TCM Prescription: Shan Ju Jiang Ya Tablet



Prescription Description
Prescription IDTCMF196
Pinyin NameShan Ju Jiang Ya Pian 
Chinese Name山菊降压片
English NameShan Ju Jiang Ya Tablet
Function Description头痛眩晕, 耳鸣健忘, 腰膝酸软, 五心烦热, 心悸失眠; 高血压病见上述证候者
IndicationsTinnitus disorder, Vertigo disorder, Forgetfulness disorder, Hypertension
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
BA2Z [Hypotension, unspecified, 低血压,未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH2410 Alisma orientale 盐泽泻 TCMH2410 KC573871
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH2297 Cirsium setosum 小蓟 TCMH2297 ITSAJ4303-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 7.02181
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.64963
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PHF8, PIM1, RORC, SRC, TNKS2, TOP2A, TYR 5.97351
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 5.76827
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET 5.74105
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.49002
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, RORC, SRC, TYR 5.45946
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 5.45946
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.29157
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.24853
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FUT7, GLO1, PIM1, TYR, XDH 5.23561
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.14571
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EPHX2, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.14571
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, RORC, SRC, TYR 4.98769
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.88987
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.88987
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, RORC, SRC, TYR 4.88987
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.87934
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.8424
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.73567
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.61997
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.61026
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, MET, SRC, TNKS, TNKS2, XDH 4.57468
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PHF8, TYR, XDH 4.49364
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37804
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EPHX2, KDR, SRC 4.31967
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.31706
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 4.31706
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.22638
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.2007
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC 4.17394
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.99203
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.94521
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.94037
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.94037
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 3.94037
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.87826
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 3.87826
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.87596
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 3.84227
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.84197
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.84197
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, SRC, TNKS, TNKS2 3.84197
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.84197
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.84197
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.84197
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.7963
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 3.74171
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.72592
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.65292
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.58421
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PTPN1, RORC, SRC, TOP2A, TYR 3.56869
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, MET 3.52863
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.50227
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 3.45172
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC, TOP2A 3.45172
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PHF8, SRC, TYR 3.33275
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, EPHX2, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, SRC, TNKS2, TYR 3.31499
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MMP9, PHF8, PIM1, RORC, SRC, TYR 3.26559
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.24157
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.23143
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.17199
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 3.14705
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 3.1373
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.07594
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.05249
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.95549
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91424
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.88805
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.87384
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.85897
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.81644
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.81644
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.81644
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.79276
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, SRC 2.79276
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, SRC 2.79276
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EPHX2, FABP3, FABP4, FLT3, MET, SRC 2.77613
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, SRC 2.73185
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.71337
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.67788
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.65027
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.63524
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.63524
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.62951
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3 2.62373
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX2, RORC 2.61391
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.54319
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.51732
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.51032
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.49226
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.49226
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.49152
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.46603
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP3, KDR, SRC 2.46534
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.44814
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.44814
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.44784
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44784
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.43942
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC 2.43942
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, RORC, SRC, TOP2A 2.4381
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, IGF1R, MMP2, MMP9, RORC, SRC 2.4065
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.39256
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.36913
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31482
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 2.29804
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.28009
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1 2.2768
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2768
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, FLT3, RORC, SRC 2.25332
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.2313
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PTPN1, SRC, XDH 2.22146
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PTPN1, SRC, TNKS 2.21644
[BP] GO:0070213 None TNKS, TNKS2 2.21644
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21644
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.21644
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EPHX2, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.21493
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CBR1, CDK6, CYP1A1, FABP4, FLT3, FUT7, GLO1, KDR, MMP2, MMP9, RORC, TOP2A 2.20273
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.20273
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, EPHX2, FABP3, FLT3, RORC, SRC 2.19355
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.16986
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, FLT3, MET, PIM1, SRC, TYR 2.16815
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.16381
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, BCL2, CDC25B, CSNK2A1, EPHX2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.15504
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, TNKS, TOP2A 2.151
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 2.14425
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.13455
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.11557
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A 2.10681
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.08931
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.0811
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.06408
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.05151
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1 2.04943
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, PIM1, TYR 2.03513
[BP] GO:0009615 response to virus BCL2, CDK6, CHRM2, CYP1A1, MMP12, SRC 2.02389
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.00282
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.49415
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.91423
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 1.90255
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, AURKB, BCL2, CA1, CA2, CA7, CBR1, CDC25B, CDK6, CSNK2A1, EPHX2, FABP3, FABP4, FLT3, GLO1, HSD17B1, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 1.62602
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, AURKB, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 1.3649
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 12.4632
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, TNKS, TYR, XDH 10.1657
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 8.17485
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.17485
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.65819
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PHF8, TYR, XDH 5.26033
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.14571
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 4.96063
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PTPN1, RORC, TNKS 4.88987
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.7221
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 4.63636
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, XDH 3.99455
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.84197
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.67887
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.67775
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP2A 3.47317
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.34526
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.24157
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, TYR 3.07594
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.90045
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.85289
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.81604
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.77927
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.77259
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.53112
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.43544
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.29793
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.28009
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PTPN1, SRC 2.25058
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.03836
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PTPN1, SRC 2.03671
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.02337


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5919
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.5233
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5201
Metabolic pathways_Homo sapiens_hsa01100 CBR1, EPHX2, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.3848
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.421
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.9274
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1425
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7708
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.8248
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.3592
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KDR, BCL2, MET, IGF1R 2.7438
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.8526
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2019
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.4187
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8681
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2 2.4187
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.2947
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.961
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1578
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.9547
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.3074
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.961
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.8729
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7612
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.8097
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2287
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4511
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.3919
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4501
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4199
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4346
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3786
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2111
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1172
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2031
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.378
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1 1.0774
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1625
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3919
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2763
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2287
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1319
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.2364
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1952
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0677
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9727
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8732
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0677
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8884
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0368
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9638
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8536
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8312
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7673
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0431
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.765
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1 0.7716
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.7442
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7962
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8661
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3181
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4357
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4254
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.4212
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4156
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4862
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.5322
Platelet activation_Homo sapiens_hsa04611 SRC 0.5123
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4862
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5322
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4556
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4751
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4154
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4862
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5738
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5123
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4946
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4862
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5123
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5144
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5123
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5599
Axon guidance_Homo sapiens_hsa04360 MET 0.5075
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5632
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5297
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5667
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5738
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5738
Gap junction_Homo sapiens_hsa04540 SRC 0.5738
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5667
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5738
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5738
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5667
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5738
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6218
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6223
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6362
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6214
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6362
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6362
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6362
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6362
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6362
Bile secretion_Homo sapiens_hsa04976 CA2 0.6227
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6289
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6362
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6289
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6578
Shigellosis_Homo sapiens_hsa05131 SRC 0.6362
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6897
Malaria_Homo sapiens_hsa05144 MET 0.7001
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7199
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.765
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7943
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8312
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.838
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8119
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8614
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8312
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8536
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1904
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0677


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)