TCM Prescription: San Jiu Wei Tai Capsule



Prescription Description
Prescription IDTCMF216
Pinyin NameSan Jiu Wei Tai Jiao Nang 
Chinese Name三九胃泰胶囊
English NameSan Jiu Wei Tai Capsule
Function Description胃脘痛, 腹胀
IndicationsStomach ache disorder, Gastritis
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
DA42 [Gastritis, 胃炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1761 Evodia lepta 三叉苦 TCMH1761
TCMH1165 Murraya paniculata 九里香 TCMH1165 ITSAJ1731-14
TCMH1278 Radix zanthoxyli 两面针 TCMH1278
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.16653
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.16653
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, SMAD3, SRC, TEK, TYR 9.0243
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.75797
[BP] GO:0042221 response to chemical ABCB1, ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TYR 8.40095
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.92841
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.81477
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 7.58765
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, SRC, TEK, TYR 7.36822
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.33252
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.2492
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 7.17634
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.08744
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.0042
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 6.99863
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.98666
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SRC, TEK 6.76237
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 6.73766
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 6.62312
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.43927
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 6.3737
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.32844
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.28766
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 6.18517
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALDH2, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, PIM1, PPARA, TYR, XDH 6.10152
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, TYR 6.09896
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.00554
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 5.95754
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.95239
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.81685
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 5.74593
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.6126
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, SRC, TYR 5.51032
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FLT3, SRC, TEK, TYR 5.48001
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.46916
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.44199
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK 5.41167
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.40705
[BP] GO:0030335 positive regulation of cell migration ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.22819
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.22819
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.21703
[BP] GO:2000147 positive regulation of cell motility ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.0893
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.05562
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.97119
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 4.95419
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.95419
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 4.89018
[BP] GO:0040017 positive regulation of locomotion ADRA2A, DRD1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.83933
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.76967
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.7391
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 4.72314
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD17B1, HSD17B2 4.68022
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPRS, SMAD3, SRC, XDH 4.67507
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPRS, SMAD3, SRC, XDH 4.66096
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 4.64128
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TNKS, XDH 4.61718
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADRA2A, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 4.58654
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, XDH 4.58654
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, XDH 4.53638
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, CYP19A1, DRD1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 4.49228
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.49203
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.46389
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.43817
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, XDH 4.37569
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 4.37569
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, TYR 4.33845
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TNKS, XDH 4.33756
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, SMAD3, SRC 4.32172
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.30701
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.19114
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.19114
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, EGFR, KDR, SRC, TNKS, TNKS2 4.15785
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.07508
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK, XDH 4.07508
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.07508
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.04711
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 4.0394
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.98213
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.97171
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.92922
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 3.92692
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS 3.9246
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, EGFR, FLT3, INSR, KDR, SRC, TEK, XDH 3.91212
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 3.91212
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.91212
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, SRC, TEK 3.89645
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.88558
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.88
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 3.86557
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, XDH 3.86522
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.86355
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.86355
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.83877
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.83264
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.83068
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, HSPA1A 3.82774
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.81585
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, AURKB, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.78336
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 3.77517
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.77027
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.75978
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 3.69724
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, AURKB, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, TNKS, XDH 3.68329
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.68329
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.67202
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.66076
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.64158
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.58232
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA 3.57108
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.57108
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.52931
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 3.40337
[BP] GO:0009056 catabolic process ACHE, ADORA1, ALDH2, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 3.39826
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 3.39826
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.38587
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, EGFR, GPR35, HSPA1A, INSR, MMP9, PPARA, SMAD3, SRC 3.32172
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 3.28657
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.28555
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.28555
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28555
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.28555
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 3.28137
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR, SRC, TEK 3.2527
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.2507
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 3.21855
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.21555
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.21555
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 3.17817
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.16706
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA2A, ADRA2C, AURKB, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MMP9, SMAD3, SRC, TEK, TNKS, XDH 3.12768
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 3.12645
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, EGFR, ESR1, FABP4, KDR, MET, PPARA, PTPRS, SMAD3, TEK 3.10464
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PTPRS, SMAD3, SRC, TEK 3.08475
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 3.07094
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, ALOX15, DRD1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 3.0506
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 3.04575
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, EGFR, TNKS, TNKS2 3.02108
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.01777
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 3.00356
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.99439
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.9799
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.93259
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 2.93259
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2 2.93259
[BP] GO:0009115 None AOX1, XDH 2.93259
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.92877
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.90923
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.89832
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 2.85363
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, EGFR, ESRRB, FLT3, INSR, KDR, MMP9, SRC, TEK, XDH 2.85033
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 2.83727
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.76697
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, SRC 2.76697
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, EGFR, MMP9 2.75471
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, SRC, TEK, TNKS 2.74832
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.74036
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.73987
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.72724
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.72724
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.72724
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.72724
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.71721
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.71321
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, AXL, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, SRC 2.70919
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.69526
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, EGFR, FABP3, KDR, SRC 2.69526
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, PPARA, SRC, TEK 2.6933
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.68174
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.64245
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.64076
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.64076
[BP] GO:0051128 regulation of cellular component organization ALOX15, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.64076
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, SRC 2.61442
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.61361
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.58509
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.58509
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.54434
[BP] GO:0046110 None AOX1, XDH 2.54349
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54349
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, PPARA, PTPRS, SMAD3, TEK 2.54349
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.51991
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.51991
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.51991
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.51991
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.51044
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.50979
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.46573
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, PPARA, SMAD3, SRC, TNKS, TNKS2 2.46482
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.46482
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.46482
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.45267
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45061
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.44532
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, EGFR, FLT3, INSR, KDR, MMP9, SRC, TEK, XDH 2.44532
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, KDR, SRC 2.44129
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, EGFR 2.42639
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.42387
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40007
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.3992
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.38587
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.38587
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, DRD1, EGFR, INSR, SMAD3, SRC 2.38587
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.37416
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALDH2, ALOX15, CYP19A1, CYP1A1, CYP1B1, DRD1, TYR 2.36994
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.35714
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.35714
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35714
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, KDR, SRC 2.35312
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.33045
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ADRA2C, AURKB, EGFR, FLT3, INSR, SRC, TEK, TNKS 2.32514
[BP] GO:0035625 None ADRA2A, ADRA2C 2.32514
[BP] GO:0032811 None ADRA2A, ADRA2C 2.32514
[BP] GO:0070213 None TNKS, TNKS2 2.32514
[BP] GO:0006145 None AOX1, XDH 2.32514
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32514
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32514
[BP] GO:0051894 None KDR, SMAD3, TEK 2.32514
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32514
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.29669
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.28655
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, DRD1, EGFR 2.28418
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.27534
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.27534
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.27119
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, SRC, TEK 2.25494
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.24872
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.23863
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.23863
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23863
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, PPARA, SMAD3, SRC, TNKS, TNKS2 2.23287
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AXL, CA2, CYP1B1, EGFR, ESRRB, HSPA1A, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 2.23206
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.22316
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PTPRS, SMAD3, SRC, XDH 2.217
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.21676
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.21455
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.20017
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, EGFR, FLT3, SRC 2.15823
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.15514
[BP] GO:0032845 None ADORA1, ADRA2A, SRC, TNKS, TNKS2 2.15149
[BP] GO:0035624 None ADRA2A, ADRA2C 2.15019
[BP] GO:0014060 None ADRA2A, ADRA2C 2.15019
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.14417
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, DRD1 2.14262
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.14262
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.14262
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C 2.12801
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.12599
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.12083
[BP] GO:0051098 regulation of binding AURKB, MET, MMP9, PPARA, SMAD3, SRC, TNKS 2.12083
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.12083
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.1096
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, PPARA, SMAD3, SRC, TNKS, TNKS2 2.10354
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.09922
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09673
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09673
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.08476
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.08476
[BP] GO:1901890 None KDR, SMAD3, TEK 2.0588
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.0588
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, AURKB, EGFR, ESR1, FLT3, HSPA1A, INSR, SMAD3, SRC, TEK, TNKS, XDH 2.05628
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.04608
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CBR1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PTPRS, SMAD3, SRC, TEK 2.04608
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.04608
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.04608
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.04608
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.04341
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, SMAD3 2.0391
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.03251
[BP] GO:2000273 None ADORA1, ADRA2A, ADRA2C 2.03251
[BP] GO:0046113 None AOX1, XDH 2.02522
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.02522
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.0099
[BP] GO:0050793 regulation of developmental process ADRA2C, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, INSR, KDR, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 2.00539
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.00212
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 3.48667
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, EGFR, ESR1, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPRS, SMAD3, SRC, TEK 3.40845
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, AXL, CA2, CA4, CA9, DRD1, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SRC, TEK 3.25351
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CA4, DRD1, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, TEK 2.89832
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 2.42484
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA2A, CA2, CA4, CA9, DRD1, EGFR, INSR, MET, SRC, TEK 2.33607
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA2C, AKR1B1, ALDH2, ALPL, AOX1, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.15019
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, TEK 2.09902
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, TNKS, TYR, XDH 11.9624
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 11.4751
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, ALDH2, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPRS, SRC, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 10.4178
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.071
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.45745
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.81693
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.43927
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, SMAD3, TNKS 5.68155
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.64682
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.51032
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 5.44199
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, TNKS, TNKS2, TYR, XDH 5.22819
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.93229
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.82084
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALDH2, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 4.71912
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.46389
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, TNKS, TNKS2, TYR, XDH 4.40965
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 4.30194
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.27118
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.07714
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC 4.06024
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.97228
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.97228
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TUBB3, XDH 3.83264
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.83068
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.76405
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 3.71559
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, XDH 3.68329
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.68329
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.66072
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TUBB3, XDH 3.63135
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.51489
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.40845
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.40337
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, CBR1, HSD17B1, HSD17B2, XDH 3.19377
[MF] GO:0000166 nucleotide binding ABCB1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TUBB3, XDH 3.18601
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TUBB3, XDH 3.18546
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.02108
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 3.00356
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, PPARA 2.97177
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93259
[MF] GO:0016903 None AKR1B1, ALDH2, AOX1, XDH 2.87565
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.84293
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.83326
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.76216
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH 2.65441
[MF] GO:0004938 None ADRA2A, ADRA2C 2.54349
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.50979
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, DRD1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.50979
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1 2.50408
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, SMAD3, TYR, XDH 2.45188
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.37633
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.33607
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32514
[MF] GO:0032795 None ADORA1, ADRA2A 2.32514
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.32514
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.29669
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.27174
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.22613
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPRS, SRC, TEK 2.15149
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.15019
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15019
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TUBB3 2.1281
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.12801
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.04608
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TUBB3 2.04078
[MF] GO:0004936 None ADRA2A, ADRA2C 2.02522
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02522
[MF] GO:0043546 None AOX1, XDH 2.02522


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.7033
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2494
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.8199
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.1212
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1212
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.4015
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 5.4376
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4376
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, FUT7, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.2014
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.2014
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.678
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.4207
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1018
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1013
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA2C, ADRA2A 2.8677
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1352
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, DRD1, ADRA2C, ADRA2A 2.7849
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1, EGFR 2.8677
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, MMP9, MET, EGFR 2.6637
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 2.9586
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3845
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5688
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6688
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3418
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3685
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2483
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.2727
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2205
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1757
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1716
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9872
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2162
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.244
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8142
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9187
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4637
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4364
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4592
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, PPARA 1.1613
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9543
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2572
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0699
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3002
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0802
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3373
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2537
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0491
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9543
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0674
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0687
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15 0.9401
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.16
Glycerolipid metabolism_Homo sapiens_hsa00561 ALDH2, AKR1B1 1.3184
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9197
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9197
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9197
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2347
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8368
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8474
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9133
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8945
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8222
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2198
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8179
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8262
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8074
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4592
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7932
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7932
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR 0.7289
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6706
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6576
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2569
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3227
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3572
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3643
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3495
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3572
Alcoholism_Homo sapiens_hsa05034 DRD1 0.3572
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3572
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3489
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3925
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.4143
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3925
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4186
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4283
Platelet activation_Homo sapiens_hsa04611 SRC 0.4464
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4464
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4464
Axon guidance_Homo sapiens_hsa04360 MET 0.4411
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.4387
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4768
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4768
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5028
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5016
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.494
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5028
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5016
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5016
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.504
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5036
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5085
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5223
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5223
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5328
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6849
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5216
Peroxisome_Homo sapiens_hsa04146 XDH 0.5337
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5683
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.549
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5667
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5552
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5807
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.594
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 ALDH2, AKR1B1 1.6718
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.594
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5941
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8228
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6096
Shigellosis_Homo sapiens_hsa05131 SRC 0.5941
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6008
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5941
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.594
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.633
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6499
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.636
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.636
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6499
Malaria_Homo sapiens_hsa05144 MET 0.6576
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.6576
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.657
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6576
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6598
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9872
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6637
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6724
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7073
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6724
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7418
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7018
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7849
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8074
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7817
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7737
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7932
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7817
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8074
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8074
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8074
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.8222
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9646
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0463
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2481


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)