TCM Prescription: Bawei Qingxin Chenxiang Powder



Prescription Description
Prescription IDTCMF2087
Pinyin NameBa Wei Qing Xin Chen Xiang San
Chinese Name八味清心沉香散
English NameBawei Qingxin Chenxiang Powder
Function Description心肺火盛, 胸闷不舒, 胸胁闷痛, 心跳气短
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationHeart
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH741 Fructus choerospondiatis 广枣 TCMH741
TCMH2066 Santalum album 檀香 TCMH2066 ITSAJ4584-14
TCMH2726 Pterocarpus indicus 紫檀 TCMH2726 ITSAA3130-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1741 Myristica fragrans 肉豆蔻 TCMH1741 GENG137-13, GBVH1657-11
TCMH2102 Concretio silicea bambusae 天竺黄 TCMH2102
TCMH147 Glehnia littoralis 北沙参 TCMH147 ITSAF389-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT48 SCN5A Sodium channel protein type V alpha subunit Ion channel Q14524
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1312 Enterococcus durans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound ADRB2, AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SRC, TEK, TRPV1, TYR 8.41209
[BP] GO:0010033 response to organic substance ADRB2, AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 8.40843
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 8.40843
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.78344
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.77122
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TRPV1 7.72776
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.66903
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 7.30903
[BP] GO:0042221 response to chemical ADRB2, AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 7.19175
[BP] GO:0009719 response to endogenous stimulus ADRB2, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 6.85851
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 6.82072
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, ADRB2, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.82072
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, ADRB2, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 6.82072
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.82072
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82072
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ADRB2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.43637
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ADRB2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.37709
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.37559
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.37559
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 6.26756
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, ADRB2, AKR1B1, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC, TRPV1 6.25867
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD17B1, HSD17B2 6.19801
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.15515
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.04379
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, ADRB2, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TRPV1 6.04379
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HSPA1A, PIM1, PPARA, TYR, XDH 5.95882
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 5.90471
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.86932
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.8246
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.69554
[BP] GO:0070887 cellular response to chemical stimulus ADRB2, AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC, TRPV1 5.6858
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.647
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, AXL, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 5.5949
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.55647
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.53299
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH 5.4825
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SRC, TEK, TRPV1 5.47638
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.44303
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.20026
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.18974
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.1803
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.14514
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.13163
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 5.11389
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.08009
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.07407
[BP] GO:0051716 cellular response to stimulus ADRB2, AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TRPV1 5.07407
[BP] GO:0071310 cellular response to organic substance ADRB2, AKR1B1, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC, TRPV1 5.05917
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, RORC, SRC, TEK, TRPV1, TYR 5.05917
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GRIK5, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.04135
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ADRB2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.98638
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ADRB2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.98638
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.95227
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, ADRB2, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.89885
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.89885
[BP] GO:1901701 cellular response to oxygen-containing compound ADRB2, AKR1B1, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, RORC, SRC, TRPV1 4.89673
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, CA2, CYP1A1, EGFR, GRM1, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 4.8394
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.82493
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.77279
[BP] GO:0044236 multicellular organism metabolic process ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9, TRPV1 4.65292
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRB2, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 4.55909
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.51271
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.49958
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, TRPV1 4.47292
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ADRB2, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.45548
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.438
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR 4.40985
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.39423
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA 4.37007
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ADRB2, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.31853
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 4.309
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.2826
[BP] GO:0044237 cellular metabolic process ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 4.23125
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.21322
[BP] GO:0010243 response to organonitrogen compound ADRB2, AKR1B1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 4.12224
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.12224
[BP] GO:1901652 response to peptide ADRB2, AKR1B1, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 4.10001
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 4.08351
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.05371
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRB2, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.02815
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.93367
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 3.92302
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.92302
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, TYR, XDH 3.89898
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.89533
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRB2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.83833
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.82902
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.77282
[BP] GO:1901698 response to nitrogen compound ADRB2, AKR1B1, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.77281
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.68076
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRB2, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.66564
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.66564
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.65621
[BP] GO:0007188 None ADORA1, ADRB1, ADRB2, GRM1, GRM3, GRM5, GRM8 3.65621
[BP] GO:0042391 None ADORA1, ADRB2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.63778
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63778
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK 3.63778
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.63778
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.63778
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.63778
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRB2, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.58686
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HSD17B1, HSD17B2 3.58012
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRB2, EGFR, FLT3, GRM1, INSR, KDR, PTPN1, SRC, TEK, XDH 3.56661
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, ADRB2, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.5648
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.54941
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRB2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 3.5426
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRB2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 3.52711
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.50367
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.49156
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRB2, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK 3.47986
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.47638
[BP] GO:0031649 None ADRB1, ADRB2, TRPV1 3.47558
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 3.47158
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, HSPA1A 3.46642
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.45837
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.45582
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, ADRB2, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 3.45277
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH 3.44987
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRB2, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.44901
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.406
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRB2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.37682
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PTPN1, SRC 3.37682
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.37682
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 3.36838
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, SLC1A1, SMAD3, TRPV1 3.36238
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.35512
[BP] GO:0002024 None ADRB1, ADRB2, TRPV1 3.35512
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.34494
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC 3.33536
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, ADRB2, AKR1B1, MET, TRPV1 3.31841
[BP] GO:0007187 None ADORA1, ADRB1, ADRB2, GRM1, GRM3, GRM5, GRM8 3.31841
[BP] GO:0001659 None ADORA1, ADRB1, ADRB2, TRPV1 3.28953
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.26025
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.26025
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRB2, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TRPV1 3.25543
[BP] GO:0071495 cellular response to endogenous stimulus ADRB2, AKR1B1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, SMAD3, SRC, TRPV1 3.25125
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRB2, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 3.24061
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, ADRB2, AXL, CA2, CYP1B1, EGFR, ESRRB, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1 3.23871
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.23871
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23871
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.23708
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.23366
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.22765
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.21117
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.20944
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.19246
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.18476
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.08545
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, ADRB2, AURKB, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 3.08153
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 3.04101
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.00842
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.00842
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 2.97518
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.97407
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 2.97266
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRB2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.95969
[BP] GO:0007154 None ADORA1, ADRB1, ADRB2, AXL, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK, TRPV1 2.9588
[BP] GO:0071417 cellular response to organonitrogen compound ADRB2, AKR1B1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 2.95509
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRB2, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PTPN1, SRC 2.9455
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.9174
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91552
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.90885
[BP] GO:0009115 None AOX1, XDH 2.90885
[BP] GO:0007267 None ADORA1, ADRB1, ADRB2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.90661
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, ADRB2, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TRPV1 2.90661
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC 2.88432
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.88432
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.88432
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.87292
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.85937
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, ADRB2, EGFR, GPR35, GRM1, SLC1A1, SMAD3, TRPV1 2.85869
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.85869
[BP] GO:0045776 None ADORA1, ADRB1, ADRB2, PPARA 2.85145
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.84451
[BP] GO:1990845 None ADRB1, ADRB2, TRPV1 2.84451
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR, XDH 2.82411
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.8176
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.80474
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.7989
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 2.76563
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.76563
[BP] GO:0003018 None ADORA1, ADRB1, ADRB2, EGFR, SRC, TEK 2.76563
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, ADRB2, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.74873
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRB2, CDC25B, EGFR, ESR1, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.74024
[BP] GO:1901699 cellular response to nitrogen compound ADRB2, AKR1B1, EGFR, GRM5, IGF1R, INSR, MMP2, SRC, TRPV1 2.73726
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.69471
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.68652
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.68652
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.68409
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, ADRB2, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC 2.67269
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, XDH 2.67086
[BP] GO:0030335 positive regulation of cell migration EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.64303
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.60694
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.59282
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.59282
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.59282
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.59282
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.58476
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.55943
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADRB2, AKR1B1, AOX1, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 2.55943
[BP] GO:0023052 None ADORA1, ADRB1, ADRB2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, TEK 2.54497
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRB2, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.54497
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SRC, TRPV1 2.54497
[BP] GO:2000147 positive regulation of cell motility EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.54397
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.54355
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.54355
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.53042
[BP] GO:0099566 None GRM1, GRM5 2.53042
[BP] GO:0046110 None AOX1, XDH 2.53042
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53042
[BP] GO:0002025 None ADRB1, ADRB2 2.53042
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.52647
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, ADRB2, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TRPV1 2.52647
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 2.5133
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.50186
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.50186
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.48699
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.48699
[BP] GO:0051272 positive regulation of cellular component movement EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.4823
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC, TEK 2.48058
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.46338
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.44388
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.42669
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.42669
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.39877
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.38589
[BP] GO:0040017 positive regulation of locomotion EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.38247
[BP] GO:0051130 positive regulation of cellular component organization ADRB2, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.37867
[BP] GO:0010638 positive regulation of organelle organization ADRB2, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.34467
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34022
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.33415
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, SRC, TRPV1 2.33415
[BP] GO:0009968 negative regulation of signal transduction ADRB2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.33415
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, RORC, SRC 2.3175
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, SMAD3, TEK 2.30359
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRB2, CA2, CA7, EGFR 2.2963
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.2963
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29539
[BP] GO:0006793 phosphorus metabolic process ACHE, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 2.29539
[BP] GO:0006145 None AOX1, XDH 2.29539
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.29539
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29539
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.28156
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.27583
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRB2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.2681
[BP] GO:0051894 None KDR, SMAD3, TEK 2.25797
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25797
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.25495
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.25171
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.24248
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRB2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.24156
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.23688
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.23482
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.23313
[BP] GO:0003013 None ADORA1, ADRB1, ADRB2, EGFR, SRC, TEK 2.23313
[BP] GO:0043393 regulation of protein binding ADRB2, AURKB, MET, MMP9, PPARA, SRC 2.23313
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.20226
[BP] GO:1901653 cellular response to peptide ADRB2, AKR1B1, GRM5, IGF1R, INSR, SRC 2.20226
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.20226
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.19036
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.1745
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.1745
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1745
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 2.13084
[BP] GO:1904646 cellular response to amyloid-beta ADRB2, GRM5, IGF1R 2.12694
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRB2, EGFR, GRM1, INSR, PTPN1, SRC 2.10716
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.10716
[BP] GO:0050873 None ADRB1, ADRB2, FABP4 2.08865
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.08865
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.08749
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.08748
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRB2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.07519
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRB2, AXL, CA2, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC, TRPV1 2.06195
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.04942
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.02914
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.02914
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 2.01318
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.01318
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.01318
[BP] GO:1904645 response to amyloid-beta ADRB2, GRM5, IGF1R 2.01318
[CC] GO:0098590 plasma membrane region ADORA1, ADRB2, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK, TRPV1 6.26756
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 5.15866
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK, TRPV1 4.98638
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 4.85889
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 4.5935
[CC] GO:0043235 receptor complex ADRB2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.52013
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.43642
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SLC1A1, SRC, TEK, TRPV1, TYR 3.43228
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX5, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1, TYR 3.37396
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.05699
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 2.55943
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.41105
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.29539
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.29539
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 14.9226
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.43579
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 9.43579
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 8.40843
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK, TRPV1 8.40843
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 8.32384
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.1327
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.04498
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TRPV1, TYR, XDH 7.84649
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.21313
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.82072
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TYR, XDH 6.82072
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 6.70083
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 6.61202
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.56836
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.25867
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.15515
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK, TRPV1 6.15515
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.07596
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.47638
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.35581
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 5.29565
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.2517
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.21169
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.1803
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.1803
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 5.14514
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TRPV1, TYR, XDH 5.0622
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.05917
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 5.04313
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRB2, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.91603
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.82493
[MF] GO:0046872 metal ion binding ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SMAD3, TRPV1, TYR, XDH 4.81743
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.75001
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRB2, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.64568
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.55909
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.07788
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 3.76083
[MF] GO:0001540 amyloid-beta binding ACHE, ADRB2, BACE1, GRIA2, INSR 3.47986
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.35512
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.35512
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.35512
[MF] GO:0019899 enzyme binding ADRB1, ADRB2, AURKB, BACE1, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, GRM5, HSPA1A, MET, PPARA, PTPN1, SMAD3, SRC, TEK 3.31437
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.30753
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC, TRPV1 3.2876
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.01762
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.00879
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.90885
[MF] GO:0008389 None CYP2A13, CYP2A6 2.90885
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.89375
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.78284
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SLC1A1, SRC, TEK, TRPV1, XDH 2.69146
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.65578
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.53042
[MF] GO:0004939 None ADRB1, ADRB2 2.53042
[MF] GO:0099583 None GRM1, GRM5 2.53042
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.50557
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.50557
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.4942
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.48122
[MF] GO:0042802 identical protein binding ACHE, ADRB2, AOX1, CSNK2A1, EGFR, ESR1, ESR2, FLT3, GRIK5, IGF1R, KDR, MET, MMP9, SMAD3, TRPV1, TYR, XDH 2.48122
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.44426
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.41135
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.29539
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.29539
[MF] GO:0004971 None GRIA2, GRIA4 2.29539
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.29539
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, INSR, KDR, SMAD3 2.29539
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.29443
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.25171
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.19113
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.11451
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.11451
[MF] GO:0043559 insulin binding IGF1R, INSR 2.11451
[MF] GO:0051380 None ADRB1, ADRB2 2.11451
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.04942
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.04909


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.3187
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, ADRB1, TRPV1, ADRB2, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 9.2917
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9126
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.1998
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.35
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.9274
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.4706
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, ADRB2, MET, EGFR, IGF1R, HSPA1A 5.3631
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.2483
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4387
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3602
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.305
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1, ADRB2 4.8164
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.1105
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 4.0402
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.5219
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.3258
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP3A4, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 3.3097
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.9751
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, ADRB1, ADRB2, PPARA, GRIA4 3.3258
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1122
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0402
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.2323
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, ADRB2 2.8038
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.2323
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ADRB1, ADRB2, GRM1, EGFR 2.6698
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.6659
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2323
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.5769
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6484
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.2946
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5134
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2376
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.2946
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9201
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.7881
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2106
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1524
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.203
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1454
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, ADRB2 2.2376
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8867
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1955
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4831
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.714
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.58
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4505
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4337
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4508
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0908
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0964
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.0448
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0448
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0599
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9183
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9183
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0575
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8435
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9183
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8969
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9112
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8548
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRB2 1.0908
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8726
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8371
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0881
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8969
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8312
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8371
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2274
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, ADRB2 0.8153
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8099
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2977
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1769
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6476
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3286
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7951
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2901
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7951
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3055
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3127
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6249
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3225
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3294
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.292
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3218
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3225
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.3294
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3123
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3697
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2864
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3557
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3973
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.246
Platelet activation_Homo sapiens_hsa04611 SRC 0.4207
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2977
Axon guidance_Homo sapiens_hsa04360 MET 0.4126
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4207
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3487
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4475
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4475
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4475
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4719
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4645
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4719
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4719
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.481
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4804
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.49
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4855
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4907
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4998
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4907
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4988
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1 0.4907
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4907
Peroxisome_Homo sapiens_hsa04146 XDH 0.4998
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4907
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4642
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5337
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5322
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5207
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5461
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.565
Shigellosis_Homo sapiens_hsa05131 SRC 0.567
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5815
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5815
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6137
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.631
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6167
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6178
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6345
Malaria_Homo sapiens_hsa05144 MET 0.6463
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6476
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6476
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8097
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6476
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7138
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8292
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7172
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7726
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6983
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7567
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8271
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9996
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7951
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8099
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8312
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8022
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8271
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.305
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2983


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)