TCM Prescription: Decoction of Magnoliae Officinalis for Warming Middle Jiao



Prescription Description
Prescription IDTCMF2036
Pinyin NameHou Po Wen Zhong Tang
Chinese Name厚朴温中汤
English NameDecoction of Magnoliae Officinalis for Warming Middle Jiao
Function Description治脾胃虚寒, 心腹胀满, 及秋冬客寒犯胃, 时作疼痛
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH214 Alpinia katsumadai 草豆蔻 TCMH214 KY454001
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT303 KCNA3 Voltage-gated potassium channel subunit Kv1.3 Ion channel P22001
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.2881
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4945
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP2, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, SRC, TRPV1, TYR 11.8978
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PTGES, SRC, TRPV1, TYR 11.799
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, SRC, TRPV1, TYR 10.0806
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PRKCE, PTGES, SRC, TYR 9.63492
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 9.1488
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOA, MCL1, MET, MTNR1B, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, SRC, TNKS, TNKS2, TRPV1, XDH 8.41489
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 8.06015
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 8.06015
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PRKCE, PRKCG, PTGES, SRC, TRPV1, TYR 7.73745
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 7.25696
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.89353
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, PRKCD, PRKCE, PRKCG, SRC, TRPV1 6.79617
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PRKCD, PRKCE, SRC, TRPV1 6.6215
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 6.43027
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.18932
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.85129
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 5.72781
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, SRC, TRPV1 5.72781
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, KDR, PRKCD, PRKCE, SRC 5.69448
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SRC, TRPV1, XDH 5.66909
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, FLT3, KDR, MCL1, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, XDH 5.6447
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, FLT3, KDR, MCL1, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, XDH 5.62017
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 5.61243
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SRC, TRPV1, XDH 5.61058
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MTNR1B, PRKCA, PRKCE 5.50084
[BP] GO:0030168 platelet activation AXL, F2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.35358
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.35358
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.23255
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 5.17674
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, PTGES, SRC 5.10553
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SRC, TRPV1, XDH 5.04591
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, CNR1, F2, KDR, PRKCE, SRC, TNKS, TNKS2, TRPV1 4.99082
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.87666
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, MTNR1A, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 4.80482
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F2, F3, FABP4, FLT3, KDR, MCL1, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, XDH 4.75596
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.6631
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SRC 4.55246
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.4972
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TRPV1, TYR 4.40085
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.37469
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, F2, F3, FLT3, KDR, MCL1, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, XDH 4.37469
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SRC 4.3536
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, PRKCE 4.34413
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.33702
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TRPV1, TYR 4.33702
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F2, FLT3, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.32128
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, MTNR1B, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, XDH 4.30355
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.25966
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCD, SRC, TNKS2, TYR 4.25966
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, MTNR1B, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, XDH 4.20984
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.20427
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.20427
[BP] GO:0044092 negative regulation of molecular function AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TNKS 4.14908
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F2, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCD, PRKCG, SRC, TNKS2, TRPV1, TYR 4.13445
[BP] GO:0080134 regulation of response to stress CDK6, CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, IGF1R, MCL1, MET, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, XDH 4.0575
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.0575
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TRPV1, TYR 4.01297
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PRKCB, PRKCD, PRKCE, SRC, TRPV1 3.96911
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, PTGES, SRC, XDH 3.96521
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, SRC 3.96182
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PRKCB, PRKCD, PRKCE, SRC, TRPV1 3.93104
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, XDH 3.91166
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, FLT3, MCL1, MET, MTNR1B, PRKCB, PRKCE, SRC, TRPV1 3.91166
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.91166
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGES, TBXAS1 3.91166
[BP] GO:0032879 regulation of localization ACHE, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F2, F3, IGF1R, KCNA3, KDR, MET, MMP9, MTNR1B, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TRPV1 3.91166
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, XDH 3.87222
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 3.8712
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, F2, F3, FLT3, KDR, MCL1, MET, PRKCA, PRKCB, PRKCE, PTPN1, SRC, XDH 3.85802
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SRC 3.85611
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 3.76307
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.72785
[BP] GO:0007165 signal transduction AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TNKS, TNKS2, TRPV1 3.71036
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F2, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA 3.6955
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, XDH 3.62853
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, PRKCD, PRKCE, SRC, TRPV1 3.61469
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, F2, KDR, PRKCE, SRC, TRPV1 3.60829
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, MTNR1A, MTNR1B, PPARA, PRKCG, SRC 3.59771
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.53518
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, XDH 3.49676
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, TBXAS1 3.4776
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.43626
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 3.42389
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP3, FABP4, MET, MTNR1B, PRKCB, PRKCE, TRPV1 3.40742
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 3.39473
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.2898
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.22517
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.22517
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.19705
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 3.1443
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.14119
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.12817
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PRKCB, PRKCD, PRKCE, SRC, TRPV1 3.12631
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 3.04697
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, KCNA3, PPARA, PRKCB, PRKCE, TRPV1 3.04667
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SRC 3.0186
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.01044
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.01025
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TRPV1 2.99407
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.98979
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, KDR, MET, PPARA, PRKCA, PRKCD, PRKCG 2.97867
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 2.95046
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SRC 2.94386
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, F2, IGF1R, MCL1, MET, MMP9, PPARA, PRKCB, PRKCD, PTPN1, SRC, XDH 2.93017
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.93017
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F2, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.93017
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.91582
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 2.91004
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, SRC 2.88824
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, SRC 2.85825
[BP] GO:0007166 cell surface receptor signaling pathway AXL, BCL2, CA1, CSNK2A1, F2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TNKS2, TRPV1 2.85825
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.85825
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.80845
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.78369
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, PTGES, TBXAS1 2.78065
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, F2, KCNA3, MMP9, MTNR1B, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TRPV1 2.78065
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.78065
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, F2, FLT3, FUT7, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TRPV1 2.7795
[BP] GO:0009893 positive regulation of metabolic process AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.76797
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, KDR, MMP9, MTNR1A, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 2.75918
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, KDR, MMP9, MTNR1A, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 2.75918
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SRC 2.75124
[BP] GO:0035408 None PRKCA, PRKCB 2.75124
[BP] GO:0009115 None AOX1, XDH 2.75124
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7463
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.7463
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, SRC 2.7121
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, IGF1R, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.71142
[BP] GO:0032845 None BCL2, PRKCE, SRC, TNKS, TNKS2, TRPV1 2.67467
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 2.67467
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KCNA3, KDR, MAOA, MCL1, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.66617
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65978
[BP] GO:0009892 negative regulation of metabolic process AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, IGF1R, KDR, MCL1, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.64711
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.6128
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, F2, TNKS, TNKS2 2.57648
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MCL1, MET, MMP9, PRKCD, PTPN1, SRC, XDH 2.56859
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, IGF1R, MCL1, MET, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.55472
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MCL1, MMP9, PIM1, PPARA, SRC, TYR 2.54946
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, MAOA, TYR 2.54946
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SRC, TNKS, TNKS2 2.52016
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.51383
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.51383
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGES, SRC 2.50563
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MMP9, PTPN1, SRC 2.49256
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, PRKCD, SRC, TYR 2.45136
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.44722
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.44722
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.44722
[BP] GO:0009894 regulation of catabolic process BCL2, CNR1, CSNK2A1, ESRRB, KDR, MCL1, MET, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1 2.43847
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.43847
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, SRC, TRPV1, TYR 2.43718
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP2, MMP9, SRC, XDH 2.42173
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, MMP2, PPARA, PRKCD, PRKCE, PTPN1, SRC 2.42173
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, MTNR1A, SRC 2.4092
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.38969
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.38829
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES 2.38545
[BP] GO:0030335 positive regulation of cell migration BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.38545
[BP] GO:0046110 None AOX1, XDH 2.38545
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38545
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, F2, PRKCD, TRPV1, XDH 2.37858
[BP] GO:0002682 regulation of immune system process AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, F2, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC 2.37435
[BP] GO:0010676 None ESRRB, PPARA, PRKCE, SRC 2.37162
[BP] GO:0050994 None CNR1, PPARA, PRKCD, PRKCE 2.37162
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CA3, CYP1B1, MMP9, PRKCD, SRC 2.36996
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TNKS 2.36996
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F2, F3, KDR, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCE, SRC, TRPV1 2.36246
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, PRKCD, PTGES, SRC 2.34838
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.34824
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.34774
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, PPARA, PRKCD, SRC, TRPV1 2.32629
[BP] GO:0006950 response to stress ACHE, AKR1B1, AXL, BCL2, CA2, CA3, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, F2, HSD11B2, MCL1, MMP2, MMP9, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TRPV1 2.30297
[BP] GO:2000147 positive regulation of cell motility BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.29677
[BP] GO:2000145 regulation of cell motility BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.28815
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 2.24669
[BP] GO:0065009 regulation of molecular function AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TNKS, TRPV1, XDH 2.2326
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.2326
[BP] GO:0051272 positive regulation of cellular component movement BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.21415
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, CDC25B, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 2.2103
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, F2, PRKCD, PTGES, SRC 2.20185
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.20185
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.19486
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, F2, PPARA, PRKCD 2.18751
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.18412
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.18412
[BP] GO:0034097 response to cytokine AXL, BCL2, FABP4, FLT3, MCL1, PRKCA, PTGES, SRC, TRPV1 2.17909
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17552
[BP] GO:0042327 positive regulation of phosphorylation BCL2, CDC25B, ESRRB, F2, FLT3, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 2.17552
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.15382
[BP] GO:0070213 None TNKS, TNKS2 2.15382
[BP] GO:0006145 None AOX1, XDH 2.15382
[BP] GO:0038171 None CNR1, CNR2 2.15382
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15382
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.14888
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.14481
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14481
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, F2, F3, FABP4, KDR, MET, PRKCA 2.14155
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SRC, TRPV1, TYR 2.13392
[BP] GO:0040017 positive regulation of locomotion BCL2, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.13392
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, MCL1, MMP9, PRKCD, SRC, TRPV1, XDH 2.12575
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.12575
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.09776
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, MCL1, MMP9, PRKCD, SRC, TRPV1, XDH 2.09452
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.09452
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, ESR1, F2, FABP4, PPARA, PRKCD 2.07407
[BP] GO:0040012 regulation of locomotion BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.02008
[BP] GO:0051270 regulation of cellular component movement BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, SRC 2.00796
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.00247
[BP] GO:0045913 None ESRRB, PPARA, PRKCE, SRC 2.00114
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOA, MCL1, MMP2, MMP9, NQO2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.51637
[CC] GO:0016020 membrane ACHE, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KCNA3, KDR, MAOA, MCL1, MET, MMP2, MTNR1A, MTNR1B, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR 3.0217
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, CA4, PRKCA, PRKCD, PRKCE, PRKCG, PTGES, SRC, TNKS2, TYR 2.49582
[CC] GO:0005886 plasma membrane ACHE, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F2, F3, FLT3, GBA2, IGF1R, KCNA3, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TRPV1 2.2369
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA7, CBR1, CDC25B, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, MCL1, NQO2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 1.8512
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.5235
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, TBXAS1, TNKS, TYR, XDH 18.927
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 13.2551
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4101
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, TNKS 11.5572
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 11.1038
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0868
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 8.06015
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 7.73745
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.03844
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 6.84545
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.80502
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.72781
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TRPV1 5.32157
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.0867
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.27541
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.20984
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.20427
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH 4.14908
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.03799
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.84802
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.70678
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.61565
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.61565
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, TRPV1 3.55771
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50222
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.50222
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.30571
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.27674
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.2484
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.22517
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.19066
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.1443
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.1009
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.04667
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.91004
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.88824
[MF] GO:0038023 signaling receptor activity AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 2.80845
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.80845
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CDK6, CSNK2A1, F2, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, SRC, TRPV1, XDH 2.78732
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.78065
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.75124
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.75124
[MF] GO:0003845 None HSD11B1, HSD11B2 2.75124
[MF] GO:0035403 None PRKCA, PRKCB 2.75124
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, MTNR1A, NQO2 2.67467
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TRPV1, XDH 2.64731
[MF] GO:0060089 molecular transducer activity AXL, CDK6, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 2.60454
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TRPV1, XDH 2.60454
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TRPV1, XDH 2.60373
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.58193
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.55184
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.53143
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.44722
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, F2, F3, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 2.4092
[MF] GO:0008502 None MTNR1A, MTNR1B 2.38545
[MF] GO:0004949 None CNR1, CNR2 2.38545
[MF] GO:0004699 None PRKCD, PRKCE 2.38545
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.3262
[MF] GO:0004871 signal transducer activity AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, PRKCE, TRPV1 2.32309
[MF] GO:0004872 receptor activity AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 2.3154
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15382
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TRPV1 2.08932


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.863
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.5455
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.5144
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, CDK6, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, CDC25B, MCL1 7.5143
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, F3 7.0485
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, IGF1R 7.0485
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.8592
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, SRC, PRKCE, PRKCD, PRKCA, TRPV1 5.8592
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, CDK6, PRKCB, FLT3, MMP1, MMP2, BCL2, PRKCA, MMP9, MET, IGF1R 5.4572
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, SRC, KDR, BCL2, PRKCA, MET, IGF1R 4.9957
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, CNR1, KDR, PRKCA, MET, IGF1R 4.919
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2644
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, PRKCB, SRC, BCL2, PRKCA, MMP9 4.919
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, ESR2 4.7508
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.9957
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PRKCB, PRKCA, IGF1R 4.4269
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, SRC, KDR, PRKCA 4.5382
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.2018
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1962
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA 3.8395
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, MTNR1A, PRKCB, MTNR1B, PRKCA 3.7926
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.8122
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.0206
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PRKCB, BCL2, PRKCA 3.5393
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, BCL2, PRKCA, IGF1R 3.6492
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, PRKCE, PRKCD, PPARA 3.5471
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, MAOA, ALOX5, PRKCA 3.5349
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PRKCB, PRKCA 4.0206
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9586
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, SRC, PRKCA, ESR1 3.4686
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PRKCB, PRKCA 3.5393
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.4686
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, MMP2, PRKCA, MMP9 3.4686
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, PRKCE, BCL2, PRKCA 3.4686
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.7926
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, KDR, PRKCA, MET, IGF1R 3.1568
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, PRKCA, MET, MCL1, IGF1R 3.0456
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.4686
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, MAOA, PRKCA 3.3482
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.2131
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.082
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 MTNR1A, CNR2, CNR1, MTNR1B, TRPV1, F2 2.7959
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, TBXAS1, PTGES 3.4686
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, SRC, PRKCA 3.0014
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.8063
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3096
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA 2.7986
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 3.0005
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, MAOA, PRKCA 2.4175
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA 3.0005
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.8652
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 2.2952
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 2.1696
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, SRC, PRKCA 2.1696
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9935
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5261
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 1.5432
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.2272
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 1.5643
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.3925
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2169
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.2952
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 1.9759
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.9935
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.0396
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA 1.8821
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.7528
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, PRKCB, PRKCA 1.2803
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 1.8861
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 1.9045
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2 1.9555
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, SRC, PRKCD 1.243
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9252
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1 2.2482
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.2272
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3043
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.2851
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3142
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3241
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3117
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PRKCE 0.3251
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.8444
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8573
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3547
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PRKCA 0.3675
Influenza A_Homo sapiens_hsa05164 PRKCB, PRKCA 0.7124
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9252
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.9289
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3764
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6527
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7082
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0654
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3885
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8422
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3885
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.8239
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.937
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.6299
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4037
Axon guidance_Homo sapiens_hsa04360 MET 0.3985
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9176
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6517
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4037
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4397
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1314
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4672
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4864
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4873
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5002
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1535
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5024
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5013
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2211
Peroxisome_Homo sapiens_hsa04146 XDH 0.521
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.2159
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.323
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5662
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.5662
Leishmaniasis_Homo sapiens_hsa05140 PRKCB 0.5662
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5743
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5696
Bile secretion_Homo sapiens_hsa04976 CA2 0.5674
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5719
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5824
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5824
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3161
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5844
Shigellosis_Homo sapiens_hsa05131 SRC 0.5824
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5933
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6297
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4389
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4159
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 3.0049
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.6299
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6527
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6527
Malaria_Homo sapiens_hsa05144 MET 0.6542
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6527
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6542
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.6696
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6552
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6598
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6647
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCE, PRKCD 1.5643
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 3.0049
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7093
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8055
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8251
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9133
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8251
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8496
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7881
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8821
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8422
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8745
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1032
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.988
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9686
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0654
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3782
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.277


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)