TCM Prescription: Zhouju Pill



Prescription Description
Prescription IDTCMF2252
Pinyin NameZhou Ju Wan
Chinese Name
English NameZhouju Pill
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1662 Pharbitis nil 牵牛子 TCMH1662
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH661 Euphorbia kansui 甘遂 TCMH661
TCMH2378 Daphne genkwa 芫花 TCMH2378
TCMH371 Radix euphorbiae pekinensis 大戟 TCMH371 ITSAJ4306-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1679 Calomelas 轻粉 TCMH1679
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.7285
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.7285
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, MCL1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TNKS, TNKS2, TRPV1, XDH 11.6819
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 10.4151
[BP] GO:0007187 None CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 10.3943
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MCL1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, TRPV1, TYR 9.06068
[BP] GO:0007193 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.45682
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2, TRPV1, TYR 8.12725
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.07186
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, TYR 7.9512
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.71614
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, MCL1, MMP2, PIK3CA, PPARA, PTGS2, TRPV1, TYR 7.47532
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.44764
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 7.19866
[BP] GO:0007188 None CHRM1, CHRM2, CHRM4, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 7.16066
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.1137
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.1137
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, TRPV1, TYR 7.0415
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX15, ALOX5, ALPL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MCL1, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, TNKS2, TRPV1, TYR 6.8941
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.83227
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.83227
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.81879
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2, TRPV1 6.75586
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.63569
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.60536
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 6.60536
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.60536
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.60536
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.29032
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.25098
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.0792
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.0792
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.98709
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.95512
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.95512
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 5.6125
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 5.58606
[BP] GO:0097746 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.57093
[BP] GO:0035296 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.57093
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 5.45754
[BP] GO:0050880 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.39046
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2, TRPV1 5.39046
[BP] GO:0035150 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.39046
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2, TRPV1 5.3847
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.3847
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C 5.35385
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.30906
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MCL1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1, TYR 5.12044
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.97596
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.94431
[BP] GO:0003018 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.94431
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CNR1, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2, TNKS, TNKS2, TRPV1 4.94431
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 4.94049
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.7954
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.77945
[BP] GO:0007154 None BCL2, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, TRPV1 4.56252
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.48927
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CHRM1, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, MMP12, MMP2, MMP9, PIM1, PTGS2 4.46944
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 4.42395
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, XDH 4.4143
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.37014
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.37014
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 4.24735
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C 4.19293
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, TRPV1 4.15326
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.15326
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 4.15326
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.15326
[BP] GO:0003013 None CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.12471
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, TNKS, TNKS2, TRPV1 4.02083
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.98933
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MCL1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, TNKS, TNKS2, TRPV1 3.94981
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.88078
[BP] GO:0007267 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.78618
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 3.76831
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 3.76831
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, TNKS, TNKS2, TRPV1, XDH 3.74288
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.70419
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.69675
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 3.67694
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.66822
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, MCL1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, TNKS2, TYR 3.62453
[BP] GO:0042592 homeostatic process AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MCL1, PIK3CA, PIK3CB, TRPV1 3.61043
[BP] GO:0003008 None AKR1B1, BCL2, CHRM1, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, TRPV1, TYR 3.5067
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 3.45039
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.43033
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.43033
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PTGS2 3.36573
[BP] GO:0023052 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.36399
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.33152
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MCL1, PIK3CA, PIK3CB, PTGS2, XDH 3.32505
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.29668
[BP] GO:0090066 None ALOX15, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.28287
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 3.24839
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C 3.21054
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.20518
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.10032
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, TRPV1 3.07988
[BP] GO:0051049 regulation of transport ACHE, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PTGS2, TRPV1 3.07988
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 3.07988
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, TNKS, TNKS2, TRPV1, XDH 3.03922
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2, TRPV1, TYR 3.02624
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.02586
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.02586
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.02299
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D 3.02299
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.99516
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2 2.96003
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HTR1A, TYR 2.92873
[BP] GO:0008283 cell proliferation ACHE, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, HTR1A, PIK3CB, PIM1, TYR 2.90248
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.88556
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 2.88257
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88257
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.86967
[BP] GO:0007610 None BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, TRPV1 2.85436
[BP] GO:0007208 None HTR2A, HTR2C 2.85105
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.83685
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.83529
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2 2.80252
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2, TRPV1, TYR 2.74909
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, TRPV1 2.73397
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, TRPV1 2.73397
[BP] GO:0010941 regulation of cell death AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, TRPV1, XDH 2.67523
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, PIK3CA 2.63743
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.63743
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.63743
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, MMP2, MMP9, PIK3CA, PTGS2, TRPV1 2.61099
[BP] GO:0009628 response to abiotic stimulus AKR1B1, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2, TRPV1, TYR 2.59158
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PTGS2, TRPV1 2.58771
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.57899
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.57555
[BP] GO:0042981 regulation of apoptotic process AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, TRPV1, XDH 2.55135
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, MCL1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, TYR 2.54709
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.51777
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.50781
[BP] GO:0043067 regulation of programmed cell death AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2B, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, TRPV1, XDH 2.50781
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, PIK3CA, PPARA, TYR 2.50051
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.49649
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, CHRM1, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.47865
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44661
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, MMP2, PIK3CA, PTGS2, TRPV1 2.39912
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.38394
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, TRPV1 2.38394
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, PTGS2, TRPV1, TYR 2.33753
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.33104
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32611
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, ALOX15, BCL2, CA1, CA12, CA2, CA7, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MCL1, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, TNKS, TNKS2, TRPV1, XDH 2.31786
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.31163
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.28643
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, MCL1, PIK3CA, PIK3CB, TRPV1 2.28509
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.27812
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, TRPV1 2.25806
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, TRPV1, TYR 2.24779
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.23263
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, PIK3CA 2.23263
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.23263
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23263
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.23263
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, TRPV1 2.22645
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.22645
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.21188
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MCL1, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.21188
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MCL1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 2.21188
[BP] GO:0070213 None TNKS, TNKS2 2.21188
[BP] GO:0038171 None CNR1, CNR2 2.21188
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21188
[BP] GO:0014827 None HTR1D, HTR2B 2.21188
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.20513
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.2027
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2027
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.19101
[BP] GO:0006936 None HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, TRPV1 2.15234
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.10341
[BP] GO:0009991 response to extracellular stimulus ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, TRPV1, TYR 2.09843
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MCL1, PIK3CA 2.08367
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.08122
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.06239
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 2.05936
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.05936
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.0527
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.04911
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.02906
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.02906
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.02906
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.01384
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MCL1, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TRPV1, TYR 6.9015
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MCL1, MPEG1, PIK3CA, PIK3CB, PTGS1, PTGS2, TBXAS1, TRPV1, TYR 6.04064
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, TRPV1 5.10603
[CC] GO:0005887 integral component of plasma membrane ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, TRPV1 4.70866
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PIM1, TRPV1 3.97372
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2, TRPV1 3.46366
[CC] GO:0031224 None ACHE, ADORA3, ALPL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, ESR1, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MCL1, MPEG1, TBXAS1, TRPV1, TYR 2.80362
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.33753
[CC] GO:0016021 None ADORA3, ALPL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, ESR1, FLT3, FUT7, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MCL1, MPEG1, TBXAS1, TRPV1, TYR 2.31163
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 21.0823
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.5026
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.7285
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.7285
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.3997
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.3997
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.8918
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.6688
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, TBXAS1, TNKS, TYR, XDH 11.5634
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4817
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.2606
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 9.27063
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 8.77047
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.89061
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.55735
[MF] GO:0038023 signaling receptor activity ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, TRPV1 6.16227
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR 6.04628
[MF] GO:0004930 None ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.03826
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 5.95793
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.70186
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TBXAS1 5.46899
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.42914
[MF] GO:0099600 transmembrane receptor activity ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, TRPV1 5.39046
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, TRPV1 5.39046
[MF] GO:0004872 receptor activity ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, TRPV1 5.39046
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TBXAS1 5.29438
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.21597
[MF] GO:0060089 molecular transducer activity ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, TRPV1 5.1953
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 5.12044
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, TBXAS1, XDH 4.87525
[MF] GO:0004871 signal transducer activity ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, TRPV1 4.7596
[MF] GO:0008144 drug binding ACHE, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, TRPV1 4.70866
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, ALOX15, ALOX5, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TYR, XDH 4.41133
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, TNKS 4.15326
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.15326
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.12471
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.56553
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.5067
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.39423
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.38891
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.33725
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 3.06533
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85105
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85105
[MF] GO:0071886 None HTR2A, HTR2C 2.85105
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.50202
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.48002
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.44661
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.44661
[MF] GO:0004949 None CNR1, CNR2 2.44661
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.31163
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21188
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21188
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.10341
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.06239
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.02906
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.02906


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 17.9714
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, HTR1E, CHRM4, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, TRPV1, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 16.5632
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 11.2125
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, CHRM1, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 9.0479
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.6863
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1 8.3126
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 6.965
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, BCL2, PIK3CB 5.9722
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.4876
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, TRPV1, HTR2A 5.0683
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.4876
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.9714
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 4.7836
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.8274
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.4618
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 3.8416
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.5556
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MCL1 3.5047
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.586
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB, MCL1 3.0768
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.0768
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3289
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0532
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.6712
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7082
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, BCL2, PIK3CB, MCL1 2.5476
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, CHRM4, PIK3CB 2.6214
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.6356
Platelet activation_Homo sapiens_hsa04611 PIK3CA, TBXAS1, PIK3CB, PTGS1 2.62
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6356
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.6214
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB, MCL1 2.4438
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, BCL2, PIK3CB, MMP9 2.398
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.871
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.4508
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.9555
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.8383
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8545
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4438
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.0739
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1 2.3076
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1868
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB 2.3875
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 1.9226
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.863
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2C, HTR2A 2.0783
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4045
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7645
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0293
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.776
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6503
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.6453
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5656
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5552
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.5168
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.4669
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB 1.2892
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.3319
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.2278
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3 0.2406
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3541
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3447
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3639
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3537
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB 1.2053
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2278
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4231
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4191
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6293
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0195
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4129
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.2278
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.2729
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.0184
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0117
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB 0.983
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9767
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 0.9944
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1969
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.7713
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.0623
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2053
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1969
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.4309
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4759
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8639
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.8517
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.4364
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.188
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1786
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4309
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.1969
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.188
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3914
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.8286
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3914
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.4022
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.4309
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5187
Melanogenesis_Homo sapiens_hsa04916 TYR 0.534
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4022
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5339
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.3436
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5656
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5461
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5456
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.5586
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4022
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5591
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5604
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.4072
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5597
Peroxisome_Homo sapiens_hsa04146 XDH 0.5789
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6191
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6191
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.6191
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6293
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6174
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6478
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6453
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6885
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7426
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7713
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1318
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9179
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8671
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9087
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8996
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8639
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9686
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9574
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1976
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.188


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)