973
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DYRK1A, ESR1, F3, FABP4, FLT3, GSK3B, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, TERT, XDH 7.97518
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.96227
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC 7.91038
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, GSK3B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAP2K1, MMP9, PIK3CB, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TERT, TRPV1 7.87766
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARD, PRKCA, PTGS2, RELA, TERT 7.75076
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, XDH 7.65094
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.60344
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DHFR, DNMT1, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, RELA, SRC, TRPV1 7.58072
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, F3, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCD, PRKCG, PTGS2, RELA, RORC, SRC, TRPV1 7.53602
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.45207
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.45207
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 7.44956
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, GLO1, HSD17B3, HTR2B, HTR2C, IDO1, PIK3CA, PIM1, PPARA, PPARD, PTGES, PTGS1, PTGS2, XDH 7.44814
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, ESR1, F3, FLT3, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SRC, TRPV1 7.44814
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, PRKCD, PRKCE, RELA, SRC 7.38474
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.38474
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, PRKCE 7.29333
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.26371
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, FABP3, FABP4, GLO1, GSK3B, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 7.16625
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 7.11555
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B3, PPARD 7.10534
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, GSK3B, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 7.10269
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCD, PTGS2, RELA, RORC, SRC, TERT, TOP2A 7.09735
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 7.06258
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC 7.06258
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, F3, FABP3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 7.01968
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, IDO1, MAOA, NQO2, PPARD, PTGS1, PTGS2, XDH 6.97581
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 6.97527
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A2, SRC, TERT, TOP2A, TRPV1, XDH 6.9514
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC, TRPV1 6.914
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.89428
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 6.73668
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 6.65787
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, XDH 6.55485
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, GSK3B, HTR7, KIT, PPARA, PRKCG, RORC, SRC, TOP2A 6.45115
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 6.45115
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, XDH 6.42086
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SRC, TERT, TRPV1 6.41185
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.4097
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.38708
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A1, SLC22A2, SLC22A3, SRC, TERT, TOP2A, TRPV1, XDH 6.35589
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.31903
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 6.3082
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC 6.29122
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 6.20308
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PRKCE, PTGS2 6.19622
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PRKCE, PTGS2 6.19622
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, RELA, SRC, TERT, TRPV1 6.16902
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, PRKCG, SRC 6.14718
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.13697
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TERT, XDH 6.1348
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, GSK3B, MAP2K1, PRKCA, PRKCB, PRKCD 6.05528
[BP] GO:0003018 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC 6.02538
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.01259
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, SRC, TERT 5.95652
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, FABP4, GSK3B, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TRPV1, XDH 5.92172
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A2, SRC, TERT, TOP2A, XDH 5.92172
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, DNMT1, ESR1, FLT3, GSK3B, HTR1B, IGF1R, KIT, MMP2, PRKCD, PRKCE, PTGS2, RELA, SRC, TRPV1 5.92172
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, TRPV1, XDH 5.88518
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SRC, TERT 5.88358
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, F3, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, XDH 5.8498
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.83923
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, SRC, TERT 5.83703
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT, XDH 5.81498
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, GSK3B, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.80455
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, GSK3B, MAP2K1, PRKCA, PRKCB, PRKCD 5.80256
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A 5.76595
[BP] GO:0097746 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 5.75488
[BP] GO:0035296 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 5.75488
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PPARD, PTGES, PTGS2, RELA, SRC 5.69139
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SRC, TERT 5.67659
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B3, PIK3CA, PIK3CB, PPARD, PTGES, PTGS1, PTGS2 5.67088
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SRC, TERT 5.65784
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, HTR1B, KDR, PRKCD, PRKCE, PTGS2, RELA, SRC, TRPV1 5.6163
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, HSD11B2, IGF1R, PPARA, PRKCD, PTGS2, RELA, SRC, TRPV1 5.54509
[BP] GO:0050880 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 5.53907
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, GSK3B, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC 5.5323
[BP] GO:0035150 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 5.51739
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, PRKCD, PTGS2, RELA, TERT 5.51739
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, GSK3B, HTR2A, HTR2B, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA 5.51017
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PPARD, PRKCA, PRKCE, PTGS2, SRC, TERT 5.51017
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2B, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, RELA, SRC, TERT, TRPV1 5.50521
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PRKCB, PRKCE, PTGS2, SRC, TERT 5.48942
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, PIK3CB, PIM1, PPARD, PRKCD, SRC 5.48436
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, GSK3B, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.42153
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PPARD, PTGES, PTGS2, RELA, SRC 5.4181
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.41755
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B3 5.40678
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.4002
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, PRKCD, SRC 5.38956
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, XDH 5.33376
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, PRKCD, SRC 5.33109
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 5.31633
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.20359
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, ESR1, F3, GSK3B, HTR2A, HTR2B, HTR2C, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, RELA, SRC, TERT, TRPV1, XDH 5.19993
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGES, PTGS1, PTGS2 5.17925
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IDO1, KDR, MAP2K1, MET, PPARA, PPARD, PRKCA, PRKCD, PRKCG, PTGS2, RELA 5.13783
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, PTGS2, TERT 5.09946
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, RELA, SRC 5.09373
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, RELA, SRC 5.09373
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.07472
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, KIT, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 5.05898
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B3, KDR, KIT, MAP2K1, PIK3CA, PPARA, PPARD, RELA, SRC 5.05437
[BP] GO:0003013 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC 5.03802
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, PRKCD, SRC, TERT 5.03802
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.01591
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, GSK3B, HTR1B, IGF1R, MMP2, PRKCD, PTGS2, RELA, SRC, TRPV1 5.00919
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, FABP4, GSK3B, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP9, PIK3CA, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TRPV1, XDH 4.97535
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.93333
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCD, PTPN1, SRC 4.83155
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PRKCD, PTGS1, PTGS2, RELA, SRC 4.79466
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 4.79095
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DHFR, HSD17B3, HTR1A, MAOA, PPARD 4.79095
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE, RELA 4.77239
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 4.69696
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1 4.67079
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, GSK3B, HTR1B, IGF1R, MMP2, PRKCD, PTGS2, RELA, SRC, TRPV1 4.63785
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, IDO1, KDR, KIT, MAP2K1, PIM1, PPARD, PRKCA, PRKCB, PTGS2, RELA, SRC, TERT 4.62885
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, RELA, SRC 4.62885
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, PIM1, PPARA, PPARD, RELA, RORC, SRC 4.60974
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 4.56958
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, TRPV1 4.56958
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 4.56855
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 4.56487
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, PTGES, PTGS1, PTGS2 4.55581
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.50053
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CNR1, CNR2, ESR1, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 4.49823
[BP] GO:0090066 None ADORA1, ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PRKCD, PRKCE, PTGS2 4.49693
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 4.48204
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PRKCD, PRKCE, PTGS2 4.46028
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, MAP3K7, MMP2, PPARA, PPARD, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC 4.45863
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PPARD, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 4.43172
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, GSK3B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, XDH 4.41394
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SRC, TERT, XDH 4.39944
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, DYRK1A, ESR1, F3, FLT3, FUT7, GLO1, GSK3B, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, TOP2A, XDH 4.3937
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.38875
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.35387
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.35089
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PRKCE, PTGS2 4.30014
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PPARD, PRKCD, PTGS2, RELA 4.29701
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 4.26451
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD, RELA 4.26451
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B3 4.26451
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, DNMT1, FABP3, KDR, MMP2, PRKCE, PTGES, PTGS2, RELA, SRC 4.2412
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, PRKCE, SRC, TRPV1 4.2412
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PRKCA, SRC 4.23817
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.23659
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 4.2103
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B3, IDO1, KIT, MAP2K1, MMP2, MMP9, PPARD, PTGS2, SRC, TOP2A 4.17171
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PPARA, PPARD, PTGES, PTGS1, PTGS2 4.16315
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 4.16315
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.1619
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 4.1619
[BP] GO:0060402 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 4.1619
[BP] GO:0006855 None ABCB1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.1619
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, HTR1A, HTR2A, HTR2C, PPARD, PRKCA, PRKCE 4.15961
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.14631
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DYRK1A, ESR1, GSK3B, IGF1R, MET, MMP9, PPARA, PPARD, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SRC, TERT, XDH 4.10858
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TERT 4.08628
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.06401
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.03882
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 4.0295
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.01202
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PRKCA, PTPN1, SRC 4.01202
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B3 4.01202
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 4.01136
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 4.0075
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.0075
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, FLT3, FUT7, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TRPV1 4.0065
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DNMT1, ESR1, GSK3B, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PRKCD, PRKCE, SRC 3.99993
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.99797
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DYRK1A, ESR1, GSK3B, HTR1B, HTR2A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SRC, TERT, XDH 3.99624
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3, IDO1 3.99624
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DYRK1A, ESR1, GSK3B, HTR1B, HTR2A, IGF1R, MET, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SRC, TERT, XDH 3.97719
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, ESR1, FLT3, GSK3B, HSD11B1, HSD17B3, HTR5A, KDR, KIT, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RELA, RORC, SRC 3.95356
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, PTGS2, TRPV1 3.95127
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, GSK3B, MAP2K1, MAP3K7, MMP9, PPARD, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, TRPV1 3.94078
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, IDO1, KIT, MAP3K7, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC 3.9326
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, GSK3B, HTR2A, HTR2B, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.87206
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.87206
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.87106
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.83304
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 3.80815
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 3.76611
[BP] GO:0060401 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.76611
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 3.763
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.73909
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, KIT, PRKCD, PRKCE, PTPN1, SRC 3.73577
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.7129
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.7129
[BP] GO:0050999 None CNR1, CNR2, DHFR, HTR2B, TERT 3.70283
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.69507
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CNR1, GSK3B, HTR2B, HTR2C, PPARD, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 3.69051
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TERT 3.68537
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.66242
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.66242
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, PRKCD, PTGES, PTGS1, PTGS2, RELA, SRC, TRPV1 3.66242
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 3.63928
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.62249
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, PPARA, PPARD 3.62249
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.59833
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PPARD, PTGS2, TERT 3.57644
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARD, PRKCA, PRKCE, SRC, TRPV1 3.57608
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PRKCD, PTGS2 3.57188
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.56152
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.54297
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.53638
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.53079
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PPARD, PRKCG, PTGS2, SRC, TRPV1 3.52503
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DYRK1A, GSK3B, IGF1R, MAP2K1, MAP3K7, MET, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH 3.51718
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.51328
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, RELA, SRC 3.50375
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.5
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 3.49613
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GSK3B, PRKCA, PTGES, PTGS2, RELA, SRC, TRPV1 3.48478
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.48469
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.47453
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.46921
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, DHFR, HTR1A, MAOA, SLC22A2 3.45349
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC, TRPV1 3.45349
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GSK3B, IDO1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 3.44631
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, HTR1A, MAOA, PTGS2, SLC22A2, SLC22A3, TRPV1 3.443
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, GSK3B, HTR2B, PPARD, PRKCD, PRKCE, PTGS2, SRC, TERT, TRPV1 3.42684
[BP] GO:0032098 None HTR2C, HTR4, PPARA, SLC22A3 3.41785
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, RELA, SRC 3.40768
[BP] GO:0050994 None ADORA1, CNR1, PPARA, PRKCD, PRKCE 3.39692
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, GSK3B, IDO1, KDR, MAP3K7, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SRC 3.39586
[BP] GO:0043279 None CNR1, HTR1B, PRKCE, PRKCG, RELA, TRPV1 3.38055
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.3706
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.36421
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA, PRKCG, RELA 3.35006
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, IDO1, PRKCG 3.32532
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESR1, F3, GSK3B, HTR2A, HTR2C, IDO1, KDR, KIT, MAP2K1, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PTGS2, RELA, RORC, SRC, TERT, TRPV1, XDH 3.31534
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARD, PRKCA, PRKCE, SRC 3.31365
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.3039
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.29928
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCD, PTPN1, SRC 3.29928
[BP] GO:0032768 None CNR1, CNR2, DHFR, HTR2B, TERT 3.29928
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 3.27772
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B3, KIT, MAP2K1, SRC 3.27563
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, PRKCD, SRC, TERT 3.27501
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B3, KIT, MAP2K1, PPARD, PTGS2, SRC 3.24574
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, KDR, KIT, MAP2K1, PPARD, PRKCA, PTGS2, RELA, TERT 3.23896
[BP] GO:0015893 None ABCB1, CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.2359
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.23427
[BP] GO:0072347 None CNR1, HTR1B, PRKCE, PRKCG, RELA 3.23427
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, PRKCD, RELA, SRC 3.22523
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 3.22387
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.218
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.20331
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, RELA, SRC, XDH 3.20224
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PPARD, PTGS2, RELA, SRC, TRPV1 3.19758
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, FABP3, IDO1, MAP2K1, PPARD, PTGES, PTGS2, TERT, XDH 3.19758
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, PPARA, PRKCD, PTGS2, RELA, SRC, TRPV1 3.19539
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.19435
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 3.19435
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC, TERT 3.19435
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 3.1812
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.18095
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TERT 3.14872
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, DHFR, HSD17B3, IDO1, PTGES, PTGS1, PTGS2 3.1469
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCD, SRC 3.14403
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.14403
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCD, SRC 3.14165
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.13822
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CNR1, CSNK2A1, GSK3B, HTR2B, PPARD, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT 3.12838
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.12172
[BP] GO:0071456 cellular response to hypoxia BCL2, PPARD, PRKCE, PTGS2, SRC, TERT 3.11356
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.10477
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.10477
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.09343
[BP] GO:0046627 None PRKCB, PRKCD, PTPN1, RELA 3.09343
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.07517
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP4, FLT3, GLO1, GSK3B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.0579
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.05786
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.05786
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.03171
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCD, SRC 3.02624
[BP] GO:0043278 None CNR1, PRKCE, PRKCG, RELA 2.98951
[BP] GO:0014072 None CNR1, PRKCE, PRKCG, RELA 2.98951
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.98534
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.98534
[BP] GO:0019371 None PTGES, PTGS1, PTGS2 2.98534
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, GSK3B, IDO1, PPARD, PRKCD, PTGES, PTGS2, RELA, SRC 2.98534
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, PPARD, PRKCE, PTGS2, SRC, TERT 2.97338
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, MMP9, PRKCD, PTGS2, PTPN1, RELA, SRC, TERT 2.94759
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, PPARD, SRC, TERT 2.94759
[BP] GO:1900076 regulation of cellular response to insulin stimulus PRKCB, PRKCD, PTPN1, RELA, SRC 2.94759
[BP] GO:1900077 None PRKCB, PRKCD, PTPN1, RELA 2.94759
[BP] GO:1902893 None PPARA, PPARD, RELA, TERT 2.94759
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.94759
[BP] GO:0051282 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.93652
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, DHFR, PRKCD, PTGS2, TRPV1, XDH 2.92806
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 2.91684
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PPARD, PTGES, PTGS1, PTGS2 2.90191
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD, PRKCD 2.9013
[BP] GO:0007208 None HTR2A, HTR2C 2.9013
[BP] GO:0035408 None PRKCA, PRKCB 2.9013
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, KIT, MAP3K7, PIM1, PRKCB, RELA 2.89577
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.8853
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.8853
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, FABP4, HTR1B, HTR1E, IGF1R, MMP9, PPARA, PPARD, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TRPV1, XDH 2.8777
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA, TRPV1 2.84737
[BP] GO:0032147 activation of protein kinase activity ADORA1, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.84737
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, GSK3B, HTR2A, HTR2C, KDR, KIT, MAP2K1, PPARA, PPARD, PRKCA, PRKCB, PTGS2, RELA, RORC, TERT, TRPV1, XDH 2.83813
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOA, MMP1, MMP2, MMP9, PIK3CB, PPARD, SRC, XDH 2.8322
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.82294
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.82035
[BP] GO:0038093 Fc receptor signaling pathway KIT, MAP3K7, PIK3CA, PIK3CB, PRKCD, PRKCE, RELA, SRC 2.81435
[BP] GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling APP, ESR1, HTR2B, MAP3K7, PRKCB, PRKCE, PTGS2, RELA 2.81435
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.81435
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, PRKCE, RELA, SRC 2.81121
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PRKCE, PTGS2 2.7981
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.79143
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.79143
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.79143
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PPARD, PTGS2, RELA, SRC, TRPV1 2.76021
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DYRK1A, ESR1, F3, FLT3, FUT7, GSK3B, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, TOP2A 2.75663
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.73812
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.73812
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 2.73812
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, GSK3B, HTR1B, HTR2A, MMP9, PRKCB, PRKCE, PTGS2 2.73625
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, CNR1, IDO1, MAP3K7, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, RELA, SRC 2.71455
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B3 2.70955
[BP] GO:0002768 immune response-regulating cell surface receptor signaling pathway BCL2, KIT, MAP3K7, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, SRC 2.70501
[BP] GO:0043123 None APP, HTR2B, MAP3K7, PRKCB, PRKCE, PTGS2, RELA 2.70361
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GSK3B, PIK3CA, PPARA, PRKCG, TERT 2.70361
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, KIT, PIK3CA, PPARD 2.70211
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.70211
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.70211
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.70211
[BP] GO:0071453 cellular response to oxygen levels BCL2, PPARD, PRKCE, PTGS2, SRC, TERT 2.69846
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TERT, XDH 2.69846
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, GSK3B, KDR, PIK3CB, PRKCE, SRC 2.68056
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 2.67246
[BP] GO:0031349 positive regulation of defense response CNR1, FABP4, IDO1, MAP3K7, MMP2, PRKCD, PRKCE, PTGS2, RELA, SRC 2.66241
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, ESR1, IDO1, KIT, MAP3K7, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SRC 2.64728
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, PPARA, PPARD, RORC, SRC 2.64728
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.63462
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PPARD, PRKCD, PTGES, PTGS2, RELA, SRC 2.63436
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.63436
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, PPARD, PRKCA, PRKCD, PTGS2, SRC 2.63099
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, ESR1, F3, GSK3B, IDO1, KDR, KIT, MAP2K1, PIM1, PPARD, PRKCA, PRKCB, PTGS2, RELA, SRC, TERT, XDH 2.62151
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.62151
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.62151
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.62151
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, PPARD, PTGS2, RELA, TRPV1 2.62096
[BP] GO:0032870 cellular response to hormone stimulus APEX1, AR, ESR1, FLT3, KIT, PRKCD, PRKCE, RELA, SRC 2.59348
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, PRKCD 2.59348
[BP] GO:0050673 epithelial cell proliferation ESR1, KIT, MAP2K1, PIK3CB, PPARD 2.59348
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARD, PTGS2, RELA 2.59348
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGES, PTGS1, PTGS2 2.59005
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGES, PTGS1, PTGS2 2.57949
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, IDO1, KIT, PPARD, PRKCD, PTGES, PTGS2, RELA, SRC, TRPV1 2.57266
[BP] GO:0001667 ameboidal-type cell migration CYP1B1, HTR2B, KDR, KIT, PIK3CA, PPARD 2.57266
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, DNMT1, ESR1, GSK3B, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PIK3CB, PPARD, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TOP2A 2.56484
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CNR1, GSK3B, HTR2B, PPARD, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.55974
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 2.55026
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.55026
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.54954
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.54954
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.54954
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.54954
[BP] GO:0007267 None ADORA1, AR, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 2.517
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, PPARA, PPARD, PRKCD, PTGS2, RELA, RORC, SRC, TERT, TOP2A, TRPV1 2.50261
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50261
[BP] GO:0071396 cellular response to lipid AR, AXL, ESR1, FLT3, PPARD, PRKCE, RELA, RORC, SRC 2.49582
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PPARD, PTGES, PTGS1, PTGS2 2.49582
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A1, SLC22A2, SRC, TERT, TOP2A, TRPV1, XDH 2.4852
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, HTR2B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PPARD, PRKCD, PTGS2, RORC, SRC, TERT, TOP2A 2.48199
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.48199
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, GSK3B, HTR2A, KDR, MAP3K7, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.47853
[BP] GO:0060359 None CNR1, HTR1B, PRKCE, PRKCG, RELA 2.47478
[BP] GO:0051341 None CNR1, CNR2, DHFR, HTR2B, TERT 2.47478
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, F3, FABP4, IDO1, KDR, MET, PRKCA, PTGS2 2.47324
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, DHFR, SLC22A2 2.46669
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, PRKCA, TERT 2.44417
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.43074
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, HTR2B, HTR2C, PPARD, PRKCA, PRKCE, SRC 2.42915
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PPARD, PTGES, PTGS1, PTGS2 2.42135
[BP] GO:0009410 None CNR1, CNR2, HTR1B, PRKCE, PRKCG, RELA 2.41516
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.41503
[BP] GO:0051000 None DHFR, HTR2B, TERT 2.41503
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, IDO1, PTGES, PTGS1, PTGS2 2.38662
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.38662
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, PRKCA, PRKCE, SRC, TERT 2.3771
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.37228
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.36964
[BP] GO:0009266 None ADORA1, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 2.35774
[BP] GO:0050865 regulation of cell activation APP, AXL, BCL2, CNR1, CNR2, IDO1, MAP3K7, PIK3CA, PRKCA, PRKCD, SRC 2.3577
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.35
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.35
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.3338
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, PIK3CB, PRKCG, PTPN1, SRC 2.32808
[BP] GO:0002429 immune response-activating cell surface receptor signaling pathway BCL2, MAP3K7, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, SRC 2.30563
[BP] GO:0042752 None ADORA1, PPARA, PRKCG, RORC, TOP2A 2.27472
[BP] GO:0032091 negative regulation of protein binding AURKB, GSK3B, MET, PPARA, PRKCD 2.27472
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, GSK3B, MET, MMP1, PRKCE, SRC 2.26009
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, GSK3B, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TOP2A 2.24948
[BP] GO:0051223 None ACHE, APP, CACNA1C, CNR1, GSK3B, HTR2B, PPARD, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.24109
[BP] GO:1901374 None SLC22A1, SLC22A2 2.24079
[BP] GO:0038171 None CNR1, CNR2 2.24079
[BP] GO:0015874 None SLC22A1, SLC22A2 2.24079
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24079
[BP] GO:0014827 None HTR1D, HTR2B 2.24079
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.23123
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.23123
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.23123
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DYRK1A, ESR1, FABP4, GSK3B, IGF1R, KDR, MAP2K1, MMP9, PPARA, PPARD, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TRPV1, XDH 2.2108
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, GSK3B, KDR, KIT, MET, MMP1, PRKCA, PRKCE, SRC 2.20029
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.19513
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, GSK3B, KDR, PIK3CB, SRC 2.18691
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.18691
[BP] GO:0022603 regulation of anatomical structure morphogenesis AR, BCL2, CYP1B1, ESR1, F3, KDR, KIT, MAP2K1, PIM1, PRKCA, PRKCB, PTGS2, SRC, TERT, XDH 2.17816
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.17447
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.16724
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CNR1, CNR2, KDR, SRC, TRPV1 2.15955
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.15955
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, CSNK2A1, DHFR, HTR2B, HTR2C, PIK3CA, PIK3CB, PPARD, PTGS2 2.14985
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, PPARA, PPARD, RORC, SRC 2.13097
[BP] GO:0046890 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.13097
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.1304
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.12211
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.12211
[BP] GO:1903034 regulation of response to wounding F3, MAP2K1, PPARD, PRKCA, PRKCD, PRKCE 2.1199
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.11918
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, PRKCB, PRKCD, RORC 2.10932
[BP] GO:0006816 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, TRPV1 2.10183
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA 2.09158
[BP] GO:0045600 positive regulation of fat cell differentiation HTR2A, HTR2C, PPARD, PTGS2 2.09104
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.09104
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, PPARA, PPARD, PRKCD 2.08423
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, KIT, MAP3K7, PRKCB, RELA 2.08359
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.07528
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07528
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.07421
[BP] GO:1903827 regulation of cellular protein localization APP, AR, BCL2, CSNK2A1, GSK3B, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TERT 2.06713
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, FLT3, FUT7, GSK3B, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TOP2A 2.0628
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, KIT, PTPN1, SRC 2.0628
[BP] GO:0002764 immune response-regulating signaling pathway BCL2, KIT, MAP3K7, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, SRC 2.05572
[BP] GO:0006109 regulation of carbohydrate metabolic process GSK3B, HTR2A, PPARA, PRKCE, RORC, SRC 2.05156
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.05156
[BP] GO:0010641 None F3, SRC 2.05156
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.05156
[BP] GO:0046618 None SLC47A1, SLC47A2 2.05156
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, GSK3B, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TOP2A 2.04433
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, ESR1, FLT3, FUT7, GSK3B, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TOP2A 2.04433
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MAP2K1, MET, PPARA, PPARD, PRKCD, PTGS2, RELA, RORC, SRC, TERT, TOP2A, TRPV1 2.04331
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.04199
[BP] GO:0032770 None DHFR, HTR2B, TERT 2.03214
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, GSK3B, HTR2B, PPARD, PRKCD, PRKCE, PTGS2, SRC 2.02979
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.02359
[BP] GO:0050778 positive regulation of immune response BCL2, CNR1, IDO1, MAP3K7, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, SRC 2.02359
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DYRK1A, ESR1, GSK3B, IGF1R, MET, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SRC, TERT, XDH 2.02359
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, FABP3, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MMP9, PPARA, PPARD, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TRPV1, XDH 2.01655
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.01414
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, BCL2, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, HTR2B, KDR, KIT, MAP2K1, MMP2, MMP9, PPARD, PTGS2, RORC, TOP2A 2.00704
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, GLO1, GSK3B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TRPV1 11.9998
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TRPV1 8.80778
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TRPV1 7.0282
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TRPV1 6.37782
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.16736
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1 4.81698
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, HSD17B3, HTR5A, KDR, MAP2K1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.53079
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.36546
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TOP2A, TRPV1, XDH 2.39016
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR2A, HTR4, HTR5A, IDO1, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TERT, TOP2A, TRPV1, XDH 2.24784
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, ESR1, F3, FLT3, FUT7, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PTGES, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TRPV1 2.10183
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 15.7829
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7829
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7829
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.7829
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.7829
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.3208
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, FLT3, GSK3B, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 12.097
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCG, PTPN1, RORC, XDH 11.4388
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.4208
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, KIT, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TERT, TOP2A, TRPV1, XDH 10.2934
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.2929
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, F3, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 10.033
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.72953
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.87889
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.52976
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 7.66392
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA, PPARD, RORC, TRPV1 7.58072
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA, PPARD, PRKCE, RORC, TRPV1 7.45207
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 7.18137
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PPARD, PRKCA, PRKCB, PRKCG, PTPN1, RORC 6.97527
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B3, IDO1, MAOA, NQO2, PTGS1, PTGS2, XDH 6.97527
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.57146
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA, PPARD, RORC, TRPV1 6.53828
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA, PPARD, RORC, TRPV1 6.27701
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.16902
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, FLT3, GSK3B, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SRC, TERT, TOP2A, TRPV1, XDH 6.13667
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TERT 6.12891
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, FLT3, GSK3B, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TERT, TOP2A, TRPV1, XDH 5.89325
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.79805
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 5.79805
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.75783
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, RELA, SRC, TOP2A, TRPV1, XDH 5.69139
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, PRKCD, SRC 5.48436
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, GLO1, IDO1, KIT, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TERT, TOP2A, TRPV1, XDH 5.3763
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, TRPV1 5.28171
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, TRPV1 5.28171
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 5.09946
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 5.09715
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B2, HSD17B1, IDO1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 4.84928
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.69696
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 4.68526
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS1, PTGS2, SRC 4.57438
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 4.52245
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 4.47979
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.4547
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, DYRK1A, GSK3B, MAP2K1, MAP3K7, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 4.39944
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS1, PTGS2, SRC 4.36416
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.35089
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.23087
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.73909
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.6834
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, SHBG 3.52116
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, PPARA, PPARD, RORC 3.50375
[MF] GO:0004879 nuclear receptor activity AR, ESR1, PPARA, PPARD, RORC 3.50375
[MF] GO:0005496 steroid binding AR, ESR1, HSD11B2, HSD17B1, RORC, SHBG 3.5
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.48353
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B3, XDH 3.43868
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PPARD, RORC, SHBG, TRPV1 3.35087
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.32214
[MF] GO:0015238 None ABCB1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.31154
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, FLT3, GSK3B, PIM1, PPARA, PPARD, PRKCB, RELA, SRC, TERT 3.31154
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.29928
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.29928
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B3 3.23896
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.23896
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.22523
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.22523
[MF] GO:0051059 None APEX1, GSK3B, PPARD, RELA 3.19435
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.19158
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, PPARA, PPARD, RORC 3.18095
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.14905
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.14403
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B3 3.14403
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.05849
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.03171
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.98534
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.9013
[MF] GO:0003845 None HSD11B1, HSD11B2 2.9013
[MF] GO:0035403 None PRKCA, PRKCB 2.9013
[MF] GO:0071886 None HTR2A, HTR2C 2.9013
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.8853
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.88246
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 2.84737
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DYRK1A, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 2.83882
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B3 2.8322
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, ESR1, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP9, NQO2, PTGS2, RELA, SLC22A1, TERT, TOP2A, TRPV1, XDH 2.66079
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TOP2A, TRPV1, XDH 2.59348
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, DYRK1A, MAP2K1, PRKCG 2.59348
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.50261
[MF] GO:0015307 None SLC47A1, SLC47A2 2.50261
[MF] GO:1901375 None SLC22A1, SLC22A2 2.50261
[MF] GO:0004949 None CNR1, CNR2 2.50261
[MF] GO:0005333 None SLC22A1, SLC22A2 2.50261
[MF] GO:0005277 None SLC22A1, SLC22A2 2.50261
[MF] GO:0008513 None SLC22A1, SLC22A2 2.50261
[MF] GO:0004699 None PRKCD, PRKCE 2.50261
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.49582
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.48199
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.43157
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.28515
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.28495
[MF] GO:0005497 None AR, SHBG 2.24079
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.07528


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, MAP2K1, HTR1E, PRKCB, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 26.8207
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, GSK3B, MAP2K1, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET, PPARD 11.4998
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, TRPV1, HTR2A 11.4998
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, TRPV1, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 10.7873
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3, RELA 10.1663
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, MAP2K1, DNMT1, ABCB1, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 9.5574
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA, HTR6, PIK3CA, ADORA1, PPARA 9.5574
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, MAP2K1, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, IGF1R, PIK3CA, KDR, MET 9.5046
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 9.5574
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, MAP2K1, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB, RELA 9.5574
Focal adhesion_Homo sapiens_hsa04510 PRKCG, GSK3B, MAP2K1, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 8.3663
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, CNR1, KIT, KDR, PRKCA, PIK3CB, MET, IGF1R 8.2452
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA, PPARD 8.3459
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, MAP2K1, HTR7, PIK3CA, PRKCB, KIT, KDR, PRKCA, PIK3CB, MET, RELA, IGF1R 7.9097
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, HTR6, HTR7, PRKCB, HTR2B, HTR2C, PRKCA, CACNA1C, HTR2A, HTR5A, HTR4 7.8844
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.4464
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, MAP2K1, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB 7.8114
Hepatitis B_Homo sapiens_hsa05161 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9, RELA 7.6619
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, MAP2K1, PIK3CA, PRKCB, BCL2, PRKCA, CACNA1C, PIK3CB 7.5319
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, MAP2K1, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB, RELA, IGF1R 7.7585
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 8.3153
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PIK3CA, PRKCB, PRKCE, PRKCD, PIK3CB, PPARA, RELA 7.582
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, GSK3B, MAP2K1, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 7.334
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, GSK3B, MAP2K1, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB 7.133
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 7.0876
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1 6.7528
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 6.9512
Gap junction_Homo sapiens_hsa04540 PRKCG, MAP2K1, PRKCB, SRC, HTR2B, HTR2C, PRKCA, HTR2A 7.1104
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.4549
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, PRKCA, CACNA1C, PIK3CB, PTGS2 6.3653
Glioma_Homo sapiens_hsa05214 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB, IGF1R 6.7528
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, MAP2K1, PIK3CA, KIT, KDR, BCL2, PRKCA, PIK3CB, MET, RELA, IGF1R 5.3826
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 6.4674
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, PRKCB, SRC, MMP2, PRKCD, PRKCA, CACNA1C 5.8069
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, ALOX15, HSD17B3, AKR1B1, PTGS2, CYP19A1, PTGS1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH, PTGES, IDO1 5.1468
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.2837
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB 5.8069
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, PIK3CA, PRKCD, BCL2, PIK3CB, RELA 5.1102
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, PIK3CA, PRKCB, PIK3CB, RELA 5.1726
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.8069
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, PIK3CA, PRKCB, SRC, PRKCD, PIK3CB, RELA 4.8608
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET 5.3613
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, MAP2K1, PRKCB, PRKCE, PRKCD, PRKCA, CACNA1C 5.1102
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.1403
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, GSK3B, CSNK2A1, PRKCB, PRKCA, MAP3K7, PPARD 4.6594
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.712
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.1582
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, PRKCA, PIK3CB 6.7111
Melanogenesis_Homo sapiens_hsa04916 PRKCG, GSK3B, MAP2K1, PRKCB, KIT, PRKCA 4.4925
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, RELA 4.4925
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, CACNA1C, PTGS2 4.4756
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, PRKCE, ADORA1, CACNA1C, PIK3CB 4.2828
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2, MAP3K7, RELA 4.6586
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 4.4256
Influenza A_Homo sapiens_hsa05164 GSK3B, MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB, RELA 4.1733
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, MAP2K1, PRKCB, PRKCA, CACNA1C, MAP3K7, RELA, CDC25B 4.0308
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.1686
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 3.8441
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GSK3B, PRKCB, MAOA, PRKCA, CACNA1C 3.9755
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB 3.8831
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.8771
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2391
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2481
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.2743
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.4503
Long-term depression_Homo sapiens_hsa04730 PRKCG, MAP2K1, PRKCB, PRKCA, IGF1R 4.4503
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.1582
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.5712
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA, CACNA1C 3.909
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.4212
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, MAP2K1, PRKCB, PRKCA, CACNA1C 4.2828
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, MAOA, PRKCA, CACNA1C 4.2577
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 3.8771
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4034
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4218
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 4.1679
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6144
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1, IDO1 5.1822
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.5712
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCE, PRKCD, CACNA1C, PIK3CB 4.8608
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 2.9263
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.0233
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4381
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1, PIK3CA, BCL2, PIK3CB 4.4022
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4381
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4468
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4381
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, PPARA, RELA 3.0141
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, MAP2K1, PIK3CA, PIK3CB 2.9359
Peroxisome_Homo sapiens_hsa04146 XDH 0.4569
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, PIK3CA, PIK3CB, IGF1R 2.9031
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, KIT, PRKCA, PIK3CB 2.8801
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, CACNA1C, PIK3CB 2.8318
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 0.815
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4569
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.8897
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, PIK3CB, PPARA, RELA 2.8
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.8063
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4717
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA, CACNA1C 3.7773
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.2021
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4695
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.8684
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0957
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.2601
Pertussis_Homo sapiens_hsa05133 RELA 0.4833
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.8193
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.4868
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.1329
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, PIK3CA, TERT, PIK3CB, RELA 1.8716
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB 1.5245
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4857
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.5822
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGES, PTGS1 4.4022
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.9289
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, GSK3B, APP, CACNA1C 1.8514
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2951
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.1725
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4947
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, MAP3K7, IGF1R 2.2736
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5364
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA, CACNA1C 2.3976
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0515
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.6765
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 3.0364
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.6811
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA, CACNA1C 2.6684
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.7293
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.6556
Legionellosis_Homo sapiens_hsa05134 RELA 0.5907
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5907
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5907
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PRKCA, PIK3CB 3.1395
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2, MAP3K7, RELA 3.0364
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA, CACNA1C 2.8318
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9458
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.8486
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.0233
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6119
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6119
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6144
Malaria_Homo sapiens_hsa05144 MET 0.6144
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2154
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.1844
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6144
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.0364
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2073
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.1844
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2154
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.2204
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2636
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.261
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.261
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.636
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.261
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.648
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6419
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC22A1 2.0908
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.0908
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3491
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3249
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1358
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2022
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6826
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1, PIK3CA, PIK3CB 3.5664
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6826
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7303
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7918
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA 0.7303
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7706
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4676
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7481
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.815
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.7233
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8219
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7809
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA, IDO1 4.1679
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.6173
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.815
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8517
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8486
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7042
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7991
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8677
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9237
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9884
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0504
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.4475
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2849


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)