TCM Prescription: Double Yin Fries



Prescription Description
Prescription IDTCMF2092
Pinyin NameEr Yin Jian
Chinese Name二阴煎
English NameDouble Yin Fries
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 11.7162
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA 9.90215
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.93173
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.59882
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.24829
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, PPARA, TYR, XDH 7.24829
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.77675
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.69265
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, PPARA, TYR 6.69265
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 6.68799
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.54971
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, TYR 6.29506
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, HSD11B2, TYR 6.28381
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F3, FABP3, FABP4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TNKS, TNKS2, XDH 6.1551
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.01976
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, GBA2, TYR 5.84279
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, PPARA, TYR 5.6352
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.33088
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 5.22307
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.02881
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, HSD11B2, PPARA 4.93155
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, HSD11B2, PPARA 4.89787
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.57449
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 4.56582
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, HSD11B2, HSD17B2, PPARA, TYR 4.24075
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, PPARA, TYR 3.99125
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.96048
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, PPARA, TNKS2, TYR 3.89577
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, GBA2, HSD11B1, HSD17B2, PPARA, TYR 3.84753
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.84753
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.84753
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, PPARA 3.3825
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 3.37366
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.33072
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, PTPN1, TNKS, TNKS2, XDH 3.18897
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, PTPN1, TNKS, TNKS2, XDH 3.17272
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1 3.09375
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.0008
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.0008
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.86952
[BP] GO:0009115 None AOX1, XDH 2.83199
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, XDH 2.81831
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.8091
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, XDH 2.70293
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1 2.66045
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4 2.64151
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.62673
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.60776
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, XDH 2.60477
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, DRD1, TNKS, TNKS2 2.5783
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APP, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TYR, XDH 2.5783
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.55059
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45264
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, PPARA, PTPN1, TNKS, TNKS2, XDH 2.44892
[BP] GO:0046110 None AOX1, XDH 2.44892
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44892
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.3583
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30559
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.20276
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, TYR 2.19288
[BP] GO:0070213 None TNKS, TNKS2 2.19288
[BP] GO:0006145 None AOX1, XDH 2.19288
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.19288
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.19275
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.17105
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.14915
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, FABP3, HSD11B2 2.14915
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2 2.13961
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.12411
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, PPARA, PTPN1, TNKS, TNKS2, XDH 2.11491
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4 2.09026
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.07892
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, GBA2 2.06659
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.04662
[BP] GO:0043696 None CDK6, ESRRB 2.0307
[BP] GO:0043697 None CDK6, ESRRB 2.0307
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.02579
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, PPARA 2.02579
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.92399
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2 2.83199
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, APP, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 2.02579
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FUT7, GBA2, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 1.28356
[CC] GO:0097386 None AKR1B1, APP 1.16527
[MF] GO:0046914 transition metal ion binding AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS, TYR, XDH 11.7162
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 11.0515
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.05903
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.30508
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.28381
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.11639
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 6.02673
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.84279
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTPN1, TNKS, TNKS2, TYR, XDH 5.80744
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.60502
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 5.42645
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 4.94094
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS 4.9311
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.49845
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.41124
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.39939
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.3515
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.3515
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.04865
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.97912
[MF] GO:0008289 lipid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.96048
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.90387
[MF] GO:0046872 metal ion binding ALPL, AOX1, APP, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 3.89577
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.80527
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.68313
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.4553
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, XDH 3.37366
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.33072
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 3.00822
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.85582
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.83199
[MF] GO:0003845 None HSD11B1, HSD11B2 2.83199
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.5783
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.44892
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.44892
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.19288
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.19288
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.19288
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.0307
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0307


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 12.5969
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.5969
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.0035
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.6891
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.9516
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.5916
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.7778
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.7972
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.3604
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.3604
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.8277
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, CDC25B 1.6621
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, PPARA 1.3743
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.841
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.484
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7932
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.841
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0053
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4603
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.3493
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6293
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7932
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8277
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.3435
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, F3 1.1782
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3493
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2516
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2205
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1 1.1497
Estrogen signaling pathway_Homo sapiens_hsa04915 ESR1, ESR2 1.1807
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1407
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2175
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.1428
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 1.0142
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2 0.9805
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.076
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.9296
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8972
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8011
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2 0.5852
Pathways in cancer_Homo sapiens_hsa05200 CDK6, BCL2 0.5427
Glioma_Homo sapiens_hsa05214 CDK6 0.6243
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5658
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.5852
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6196
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6243
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5658
Melanoma_Homo sapiens_hsa05218 CDK6 0.6225
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5658
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6253
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6243
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6196
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5638
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5105
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6243
Gap junction_Homo sapiens_hsa04540 DRD1 0.5852
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5677
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5852
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.5339
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5328
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6586
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5105
Serotonergic synapse_Homo sapiens_hsa04726 APP 0.5427
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5105
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.5107
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.5105
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5677
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6225
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.5339
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.5105
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4658
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.5105
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4974
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5105
Peroxisome_Homo sapiens_hsa04146 XDH 0.5872
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6003
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3647
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4617
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4658
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4617
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6225
Alcoholism_Homo sapiens_hsa05034 DRD1 0.4617
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4617
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.4337
Proteoglycans in cancer_Homo sapiens_hsa05205 ESR1 0.4337
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.4337
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4564
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6972
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6889
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.697
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.697
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6972
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7567
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8345
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8529
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2726
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8791
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8732
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9927
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.076
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3045


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)