TCM Prescription: Lung Dispersing Interior Modulation Recipe



Prescription Description
Prescription IDTCMF2194
Pinyin NameXie Fei Tiao Zhong Fang
Chinese Name
English NameLung Dispersing Interior Modulation Recipe
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH78 Platycodon grandiflorum 白桔梗 TCMH78 ITSAJ4293-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, POLA1, POLB, PPARA, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 10.4134
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, SLC6A3, SRC, TYR 9.51469
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, POLB, PPARA, SLC6A3, SRC, TYR 9.0003
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, POLB, PPARA, SLC6A2, SLC6A3, SRC, TYR 8.80862
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 7.66013
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.50125
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, FLT3, HSD11B2, SLC6A3, SRC, TYR 6.46766
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, FABP3, HSD11B2, KDR, POLB, SLC6A2, SLC6A3, SRC 6.40668
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.34691
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.34691
[BP] GO:0007193 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 6.23479
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 6.19513
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.0221
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 5.87529
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SLC6A3, SRC 5.76998
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.76079
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, KDR, POLB, SLC6A3, SRC 5.56439
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.49331
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, GBA2, SLC6A3, TYR 5.43937
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PIM1, PPARA, TBXAS1, TYR, XDH 5.14932
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, PTPRS, SRC, TYR 5.11208
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 5.01189
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.97928
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, DRD2, DRD3, DRD4, GRIK5, GRM1, GRM3, GRM5, GRM8 4.97928
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, SLC6A3, TYR 4.97928
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.88315
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SLC6A2, SLC6A3, SRC, TNKS2, TYR 4.87587
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.87483
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.85055
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.76028
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.71253
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SLC6A2, SLC6A3, SRC, TYR 4.61136
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.6106
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.6106
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SLC6A3, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 4.53649
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.50478
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, SLC6A3, SRC, TNKS2, TYR 4.48138
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.47132
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SLC1A1, SLC6A3, SRC, TNKS, TNKS2, XDH 4.44692
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, GBA2, MET, PPARA, TBXAS1 4.41341
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.35972
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, POLA1, POLB, SRC 4.35972
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SRC 4.32081
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.31344
[BP] GO:0007188 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.31344
[BP] GO:0007268 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.27448
[BP] GO:0098916 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.27448
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 4.24735
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.23263
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.22786
[BP] GO:0099536 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.21647
[BP] GO:0099537 None CHRM2, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 4.21647
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.19821
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, POLB, PPARA, PTPRS, SLC6A3, SRC, TYR 4.13944
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SLC6A3, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 4.12883
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.09109
[BP] GO:1900543 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.09109
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.09109
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, SLC6A2, SLC6A3 4.0905
[BP] GO:0045980 None DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 4.0692
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 3.92739
[BP] GO:0007187 None CHRM2, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 3.91427
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 3.90189
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, GRIK5, SLC1A1, SLC6A2, SLC6A3 3.87801
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.83937
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.83937
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, F3, FLT3, GRM1, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.80191
[BP] GO:0030818 None DRD2, DRD3, DRD4, GRM3, GRM8 3.79752
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, SLC6A3 3.78891
[BP] GO:0030803 None DRD2, DRD3, DRD4, GRM3, GRM8 3.72125
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 3.71464
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 3.68593
[BP] GO:0030815 None DRD2, DRD3, DRD4, GRM3, GRM8 3.6539
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 3.6539
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2 3.63132
[BP] GO:1900372 None DRD2, DRD3, DRD4, GRM3, GRM8 3.63099
[BP] GO:0030809 None DRD2, DRD3, DRD4, GRM3, GRM8 3.63099
[BP] GO:0030800 None DRD2, DRD3, DRD4, GRM3, GRM8 3.59038
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, PPARA, SRC 3.58683
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD3, DRD4, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.57521
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD3, DRD4, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.52273
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, DRD2, DRD3, KDR, SRC, TNKS, TNKS2 3.48181
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 3.46813
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.45317
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.42582
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, SRC 3.41092
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.40292
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, POLA1, POLB, PTPN1, SRC 3.38558
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 3.38558
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD2, DRD3, DRD4, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, PPARA, SLC6A3, SRC, TYR 3.38558
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, SRC 3.35131
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.32118
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.32118
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.32118
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD2, GRM1, GRM3, GRM5, GRM8 3.31537
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, SLC6A3 3.26196
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25932
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, DRD4, F3, FLT3, GRM1, KDR, MET, PTPN1, SRC, XDH 3.24751
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.24104
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESRRA, F3, FABP4, FLT3, GRM1, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.24104
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.15137
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTPN1, PTPRS, SLC6A3, SRC, TNKS, TNKS2, XDH 3.12454
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 3.09258
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.08517
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, SLC6A3, TNKS2 3.08517
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.08517
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.04938
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.04938
[BP] GO:0007194 None DRD2, DRD3, DRD4, GRM3 3.03701
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, POLA1, SRC, TYR 3.03206
[BP] GO:0031280 None DRD2, DRD3, DRD4, GRM3 2.93459
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, F3, GRIK5, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 2.93048
[BP] GO:0034776 None DRD2, DRD3, DRD4 2.92606
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.92593
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 2.90232
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, XDH 2.90232
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.88128
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.86453
[BP] GO:0051350 None DRD2, DRD3, DRD4, GRM3 2.86247
[BP] GO:0060078 None DRD4, GRIA2, GRIA4, GRIK5, GRM5 2.83297
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.82168
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 2.78882
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, TBXAS1 2.76472
[BP] GO:0009115 None AOX1, XDH 2.75415
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC 2.75027
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.75027
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.75027
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, PPARA, SRC 2.74311
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.73585
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.73585
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 2.72495
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A3, SRC, TBXAS1, TNKS, TNKS2, TUBB3, TYR, XDH 2.67847
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SLC6A3, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.66817
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66522
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.66522
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, XDH 2.66522
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, DRD2, DRD4, ESRRB, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.63526
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.59303
[BP] GO:0007154 None AXL, BCL2, CHRM2, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.57843
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, GRM1, HSD11B2, MMP2, POLB, PPARA, SRC, TYR 2.5766
[BP] GO:0007267 None CHRM2, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.55989
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, TNKS, TNKS2 2.55989
[BP] GO:0045761 None DRD2, DRD3, DRD4, GRM3 2.54824
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.54399
[BP] GO:0022898 None ABCB1, BCL2, DRD2, DRD3, DRD4, GRM5, MMP9 2.54399
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.5132
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.5132
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, SRC 2.49334
[BP] GO:1900542 None DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8, PPARA 2.48448
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.47643
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, PTPRS, SLC6A3, SRC, TNKS, TNKS2, TYR, XDH 2.46325
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.44452
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3 2.44452
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CDK6, CYP19A1, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PTPN1, PTPRS, SLC6A3, SRC, XDH 2.42788
[BP] GO:0030817 None DRD2, DRD3, DRD4, GRM3, GRM8 2.42788
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, BCL2, CDC25B, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.41926
[BP] GO:0006140 None DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8, PPARA 2.41918
[BP] GO:0032409 None ABCB1, BCL2, DRD2, DRD3, DRD4, GRM5, MMP9 2.40974
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.39031
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.38911
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, DRD2, DRD4, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.38911
[BP] GO:0099566 None GRM1, GRM5 2.38911
[BP] GO:0051944 None DRD2, DRD4 2.38911
[BP] GO:0046110 None AOX1, XDH 2.38911
[BP] GO:0060160 None DRD2, DRD3 2.38911
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38911
[BP] GO:0051586 None DRD2, DRD4 2.38911
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 2.38911
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.38911
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SLC6A3, SRC, XDH 2.37401
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, ESR1, FABP3, GRM1, GRM5 2.36732
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.35876
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.33971
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.33971
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.33971
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.33007
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.30799
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, DRD2, DRD4, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.28659
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.2838
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.2838
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.2838
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.27725
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.27389
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.26261
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.2555
[BP] GO:2000145 regulation of cell motility ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 2.24946
[BP] GO:0023052 None CHRM2, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.23562
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.23408
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.20803
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.18919
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.18713
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.1827
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.18026
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.18026
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, XDH 2.17917
[BP] GO:0044093 positive regulation of molecular function ABCB1, AURKB, BCL2, CDC25B, DRD2, DRD4, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MET, MMP9, PTPN1, SRC, TNKS, XDH 2.17879
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.16841
[BP] GO:0030814 None DRD2, DRD3, DRD4, GRM3, GRM8 2.16664
[BP] GO:0045936 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.16447
[BP] GO:0010563 None DRD2, DRD3, DRD4, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.16447
[BP] GO:0070213 None TNKS, TNKS2 2.16447
[BP] GO:0006145 None AOX1, XDH 2.16447
[BP] GO:0051582 None DRD2, DRD4 2.16447
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.16447
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.16447
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.16447
[BP] GO:0031279 None DRD2, DRD3, DRD4, GRM3 2.15952
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.15682
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.15273
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.15273
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.15273
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A3, SRC, TNKS, TNKS2, XDH 2.15084
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, PTPRS, SLC6A3, SRC, TNKS, TNKS2, XDH 2.14884
[BP] GO:0051339 None DRD2, DRD3, DRD4, GRM3 2.14416
[BP] GO:0030802 None DRD2, DRD3, DRD4, GRM3, GRM8 2.14416
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, TBXAS1, TYR 2.12631
[BP] GO:0050790 regulation of catalytic activity ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MMP9, PTPN1, SRC, TNKS, XDH 2.10867
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.10665
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.09628
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 2.08498
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, GRM1, KDR, MET, MMP9, PIM1, PTPRS, SLC1A1, SLC6A3, SRC, TNKS2, XDH 2.06739
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.06578
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.05585
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.01662
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.01662
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.01662
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.01662
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, SRC 2.01149
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.01123
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.01027
[BP] GO:1900371 None DRD2, DRD3, DRD4, GRM3, GRM8 2.00562
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A3, SRC 4.48138
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, AXL, CA4, CHRM2, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, SLC6A2, SLC6A3 4.47924
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM2, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, SLC6A2, SLC6A3, SRC 4.16793
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A3, SRC, TBXAS1, TNKS, TNKS2, TYR 4.12883
[CC] GO:0044456 None ACHE, CHRM2, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SLC6A3, SRC 4.06467
[CC] GO:0098590 plasma membrane region ABCB1, CA2, CA4, CA9, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC 3.78891
[CC] GO:0005887 integral component of plasma membrane ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1, SLC6A2, SLC6A3 3.68614
[CC] GO:0043005 None CA2, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SLC6A2, SLC6A3, SRC, TUBB3 3.5157
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A3, SRC, TBXAS1, TYR 3.51139
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.23227
[CC] GO:0097060 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.76472
[CC] GO:0042995 cell projection AKR1B1, CA2, CDK6, CHRM2, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SLC6A2, SLC6A3, SRC, TUBB3 2.75027
[CC] GO:0120025 None AKR1B1, CA2, CDK6, CHRM2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SLC6A2, SLC6A3, SRC, TUBB3 2.51111
[CC] GO:0014069 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.07813
[CC] GO:0099572 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.07813
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 10.7367
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.51469
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A3, SRC, TBXAS1, TNKS, TNKS2, TUBB3, TYR, XDH 9.51469
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.68646
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TUBB3, TYR, XDH 7.47076
[MF] GO:0030594 None CHRM2, DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.33752
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.25695
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 6.04042
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, SLC6A2, SLC6A3, TBXAS1, TNKS, TNKS2, TYR, XDH 5.87529
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.84164
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.83922
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.72131
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CDK6, CHRM2, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 5.65478
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 5.24382
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 5.18416
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA 4.61136
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 4.6106
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.32081
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SLC1A1, SLC6A2, SLC6A3, TBXAS1, TNKS, TNKS2, TYR, XDH 4.23263
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A3, SRC 4.0982
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.03944
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.90189
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 3.73406
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, DRD2, DRD3, DRD4, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 3.73406
[MF] GO:1901338 None DRD2, DRD3, DRD4, SLC6A3 3.7079
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.69766
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.63099
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.63099
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.51307
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.50897
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.42582
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.33809
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.32118
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.31537
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.29215
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.23227
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.18757
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3 2.92593
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.90362
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.89791
[MF] GO:0004952 None DRD2, DRD3, DRD4 2.8312
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.78849
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.75415
[MF] GO:0003845 None HSD11B1, HSD11B2 2.75415
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.75027
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.5766
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.54824
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.51707
[MF] GO:0005330 None SLC6A2, SLC6A3 2.38911
[MF] GO:0099583 None GRM1, GRM5 2.38911
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.33971
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.33971
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.2838
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.23408
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.16447
[MF] GO:0004971 None GRIA2, GRIA4 2.16447


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.6998
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.533
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6334
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, CHRM2, GRIA2, GRM5, ADORA3, GRIK5, GRM8, DRD2, DRD3, DRD4, GRM1, GRIA4 7.7001
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.5444
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.7044
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.421
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.8626
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 3.9083
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.9083
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9083
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.8187
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.8187
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.0725
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, DRD2, GRM1 3.7602
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8187
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8052
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 3.1689
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.5487
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.4582
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.4582
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0329
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, DRD2, PPARA, GRIA4 2.2743
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.2629
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.1955
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KDR, BCL2, MET, IGF1R 2.0579
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.021
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0294
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1028
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.0294
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0294
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0336
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9927
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.988
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7445
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.5516
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2968
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1981
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, GRM5, GRM1 1.1178
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.9978
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.937
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2224
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1595
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1939
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9784
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9682
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9378
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1433
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9485
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9978
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8755
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8371
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9122
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2034
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0607
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9582
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1394
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15 0.8671
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8371
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8456
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.1357
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8456
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8456
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1205
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7739
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.8389
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7849
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2968
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.7685
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8312
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7685
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7685
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6451
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.6428
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6428
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2089
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2091
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5918
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.5704
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2842
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2911
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.316
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2908
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3 0.3166
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.343
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3364
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3396
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3551
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3311
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3551
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3535
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3658
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3832
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3832
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3879
Axon guidance_Homo sapiens_hsa04360 MET 0.3783
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4149
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4388
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4385
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4281
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4426
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4472
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4595
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4468
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4466
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4675
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4595
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4595
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4595
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4872
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4595
Peroxisome_Homo sapiens_hsa04146 XDH 0.4675
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4595
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5005
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4783
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4992
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5124
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5271
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5271
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.514
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5688
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.678
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5271
Shigellosis_Homo sapiens_hsa05131 SRC 0.5271
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5349
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.5704
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5704
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6957
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5555
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5704
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6341
Malaria_Homo sapiens_hsa05144 MET 0.6015
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6092
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6054
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6092
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6092
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6517
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.622
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8713
DNA replication_Homo sapiens_hsa03030 POLA1 0.6792
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7305
Base excision repair_Homo sapiens_hsa03410 POLB 0.7097
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7528
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7719
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7685
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8671
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9378
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0216
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.192


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)