TCM Prescription: Exterior Sydrome and Heat Reduction Recipe



Prescription Description
Prescription IDTCMF1952
Pinyin NameJie Biao Tui Re Fang
Chinese Name解表退热方
English NameExterior Sydrome and Heat Reduction Recipe
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH420 Lophatherum gracile 淡竹叶 TCMH420 GBVY2724-14, GBVT2442-13
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, PTGS2 8.33112
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 8.31975
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC, TYR 8.07898
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, NR3C1, PTGS2, RORC, SRC, TYR 8.01987
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FUT7, IDO1, PIM1, PTGS2, TYR, XDH 7.61389
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, PTGS2, SRC, XDH 7.19148
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 7.14667
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 7.06445
[BP] GO:0042221 response to chemical AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC, TYR 7.06445
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 7.06445
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, GSK3B, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 7.06445
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 6.72336
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 6.70723
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 6.47678
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PTGS2, RORC, SRC, TYR 6.47678
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 6.47183
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 6.34331
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 6.27909
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 6.14678
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 6.02715
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 6.02715
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.91103
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 5.85067
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 5.85067
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.84826
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 5.78173
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 5.76791
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC 5.72321
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, NR3C1, PTGS2, RORC, SRC, TYR 5.68689
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS2 5.48505
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS2 5.47482
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, NR3C1, PTGS2, RORC, SRC 5.46766
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS2 5.30707
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, FUT7, GSK3B, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIM1, PTGS2, RORC, SRC, TYR 5.29262
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, KIT, MET, PTGS2 5.13024
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 5.09094
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PTGS2, SRC 5.03533
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 4.98084
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 4.94931
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSD17B2, KDR, KIT, MET, PTGS2, SRC, XDH 4.77559
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, XDH 4.75562
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC 4.73914
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, GSK3B, IGF1R, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 4.69271
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, HSD17B2, KDR, KIT, MMP9, PGR, PIM1, PTGS2, RORC, SRC, TYR 4.48279
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, FLT3, KDR, KIT, MET, PTGS2, PTPN1, SRC, XDH 4.27856
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS2 4.26133
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC, TYR 4.10377
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS2 4.10377
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 4.10377
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, FLT3, NR3C1, PTGS2, RORC, SRC 4.02592
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2 3.97228
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 3.95981
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, RORC, SRC, TYR 3.94831
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.94618
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.91048
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.90464
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.83662
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.82623
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.80471
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.80471
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.79519
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.76942
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, NR3C1, PTGS2, SRC 3.63568
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PTGS2 3.61707
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, IDO1 3.61707
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 3.61511
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.59506
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.5743
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 3.5743
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC 3.57118
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 3.54042
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, XDH 3.54042
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PTGS2, SRC 3.53517
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.53122
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, HSD17B2, IDO1, KIT, MMP2, MMP9, PGR, PTGS2, SRC 3.53122
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, KIT, SRC, TYR 3.47636
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2 3.43841
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, IDO1, PIM1, PTGS2, TYR 3.42438
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.41639
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.37886
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, SRC, XDH 3.29414
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 3.28312
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.27995
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.26881
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 3.25887
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DHFR, FABP4, GSK3B, IDO1, IGF1R, MET, MMP12, MMP2, PTGS2, PTPN1, SRC, XDH 3.17782
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PTGS2, SRC, TYR 3.14667
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, IDO1, PTGS2 3.12804
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.12443
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.12443
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, KIT, PTGS2, RORC, SRC 3.08142
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.05459
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.05459
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 3.05459
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 3.05459
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, IDO1, PIM1, PTGS2, TYR 3.05409
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CBR1, CDC25B, CYP1A1, FABP4, FLT3, FUT7, GSK3B, KDR, KIT, MET, MMP2, MMP9, PGR, PTGS2, RORC, SRC 3.0405
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, IDO1, PIM1, PTGS2, TYR 2.9858
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, RORC, SRC 2.95847
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.95689
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.95689
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, KIT, PTPN1, SRC, XDH 2.95689
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.95505
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, KIT, MET, PIM1, SRC, TYR 2.95505
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 2.9273
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.90413
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PTGS2, SRC, TYR 2.90413
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC 2.86203
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.85967
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.85211
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, GSK3B, KIT, PGR, RORC, SRC 2.85133
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 2.84436
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.84436
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DHFR, TYR 2.75648
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, KIT, PGR, PTGS2, SRC 2.75054
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.74307
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.74091
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 2.71862
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 2.71862
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.71862
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, XDH 2.69798
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.6683
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.66665
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.66032
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, SRC 2.65749
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.64707
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PTGS2, SRC 2.6153
[BP] GO:0030335 positive regulation of cell migration APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.59474
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, DHFR, FABP3, KDR, NR3C1, PTGS2, SRC 2.59474
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.58944
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.57572
[BP] GO:0060748 None AR, PGR 2.57364
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57364
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.53902
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, NR3C1, PTGS2, SRC 2.52193
[BP] GO:0003006 developmental process involved in reproduction AR, AXL, CDC25B, CYP19A1, HSD17B2, KIT, PGR, PTGS2, SRC 2.5114
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.51029
[BP] GO:2000147 positive regulation of cell motility APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.5091
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.49224
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.49159
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.46473
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.43894
[BP] GO:0051272 positive regulation of cellular component movement APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.43729
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC 2.43462
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.43353
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, GSK3B, IDO1, SRC, XDH 2.43317
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 2.43101
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, PTPN1, SRC 2.42634
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.4106
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.40095
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PTGS2, SRC 2.39249
[BP] GO:0040017 positive regulation of locomotion APP, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.34937
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.34691
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33015
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33015
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.33015
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.3209
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.31632
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.31632
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.27732
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.27732
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, KIT, MMP2, PTGS2, SRC, TYR 2.26326
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.26326
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 2.25585
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.24552
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, FLT3, GSK3B, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.23754
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.2356
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.2356
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, IGF1R, KIT, PTPN1, SRC 2.2356
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.2356
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 2.2356
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, CDC25B, FLT3, KDR, KIT, MMP9, PTGS2, PTPN1, SRC, XDH 2.23492
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.20604
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.20604
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, KIT, MMP9, RORC 2.20494
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, RORC 2.19938
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.19234
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.18168
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.18168
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.18168
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.17782
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, KIT, SRC 2.14122
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC 2.13956
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.12776
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.11271
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, IDO1, PTGS2, XDH 2.10581
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC 2.09636
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.09324
[BP] GO:0021700 developmental maturation APP, AXL, CDC25B, MMP2, PGR 2.08335
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.08335
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.08331
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.0775
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, PTPN1, SRC 2.07698
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGS2 2.07501
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.07305
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.07062
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.04388
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.04388
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.03832
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, SRC 2.03832
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3 2.03052
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, IDO1, KIT, MMP2, MMP9, PTGS2, PTPN1, SRC 2.03052
[BP] GO:0071695 None APP, CDC25B, MMP2, PGR 2.0064
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MMP9, PTGS2, PTPN1, SRC 2.0064
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, KDR, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 3.66471
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA7, CBR1, CDC25B, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, NR3C1, NR3C2, PGR, PIM1, PTPN1, SRC, TYR, XDH 2.49857
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.04388
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.84093
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FLT3, HSD17B2, NR3C2, PTGS2, PTPN1 1.5473
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TYR, XDH 13.391
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 9.88994
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 9.62667
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.31975
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 7.19148
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, IDO1, PTGS2, SRC 5.91877
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PTPN1, RORC 5.91382
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 5.85067
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, IDO1, PTGS2, SRC 5.7716
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 5.47482
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.47482
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.47482
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.19641
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, HSD17B1, IDO1, PTGS2, SRC, XDH 4.77559
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.76069
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.65464
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 4.44694
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS2, TYR 4.26133
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 4.21551
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, XDH 4.18062
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.95981
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.88972
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, RORC 3.88601
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.66471
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.59506
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.49054
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 3.24751
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.05409
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.99291
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.86304
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.84436
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.75655
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.66837
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, RORC 2.31632
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.31632
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.31632
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.27732
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 2.23906
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 2.2356
[MF] GO:0008289 lipid binding AR, AXL, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, RORC 2.20604
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC 2.16424
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.14511
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.11271
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6 2.0549
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04388
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.03995
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DHFR, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 2.03052


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.1926
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.8
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, FLT3, MMP1, MMP2, KIT, PTGS2, MMP9, MET, IGF1R 5.8801
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, PTGS2, TYR, CYP19A1, DHFR, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, IDO1 5.9017
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.4959
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.8801
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 4.7488
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.7488
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.8716
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.3839
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3815
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 2.9834
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.8286
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 2.7703
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.4651
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.5021
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.5021
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.4651
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2 2.4651
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KIT, KDR, MET, IGF1R 2.0831
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.4077
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4261
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2127
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, IGF1R 2.1117
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 2.0397
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.9698
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.3897
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0397
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT, TYR 2.0397
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2 1.9423
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.7929
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.8645
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1415
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3615
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.3602
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.2253
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2075
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1 1.079
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.376
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0907
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B 1.0907
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.3747
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4829
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2253
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3044
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.199
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.0678
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0678
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.9889
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0623
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 1.0442
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.033
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.9889
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9743
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.9889
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.9889
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9889
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9201
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.5424
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8993
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.8993
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.8044
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.8431
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6809
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9698
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3148
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.3145
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3672
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.378
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4156
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4055
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.3844
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4156
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4152
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4461
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B 0.4549
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4538
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4683
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4934
Platelet activation_Homo sapiens_hsa04611 SRC 0.5099
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5122
Hepatitis C_Homo sapiens_hsa05160 GSK3B 0.4934
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5078
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.497
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5334
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5541
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5146
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5645
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5683
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5541
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5572
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5763
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5683
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5763
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5763
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5683
Gap junction_Homo sapiens_hsa04540 SRC 0.5763
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5763
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5763
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8645
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1117
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6265
Peroxisome_Homo sapiens_hsa04146 XDH 0.5854
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6258
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6265
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6536
Bile secretion_Homo sapiens_hsa04976 CA2 0.6282
Glioma_Homo sapiens_hsa05214 IGF1R 0.6536
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6554
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6525
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6536
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6536
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9423
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6536
Shigellosis_Homo sapiens_hsa05131 SRC 0.6536
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.7029
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6853
Malaria_Homo sapiens_hsa05144 MET 0.7162
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7133
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.8044
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.838
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.838
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.871
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8867
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9076
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8788
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8993
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9889
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.0681


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)