TCM Prescription: San Jin Tablet



Prescription Description
Prescription IDTCMF218
Pinyin NameSan Jin Pian 
Chinese Name三金片
English NameSan Jin Tablet
Function Description热淋
IndicationsHeat stranguria disorder, Acute prostatitis, Chronic prostatitis, Salmonella pyelonephritis, Chronic pyelonephritis, Cystitis, Urethritis
Disease ICD-11 Category SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ];
GA91.Y [Other specified inflammatory and other diseases of prostate, 其他特指的前列腺炎性疾病 ];
GA91.0 [Chronic prostatitis, 慢性前列腺炎 ];
GC2Z [Diseases of the urinary system, unspecified, 泌尿系统疾病，未特指的 ];
GB55.Z [Chronic tubulo-interstitial nephritis, unspecified, 慢性肾小管-间质肾炎，未特指的 ];
GC00 [Cystitis, 膀胱炎 ];
GC02.Y [Other specified urethritis and urethral syndrome, 其他特指的尿道炎和尿道综合征 ];
Human Tissues Associated with IndicationBladder
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1132 Radix rosae laevigatae 金樱根 TCMH1132
TCMH37 Smilax china 菝葜 TCMH37 CPBOL4044-11
TCMH2433 Akebia puinata 羊开口 TCMH2433
TCMH1118 Lygodium japonicum 金沙藤 TCMH1118 ITSAJ4232-14
TCMH1033 Centella asiatica 积雪草 TCMH1033 ITSAJ4523-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT754 GSTP1 Glutathione S-transferase Pi Transferase P09211
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT865 GSTA1 Glutathione S-transferase A1 Transferase P08263


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.5169
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.3522
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 10.0443
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR 9.87184
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 9.85935
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 9.4508
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 8.99737
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.87625
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.87283
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 8.11837
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.11837
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TERT 8.11532
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.10682
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.98668
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.98668
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR 7.84918
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 7.77972
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.70122
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 7.54111
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT 7.47743
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 7.38297
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 7.37708
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.32747
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.30729
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT 7.24061
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 7.23418
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 7.17558
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 7.17558
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 7.17558
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.16092
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 7.13795
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TEK, TYR 7.11043
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.11043
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.05955
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.04441
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.95657
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.92842
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 6.73296
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 6.69144
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 6.61723
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.54133
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 6.40128
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.149
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.12971
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.11242
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR 6.02001
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.95253
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.95221
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.94719
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.89357
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.84661
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 5.84614
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.80377
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.71854
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.70807
[BP] GO:0019220 regulation of phosphate metabolic process APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.70208
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 5.65906
[BP] GO:0051174 regulation of phosphorus metabolic process APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.65906
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.64759
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.61031
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.56783
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.46266
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.44793
[BP] GO:0080134 regulation of response to stress APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.43297
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.38112
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.32655
[BP] GO:0048583 regulation of response to stimulus AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.29729
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 5.26823
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.25874
[BP] GO:0065009 regulation of molecular function APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.23259
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.21223
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.19683
[BP] GO:0030334 regulation of cell migration APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.14814
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.13106
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.95681
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 4.93612
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 4.92295
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.89965
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.89965
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.88571
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.87914
[BP] GO:2000145 regulation of cell motility APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 4.84434
[BP] GO:0032879 regulation of localization ACHE, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 4.7533
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 4.7533
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 4.64072
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.59613
[BP] GO:0042325 regulation of phosphorylation APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.58947
[BP] GO:0040012 regulation of locomotion APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 4.46252
[BP] GO:0051270 regulation of cellular component movement APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 4.44865
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.41227
[BP] GO:0001932 regulation of protein phosphorylation APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.39774
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.34145
[BP] GO:0031399 regulation of protein modification process APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.28135
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.25299
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2, TERT 4.23865
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.18702
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.18267
[BP] GO:0001934 positive regulation of protein phosphorylation APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.18267
[BP] GO:0051247 positive regulation of protein metabolic process APP, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.16865
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.07129
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.07043
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.02225
[BP] GO:0042327 positive regulation of phosphorylation APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.97183
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 3.96693
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.9633
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.95391
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.94226
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.93765
[BP] GO:0006950 response to stress ACHE, AKR1B1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 3.91212
[BP] GO:0001666 response to hypoxia CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 3.90612
[BP] GO:0043408 regulation of MAPK cascade APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.88899
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.86708
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.84774
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.84774
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.83274
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 3.82883
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 3.77369
[BP] GO:0044093 positive regulation of molecular function APP, AURKB, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.76682
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AURKB, CDC25B, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 3.7192
[BP] GO:0009893 positive regulation of metabolic process APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 3.7014
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 3.68325
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.68154
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.66616
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 3.6439
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.63098
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.60269
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD17B1, HSD17B2 3.59806
[BP] GO:0070482 response to oxygen levels CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 3.58843
[BP] GO:0043410 positive regulation of MAPK cascade APP, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.58843
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.58496
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.5585
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 3.5585
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.5585
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.5579
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 3.557
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.55142
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 3.54527
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.54527
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.53732
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.52175
[BP] GO:0032268 regulation of cellular protein metabolic process APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.50311
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 3.49399
[BP] GO:0010648 negative regulation of cell communication ACHE, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.49245
[BP] GO:0023057 negative regulation of signaling ACHE, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.4783
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.46641
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 3.46641
[BP] GO:0051049 regulation of transport ACHE, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT 3.46358
[BP] GO:0048585 negative regulation of response to stimulus CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.42068
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK 3.41694
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.37206
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.35922
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.34588
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.34203
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 3.33263
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.30678
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT 3.30551
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.28631
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC 3.25254
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.2023
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.19487
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 3.18835
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 3.18835
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.17712
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC, TERT 3.17566
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 3.17384
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.15886
[BP] GO:0031401 positive regulation of protein modification process APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.15501
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TERT 3.12459
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.12147
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK 3.11672
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK 3.11672
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 3.10235
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.08078
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.07793
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 3.05303
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.03335
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, PPARA, PTGS2, RORC, SRC, TEK 3.03335
[BP] GO:0051246 regulation of protein metabolic process APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.02927
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.99736
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 2.99258
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.9803
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.9803
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.9803
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.9803
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.9803
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, PIK3CB, SMAD3, SRC, TEK 2.94148
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.92583
[BP] GO:0070920 None EGFR, ESR1, TERT 2.92583
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.89238
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.87033
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.85823
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.85113
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.82634
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.82634
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.81138
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC 2.81015
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.79626
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.79626
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.75895
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 2.75895
[BP] GO:0030155 regulation of cell adhesion CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.75895
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.75052
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.74193
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.72416
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.71986
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.71986
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.70249
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.69895
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.68996
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.68397
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.67129
[BP] GO:0033674 positive regulation of kinase activity CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.67129
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, EGFR, PTGS2 2.66425
[BP] GO:0009968 negative regulation of signal transduction DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 2.65972
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.63227
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.61916
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.61916
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.60967
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.60967
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.60763
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.5926
[BP] GO:2001234 negative regulation of apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.58512
[BP] GO:0009888 tissue development ALPL, CYP1B1, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.5792
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CYP1B1, EGFR, ESR1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, XDH 2.57783
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.56916
[BP] GO:0009892 negative regulation of metabolic process APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.5489
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.5489
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.5489
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.54155
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.54106
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.52176
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, PTGS2, SRC 2.51492
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.4944
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PTGS2, SRC 2.47374
[BP] GO:0051894 None KDR, SMAD3, TEK 2.47374
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.47374
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, PIK3CB, PTGS2 2.44776
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.43859
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.43859
[BP] GO:0051248 None APP, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.43289
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALPI, CSNK2A1, EGFR, MET, PIK3CA, PIK3CB 2.43289
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK 2.4269
[BP] GO:0009894 regulation of catabolic process CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 2.40529
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.39534
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.39448
[BP] GO:1903393 None KDR, SMAD3, TEK 2.38867
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.36368
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, CSNK2A1, EGFR, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.35539
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, EGFR, KDR, PIK3CB, PTGS2, SRC 2.34889
[BP] GO:0010638 positive regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.3479
[BP] GO:0050900 leukocyte migration FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.33339
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 2.329
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.31638
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.30942
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.29188
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.29187
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, FABP4, KDR, MET, PPARA, PTGS2, SMAD3, TEK 2.28777
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.26979
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, CA2, CA9, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, SMAD3, SRC, TEK 2.26134
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, KDR, PTGS2, TEK, TERT 2.25714
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, PTGS2, SRC 2.24518
[BP] GO:0051050 positive regulation of transport ACHE, APP, AXL, CA2, CYP19A1, EGFR, INSR, PTGS2, SMAD3, SRC, TERT 2.24071
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.23714
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.23714
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.23714
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, GPR35, PIK3CB, SMAD3 2.23714
[BP] GO:0051239 regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, EGFR, ESR1, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 2.23714
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, PTGS2, SMAD3 2.22147
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.22147
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.22147
[BP] GO:0008286 None IGF1R, INSR, PIK3CA, PTPN1 2.22147
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.22147
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.21836
[BP] GO:1901890 None KDR, SMAD3, TEK 2.21015
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.21015
[BP] GO:2000352 None KDR, TEK, TERT 2.21015
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.21015
[BP] GO:1901989 None APP, CDC25B, CYP1A1, TERT 2.19251
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, CSNK2A1, DUSP3, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.1875
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.18414
[BP] GO:0019222 regulation of metabolic process ACHE, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.17962
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PTGS2, TEK 2.17746
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.16957
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 2.16833
[BP] GO:2001233 regulation of apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 2.16833
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.16371
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.14742
[BP] GO:1902893 None PPARA, SMAD3, TERT 2.14742
[BP] GO:0010907 None INSR, PPARA, SRC 2.14742
[BP] GO:0106027 None APP, IGF1R, INSR 2.14742
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.1372
[BP] GO:1990535 None APP, INSR 2.13593
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.12469
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.12469
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, EGFR, ESR1, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH 2.12407
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, PTPN1 2.12306
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.11697
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A 2.113
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.10734
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, INSR, TERT 2.09686
[BP] GO:0080090 regulation of primary metabolic process APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.09517
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, FABP3, IGF1R, INSR, KDR, MET, PPARA, PTGS2, RORC, SMAD3, SRC, TERT 2.08108
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.07571
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGS2, SRC 2.07571
[BP] GO:0052548 None APP, CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.0738
[BP] GO:0043434 None FABP3, INSR, PPARA, PTGS2, SRC, TEK 2.06947
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, PTGS2, TEK, TERT 2.06591
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, PIM1, PPARA, RORC, SRC 2.06591
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, PTGS2, SMAD3 2.06552
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC 2.06552
[BP] GO:0045124 None CA2, EGFR, SRC 2.06278
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.06278
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, SRC 2.06278
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 2.05809
[BP] GO:0031323 regulation of cellular metabolic process ACHE, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.05179
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.04547
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, SRC 2.0415
[BP] GO:0006820 anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.04126
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.03752
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, PTGS1, PTGS2 2.03752
[BP] GO:0009611 response to wounding ACHE, CYP1A1, EGFR, PPARA, SMAD3 2.03564
[BP] GO:0006644 phospholipid metabolic process ACHE, ALPI, CSNK2A1, EGFR, MET, PIK3CA, PIK3CB 2.03096
[BP] GO:0010906 None INSR, PPARA, RORC, SRC 2.03024
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, EGFR, ESR1, PTGS2, SRC 2.02505
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, TEK 2.0161
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR 2.0161
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1 2.01457
[BP] GO:0007566 embryo implantation MMP2, MMP9, PTGS2 2.01457
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, TYR 2.00609
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, PTGS2, SMAD3 2.00319
[CC] GO:0005886 plasma membrane ACHE, ALPI, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 3.08078
[CC] GO:0016020 membrane ACHE, ALOX5, ALPI, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TYR 2.90261
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.73707
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.72156
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.31503
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, APP, AURKB, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TYR, XDH 2.27475
[CC] GO:0044425 membrane part ACHE, ALPI, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR 2.20958
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.13593
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TYR, XDH 12.4215
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR, XDH 12.0442
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 11.5169
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.43164
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.98668
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.30729
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK 7.16092
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.17762
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.02028
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.89215
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.84195
[MF] GO:0008270 zinc ion binding ALPI, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 5.67728
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TYR, XDH 5.54513
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.46851
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.42199
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 5.34222
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.27268
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TYR, XDH 5.1962
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.77534
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.7533
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 4.54563
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.48123
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.23865
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.02786
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.84774
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.77369
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.57577
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.5728
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 3.47654
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.46358
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.43365
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.35922
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.35922
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.35482
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.35482
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.32706
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK 3.24769
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.14255
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.08078
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.07774
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.06
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TYR, XDH 3.01176
[MF] GO:0032403 protein complex binding ACHE, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.86756
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.85823
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.85806
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.68996
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.67372
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.54155
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.54155
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.51541
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.44826
[MF] GO:0051425 None APP, INSR 2.43859
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.43835
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.4102
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.40464
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.35342
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.34687
[MF] GO:1901363 heterocyclic compound binding APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.31503
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.26979
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.26979
[MF] GO:0043559 insulin binding IGF1R, INSR 2.26095
[MF] GO:0097367 carbohydrate derivative binding APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.23247
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.21015
[MF] GO:0019899 enzyme binding ALPI, APP, AURKB, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, HSPA1A, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 2.20664
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PTPN1, SMAD3 2.16643
[MF] GO:0004035 alkaline phosphatase activity ALPI, ALPL 2.13593
[MF] GO:0035258 None ESR1, FLT3, SMAD3, SRC 2.13582
[MF] GO:0097159 organic cyclic compound binding APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, XDH 2.12469
[MF] GO:0001221 transcription cofactor binding ESR1, PPARA, TERT 2.03752
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.03096
[MF] GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity PIK3CA, PIK3CB 2.03096
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1 2.03096


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.7291
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.8309
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 8.1284
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 8.0999
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.4768
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.1284
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 6.7349
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.838
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 6.7349
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, ALPI, XDH 5.6366
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.565
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.8233
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 5.3072
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.0882
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 5.0131
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.8831
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.8831
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.5024
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.9412
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.8831
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.8413
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.3018
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB 4.2348
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.6221
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 4.0911
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.7357
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, PIK3CB, MMP9 3.5875
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.9462
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.7251
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.4636
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.6061
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.5967
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, EGFR, IGF1R 3.3371
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 3.3635
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.6641
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 3.1979
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.5109
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 3.2566
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 3.0373
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 3.0175
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.9237
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.9698
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, HSPA1A 2.9698
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.9698
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.9059
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.7883
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.8167
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.7418
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.761
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.7418
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.6792
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.2623
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.4182
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 2.1908
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.9562
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.2415
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.9439
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.3204
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.909
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 2.2107
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.8167
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 2.125
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.7349
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 2.187
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.569
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.3774
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.9698
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, INSR, PIK3CB 1.6753
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.9
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.6364
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35 0.2655
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.6792
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.5777
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.4936
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 3.1754
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3963
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3884
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.4072
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, PIK3CB, PPARA 1.5229
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3947
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3954
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4072
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, PIK3CB 2.7418
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4355
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4794
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.6515
Axon guidance_Homo sapiens_hsa04360 MET 0.4957
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.0864
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5042
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0878
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 1.052
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.1061
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 1.0796
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1194
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.185
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, PIK3CB 1.185
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.7418
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.1636
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.153
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5741
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2739
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5741
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5847
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2847
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5741
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.584
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3606
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3115
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3232
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6075
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6075
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.6189
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.3779
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6064
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.3606
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.3914
Peroxisome_Homo sapiens_hsa04146 XDH 0.6202
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6602
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6461
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6582
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6698
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.5291
Bile secretion_Homo sapiens_hsa04976 CA2 0.6676
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5777
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.672
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5471
Shigellosis_Homo sapiens_hsa05131 SRC 0.6921
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7203
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.656
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.605
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.605
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.7518
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.6647
Malaria_Homo sapiens_hsa05144 MET 0.7948
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8083
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8133
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.8755
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.9219
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.9219
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.965
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 1.011
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9851
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.1812
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 2.0425
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.1316
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0191
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9747
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.011
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3673
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.7418
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4684


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)