TCM Prescription: Hepatitis B Decoction



Prescription Description
Prescription IDTCMF2350
Pinyin NameYi Gan Tang
Chinese Name益肝汤
English NameHepatitis B Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH201 Bombyx mori 蚕砂 TCMH201 AGIRI001-17
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT605 EDNRA Endothelin receptor ET-A GPCR P25101
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GAA, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, XDH 15.4722
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SRC, TEK, TYR 13.4382
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 12.9026
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCHE, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 11.4122
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BCHE, CA2, CA7, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 11.4122
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BCHE, CA2, CA7, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 11.4122
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9656
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.7213
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.705
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CHRNA3, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SLC6A2, SLC6A3, SMAD3 10.2901
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1914
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCHE, BCL2, CHRNA3, CHRNA7, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP4, GAA, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 10.167
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, PTGS2, RORC, SLC6A3, SRC, TEK, TYR 9.91341
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 9.90687
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCHE, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.90687
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCHE, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.74963
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.58839
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.51916
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 9.51916
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 9.11321
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.97905
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.85704
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.85704
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCHE, BCL2, CDC25B, CHRNA7, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.8492
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA6, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR 8.81564
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, SMAD3 8.70265
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 8.50083
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.48869
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CHRNA7, CYP1B1, DRD2, DRD4, EGFR, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.46523
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GAA, GLO1, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 8.43447
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.33511
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCHE, BCL2, CA9, CHRNA3, CHRNA7, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, FABP3, KDR, PTGS2, SLC6A2, SLC6A3, SRC 8.29937
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, BCHE, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A3, SRC, TEK, TYR 8.29937
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.29937
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCHE, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 8.26971
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, BCHE, CHRNA7, DRD1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A3, SRC, TEK, TYR 8.06472
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.9934
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 7.751
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 7.65745
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.54098
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD4, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.54098
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 7.35784
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.14765
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CHRNA3, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EGFR, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.07335
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SLC6A3, SRC 7.05947
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CHRNA7, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, KDR, SLC6A3, SRC 6.93775
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.55344
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, PIK3CB, SMAD3 6.52031
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.52003
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.49461
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.46435
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.46435
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.4262
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.42413
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.40329
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.38061
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.37875
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 6.37875
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, BCHE, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, HSPA1A, SLC6A3 6.33972
[BP] GO:0007193 None ADORA1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 6.31318
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GAA, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3 6.30528
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CHRNA7, CYP1A1, DRD2, EDNRA, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 6.29057
[BP] GO:0060078 None ADORA1, CHRNA3, CHRNA7, DRD4, GRIA2, GRIA4, GRIK5, GRM5 6.29057
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRNA7, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 6.2856
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 6.26122
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, DRD4, SLC6A3, TYR 6.26122
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, NQO2, PTGS1, RORC 6.26122
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.25866
[BP] GO:0007610 None BCHE, BCL2, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EGFR, GAA, GRM1, GRM5, INSR, PPARA, PTGS2, SLC6A3 6.25866
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.25866
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EDNRA, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GLO1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR 6.25283
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 6.21615
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.21291
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, DRD2, EDNRA, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 6.19551
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.19461
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CHRNA7, CYP1A1, DRD1, DRD2, DRD3, EDNRA, EGFR, GRM1, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 6.17997
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 6.16113
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.161
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, CHRNA7, DRD1, DRD2, DRD4, EGFR, PTGS2 6.09175
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 6.09175
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.08797
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.0863
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.04542
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.03034
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3 6.0083
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 5.96574
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 5.95586
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.89662
[BP] GO:0032225 None DRD1, DRD2, DRD3, DRD4, PTGS2 5.88596
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD2, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.86733
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 5.85775
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, DRD2, EDNRA, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 5.8552
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, BCHE, CSNK2A1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.75559
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC 5.75559
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.73928
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.73928
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.73901
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.71383
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 5.67199
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.6514
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 5.6489
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD17B1, HSD17B2 5.59533
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.59244
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GAA, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.58003
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 5.56559
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A 5.55235
[BP] GO:0032147 activation of protein kinase activity ADORA1, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC 5.54295
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.53727
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.50351
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 5.48952
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.46989
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.44836
[BP] GO:0055074 calcium ion homeostasis BCL2, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 5.43074
[BP] GO:0051940 None DRD1, DRD2, DRD3, DRD4 5.40046
[BP] GO:0051584 None DRD1, DRD2, DRD3, DRD4 5.40046
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 5.3777
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC 5.37722
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CHRNA3, CYP19A1, DRD1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 5.37722
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.36821
[BP] GO:0042391 None ADORA1, BCL2, CHRNA3, CHRNA7, DRD1, DRD4, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 5.36334
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.3475
[BP] GO:1900543 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8, PPARA 5.3397
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.3397
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 5.31831
[BP] GO:0045980 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8, PPARA 5.30294
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 5.29602
[BP] GO:0007188 None ADORA1, DRD1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 5.29208
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.27952
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, DRD4, SLC6A3 5.27952
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.23951
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, CHRNA7, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 5.23261
[BP] GO:0030818 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 5.22521
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, SLC6A3, TYR 5.22296
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.2029
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.1985
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 5.19048
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.17222
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.15248
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EDNRA, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.13733
[BP] GO:0030803 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 5.13532
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CHRNA3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 5.07545
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, CHRNA7, DRD2, DRD4, EGFR, FLT3, GRM1, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 5.05684
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SLC6A3, SMAD3, TEK 5.03752
[BP] GO:0030815 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 5.03067
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, PIK3CB, PTGS2 5.02756
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.01875
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.99166
[BP] GO:0007268 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.99166
[BP] GO:0098916 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.99166
[BP] GO:1900372 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 4.99166
[BP] GO:0030809 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 4.99166
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 4.98564
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 4.95759
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.95224
[BP] GO:0030800 None DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 4.94668
[BP] GO:0099536 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.90529
[BP] GO:0099537 None CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.90529
[BP] GO:0007626 None CHRNA3, DRD1, DRD2, DRD3, DRD4, GAA, GRM1, GRM5, SLC6A3 4.8621
[BP] GO:0043408 regulation of MAPK cascade ADORA1, CHRNA7, DRD2, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.82926
[BP] GO:0060359 None CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, SLC6A3 4.79376
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.79376
[BP] GO:0007187 None ADORA1, DRD1, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.79306
[BP] GO:0042417 None DRD1, DRD2, DRD3, DRD4, SLC6A3 4.77642
[BP] GO:0055065 metal ion homeostasis BCL2, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 4.76927
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 4.76927
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.76123
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.74476
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.74476
[BP] GO:0003008 None ADORA1, AKR1B1, BCHE, BCL2, CHRNA7, CYP1B1, DRD1, DRD2, DRD3, EDNRA, EGFR, GAA, GRM1, GRM5, GRM8, INSR, PIK3CA, PTGS2, SLC6A3, SRC, TEK, TYR 4.72364
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.69246
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.67713
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.64948
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCHE, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.64519
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 4.63211
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCHE, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.62673
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.60511
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 4.5967
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, DRD4, GPR35, MMP9, PTGS2 4.59422
[BP] GO:0060134 None DRD1, DRD2, DRD3, SLC6A3 4.56722
[BP] GO:0006875 cellular metal ion homeostasis BCL2, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 4.55165
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EDNRA, EGFR, ESR1, FLT3, GAA, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 4.52941
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CHRNA7, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD4, EDNRA, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SMAD3, SRC, TEK, TOP2A 4.52692
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.52692
[BP] GO:0030817 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 4.52391
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, RORC, TOP2A 4.52391
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, CHRNA7, DRD4, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 4.49486
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.47039
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.46982
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.46982
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.44573
[BP] GO:0051580 None DRD1, DRD2, DRD3, DRD4 4.44573
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GAA, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SLC6A3, SRC, XDH 4.44573
[BP] GO:0008217 None ADORA1, DRD2, DRD3, EDNRA, PPARA, PTGS1, PTGS2, SMAD3 4.44072
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.42534
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.39601
[BP] GO:0050890 None ADORA1, BCHE, CHRNA7, DRD1, DRD2, DRD3, EGFR, GRM5, INSR, PTGS2 4.39601
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 4.39594
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, DRD1, DRD2, PTGS2 4.39018
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CHRNA3, CHRNA7, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GAA, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC1A1, SLC6A3, SMAD3, SRC, TEK, XDH 4.35996
[BP] GO:1901652 response to peptide AKR1B1, APEX1, CHRNA7, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.32919
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.32778
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.30996
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.28318
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 4.27955
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.27514
[BP] GO:0044057 None ADORA1, ADORA3, CHRNA3, DRD2, DRD3, EGFR, GAA, GPR35, GRM1, HCAR2, PTGS2, SLC1A1, SMAD3 4.26949
[BP] GO:0060079 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 4.2117
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 4.17663
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 4.15803
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.09248
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 4.09248
[BP] GO:0030814 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 4.07984
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CHRNA7, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SLC1A1, SLC6A3, SMAD3, SRC, TEK 4.06593
[BP] GO:0030802 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 4.00826
[BP] GO:1900542 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8, INSR, PPARA 4.00471
[BP] GO:0007611 None BCHE, CHRNA7, DRD1, DRD2, DRD3, EGFR, GRM5, INSR, PTGS2 3.991
[BP] GO:0051952 None ADORA1, CHRNA3, DRD1, DRD2, DRD3, DRD4 3.98186
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.9797
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, DRD4, EGFR, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC 3.93703
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EDNRA, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.92705
[BP] GO:0006140 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8, INSR, PPARA 3.91011
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.90978
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.89692
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, SLC6A2, TEK 3.8569
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.84673
[BP] GO:0048148 None DRD1, DRD2, DRD3, DRD4 3.83747
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.82861
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2, SLC6A3 3.82861
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 3.80903
[BP] GO:1900371 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 3.80149
[BP] GO:0030808 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 3.78213
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.75361
[BP] GO:0050877 None ADORA1, BCHE, CHRNA7, CYP1B1, DRD1, DRD2, DRD3, EGFR, GAA, GRM1, GRM5, GRM8, INSR, PTGS2, SLC6A3, TYR 3.7243
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.7193
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.7193
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.66698
[BP] GO:0007612 None BCHE, DRD1, DRD2, DRD3, GRM5, INSR, PTGS2 3.66698
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, CHRNA7, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.66698
[BP] GO:0051246 regulation of protein metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.65825
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CHRNA7, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 3.64147
[BP] GO:0009820 alkaloid metabolic process BCHE, CYP1A2, CYP3A4 3.64147
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.64147
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.64147
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.64047
[BP] GO:2001023 None CHRNA3, DRD1, DRD2, DRD3, DRD4, MET 3.63438
[BP] GO:0051588 None CHRNA3, DRD1, DRD2, DRD3, DRD4, GRIK5 3.61028
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CHRNA3, DRD1, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9, PTGS2 3.58424
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.57367
[BP] GO:0030799 None DRD1, DRD2, DRD3, DRD4, EDNRA, GRM3, GRM8 3.56489
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.5529
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, CHRNA7, DRD4, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 3.50825
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, DRD1, DRD2, DRD3, DRD4, EDNRA, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, SRC 3.50825
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.48314
[BP] GO:0007267 None ADORA1, CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.45943
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, SLC6A3, SMAD3, TEK 3.45786
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EDNRA, EGFR, ESR1, MET, SMAD3, SRC 3.423
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 3.423
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD4 3.42143
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2, SRC 3.33434
[BP] GO:0003018 None ADORA1, DRD1, EDNRA, EGFR, PTGS2, SRC, TEK 3.33434
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 3.32393
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.31799
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.30253
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.29934
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.29028
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.25562
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.24513
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.21623
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.1947
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.16738
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.16738
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.16738
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, PTGS1, PTGS2 3.15167
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.13847
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, DRD4, GPR35, PTGS2 3.13464
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.12085
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.11978
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC 3.11056
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, DRD1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.10024
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.09317
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.09317
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.09317
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, PIK3CA, SLC6A3 3.0836
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.0836
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.0836
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.05273
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.05273
[BP] GO:0045936 None DRD2, DRD3, DRD4, DUSP3, EDNRA, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 3.03477
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.03357
[BP] GO:0010563 None DRD2, DRD3, DRD4, DUSP3, EDNRA, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 3.02991
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.02022
[BP] GO:0023052 None ADORA1, CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 3.01883
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, PIK3CA 3.00976
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 3.00256
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TOP2A 2.97083
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.95371
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.94691
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A3 2.94343
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.94343
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.94157
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.92002
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, FABP3, GAA, GRIA2, GRIA4, GRIK5, HSPA1A, MGAM, MMP12, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.91704
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 2.91565
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.90874
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.88711
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.88711
[BP] GO:0032413 None DRD2, DRD3, DRD4, GPR35, MMP9 2.87762
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD4 2.87652
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.87652
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.87622
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.87217
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC 2.85933
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.85632
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8536
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD4 2.83639
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 2.83281
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 2.82839
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, FABP3, GAA, GRIA2, GRIA4, GRIK5, HSPA1A, MGAM, MMP12, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.81643
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCHE, BCL2, CDC25B, CHRNA7, CYP1A1, DRD1, DRD2, EDNRA, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 2.77416
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, FABP3, GAA, GRIA2, GRIA4, GRIK5, HSPA1A, MGAM, MMP12, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, XDH 2.75859
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.75808
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.75808
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CHRNA7, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EDNRA, ESR1, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.73193
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EDNRA, EGFR, ESR1, MET, SMAD3, SRC 2.73025
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade CHRNA7, DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.71768
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.71768
[BP] GO:0035094 response to nicotine BCL2, CHRNA7, DRD2, SLC6A3 2.71768
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.71768
[BP] GO:0032410 None DRD2, DRD3, DRD4, GPR35, MMP9 2.68928
[BP] GO:1904063 None DRD2, DRD3, DRD4, GPR35, MMP9 2.68928
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.67891
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.67533
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A3 2.67533
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2 2.65976
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.65976
[BP] GO:0003013 None ADORA1, DRD1, EDNRA, EGFR, PTGS2, SRC, TEK 2.65679
[BP] GO:0030534 None CHRNA3, DRD1, DRD2, DRD3, DRD4, PPARA 2.64641
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.64641
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.64641
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.63013
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, EDNRA, ESR1, GPR35, GRM1, GRM5, SMAD3 2.61296
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 2.61296
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.60257
[BP] GO:0000187 activation of MAPK activity CHRNA7, DRD4, GRM1, INSR, PIK3CB, PTPN1 2.6002
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.60007
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60007
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.58738
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.57888
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD4 2.57888
[BP] GO:0009410 None DRD1, DRD2, DRD3, DRD4, EGFR, SLC6A3 2.55699
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.54324
[BP] GO:0035239 tube morphogenesis BCL2, EDNRA, EGFR, ESR1, MET, SMAD3, SRC 2.54324
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.5416
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.52928
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.52928
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.52928
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MMP12, SRC 2.52916
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CHRNA3, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, MMP12, SRC 2.52916
[BP] GO:0099566 None GRM1, GRM5 2.52916
[BP] GO:0051944 None DRD2, DRD4 2.52916
[BP] GO:0000023 None GAA, MGAM 2.52916
[BP] GO:0060160 None DRD2, DRD3 2.52916
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52916
[BP] GO:1905144 None CHRNA3, CHRNA7 2.52916
[BP] GO:0051586 None DRD2, DRD4 2.52916
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, EDNRA, ESR1, MET, SRC 2.51427
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.49238
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.48659
[BP] GO:0034766 None DRD2, DRD3, DRD4, GPR35, MMP9 2.47888
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.46543
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, DRD4, EDNRA, FABP3, MMP12, PPARA, SLC1A1, SLC6A2, SLC6A3 2.46447
[BP] GO:0045766 positive regulation of angiogenesis CHRNA7, CYP1B1, F3, KDR, PTGS2, TEK 2.45939
[BP] GO:0048167 None ADORA1, CHRNA7, DRD1, DRD2, GRM5, PTGS2 2.45939
[BP] GO:0090087 None ACHE, ADORA1, CA2, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.43807
[BP] GO:0022898 None BCL2, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.41477
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.41477
[BP] GO:0042053 None DRD1, DRD4, SLC6A3 2.41087
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.41087
[BP] GO:0042069 None DRD1, DRD4, SLC6A3 2.41087
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.41087
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.40707
[BP] GO:2001258 None DRD2, DRD4, GPR35, MMP9 2.40573
[BP] GO:0009653 anatomical structure morphogenesis AXL, BCL2, CA2, CA9, CHRNA7, CYP1B1, DRD2, EDNRA, EGFR, ESR1, GAA, INSR, MET, MMP2, SMAD3, SRC, TEK 2.40383
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 2.39991
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.37613
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.37221
[BP] GO:0034763 None DRD2, DRD3, DRD4, GPR35, MMP9 2.37043
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CHRNA3, CHRNA7, CSNK2A1, DRD2, DRD3, EGFR, ESR1, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TOP2A 2.36827
[BP] GO:0051172 None APEX1, AURKB, CHRNA7, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.36827
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.35533
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.35533
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.35533
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.35533
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.35533
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.35257
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.34241
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.33862
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.32509
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, DRD4, SLC6A2 2.32509
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.32509
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.315
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.30041
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A3 2.30041
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.30041
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.30041
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.29994
[BP] GO:0007613 None CHRNA7, DRD1, DRD2, INSR, PTGS2 2.28873
[BP] GO:0032409 None BCL2, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.2865
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 2.2865
[BP] GO:0051046 None ACHE, ADORA1, CHRNA3, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, MMP12, SRC 2.28185
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.28185
[BP] GO:0051582 None DRD2, DRD4 2.28185
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28185
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, BCL2, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.25509
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.25118
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.25118
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.24232
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.24124
[BP] GO:1904018 positive regulation of vasculature development CHRNA7, CYP1B1, F3, KDR, PTGS2, TEK 2.20301
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.20018
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.20018
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.20018
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.20018
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.20018
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20018
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, EGFR, PTGS2, SRC, TYR 2.19258
[BP] GO:0045927 positive regulation of growth BCL2, CSNK2A1, DRD2, EGFR, INSR, PIM1, SLC6A3 2.16769
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, MMP12, SRC 2.16769
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.15806
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, GAA, HSPA1A, MGAM, PIK3CB, SLC6A3, SRC, XDH 2.15505
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.15184
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.15184
[BP] GO:0051894 None KDR, SMAD3, TEK 2.15184
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15184
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, SLC6A3 2.15024
[BP] GO:0034762 None BCL2, CA2, DRD1, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.15024
[BP] GO:0060341 regulation of cellular localization BCL2, CHRNA3, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EGFR, GRIK5, PTGS2, PTPN1, SMAD3, SRC 2.14075
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.13478
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.13027
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.12908
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PIK3CA, PIM1, SLC6A3, SMAD3 2.12818
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.11787
[BP] GO:0050927 None F3, KDR, SMAD3 2.10663
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GAA, HSPA1A, MGAM, SLC6A3, XDH 2.1051
[BP] GO:0021853 None DRD1, DRD2 2.09566
[BP] GO:0010641 None F3, SRC 2.09566
[BP] GO:0090325 None DRD2, DRD3 2.09566
[BP] GO:1904936 None DRD1, DRD2 2.09566
[BP] GO:0042321 None ADORA1, DRD2 2.09566
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.0901
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.08931
[BP] GO:0010959 None ADORA1, BCL2, DRD1, DRD2, DRD3, DRD4, GPR35, PTGS2 2.07645
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, SRC 2.07502
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.07282
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.07282
[BP] GO:0050926 None F3, KDR, SMAD3 2.07282
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.07282
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.07282
[BP] GO:1903393 None KDR, SMAD3, TEK 2.07282
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.07282
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.07282
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.06683
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.061
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.05908
[BP] GO:0048754 branching morphogenesis of an epithelial tube BCL2, EDNRA, ESR1, MET, SRC 2.05908
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.05311
[BP] GO:0009888 tissue development ALPL, CYP1B1, GAA, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.02506
[BP] GO:0007584 response to nutrient ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 2.0211
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.01776
[BP] GO:0097746 None ADORA1, DRD1, EDNRA, EGFR, PTGS2 2.01567
[BP] GO:0035296 None ADORA1, DRD1, EDNRA, EGFR, PTGS2 2.01567
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, DRD2, DRD3, DRD4, GAA, HSPA1A, MGAM, MMP9, SLC1A1, SLC6A3, XDH 2.0152
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.0098
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CHRNA3, CHRNA7, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, XDH 2.00082
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CSNK2A1, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK 8.00436
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRNA3, CHRNA7, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, MGAM, PTGS2, SLC1A1, SRC, TEK 7.74261
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MGAM, PTGS2, SLC1A1, SLC6A2, SLC6A3, SRC, TEK 6.93775
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, FUT7, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 6.53741
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD1, DRD2, DRD3, DRD4, EDNRA, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK 6.03114
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MGAM, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SRC, TEK, TYR 5.71383
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, DRD1, DRD2, DRD3, DRD4, EDNRA, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, TEK 5.19663
[CC] GO:0044456 None ACHE, ADORA1, CHRNA3, CHRNA7, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SRC 4.32906
[CC] GO:0045121 membrane raft CHRNA3, CHRNA7, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SRC, TEK 4.12756
[CC] GO:0098857 membrane microdomain CHRNA3, CHRNA7, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SRC, TEK 4.10245
[CC] GO:0043235 receptor complex CHRNA3, CHRNA7, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.79839
[CC] GO:0014069 None ADORA1, CHRNA3, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.61829
[CC] GO:0099572 None ADORA1, CHRNA3, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.61829
[CC] GO:0098589 membrane region CHRNA3, CHRNA7, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SRC, TEK 3.47937
[CC] GO:0098794 None ADORA1, CHRNA7, DRD2, DRD4, GRIA2, GRIA4, GRM3 3.38613
[CC] GO:0097060 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.36541
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.22325
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CHRNA3, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SRC, TEK 3.11085
[CC] GO:0043005 None ADORA1, CA2, CHRNA3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC6A2, SLC6A3, SRC 3.0836
[CC] GO:0098802 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, INSR 3.05273
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRNA3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SRC, TEK 2.91364
[CC] GO:0044853 plasma membrane raft CHRNA3, CHRNA7, INSR, PTGS2, SRC 2.52916
[CC] GO:0044432 endoplasmic reticulum part BCHE, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, EGFR, FLT3, GRIA2, HSD17B2, PTGS1, PTGS2, PTPN1 2.50792
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, EGFR, GRIA2, HSD17B2, PTGS1, PTGS2 2.48828
[CC] GO:0097458 None ADORA1, CA2, CHRNA3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTGS1, PTGS2, SLC6A2, SLC6A3, SRC 2.15034
[CC] GO:0043197 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.09525
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.0901
[CC] GO:0044309 None ADORA1, DRD2, GRIA2, GRIA4, GRM3 2.07282
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRNA3, CHRNA7, CYP3A4, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MGAM, SLC1A1, SLC6A2, SLC6A3, TEK, TYR 2.0377
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.8363
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 13.1157
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 13.0633
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EDNRA, EGFR, F3, FLT3, FUT7, GAA, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TOP2A, TYR, XDH 10.3531
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2874
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.167
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 9.83002
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, DRD3, DRD4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A3, SRC, TEK, TOP2A 9.655
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, TOP2A, TYR, XDH 9.12707
[MF] GO:0030594 None CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 8.81564
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 8.69743
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK 8.57434
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK 8.57434
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 8.44398
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, EDNRA, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 8.43447
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.07772
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.98177
[MF] GO:0070405 ammonium ion binding ACHE, BCHE, CHRNA3, CHRNA7, DRD1, DRD2, DRD3, DRD4, SLC6A3 7.78877
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.78877
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 6.965
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.93775
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 6.8172
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 6.67396
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.67208
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, TYR 6.29057
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD4, SLC6A3 6.29057
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.24109
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.09422
[MF] GO:0042562 hormone binding ACHE, CHRNA3, CHRNA7, EGFR, HSD17B1, IGF1R, INSR, NQO2 6.04065
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.71383
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD4, SLC6A3 5.42822
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 5.21509
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, TOP2A, TYR, XDH 5.20804
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.18474
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.85077
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.82738
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD4 4.70354
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.56822
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.40012
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 3.93323
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SMAD3, SRC 3.80938
[MF] GO:0098960 None CHRNA3, CHRNA7, GRM1, GRM5 3.75962
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.73507
[MF] GO:0005231 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.71495
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A3, SMAD3, SRC 3.682
[MF] GO:0022824 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.64147
[MF] GO:0022835 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.64147
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.45943
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.32393
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.30275
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.30275
[MF] GO:0001540 amyloid-beta binding ACHE, BCHE, CHRNA7, GRIA2, INSR 3.2899
[MF] GO:0042802 identical protein binding ACHE, BCHE, BCL2, CHRNA7, CSNK2A1, DRD2, DRD4, EGFR, ESR1, FLT3, GRIK5, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SMAD3, TOP2A, TYR, XDH 3.1947
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SLC6A3, SMAD3 3.1947
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.92619
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.92619
[MF] GO:0008389 None CYP2A13, CYP2A6 2.92619
[MF] GO:0005230 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 2.87762
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.5974
[MF] GO:0042166 None ACHE, CHRNA3, CHRNA7 2.52928
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.52916
[MF] GO:0005330 None SLC6A2, SLC6A3 2.52916
[MF] GO:0032450 None GAA, MGAM 2.52916
[MF] GO:0099583 None GRM1, GRM5 2.52916
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.52916
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.41087
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.41087
[MF] GO:0042165 neurotransmitter binding ACHE, BCHE, CHRNA3, CHRNA7 2.37613
[MF] GO:0019899 enzyme binding AURKB, BCHE, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, F3, GRM5, HSPA1A, MET, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TOP2A 2.30044
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.28185
[MF] GO:0004971 None GRIA2, GRIA4 2.28185
[MF] GO:0004558 None GAA, MGAM 2.28185
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.28185
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.24301
[MF] GO:0004930 None ADORA1, ADORA3, DRD1, DRD2, DRD3, DRD4, EDNRA, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2 2.1893
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.10663
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09566
[MF] GO:0043559 insulin binding IGF1R, INSR 2.09566
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, MET, PTPN1, SLC6A3 2.09525
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, DRD4, DUSP3, EDNRA, EGFR, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.07882
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.05311
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, TOP2A, XDH 2.01221


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.284
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, CHRNA3, GPR35, CHRNA7, GRIK5, GRM1, GRM3, GRM5, EDNRA, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, DRD4, GRIA4 12.4719
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.3005
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, HSPA1A 7.6619
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.384
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, EDNRA, PIK3CA, BCL2, MET 6.4864
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.9241
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, EDNRA, PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA, GRIA4 6.4864
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.4843
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CHRNA7, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.1018
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 6.3629
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.8722
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.2984
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 5.4541
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 5.5423
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.4238
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, DRD3, SLC6A3, DRD4, GRIA4 4.8579
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.1082
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.7902
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.6651
Metabolic pathways_Homo sapiens_hsa01100 MGAM, GAA, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.3785
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.3565
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.378
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD1, DRD2, GRM1, EGFR 4.7347
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CHRNA3, PIK3CA, CHRNA7, BCL2, PIK3CB 4.2784
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0579
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.0158
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2, SLC6A3 4.7347
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3565
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.6639
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.2833
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.1028
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.2132
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.6639
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 EDNRA, PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 3.3674
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.4132
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.2246
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, EDNRA, CHRNA7, DRD1, GRM1, EGFR 3.2246
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.2903
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.1697
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.1535
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2948
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.6887
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.1535
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1946
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.7289
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.1369
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.0174
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, SLC6A3, GRIA4 3.1206
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5802
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.7397
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6407
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.3073
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8925
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4219
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.1535
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2959
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3298
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.08
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3298
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.2856
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.2765
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.1644
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.1842
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.1388
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0371
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.1214
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.978
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2405
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2497
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2614
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8011
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3003
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.5797
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3391
Lysosome_Homo sapiens_hsa04142 GAA 0.3616
Axon guidance_Homo sapiens_hsa04360 MET 0.3538
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3839
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3579
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3616
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2, SLC6A3 1.3723
Vascular smooth muscle contraction_Homo sapiens_hsa04270 EDNRA 0.3645
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3216
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3392
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4201
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4208
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6844
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.8486
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5504
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6529
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4332
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4323
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.0512
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8277
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2, SLC6A3 1.1755
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.7592
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.7282
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.1959
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7009
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, PTGS2, PTGS1 1.6212
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7972
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1327
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.452
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8114
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.452
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7886
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4646
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4631
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8523
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8242
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4508
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4495
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8066
Peroxisome_Homo sapiens_hsa04146 XDH 0.4646
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9638
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4766
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4832
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4969
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9747
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4949
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.068
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5095
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0006
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0447
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0122
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0578
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.054
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0322
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.1644
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1644
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2532
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.3144
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.3877
Shigellosis_Homo sapiens_hsa05131 SRC 0.5342
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1388
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.1263
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2022
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2463
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2201
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2201
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.2185
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5947
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.4751
Renin secretion_Homo sapiens_hsa04924 EDNRA, ADORA1 1.2865
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3299
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.5429
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.6887
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2782
Malaria_Homo sapiens_hsa05144 MET 0.6364
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3392
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6496
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.522
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, CHRNA7, GRIA4 2.6714
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.3686
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.6714
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4313
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.704
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7542
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7905
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8306
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7542
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7716
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8392
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7975
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8306
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7809
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8447
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7009
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0323
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1082
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0578


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)