TCM Prescription: Stone Remover Decoction



Prescription Description
Prescription IDTCMF2259
Pinyin NameChai Hu Yu Jin Pai Shi Tang
Chinese Name柴胡郁金排石汤
English NameStone Remover Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1063 Curcuma longa 姜黄 TCMH1063 ITSAP2805-14
TCMH810 Paeonia albiflora 杭芍 TCMH810 MF096543
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1450 Natrii sulfas 芒硝 TCMH1450
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT962 ENPP2 Autotaxin Hydrolase Q13822
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.053
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.053
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 15.7898
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 14.1355
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 13.7976
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TYR 12.8613
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 12.2494
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 11.871
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TYR 11.6985
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC, TYR 11.1691
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.8044
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, TYR 10.691
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 10.6835
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 10.5729
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, KIT, MMP2, PIK3CA, POLB, PPARA, PTGES, PTGS2, RELA, SRC, TYR 10.5729
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 10.5484
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 10.3274
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 9.86767
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC, TYR 9.3916
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.3916
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FUT7, HSD17B3, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.3916
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 9.23717
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC 9.0105
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TOP1, TYR 8.83915
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 8.78178
[BP] GO:0019371 None AKR1C3, CBR1, PTGES, PTGS1, PTGS2, TBXAS1 8.78178
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC, TOP1, TYR 8.77363
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 8.73399
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PIK3CA, POLB, PPARA, PTPRS, RELA, SRC, TYR 8.56818
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 8.56818
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PTGS2, RELA, SRC, TOP1 8.48025
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PPARA, PTGS2, RELA, SRC 8.43109
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 8.42693
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 8.12228
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PPARA, PTGS2, RELA, SRC 7.8662
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.85055
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, AR, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, RELA, SRC, XDH 7.8179
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 7.58052
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C 7.50048
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.00306
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 6.97479
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.89252
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.89252
[BP] GO:0007187 None CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.75004
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 6.61705
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, PTPRS, RELA, SRC, TNKS2, TYR 6.59849
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, XDH 6.44437
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SRC, XDH 6.44361
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 6.43777
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, RELA 6.37514
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.1556
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, RELA, SRC 6.14603
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.12786
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.12786
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 6.05082
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 6.04149
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, PIK3CB, PIM1, POLA1, SRC, TYR 6.03734
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 6.03003
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 5.59187
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 5.58212
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, RELA, SRC 5.57464
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, PTGS2 5.41769
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 5.38341
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGES, RELA, SRC, TNKS, TNKS2 5.33698
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SRC, XDH 5.28914
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC 5.2806
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, KIT, MAP2K1, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, RELA, SRC, TYR 5.22574
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 5.19268
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.19268
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CHRM2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.18266
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 5.1732
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HSD17B3, HTR1A, MAOA, TYR 5.15677
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CB, PPARA, PTGS2, SRC 5.12946
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.10678
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.06222
[BP] GO:0007193 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.05876
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPRS, SRC, TNKS, TOP1, XDH 5.001
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC, XDH 4.9967
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 4.88642
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 4.87379
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC 4.81488
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.79022
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TNKS, TOP1 4.63944
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 4.63944
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPRS, SRC, TNKS, TOP1, XDH 4.61897
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, RELA, SRC 4.61533
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.58536
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SRC 4.55817
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 4.47058
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC 4.40345
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.40345
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 4.34929
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.33767
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.32981
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.32981
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.32981
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.277
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 4.26491
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.26178
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, POLB, PPARA, PTGS2, RELA, SRC, TYR 4.25939
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, SRC 4.25491
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.22362
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.21011
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.20158
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.18392
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.18392
[BP] GO:0007188 None CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.16553
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, RELA 4.14543
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 4.12578
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.12578
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, RELA, SRC 4.09201
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, SRC, XDH 4.08422
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS, TOP1 4.08422
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.07545
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.05461
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 4.01626
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 3.97875
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 3.97804
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.95884
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 3.95154
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.95154
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.95154
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.95154
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, POLB, PTGS2, RELA 3.93763
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 3.93305
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 3.93305
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.87371
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.86338
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 3.81421
[BP] GO:0007154 None AKR1C3, AR, AXL, BCL2, CACNA1C, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.79847
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.78128
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.78128
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B2, HSD17B3, KIT, MAP2K1, MMP2, MMP9, PTGS2, SRC 3.70923
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 3.70005
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, AR, BCL2, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 3.70005
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.67705
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 3.6373
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.63672
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.63228
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.62744
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.62744
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.61716
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, PTGS2, SRC 3.57275
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.53474
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 3.5205
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A6, CYP2D6 3.4941
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A6, CYP2D6 3.4941
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.4941
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TYR 3.46756
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 3.46756
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TYR 3.44585
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.44585
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 3.44
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 3.4204
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 3.41952
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.41952
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.41791
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.36723
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.34922
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.3248
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.3248
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.3248
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 3.32402
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, KIT, PPARA, SRC, TOP1 3.31601
[BP] GO:0006693 None AKR1C3, PTGES, PTGS1, PTGS2 3.29856
[BP] GO:0006692 None AKR1C3, PTGES, PTGS1, PTGS2 3.29856
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC 3.29472
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.29465
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 3.25488
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, TOP1, XDH 3.25289
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.25218
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.23979
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.23979
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.17927
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP1 3.17736
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 3.17494
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.15529
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.15446
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.15446
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.15446
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, ESR1, F10, F3, FLT3, FUT7, HTR1A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.15015
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.13792
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.12663
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.11765
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, RELA, SRC 3.10874
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.10874
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.10564
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PTGS2, SRC, TYR 3.10105
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.08978
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, POLB, TYR 3.07561
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.07561
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.07561
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.07561
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, RELA, SRC 3.06614
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.06564
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.06564
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.06564
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CNR1, CYP1B1, ESR1, F3, HTR2A, HTR2B, HTR2C, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, RELA, SRC, TNKS2, XDH 3.0565
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTGS2, RELA, SRC 3.0565
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.04663
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SRC, TNKS, XDH 3.04378
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.00944
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1 3.00484
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, TYR 2.98972
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TYR 2.98361
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.97214
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, PIM1, PPARA, RELA, SRC 2.97214
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.95822
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.95822
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.95822
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HSD17B3 2.95132
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TNKS, XDH 2.92845
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAP2K1, MMP9, PIK3CB, PPARA, PTGS2, SRC 2.9159
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.90852
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, CACNA1C, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.90741
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, HTR1A, MAOA 2.87926
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.87175
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PTGS2, PTPRS, RELA, SRC, XDH 2.8368
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.8368
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 2.8368
[BP] GO:0007208 None HTR2A, HTR2C 2.8368
[BP] GO:0016488 None AKR1B10, AKR1C3 2.8368
[BP] GO:0016487 None AKR1B10, AKR1C3 2.8368
[BP] GO:0016107 None AKR1B10, AKR1C3 2.8368
[BP] GO:0006714 None AKR1B10, AKR1C3 2.8368
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AR, AURKB, BCL2, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, RELA, SRC, TNKS, XDH 2.83516
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.82973
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 2.82379
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TNKS 2.7952
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, MAOA 2.79335
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.78716
[BP] GO:0043406 positive regulation of MAP kinase activity FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 2.77466
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.77062
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.77062
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.77062
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.76319
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, PTGS2, RELA, TYR 2.75619
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SRC, XDH 2.75619
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC 2.7504
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, HSD17B3, PTGES, PTGS1, PTGS2 2.74989
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, MAOA, TYR 2.74793
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 2.74793
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2 2.72229
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.69734
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.68138
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 2.67919
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.64953
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, POLB, RELA, SRC 2.6234
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.60524
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SRC 2.60524
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KDR, PTGS2, RELA, SRC 2.59727
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 2.59626
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.5711
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.56622
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.55586
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, PPARA, PTGS2, PTPRS, RELA 2.55161
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.54307
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 2.54307
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.54307
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.5253
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.5253
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.5253
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC 2.52206
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.47383
[BP] GO:0008217 None AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.45817
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 2.45656
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.44883
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, KIT, MAP3K7, PIM1, RELA 2.43714
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43315
[BP] GO:0016095 None AKR1B10, AKR1C3 2.43315
[BP] GO:0023052 None AR, CACNA1C, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.42264
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.41691
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.38491
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.38428
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 2.38428
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.31891
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31661
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.30623
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, HSD17B3, TYR 2.28041
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.25659
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.21366
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.21251
[BP] GO:0007267 None AR, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.20341
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.19159
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TUBB3 2.17104
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.17104
[BP] GO:0070213 None TNKS, TNKS2 2.16133
[BP] GO:0038171 None CNR1, CNR2 2.16133
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.16133
[BP] GO:0014827 None HTR1D, HTR2B 2.16133
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.14869
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.14231
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 2.13623
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.12366
[BP] GO:0009605 response to external stimulus AKR1C3, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, KIT, PTGES, PTGS2, RELA, SRC, TYR 2.12195
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.09986
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.09986
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.09986
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.09223
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.09223
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, RELA, SRC 2.08652
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, XDH 2.08652
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.07932
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.07886
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.07402
[BP] GO:0051338 regulation of transferase activity APP, AURKB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC, TNKS 2.07039
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.06098
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.06098
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.06022
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.05914
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.05131
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05131
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, KDR, KIT, MAP2K1, PTGS2, RELA 2.04901
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, ESR1, KIT, PTGS2, SRC 2.04591
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.03713
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PIK3CB, SRC 2.03412
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.03412
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA, RELA 2.02914
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TYR 8.42278
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TYR 6.23422
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F10, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC 6.15819
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, CHRM2, CNR1, CNR2, F10, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 6.12559
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, F10, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTGS2, PTPRS, SRC 5.51633
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 4.58927
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.3248
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, TBXAS1 2.99448
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, F10, FLT3, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, TBXAS1 2.98104
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, AR, AURKB, BCL2, CA2, CA4, CA7, CACNA1C, CBR1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR4, HTR5A, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 2.85646
[CC] GO:0031224 None ABCB1, ACHE, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, ESR1, F10, F3, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PTGES, PTPRS, TBXAS1, TYR 2.54823
[CC] GO:0031233 None CA4, F10, F3 2.25231
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.053
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.053
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.053
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.053
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7374
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGES, PTGS1, PTGS2, PTPRS, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 15.2994
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.5257
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 11.0883
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, F10, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGES, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 10.7232
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.6393
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.3274
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, TBXAS1, TNKS, TYR, XDH 9.46025
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.24763
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TYR, XDH 8.48508
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1 7.95954
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 7.8697
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGS1, PTGS2, TBXAS1, TYR 7.46076
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 7.00306
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B2, HSD17B1, NQO2, POLA1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 6.89942
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, TBXAS1, TYR 6.88261
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.79217
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC, TBXAS1 6.74287
[MF] GO:0038023 signaling receptor activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.61705
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6 6.38559
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.28958
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, TBXAS1, XDH 6.18046
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.12786
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.12786
[MF] GO:0004871 signal transducer activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA 6.12559
[MF] GO:0004872 receptor activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 5.66552
[MF] GO:0060089 molecular transducer activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 5.41769
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.37958
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.37958
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 5.09155
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.03516
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.57163
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.2884
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TOP1 3.86338
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.76428
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.75137
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.70005
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.69716
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.67638
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TOP1 3.63938
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, F10, KIT, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TYR, XDH 3.63938
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, SHBG 3.61651
[MF] GO:0097159 organic cyclic compound binding ABCB1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, RELA, SHBG, SRC, TBXAS1, TOP1, TUBB3, XDH 3.37294
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.28641
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTPRS, RELA, SRC, TOP1, TUBB3, XDH 3.27504
[MF] GO:0004930 None ADORA3, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.21525
[MF] GO:1901363 heterocyclic compound binding ABCB1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, RELA, SRC, TBXAS1, TOP1, TUBB3, XDH 3.04594
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.95822
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6, CYP2D6 2.91561
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 2.85325
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.8368
[MF] GO:0045550 None AKR1B10, AKR1C3 2.8368
[MF] GO:0003845 None HSD11B1, HSD11B2 2.8368
[MF] GO:0071886 None HTR2A, HTR2C 2.8368
[MF] GO:0005496 steroid binding AR, ESR1, HSD11B2, HSD17B1, SHBG 2.5605
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 2.54307
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, SHBG 2.53451
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.43315
[MF] GO:0047718 None AKR1B10, AKR1C3 2.43315
[MF] GO:0004949 None CNR1, CNR2 2.43315
[MF] GO:0047045 None AKR1C3, HSD17B3 2.43315
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, TNKS 2.42434
[MF] GO:0005497 None AR, SHBG 2.16133
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.14869
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.14833
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.07955
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.07935


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, CYP2D6, ALOX5 24.4268
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.4359
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 11.3033
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 10.4359
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, MAP2K1, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA, HTR6, PIK3CA, PPARA 9.9821
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 8.2558
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, AKR1C3, PTGS2, PTGES, PTGS1 8.2558
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET 7.5381
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA 7.0742
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.5622
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, CACNA1C, HTR2A, HTR5A, HTR4 5.988
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.3876
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 5.8824
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.5824
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 8.7254
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.5914
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 5.5333
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.068
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.5914
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 5.389
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, KIT, KDR, PIK3CB, MET, RELA, IGF1R 5.3493
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.3956
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 4.8681
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET 5.4162
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 5.3082
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.8033
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 4.7226
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.6297
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 4.5447
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, TUBB3, HTR2B, HTR2C, HTR2A 4.8589
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.5441
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.2165
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, PIK3CB, RELA 4.1869
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.6289
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.2241
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.5902
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 4.1813
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 3.8844
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.1049
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.8204
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.4263
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.4558
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.6674
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.2005
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.2256
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.1903
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 3.1131
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.0746
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 2.9867
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.0373
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, IGF1R 3.1903
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, BCL2, PIK3CB 3.2427
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, CACNA1C, PIK3CB 2.6792
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.1903
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.5464
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 3.0686
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.1903
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.4915
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.7467
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 2.8066
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.6457
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB, RELA 2.3398
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 3.0686
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.7005
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, PIK3CA, SRC, PIK3CB 2.27
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA, RELA 2.4927
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2 3.1319
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1319
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9801
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3839
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.229
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, MAP3K7, IGF1R 2.3227
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, RELA 2.229
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.9897
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.1533
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, KIT, PIK3CB 2.1367
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 2.1019
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA, RELA 2.0783
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2851
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.0184
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3106
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA 1.8775
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.9252
Axon guidance_Homo sapiens_hsa04360 MET 0.3693
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4027
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA 1.4031
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6739
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4283
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3717
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4391
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB, RELA 1.3946
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6655
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4556
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6994
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4544
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4556
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8097
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1, PIK3CA, PIK3CB 1.4399
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.4689
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7989
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4697
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.5629
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4697
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.1885
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.7747
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4697
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4782
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.8505
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2229
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4798
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.7747
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.7719
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.8474
Peroxisome_Homo sapiens_hsa04146 XDH 0.4857
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8931
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4893
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4857
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.7459
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5005
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.7719
Pertussis_Homo sapiens_hsa05133 RELA 0.5122
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5144
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5144
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0373
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.1686
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.1019
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.5604
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1128
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1128
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5604
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2275
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.5574
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1686
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB 2.3598
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.2137
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.4409
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1885
Legionellosis_Homo sapiens_hsa05134 RELA 0.6126
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6126
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.267
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.263
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.263
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.267
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3029
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2946
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6362
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6411
Malaria_Homo sapiens_hsa05144 MET 0.6461
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3113
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3717
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3717
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.5236
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6596
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3946
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3739
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6767
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.7491
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.501
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7086
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.756
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5629
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8167
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5488
DNA replication_Homo sapiens_hsa03030 POLA1 0.7476
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7989
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8428
Base excision repair_Homo sapiens_hsa03410 POLB 0.7768
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8505
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8539
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8428
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.755
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8085
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8775
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7399
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8784
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.057
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0152
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0901
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2626


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)