TCM Prescription: Decoction for Warming Liver



Prescription Description
Prescription IDTCMF2044
Pinyin NameNuan Gan Jian
Chinese Name暖肝煎
English NameDecoction for Warming Liver
Function Description治肝肾阴寒, 小腹疼痛, 疝气等证
IndicationsLower abdominal colic disorder
Disease ICD-11 Category SB07 [Lower abdominal colic disorder (TM1), 疝气 (TM1) ];
Human Tissues Associated with IndicationLiver, Kidney
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2295 fructus foeniculi 小茴香 TCMH2295
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 16.0591
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.9891
[BP] GO:0044281 small molecule metabolic process AKR1B1, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, PPARA, XDH 8.60791
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 8.15588
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.5661
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.93678
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.93678
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.48155
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.09337
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, HSD17B1, PPARA 5.62887
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD17B1 5.59255
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.51009
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.30326
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.61385
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.59291
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.17645
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD17B1 4.1721
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 4.04362
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 4.04362
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PPARA, XDH 3.90182
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.79608
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.79608
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.79608
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, MMP2, MMP9, PPARA 3.77373
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, PPARA 3.7011
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, MMP1, MMP2, PPARA, XDH 3.61681
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.55316
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MMP1, MMP2, MMP9, XDH 3.45476
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.3392
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 3.29383
[BP] GO:0009725 response to hormone AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, PPARA 3.29383
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.15561
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F2, FABP3, FABP4, HCAR2, HSD17B1, PPARA, XDH 3.15403
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.12679
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.10469
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, F2, PPARA 3.06147
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.05226
[BP] GO:0055114 oxidation-reduction process AKR1B1, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH 3.02096
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.98081
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.94355
[BP] GO:0009115 None AOX1, XDH 2.8522
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.82053
[BP] GO:0044255 cellular lipid metabolic process ACHE, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, PPARA 2.76575
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, FABP3, MMP2, MMP9, XDH 2.71957
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9 2.71957
[BP] GO:0009719 response to endogenous stimulus AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, MMP2, PPARA 2.7017
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.58074
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.58074
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.47562
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, F2, FABP3, HCAR2, PPARA 2.45487
[BP] GO:0010033 response to organic substance AKR1B1, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, MMP2, PPARA 2.45487
[BP] GO:0046110 None AOX1, XDH 2.45487
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45487
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, PPARA 2.43646
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37929
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 2.36448
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.33591
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.33591
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, MMP9, PPARA 2.32447
[BP] GO:1901568 fatty acid derivative metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.2827
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.2746
[BP] GO:0033993 response to lipid BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3 2.2746
[BP] GO:0014070 response to organic cyclic compound BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA 2.25937
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.25937
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.24081
[BP] GO:0006145 None AOX1, XDH 2.24081
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24081
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.24081
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.20096
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.18913
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.11682
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.09963
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, PPARA 2.09515
[BP] GO:0042221 response to chemical AKR1B1, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, MMP2, MMP9, PPARA 2.07079
[BP] GO:0046541 None CHRM1, CHRM3 2.05816
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.05709
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.03636
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3 2.00632
[CC] GO:0032279 None CHRM2, CHRM3 1.71264
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3 1.49428
[CC] GO:0098984 None CHRM2, CHRM3 1.4753
[CC] GO:0045202 None ACHE, CHRM1, CHRM2, CHRM3, CHRM5 1.46959
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 22.3124
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, XDH 18.963
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.9981
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5753
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA 9.99862
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 9.55085
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 9.33429
[MF] GO:0043169 cation binding ACHE, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, PPARA, XDH 8.28073
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.85678
[MF] GO:0043167 ion binding ACHE, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PPARA, XDH 7.40339
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.05406
[MF] GO:0046872 metal ion binding AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, PPARA, XDH 6.93678
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.93678
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.19417
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.85168
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F2, HSD17B1, MMP1, MMP2, MMP9, XDH 5.46518
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 5.08212
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.05409
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.84096
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1 4.6382
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.54356
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.42632
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.37088
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.37088
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH 4.36286
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.02095
[MF] GO:0016491 oxidoreductase activity AKR1B1, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH 3.77111
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.63871
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.47818
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.27506
[MF] GO:0008289 lipid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HSD17B1, PPARA 3.2086
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.91236
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.8522
[MF] GO:0008389 None CYP2A13, CYP2A6 2.8522
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F2, HCAR2, PPARA 2.79872
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.68841
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.45487
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F2, HCAR2, PPARA 2.32447
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.24081
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24081
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.24081
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.24081
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F2, HCAR2, PPARA 2.24081
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.05816
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05816
[MF] GO:0008081 None ADORA1, CHRM1, CHRM3, CHRM5 2.05445


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 23.9259
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.9586
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.5213
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 5.7247
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.3391
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 5.4772
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, F2 4.7395
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.7645
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, CYP19A1 4.4669
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.9842
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 3.3944
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, ESR2 3.4006
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.9842
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, CHRM5, F2 3.3002
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 2.5459
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, HSD17B1, CYP1A2, CYP1A1, AOX1, AKR1B1, CYP3A4, CYP19A1, XDH 2.3212
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.3002
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 3.1762
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.7994
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 2.069
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9, ESR1 1.476
Pathways in cancer_Homo sapiens_hsa05200 MMP1, MMP2, BCL2, MMP9 1.476
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.6169
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.476
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.469
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2 1.2711
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.476
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, CYP1B1, MMP9 1.1717
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, BCL2 1.0447
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.3104
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.2987
Hepatitis B_Homo sapiens_hsa05161 BCL2, MMP9 1.0271
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1716
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.9772
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9458
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 2.1405
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8539
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3212
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.6207
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.6207
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.6207
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.6211
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6207
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6351
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.6207
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.6207
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.6207
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5931
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6672
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5794
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5794
Peroxisome_Homo sapiens_hsa04146 XDH 0.6207
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.6207
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5921
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6629
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6207
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6207
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5358
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5358
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.5648
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5645
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5358
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.5648
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6786
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6105
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.5358
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.5358
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.524
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5358
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4883
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5259
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4814
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4814
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.451
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.4814
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4768
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7452
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7293
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7452
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8817
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.848
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8652
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8459
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8854
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9045
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4196


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)