TCM Prescription: Roundworm Stablizing Decoction of Fructus Mume



Prescription Description
Prescription IDTCMF2291
Pinyin NameWu Mei Tang
Chinese Name乌梅汤
English NameRoundworm Stablizing Decoction of Fructus Mume
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH1106 Fructus meliae toosendan 金铃子 TCMH1106
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.1681
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.2551
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 9.87157
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 9.53511
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 9.07032
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GLO1, PIM1, PPARA, TYR, XDH 8.94682
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 8.67704
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 8.29658
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.25385
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, SRC, TYR 7.96905
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, SRC, TOP2A, TYR, XDH 7.85065
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 7.73883
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, PPARA, SRC, XDH 7.38196
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, F2, KDR, SRC 7.24466
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, HCAR2, KDR, MET, MMP9, SRC, XDH 7.04958
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, HCAR2, KDR, MET, MMP9, SRC, XDH 7.02677
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.92011
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 6.9169
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 6.8421
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, KDR, SRC 6.69798
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 6.52868
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR 6.52616
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 6.46961
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 6.41496
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 6.40055
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 6.38019
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, SRC, TYR 6.33272
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, FLT3, MET, SRC 6.33079
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, SRC, TOP2A, XDH 6.27634
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 6.08059
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.00004
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, PPARA, SRC 5.99044
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, SRC 5.98835
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, SRC 5.97501
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIM1, SRC, TOP2A, XDH 5.63544
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, SRC 5.61424
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.6066
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, ERBB2, F2, PPARA 5.60019
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD17B1, HSD17B2 5.58315
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, PPARA 5.54257
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.51752
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, KDR, SRC 5.46041
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.32897
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TOP2A, TYR 5.29972
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 5.28475
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 5.21584
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 5.1058
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, SRC, TOP2A 5.1058
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, ERBB2, F3, MET, SRC, XDH 5.1018
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, SRC, XDH 5.07634
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, SRC, XDH 4.98126
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, SRC, XDH 4.87357
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, F2, HCAR2 4.87357
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 4.85313
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.79224
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, F3, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, SRC 4.791
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, ALOX5, ALPL, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRB, F2, F3, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR 4.791
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, EGFR, ERBB2, F2, F3, FLT3, KDR, MET, SRC, XDH 4.77399
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.62472
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR 4.53971
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.49101
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.47849
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 4.45733
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.4309
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.38225
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F2, F3, FLT3, KDR, MET, MMP9, SRC, XDH 4.34044
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, TYR 4.33495
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 4.28432
[BP] GO:0045776 None ADORA1, ADRB1, DRD2, DRD3, PPARA 4.2626
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, MET 4.21815
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 4.18159
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, MMP2, PPARA, SRC, TYR 3.91361
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, PPARA 3.90986
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MET, MMP9, PIM1, SRC 3.90195
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESRRA, F2, F3, FABP4, FLT3, KDR, MET, MMP2, MMP9, SRC, XDH 3.86785
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, ERBB2, F2, FLT3, IGF1R, KDR, MET, SRC, TOP2A 3.85659
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.83436
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 3.80343
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 3.80343
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, TYR 3.78721
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.78721
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.7793
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.70969
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.68258
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIM1, SRC, TYR 3.68183
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.68183
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.68183
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP4, KDR, MET, PPARA 3.66857
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.60795
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3 3.59409
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.56237
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, EGFR, MMP9, SRC 3.56237
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, SRC, XDH 3.56237
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.56237
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, SRC, XDH 3.52011
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.52011
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.52011
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, SRC, XDH 3.50842
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, SRC, XDH 3.50842
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, SRC 3.50345
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.49126
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, AURKB, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, SRC, TOP2A, XDH 3.47967
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, SRC 3.47967
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, MET 3.43602
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, F2, FABP3, FLT3, HCAR2, PPARA, SRC 3.39957
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR 3.38282
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 3.38282
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, KDR, MET, PPARA, SRC, TOP2A 3.35745
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2 3.34556
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MMP9, PIM1, SRC 3.33141
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.32968
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.29746
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.28403
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 3.28344
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, IGF1R, MET, MMP9, PPARA, SRC, XDH 3.27833
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25526
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.23609
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, SRC, TOP2A, XDH 3.22921
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TOP2A 3.2149
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 3.20189
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, AURKB, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, SRC, TOP2A, XDH 3.16568
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.16568
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, AXL, BCL2, CA2, CACNA1C, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PIM1, SRC, XDH 3.16317
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.15634
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 3.14504
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PIM1, SRC 3.12332
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, EGFR 3.11363
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, EGFR 3.11363
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 3.09067
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2 3.071
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.03724
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.96609
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 2.94915
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F2, MMP2, MMP9, PPARA, SRC, TOP2A 2.94915
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94684
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.94684
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, XDH 2.93642
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC 2.91317
[BP] GO:0009115 None AOX1, XDH 2.90457
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 2.88401
[BP] GO:0019932 second-messenger-mediated signaling ADRB1, CACNA1C, DRD1, DRD2, DRD3, EGFR, KDR 2.88063
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.87893
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.87687
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.87687
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.87373
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.87373
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, SRC, XDH 2.86076
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AXL, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC 2.85522
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.85315
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, SRC, XDH 2.85139
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PPARA, SRC, XDH 2.8124
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.79566
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, SRC, TOP2A, XDH 2.75587
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, AXL, BCL2, CYP1A1, DRD1, DRD2, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, SRC, TOP2A 2.75355
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.75219
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.75016
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, TOP2A 2.74623
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.73906
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, MMP9, PPARA, SRC 2.73024
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.72778
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.72778
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, XDH 2.72085
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.71615
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.71308
[BP] GO:0045927 positive regulation of growth BCL2, CSNK2A1, DRD2, EGFR, ERBB2, F2, PIM1 2.71308
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, DRD1, DRD2, EGFR, ERBB2, ESRRB, F2, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, SRC, XDH 2.71308
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.6826
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.67898
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.67713
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, MMP2, MMP9, SRC, TOP2A 2.63011
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA 2.62741
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.61929
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, AURKB, BCL2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FABP4, FLT3, IGF1R, MMP9, SRC, XDH 2.60291
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.60291
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, F2, MMP9 2.60291
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.59987
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.58147
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.58147
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, DRD3 2.57409
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, MMP2, MMP9, SRC 2.55993
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, AURKB, BCL2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PIM1, PPARA, SRC, XDH 2.54497
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.54066
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.54066
[BP] GO:0046110 None AOX1, XDH 2.54066
[BP] GO:0060160 None DRD2, DRD3 2.54066
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54066
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, SRC 2.52923
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2 2.51788
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F2, PPARA 2.51788
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.50977
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.50621
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.50621
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.49742
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.49742
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.49742
[BP] GO:0009416 response to light stimulus AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, TYR 2.4715
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, PPARA, SRC, TOP2A 2.46903
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR 2.45199
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.45199
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.44186
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, SRC, XDH 2.43466
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.42616
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.42015
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.40729
[BP] GO:0040008 regulation of growth ADRB1, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, ESR2, F2, PIM1 2.40729
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, ERBB2, FABP3, FABP4, MET 2.39369
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.39267
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.39107
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, SRC 2.38055
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.3502
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.3502
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.34282
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34282
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.34073
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.34037
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, DRD2, DRD3, EGFR, ERBB2, F2, HCAR2, SRC 2.33411
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.31183
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, CACNA1C, DRD1, DRD2, DRD3, EGFR, ESR1, F2 2.30985
[BP] GO:0006145 None AOX1, XDH 2.30985
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30985
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30482
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, KDR, MET, PPARA, SRC, TOP2A 2.30482
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.29337
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, BCL2, DRD2, DRD3 2.28601
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.28601
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, DRD1, EGFR, ERBB2, ESR1, FLT3, IGF1R, MMP2, SRC 2.28411
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, KDR, MMP1, MMP9, SRC 2.24955
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, DRD2, EGFR, ERBB2, ESRRB, F2, FLT3, KDR, MMP9, SRC, XDH 2.24955
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.24684
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, SRC, XDH 2.23312
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.22888
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.21931
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.21931
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.21931
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.21117
[BP] GO:0034762 None BCL2, CA2, CACNA1C, DRD1, DRD2, DRD3, F2, MMP9 2.19596
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2 2.1926
[BP] GO:0007189 None ADRB1, DRD1, DRD2, DRD3 2.18437
[BP] GO:0045745 None DRD2, DRD3, F2 2.17649
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, IGF1R, KDR, MET, SRC 2.17643
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.16584
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, MMP9 2.16158
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, PPARA, SRC, TOP2A 2.16017
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.14455
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.14455
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, KDR, MET, MMP1, MMP9, SRC 2.14455
[BP] GO:0021853 None DRD1, DRD2 2.14455
[BP] GO:0010641 None F3, SRC 2.14455
[BP] GO:0090325 None DRD2, DRD3 2.14455
[BP] GO:1904936 None DRD1, DRD2 2.14455
[BP] GO:0042321 None ADORA1, DRD2 2.14455
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, F2 2.14037
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD2, DRD3, EGFR, HCAR2, SRC 2.13928
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3 2.125
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.125
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.125
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, ESRRB, PPARA 2.11623
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, AURKB, BCL2, DRD2, EGFR, ERBB2, ESR1, ESR2, F2, F3, FLT3, MET, MMP9, SRC, XDH 2.11573
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.10693
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, DRD1, DRD2, EGFR, ERBB2, F2, FABP4, FLT3, IGF1R, KDR, MMP9, SRC, XDH 2.10533
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.09138
[BP] GO:0008217 None ADORA1, ADRB1, DRD2, DRD3, PPARA 2.07897
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.07869
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.07869
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 2.07869
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.0729
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.07192
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, ERBB2, F2, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.06402
[BP] GO:0006140 None ADRB1, DRD1, DRD2, DRD3, ESRRB, PPARA 2.06217
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, SRC 2.05873
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.04717
[BP] GO:0045744 None DRD2, DRD3, MET 2.04717
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.04717
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.02114
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, SRC 2.02114
[BP] GO:0003018 None ADORA1, ADRB1, DRD1, EGFR, SRC 2.02114
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.02114
[BP] GO:0010959 None ADORA1, BCL2, CACNA1C, DRD1, DRD2, DRD3, F2 2.02114
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.02114
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.02114
[BP] GO:0042596 None ADRB1, BCL2, DRD1 2.02114
[BP] GO:0007188 None ADORA1, ADRB1, DRD1, DRD2, DRD3 2.02114
[BP] GO:0021843 None DRD1, DRD2 2.02114
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02114
[BP] GO:0046113 None AOX1, XDH 2.02114
[BP] GO:0021830 None DRD1, DRD2 2.02114
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.02114
[BP] GO:0021826 None DRD1, DRD2 2.02114
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.02114
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TOP2A, XDH 2.01704
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, SRC, TOP2A, TYR, XDH 2.87687
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SRC 2.80343
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, GLO1, HCAR2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, SRC, TYR 2.58441
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.53961
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRB1, AKR1B1, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 2.29127
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, F2, F3, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MET, SRC, TYR 2.17525
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.2845
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 17.8665
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TOP2A, TYR, XDH 15.2893
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.3338
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.2297
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 10.1856
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, TOP2A, TYR, XDH 10.1798
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ERBB2, F2, F3, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, SRC, TOP2A, TYR, XDH 9.6064
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.62462
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, PPARA 8.14313
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, TOP2A, TYR, XDH 7.69372
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.1173
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.09155
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.36835
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 6.27634
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.23975
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 6.06025
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.58315
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.58315
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.51752
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 5.5021
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 5.48764
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.29972
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 5.28475
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.96064
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 4.84829
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.68186
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.50261
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1 4.10346
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 4.05747
[MF] GO:1901338 None ADRB1, DRD1, DRD2, DRD3 3.99067
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.94991
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.94991
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.6109
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD17B1, PPARA 3.56237
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.38282
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.38282
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.03724
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.00909
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, IGF1R, KDR, MET 2.94915
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HCAR2, IGF1R, KDR, MET 2.94915
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.94684
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.90457
[MF] GO:0008389 None CYP2A13, CYP2A6 2.90457
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, TOP2A, TYR, XDH 2.86076
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, SRC 2.78873
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.58423
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.54066
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRB1, AXL, BCL2, DRD2, EGFR, ERBB2, TOP2A, TYR 2.53961
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.44186
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, SRC 2.40729
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30985
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.30985
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.30985
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD17B1, HSD17B2, XDH 2.21931
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.17195
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3 2.16818
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.14455
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.14455
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02114
[MF] GO:0043546 None AOX1, XDH 2.02114


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.66
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8356
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.5415
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.9296
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 6.3762
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.5928
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 5.5928
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2 4.9927
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.3827
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 4.3695
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, ADRB1, CACNA1C, DRD1, DRD2, PPARA 4.4289
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 4.4207
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.5931
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, CYP2A6, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.6716
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, DRD1, DRD2, EGFR 4.1039
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, ADRB1, DRD1, F2, DRD2, DRD3 3.6696
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR 3.5002
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, EGFR, IGF1R 3.4046
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1277
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.9948
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.3779
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.3671
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.9731
Calcium signaling pathway_Homo sapiens_hsa04020 ERBB2, ADRB1, CACNA1C, DRD1, EGFR 2.8477
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.8111
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.9527
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3671
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR, IGF1R 2.7937
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C, DRD1, DRD2, DRD3 2.4667
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.1153
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.4667
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, EGFR, IGF1R 1.8085
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2061
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2008
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.02
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2476
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.311
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.7452
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.7238
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.0114
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5105
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4759
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6906
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6807
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.4686
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.426
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.426
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 1.1559
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, CACNA1C 0.9846
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.8831
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9626
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8505
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8831
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1288
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.3302
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9626
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9626
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8554
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8505
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1311
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1424
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.426
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.3277
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3747
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2186
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.118
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6615
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4661
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C, DRD1 1.3277
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7375
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7375
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.2152
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4227
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2877
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR 0.5651
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3206
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4893
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3471
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3602
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3706
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3466
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3706
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4023
Apoptosis_Homo sapiens_hsa04210 BCL2 0.419
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4171
Measles_Homo sapiens_hsa05162 CSNK2A1 0.426
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.4154
Platelet activation_Homo sapiens_hsa04611 SRC 0.4522
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4543
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4522
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4522
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4759
Axon guidance_Homo sapiens_hsa04360 MET 0.4468
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4759
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4662
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4543
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5006
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5006
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5006
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5006
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5006
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5006
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5006
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5006
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5006
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5167
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5091
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5085
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5006
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5091
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5167
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5114
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5091
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5107
Peroxisome_Homo sapiens_hsa04146 XDH 0.5167
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5248
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5167
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5411
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5544
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5691
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5411
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5691
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5691
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5807
Shigellosis_Homo sapiens_hsa05131 SRC 0.5691
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5766
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.583
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5766
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7352
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6366
Malaria_Homo sapiens_hsa05144 MET 0.648
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6517
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6517
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8652
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6517
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.309
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7066
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0323
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7899
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.823
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7815
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7375
Base excision repair_Homo sapiens_hsa03410 APEX1 0.766
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7734
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7986
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.828
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.823
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.03
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3277


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)