TCM Prescription: Yang Warming Pulse Decoction



Prescription Description
Prescription IDTCMF2181
Pinyin NameWen Yang Tong Mai Tang
Chinese Name温阳通脉汤
English NameYang Warming Pulse Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH1968 Aconitum carmichaeli 熟附块 TCMH1968 ITSAH2410-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH705 Trichosanthes kirilowii 瓜蒌 TCMH705 ITSAO4359-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH799 Sinomenium acutum 汉防己 TCMH799 ITSAJ4218-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 10.9773
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCHE, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, SRC, TYR 9.96516
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, MIF, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, XDH 9.68793
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, POLB, PPARA, PTGS2, SRC, TYR 9.59459
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, SRC, TYR 8.17934
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCHE, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 7.97052
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.94428
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.94288
[BP] GO:0033993 response to lipid ALPL, AXL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 7.77197
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 7.77197
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 7.77197
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, AURKB, AXL, BCHE, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TYR 7.77197
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, AURKB, AXL, BCHE, BCL2, CA2, CA9, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, SRC, TYR 7.75741
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.30681
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 7.26903
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC 7.13364
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.98572
[BP] GO:0014070 response to organic cyclic compound ALPL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FLT3, PTGS2, SRC, TYR 6.8758
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 6.83832
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 6.58265
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.57884
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, POLA1, SRC, TYR 6.57884
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 6.57884
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 6.55687
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, FLT3, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.46011
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 6.46011
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 6.45294
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 6.41627
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, DRD3, EGFR, KDR, MIF, PIK3CB, PTGS2, SRC 6.35107
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.32514
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC 6.32272
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.26569
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 6.26569
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AXL, BCL2, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.18393
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.16583
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, SRC 6.02573
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2 5.92176
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 5.84116
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.68319
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.51234
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FLT3, HSD17B2, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, SRC, TYR 5.44181
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, ERBB2, MET, PIK3CA, PIK3CB, SRC, XDH 5.43751
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, ALOX5, ALPL, AXL, BCHE, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 5.43751
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 5.39084
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, FABP4, FLT3, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.38432
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 5.36379
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, SRC 5.31603
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 5.29417
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 5.28077
[BP] GO:0042493 response to drug AKR1B1, AXL, BCHE, BCL2, CA9, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, KDR, POLB, PTGS2, SRC 5.27367
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, SRC 5.27367
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC 5.25716
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 5.13243
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 5.11944
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.09254
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC 4.9846
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 4.93022
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 4.84701
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.77671
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.76426
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 4.73644
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.72163
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC 4.64648
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.6061
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD3, EGFR, MMP2, POLB, PPARA, PTGS2, SRC, TYR 4.53334
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 4.4669
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD3, KDR, SRC 4.43798
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, MIF, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC 4.37378
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 4.33598
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B1, HSD17B2 4.32207
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.30567
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD3, KDR, POLB, SRC 4.30567
[BP] GO:0048545 response to steroid hormone ALPL, BCHE, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 4.29582
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.26216
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 4.25836
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, PIK3CA, PIK3CB, SRC 4.20343
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA 4.1817
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2, SRC 4.16363
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 4.15821
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 4.1412
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 4.12381
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, BCL2, EGFR, ERBB2, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.11454
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, BCL2, EGFR, ERBB2, FABP3, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.11454
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 4.07857
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.06024
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCHE, BCL2, DRD3, EGFR, ERBB2, ESR1, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SRC, XDH 4.05022
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCHE, BCL2, DRD3, EGFR, ERBB2, ESR1, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SRC, XDH 4.03604
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 3.98403
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, PTGS1, PTGS2, SRC 3.95969
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.91341
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.89317
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.89317
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA 3.821
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD3, EGFR, ERBB2, IGF1R, KDR, MET, MIF, PIK3CA, PIK3CB, POLB, SRC 3.79973
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 3.77297
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 3.7409
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, SRC, XDH 3.63424
[BP] GO:0010243 response to organonitrogen compound AKR1B1, BCHE, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.59436
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 3.58997
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, EGFR, ESR1, PPARA, SRC 3.58599
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.55907
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, AXL, BCL2, CA2, CACNA1C, CHRM2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SRC, XDH 3.54152
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, PTGS2, SRC 3.52047
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, IGF1R, PIK3CA, PIK3CB 3.51165
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD3, EGFR, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, PTGS2 3.48983
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, ESR1, IGF1R, MET, MIF, MMP9, PTGS2, SRC, XDH 3.48622
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.4851
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 3.48248
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.46073
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.44995
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BCHE, CA2, CA7, DRD3, EGFR, PTGS2 3.44995
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BCHE, CA2, CA7, DRD3, EGFR, PTGS2 3.44995
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, EGFR, ERBB2, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.44995
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, SRC, XDH 3.40522
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.39881
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.39612
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, DRD3, EGFR, ERBB2, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC 3.3888
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD3, EGFR, ERBB2, MIF, MMP12, PTGS2, SRC 3.37962
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, EGFR, FLT3, PTGS2 3.36245
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD3, EGFR, ERBB2, ESR1, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, SRC, XDH 3.34967
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA 3.33636
[BP] GO:1901698 response to nitrogen compound AKR1B1, BCHE, DRD3, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.33636
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, AURKB, BCL2, CSNK2A1, DRD3, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.32644
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.29992
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 3.29886
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 3.29257
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.29139
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CYP1A1, EGFR, PTGS2, SRC, TYR 3.29139
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, EGFR, ERBB2, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.29139
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.29139
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGS1, PTGS2 3.29139
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD3, EGFR, PIK3CB, PTGS2 3.29139
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, MIF, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 3.27536
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.25106
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.25009
[BP] GO:0008217 None ADORA1, ADRB1, DRD3, PPARA, PTGS1, PTGS2 3.23931
[BP] GO:0038128 None EGFR, ERBB2, PIK3CA, SRC 3.21349
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, XDH 3.19548
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 3.19328
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.18913
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.15807
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, MIF, PIK3CB, SRC 3.14838
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.1288
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.11143
[BP] GO:0001516 None MIF, PTGS1, PTGS2 3.11143
[BP] GO:0046457 None MIF, PTGS1, PTGS2 3.11143
[BP] GO:0045776 None ADORA1, ADRB1, DRD3, PPARA 3.10942
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 3.06409
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, AURKB, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 3.054
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, SRC 3.02508
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.02406
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.98998
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, PPARA, PTGS2, SRC 2.97847
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.97143
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation BCL2, EGFR, MIF, PIK3CA, PTGS2 2.95785
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.95785
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.95031
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.95031
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, AURKB, BCL2, CSNK2A1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.95031
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.95031
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, MIF, PIK3CB, SRC 2.93286
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 2.91558
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.9098
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.90745
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP1A1, CYP1A2, DRD3, EGFR, ERBB2, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, SRC, TYR, XDH 2.88046
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.87819
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.87819
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, EGFR, MIF, MMP12, SRC 2.85039
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.84109
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.83185
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, ERBB2, FLT3, KDR, MIF, PIK3CB, SRC, XDH 2.81529
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.80986
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 2.78078
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.78078
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.78078
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AXL, BCL2, CA1, CA2, CACNA1C, CHRM2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, SRC 2.77326
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.77326
[BP] GO:0046834 lipid phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.76615
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM2, EGFR, PTGS2 2.7591
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, DRD3, EGFR, ERBB2, MIF, MMP12, PTGS2, SRC 2.74739
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, AURKB, BCL2, DRD3, EGFR, ERBB2, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.73443
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, AURKB, BCL2, CSNK2A1, DRD3, EGFR, ERBB2, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.73352
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.72099
[BP] GO:0007584 response to nutrient ALPL, BCHE, CYP1A1, EGFR, PTGS2, TYR 2.72099
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, ESR1, FABP3, PIK3CB 2.72052
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AURKB, AXL, BCHE, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, XDH 2.71404
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.71404
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CYP1A1, EGFR, PTGS2, SRC, TYR 2.71133
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.69225
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC 2.69012
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, MET, PIK3CA 2.66532
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.66532
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.64374
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.61922
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD3, EGFR, ERBB2, ESR1, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SRC, XDH 2.61487
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, AXL, BCHE, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FABP4, FLT3, FUT7, KDR, MET, MIF, MMP2, MMP9, PTGS2, SRC 2.6132
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.60399
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.59575
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.58705
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.58705
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.58547
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.58547
[BP] GO:0006928 movement of cell or subcellular component AXL, CYP1B1, EGFR, ERBB2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.57968
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.5726
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, EGFR, ERBB2, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.54518
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.53027
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.53027
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCHE, BCL2, CHRM2, CYP1A1, CYP1A2, DRD3, EGFR, MMP12, PTGS2, SRC, TYR 2.53027
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, PTGS2 2.52337
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.52337
[BP] GO:0043408 regulation of MAPK cascade ADORA1, EGFR, ERBB2, FLT3, IGF1R, KDR, MIF, PIK3CB, SRC, XDH 2.51457
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 2.50257
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.50176
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.49575
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation BCL2, EGFR, MIF, PIK3CA, PTGS2 2.49525
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.49005
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.49005
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.47233
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.47033
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, BCL2, DRD3, PIK3CA 2.46128
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.44019
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD3, EGFR, MIF, MMP12, SRC 2.44019
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.4305
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.40334
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.40334
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, CSNK2A1, EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.39483
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CYP19A1, EGFR, ESR1, HSD17B2, PTGS2, SRC 2.3824
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, MIF, POLB, PTGS2 2.36888
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD3, MMP9, PTGS2 2.36526
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, EGFR, ESR1, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTGS2, SRC, XDH 2.36119
[BP] GO:0006693 None MIF, PTGS1, PTGS2 2.34997
[BP] GO:0006692 None MIF, PTGS1, PTGS2 2.34997
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CACNA1C, DRD3, MIF, MMP9, PTGS2 2.34191
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.33678
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.33491
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, MIF, PIK3CB, SRC 2.2956
[BP] GO:0050900 leukocyte migration FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.2956
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.27733
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, PIK3CA, TYR 2.27702
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.27333
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.27265
[BP] GO:0030258 lipid modification CYP1A1, EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.27265
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, MIF, PIK3CB 2.27265
[BP] GO:0050873 None ADRB1, FABP4, PTGS2 2.27265
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.24536
[BP] GO:0018958 None AKR1B1, BCL2, DRD3, TYR 2.24511
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, SRC 2.23556
[BP] GO:0006636 unsaturated fatty acid biosynthetic process MIF, PTGS1, PTGS2 2.23347
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.23347
[BP] GO:0045859 regulation of protein kinase activity ADORA1, EGFR, ERBB2, FABP4, FLT3, IGF1R, MIF, PIK3CA, PIK3CB, SRC 2.2308
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.23078
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, MIF, MMP9, PIK3CA, PIK3CB, SRC 2.21819
[BP] GO:1901570 None ALOX5, MIF, PTGS1, PTGS2 2.21375
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, PTGS2, SRC 2.21218
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.201
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.201
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, ESR1, PIK3CB 2.201
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.1998
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, EGFR, ERBB2, ESR1, FLT3, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.19225
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, DRD3, EGFR, PTGS2 2.18693
[BP] GO:0002793 None ACHE, ADORA1, EGFR, MIF, MMP12, SRC 2.18693
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, MIF, PIK3CB 2.18693
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.18693
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, SRC 2.18693
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, MIF, PIK3CB, SRC 2.18391
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.18276
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, AURKB, BCL2, EGFR, ERBB2, ESR1, FLT3, MET, MIF, MMP9, PIK3CA, PIK3CB, SRC, XDH 2.18041
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.17374
[BP] GO:0038127 None EGFR, ERBB2, PIK3CA, SRC 2.17374
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.14533
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, MMP2, MMP9, PTGS2, SRC 2.13911
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.13842
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, EGFR, ERBB2, FLT3, MIF, PIK3CA, PIK3CB, SRC 2.13111
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, MET, PIK3CA, PPARA 2.13073
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, EGFR, ERBB2, MIF, MMP12, PTGS2, SRC 2.12831
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.12581
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.1241
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF 2.11953
[BP] GO:0070201 None ACHE, BCL2, CACNA1C, DRD3, EGFR, ERBB2, MIF, MMP12, PTGS2, SRC 2.11953
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM2, DRD3, EGFR, PTGS2 2.11268
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TYR 2.09922
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.09879
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.09879
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2 2.0955
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.08797
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.08797
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, PTGS2, XDH 2.08527
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, BCHE, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR 2.07415
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.0686
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, EGFR, ERBB2, FABP4, FLT3, IGF1R, MIF, PIK3CA, PIK3CB, SRC 2.05807
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CYP19A1, DRD3, EGFR, MIF, MMP12, SRC 2.0534
[BP] GO:0030154 cell differentiation ADRB1, ALPL, AXL, BCHE, BCL2, CYP1A1, ERBB2, ESR1, FABP4, FLT3, FUT7, KDR, MMP2, MMP9, PTGS2 2.0534
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ERBB2, ESR1, FLT3, IGF1R, MMP2, PTGS2, SRC 2.05072
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, EGFR, ERBB2, FLT3, MIF, PIK3CA, PIK3CB, SRC 2.04242
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGS2, SRC 2.03963
[BP] GO:0043549 regulation of kinase activity ADORA1, EGFR, ERBB2, FABP4, FLT3, IGF1R, MIF, PIK3CA, PIK3CB, SRC 2.03887
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, MIF, PTGS2 2.02548
[BP] GO:0045124 None CA2, EGFR, SRC 2.02234
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CACNA1C, CSNK2A1, DRD3, EGFR, ERBB2, MIF, MMP12, PTGS2, SRC 2.02205
[BP] GO:2000146 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, MIF 2.02072
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, XDH 2.0163
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, FUT7, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TBXAS1, TYR 3.33636
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, ALOX5, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, KDR, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 3.1362
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.78811
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, FUT7, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TBXAS1, TYR 2.61469
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CSNK2A1, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, SRC 2.53027
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 10.9773
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SRC, TBXAS1, TYR, XDH 10.7757
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3965
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, TBXAS1, TYR, XDH 9.68793
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.30681
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.73218
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.46011
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 6.32514
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.02573
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.87465
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.84116
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.59965
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.38736
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.29417
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 5.29417
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.83872
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.7892
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 4.50722
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC 4.49906
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 4.19106
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 4.1824
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 4.15821
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.09973
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA 4.07508
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.98403
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 3.84318
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.78909
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.63424
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.55462
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.50697
[MF] GO:0042802 identical protein binding ACHE, BCHE, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, TYR, XDH 3.48331
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 3.44995
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.29257
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, NQO2 3.22377
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, XDH 3.02508
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.02406
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 3.02406
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.00658
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.80986
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.69943
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.64374
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, PPARA 2.60399
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, XDH 2.33339
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, XDH 2.3323
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, SRC 2.21695
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, PPARA 2.14711
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA 2.12831
[MF] GO:0004064 arylesterase activity CA1, CA2 2.09879
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRB1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, ESR1, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, XDH 2.08797
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM2, DRD3, EGFR, ERBB2, ESR1, FLT3, IGF1R, KDR, MET, PPARA 2.03963


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.0476
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, ERBB2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 9.3122
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5473
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, ERBB2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 7.5805
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, ADRB1, PIK3CB, PTGS2, PTGS1 8.1092
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, ERBB2, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 6.9702
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 7.3828
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR 6.6428
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, ERBB2, PIK3CB, MET, EGFR 6.2826
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.6203
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, ERBB2, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 5.7602
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.0619
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 5.6519
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, CACNA1C, PIK3CB 5.1439
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, POLA1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.0097
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 5.3061
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.1129
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, PIK3CA, ADORA1, ADRB1, CACNA1C, PIK3CB, PPARA 4.9179
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.7943
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.4692
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.8567
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 4.4353
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, ERBB2, PIK3CB, EGFR 4.4692
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.2193
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, ADRB1, CACNA1C, PIK3CB 4.3156
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.9
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, EGFR, IGF1R 3.7126
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.9201
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, ERBB2, PIK3CB, EGFR 3.9598
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, ERBB2, PIK3CB, EGFR 4.0724
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.945
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.6173
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.7762
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, ADRB1, CACNA1C, PIK3CB 3.6008
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 3.4866
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, ERBB2, PIK3CB, EGFR 3.7632
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.6519
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGS1 3.8438
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, ERBB2, ADRB1, CACNA1C, EGFR 3.2734
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 3.3416
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB, EGFR 2.9889
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.5502
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.7126
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 3.0529
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.427
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, CACNA1C, PTGS2, PTGS1 3.0321
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.4869
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.9889
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.9889
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, EGFR, IGF1R 2.8077
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.9889
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.8077
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1, ADRB1, DRD3 2.5571
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.5728
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.385
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.2355
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 2.2268
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.8758
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.2534
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.2268
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.2268
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 2.1082
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 2.0028
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 2.1957
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.8505
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.2603
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.8745
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.6661
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 2.3222
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.969
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.7762
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.8389
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB, EGFR 1.8274
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.6345
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.6912
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.5444
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.6041
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.6661
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.5358
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3913
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB 1.2444
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4191
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.4191
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR 0.6946
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4742
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.9194
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.0626
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.077
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0626
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0902
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.9201
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C, DRD3 1.1039
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.9187
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2444
Axon guidance_Homo sapiens_hsa04360 MET 0.5116
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5204
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2515
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2695
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3184
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2515
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.281
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 1.266
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.5267
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.5427
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.9889
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5706
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5832
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5824
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.3401
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.3536
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5969
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5959
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5969
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6075
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6089
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6101
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.6101
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.6251
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6101
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.6189
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.6253
Peroxisome_Homo sapiens_hsa04146 XDH 0.6251
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.5006
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.5006
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.6251
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.6368
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6542
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5444
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6542
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6633
Bile secretion_Homo sapiens_hsa04976 CA2 0.6609
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5139
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.6542
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.6767
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.6741
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6657
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.1698
Shigellosis_Homo sapiens_hsa05131 SRC 0.6794
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7044
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.633
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.5717
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7077
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.763
Malaria_Homo sapiens_hsa05144 MET 0.7757
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7891
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7945
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.8505
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.9523
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9378
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9278
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9739
DNA replication_Homo sapiens_hsa03030 POLA1 0.8914
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9201
Base excision repair_Homo sapiens_hsa03410 POLB 0.9187
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9481
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8914
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 2.0276
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9821
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9739
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3275
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.1368
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2151
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.5057


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)