TCM Prescription: Combined Yi Bai Multi-Ingredient Recipe



Prescription Description
Prescription IDTCMF1989
Pinyin NameFu Fang Yi Bai He Ji
Chinese Name
English NameCombined Yi Bai Multi-Ingredient Recipe
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH177 Polygonum aviculare 萹蓄 TCMH177 ITSAG3700-14
TCMH1706 Dianthus superbus 瞿麦 TCMH1706 ITSAJ4556-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 12.9769
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 10.5828
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, PRKCA, RORC, SRC, TYR 10.2774
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PRKCA, RORC, SRC, TERT, TYR 10.2203
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.93951
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA 9.63424
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.61699
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.32509
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.34489
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.34489
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, RORC, SRC, TYR 8.34386
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, RORC, SRC, TERT, TNKS2, TOP2A, TYR 8.34386
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, SRC, TERT 8.34386
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, PRKCA, SRC, TERT, TNKS, TNKS2, XDH 8.3205
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 7.97753
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, KIT, MMP2, PPARA, SRC 7.96863
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, RORC, SRC, TYR 7.48207
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.41632
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, SRC, TERT, XDH 7.07968
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.02832
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.00487
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.89748
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.45468
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC, TERT 6.40528
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TERT, TOP2A, XDH 6.37146
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, PPARA, SRC 6.29707
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCA, PTPN1, SRC, TERT, TOP2A, XDH 6.27099
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DYRK1A, ESR1, F3, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 6.2681
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, TERT 6.24864
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, GLO1, PIM1, PPARA, TYR, XDH 6.04571
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.01635
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.90965
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TNKS 5.90965
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 5.90965
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.90965
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.8991
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RORC, SRC 5.76214
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.74913
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, KIT, PPARA, RORC, SRC, TOP2A 5.74913
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, PTPN1, SRC, TNKS, XDH 5.72744
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.59383
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.54622
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 5.50364
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 5.48507
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 5.47114
[BP] GO:0009893 positive regulation of metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.45111
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, PTPN1, SRC, TNKS, XDH 5.37656
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PPARA, SRC, TYR 5.24497
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.20119
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, TYR 5.18582
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, RORC, SRC, TERT, TOP2A 5.18508
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA 5.1685
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TERT 5.15229
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, KIT, MMP9, PIM1, PPARA, RORC, SRC, TYR 5.13512
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.12335
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TOP2A, TYR 5.1214
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SRC, TERT, TOP2A, XDH 5.1214
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, GBA2, KIT, MET, PPARA 5.1024
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.09732
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.0938
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HSD11B2, KDR, SRC 5.06874
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TYR 5.05679
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 4.96226
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PRKCA, PTPN1, SRC, TERT 4.95947
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.95345
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 4.81445
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TNKS 4.80329
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.80203
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.71921
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 4.70701
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.56136
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, SRC, TERT 4.55439
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 4.46964
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, TERT 4.42672
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.42372
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, KDR, KIT, MET, MMP12, MMP2, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.42372
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.39821
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 4.32242
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.20851
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.1992
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, DRD1, ESR1, IGF1R, MMP2, MMP9, RORC, SRC 4.19904
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PRKCA, SRC, TNKS, TOP2A 4.18766
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.17233
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 4.16307
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.13152
[BP] GO:0032879 regulation of localization ABCB1, ACHE, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, SRC, TERT 4.12322
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, KIT, MET, MMP2, MMP9, RORC, SRC, TERT, TOP2A 4.12119
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SRC 4.11565
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CDK6, CYP19A1, DRD2, DYRK1A, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PRKCA, PTPN1, SRC, TERT, XDH 4.07891
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.9511
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PRKCA, PTPN1, SRC, XDH 3.93527
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, SRC, TOP2A 3.8945
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.88383
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, KDR, SRC, TNKS, TNKS2 3.85979
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 3.82321
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, ESR1, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 3.74548
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.69487
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MET, PRKCA, PTPN1, SRC, XDH 3.68588
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 3.67149
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SRC, TERT 3.63574
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.6218
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HSD11B2, KIT, MMP2, PPARA, SRC, TERT, TYR 3.5523
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.54786
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, PRKCA, SRC, TNKS 3.52062
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.48899
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.48555
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TNKS 3.46068
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.46068
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.46068
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, DRD2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.44288
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.41426
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.39876
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MET, PIM1, SRC, TYR 3.38998
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, PRKCA, TERT, TNKS, TOP2A 3.36157
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.36157
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.36157
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.34105
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.3126
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC, TERT 3.30584
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 3.30584
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 3.28575
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, PRKCA, SRC, TNKS 3.27602
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC, TERT 3.22132
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.18835
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.17422
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.17422
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 3.14749
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 3.14749
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, PRKCA, SRC, TERT 3.1071
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC 3.06859
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.053
[BP] GO:0045934 None APEX1, AURKB, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, MMP12, PPARA, PRKCA, RORC, SRC, TERT, TNKS, TNKS2 3.05255
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 3.03005
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.01015
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.00367
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.00138
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCA, TNKS 3.00138
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, TYR 3.00138
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC, TERT 2.99941
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 2.98639
[BP] GO:0019222 regulation of metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.96857
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, KIT, MET, SRC, XDH 2.95309
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT 2.9095
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT 2.9095
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, PIM1, PRKCA, SRC, TERT, TNKS, TOP2A 2.90632
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.90514
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CDK6, CYP19A1, DRD1, DRD2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.88169
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, PRKCA, TERT 2.87496
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.87496
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.87496
[BP] GO:0009115 None AOX1, XDH 2.865
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.865
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCA, TNKS 2.865
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.85993
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 2.83811
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, TNKS, TNKS2 2.80058
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.79359
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2 2.78964
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.77344
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DRD1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.75951
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, KDR, KIT, MET, MMP12, MMP9, PIM1, PRKCA, SRC, TERT 2.7396
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.7169
[BP] GO:0080090 regulation of primary metabolic process APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.66637
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.6649
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PRKCA, PTPN1, SRC 2.65049
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 2.64131
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.64011
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, KIT, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.62585
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.61653
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, DRD1, ESR1, FLT3, IGF1R, KIT, MMP2, SRC 2.61157
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PRKCA, PTPN1, SRC, XDH 2.60842
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.58278
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.57275
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, SRC 2.53303
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DRD1, DRD2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.5038
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.50047
[BP] GO:0051171 regulation of nitrogen compound metabolic process APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.49823
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DRD1, DRD2, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.49391
[BP] GO:0051247 positive regulation of protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 2.48867
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, TERT 2.48301
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.47935
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, ESR1, FLT3, FUT7, IGF1R, KDR, KIT, MET, PIM1, PRKCA, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.47935
[BP] GO:0042327 positive regulation of phosphorylation APP, BCL2, CDC25B, DRD2, ESRRB, FLT3, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 2.47935
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.47935
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.47935
[BP] GO:0046110 None AOX1, XDH 2.47935
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47935
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.47001
[BP] GO:0065009 regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC, TERT, TNKS, XDH 2.46053
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.46053
[BP] GO:0031323 regulation of cellular metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.46053
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, TERT, TNKS 2.45816
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.41854
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, SRC 2.41249
[BP] GO:2001251 None DNMT1, SRC, TNKS, TNKS2, TOP2A 2.41249
[BP] GO:0065007 biological regulation ABCB1, ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.41249
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.41249
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.41196
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, IGF1R, KIT, MET, MMP12, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.39588
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, TERT 2.37665
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.36769
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.35887
[BP] GO:0010468 regulation of gene expression APEX1, APP, AURKB, BCL2, CA9, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, KDR, KIT, MET, MMP12, PIM1, PPARA, PRKCA, RORC, SRC, TERT, TNKS, TOP2A, XDH 2.35708
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35412
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.338
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.31248
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.30142
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.30142
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.30142
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.29791
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.29233
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, KIT, TYR 2.29033
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, KDR, KIT, PIM1, PPARA, PRKCA, RORC, SRC, TERT, TNKS2, XDH 2.28578
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.28485
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 2.28485
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2 2.2704
[BP] GO:0031401 positive regulation of protein modification process APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 2.26454
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25713
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, IGF1R, MMP2, SRC 2.25517
[BP] GO:0043410 positive regulation of MAPK cascade APP, DRD2, FLT3, KDR, KIT, PRKCA, PTPN1, SRC, XDH 2.25517
[BP] GO:0070213 None TNKS, TNKS2 2.25517
[BP] GO:0006145 None AOX1, XDH 2.25517
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25517
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.25517
[BP] GO:0001932 regulation of protein phosphorylation APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 2.25112
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23993
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.22795
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC 2.22795
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2223
[BP] GO:0009889 regulation of biosynthetic process APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PRKCA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.22097
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.22097
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.20569
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, FABP3, FABP4, KIT, MET 2.20562
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, IGF1R, KIT, MMP9, PRKCA, PTPN1, SRC, TERT, TNKS, XDH 2.20049
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PRKCA 2.20049
[BP] GO:0048169 None APP, DRD2, KIT 2.17963
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.17963
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.17963
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, DRD2, ESR1, ESR2, IGF1R, KDR, KIT, MET, MMP1, MMP9, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.13613
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.13613
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13613
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.13613
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.13588
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, MET 2.13588
[BP] GO:0007165 signal transduction AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2 2.13588
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.13588
[BP] GO:0031399 regulation of protein modification process APP, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 2.13548
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.13316
[BP] GO:0001934 positive regulation of protein phosphorylation APP, BCL2, CDC25B, DRD2, FLT3, KDR, KIT, MMP9, PRKCA, PTPN1, SRC, XDH 2.13316
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.12645
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.12645
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, KDR, KIT, PIM1, PRKCA, SRC, TERT 2.12239
[BP] GO:0006357 None APP, AURKB, CA9, DNMT1, DRD2, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MET, MMP12, PPARA, RORC, TERT, TNKS, TOP2A 2.11351
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.10925
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.10828
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.10069
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TNKS, TNKS2 2.10069
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.10069
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, SRC 2.10069
[BP] GO:0021853 None DRD1, DRD2 2.10069
[BP] GO:0043696 None CDK6, ESRRB 2.10069
[BP] GO:0043697 None CDK6, ESRRB 2.10069
[BP] GO:0010641 None F3, SRC 2.10069
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.10069
[BP] GO:1904936 None DRD1, DRD2 2.10069
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, MMP12, SRC, TERT 2.09002
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, IGF1R, MMP2, SRC 2.08755
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.08344
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA 2.08257
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.08257
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, SRC 2.06009
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, SRC 2.02315
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.02315
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MMP1, MMP12, MMP9, SRC 2.01715
[BP] GO:0031326 regulation of cellular biosynthetic process APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KIT, MET, MMP12, PIM1, PPARA, PRKCA, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 2.01394
[BP] GO:0032845 None BCL2, DRD2, SRC, TNKS, TNKS2 2.01378
[BP] GO:0002244 None BCL2, FLT3, KIT, TOP2A 2.00946
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.00946
[BP] GO:1901987 None APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, TERT 2.00946
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.00813
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.00813
[BP] GO:0010628 positive regulation of gene expression APP, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, KIT, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TOP2A 2.00813
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, TERT, XDH 2.00261
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.98215
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.0441
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, KIT, MMP12, MMP2, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.69933
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.48602
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, KIT, MMP2, MMP9, PIM1, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.41249
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX5, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 2.3373
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, GBA2, GLO1, IGF1R, KDR, KIT, MET, MMP2, PIM1, PRKCA, PTPN1, SRC, TERT 2.11644
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, TNKS, TYR, XDH 18.6928
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.0628
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PRKCA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 13.9345
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PRKCA, PTPN1, RORC, TNKS 10.1481
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1299
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.1299
[MF] GO:0046872 metal ion binding ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.34489
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.80496
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 6.37146
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.2807
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, PRKCA, SRC, TOP2A 6.01635
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.80538
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.26664
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.24497
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.19939
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.19939
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.1214
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.093
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.81457
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.70834
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.66603
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.29471
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.15337
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC 4.12119
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.01136
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.97044
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.74145
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, TERT, TOP2A, TYR, XDH 3.46068
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.44288
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC 3.35184
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.34084
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.30584
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.26857
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.1071
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, SRC, XDH 3.04808
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC 3.00367
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.95966
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TERT 2.9427
[MF] GO:0019899 enzyme binding ALPI, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, ESR1, ESR2, ESRRB, F3, KIT, MET, PPARA, PRKCA, PTPN1, SRC, TNKS2, TOP2A 2.87409
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.865
[MF] GO:0003845 None HSD11B1, HSD11B2 2.865
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.7396
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.73054
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A, XDH 2.72515
[MF] GO:0097159 organic cyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.7169
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A, XDH 2.62889
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A, XDH 2.62787
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.47972
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.47935
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PRKCA, PTPN1, SRC 2.46467
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.45952
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.40987
[MF] GO:0038023 signaling receptor activity AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.25713
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25517
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.25517
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.25517
[MF] GO:0032403 protein complex binding ACHE, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.15745
[MF] GO:1901363 heterocyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.13245
[MF] GO:0060089 molecular transducer activity AXL, CDK6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.12028
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.10069
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.10069
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A, XDH 2.06518
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PRKCA, SRC, TOP2A 2.01257


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 10.5769
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9311
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7359
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH 5.4685
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, CDC25B 5.6077
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, IGF1R 4.9348
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, KIT, BCL2, PRKCA, MMP9, MET, IGF1R 4.6889
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, PRKCA, DRD2, MET, IGF1R 3.9212
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.0241
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0241
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, PRKCA, F3 3.585
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.5971
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.8914
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8617
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, PRKCA, MET, IGF1R 3.1879
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8529
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KIT, KDR, BCL2, PRKCA, MET, IGF1R 2.9183
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, PRKCA, MMP9 2.9473
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.1711
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0942
Gap junction_Homo sapiens_hsa04540 SRC, PRKCA, DRD1, DRD2 2.7713
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, PRKCA, MET, IGF1R 2.1669
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.1679
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0312
Glioma_Homo sapiens_hsa05214 CDK6, PRKCA, IGF1R 2.0719
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.1354
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.0497
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0312
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.0312
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0312
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8159
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 1.7799
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.0312
Melanogenesis_Homo sapiens_hsa04916 KIT, PRKCA, TYR 1.6998
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, PRKCA 1.6202
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, PRKCA, IGF1R 1.6799
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PRKCA 1.6202
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA, ESR1 1.5822
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA, DRD1, DRD2 1.4946
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.5822
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4208
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3167
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.4329
cAMP signaling pathway_Homo sapiens_hsa04024 DRD1, DRD2, PPARA 1.1149
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA 1.0649
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.1631
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 1.017
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0623
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9401
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.017
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8002
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7865
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0649
Morphine addiction_Homo sapiens_hsa05032 PRKCA, DRD1 1.051
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.0649
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7865
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.7865
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8908
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1278
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2, PRKCA 0.8837
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0649
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT, PRKCA 0.7841
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA, DRD1 1.2292
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8642
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.7742
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0401
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.0212
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PRKCA 1.3381
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA 0.7459
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.3045
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCA, DRD1 0.6801
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6801
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7126
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2244
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6801
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6243
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2314
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6242
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2818
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3107
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3208
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3337
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3411
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 DRD1, DRD2 0.5093
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3201
Influenza A_Homo sapiens_hsa05164 PRKCA 0.3337
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.5478
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3753
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3979
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3979
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4069
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4046
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.4505
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4069
Platelet activation_Homo sapiens_hsa04611 SRC 0.4225
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4252
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4225
Axon guidance_Homo sapiens_hsa04360 MET 0.4171
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4225
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.447
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4372
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4252
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4325
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA 0.4748
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4748
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.4816
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.4748
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4816
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.4748
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4816
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.4816
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA 0.4748
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4887
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.4895
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4895
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4598
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.702
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PRKCA 1.5805
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5093
Peroxisome_Homo sapiens_hsa04146 XDH 0.5056
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5406
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.514
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5499
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5478
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6202
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7194
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.5578
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5578
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5578
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5578
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5479
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.5645
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5478
Shigellosis_Homo sapiens_hsa05131 SRC 0.5578
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5578
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5596
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.5877
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5596
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6799
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5909
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6202
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6167
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6167
Malaria_Homo sapiens_hsa05144 MET 0.6242
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8824
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6243
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6243
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6421
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6375
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7126
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6763
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7459
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.1669
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7275
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7615
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7865
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7523
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7809
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8969
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0156
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2553


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)