TCM Prescription: Clearing and Benefiting Decoction



Prescription Description
Prescription IDTCMF1941
Pinyin NameQing Li Tang
Chinese Name
English NameClearing and Benefiting Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH454 Euphorbia humifusa 地锦草 TCMH454 GBVH2295-11, GBVH2294-11
TCMH132 Scutellaria barbata 半枝莲 TCMH132 ITSAN1801-14
TCMH2370 Commelina communis 鸭跖草 TCMH2370 GENG821-14, GBVS1147-13
TCMH1953 Pyrrosia lingua 石韦 TCMH1953 GBVQ3369-13
TCMH177 Polygonum aviculare 萹蓄 TCMH177 ITSAG3700-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.54
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.54
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 9.57236
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 8.01655
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.01655
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 7.96735
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 7.83911
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 7.67588
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F10, F3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.61965
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, MET, PPARA 7.56845
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.56845
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 7.54652
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.48398
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, SMAD3, SRC, TEK, TYR 7.3391
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.94767
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 6.86674
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TOP1, TYR 6.79122
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SLC5A1, SMAD3, SRC, TEK, TNKS2, TOP1, TYR 6.79122
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 6.79122
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 6.79122
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 6.77332
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.68542
[BP] GO:0030334 regulation of cell migration APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.60865
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FUT7, GBA2, GLO1, HSPA1A, PIM1, PPARA, TYR, XDH 6.57461
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, SRC, TEK, TYR 6.55998
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GBA2, HSD17B1, HSD17B2 6.51623
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 6.3046
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.3046
[BP] GO:2000145 regulation of cell motility APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.29476
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 6.29476
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.2764
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.11372
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.0611
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 6.0611
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.0611
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 6.0611
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.0611
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.9018
[BP] GO:0040012 regulation of locomotion APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.86442
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.85132
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.80866
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.79055
[BP] GO:0032879 regulation of localization ACHE, ALOX15, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 5.78432
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 5.63995
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.63061
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.59289
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 5.54316
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 5.5236
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, TYR 5.47091
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP4, FUT7, GBA2, MET, PPARA 5.45813
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.45813
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, FLT3, SRC, TEK, TYR 5.4458
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.41747
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 5.36563
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.28927
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.28493
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP1, TOP2A 5.23911
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 5.18146
[BP] GO:0080134 regulation of response to stress APP, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.10848
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.01144
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 5.00685
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.98854
[BP] GO:0019538 protein metabolic process ACHE, ALPI, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 4.97481
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.75452
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.75452
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.71082
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC, TOP2A 4.64813
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.62971
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 4.44079
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, EGFR, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.43443
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.38523
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.38523
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A 4.31814
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.25032
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.22495
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 4.19542
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 4.18532
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, GBA2, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 4.14818
[BP] GO:0044267 cellular protein metabolic process ALPI, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 4.10928
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, INSR, SRC 4.10455
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, EGFR, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.09173
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.02116
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.01186
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.97376
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.96048
[BP] GO:0006464 cellular protein modification process ALPI, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.90478
[BP] GO:0036211 protein modification process ALPI, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.90478
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR 3.87001
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.86994
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 3.86586
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.84674
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, TNKS, TNKS2 3.84456
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, DRD2, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 3.82292
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.7945
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TNKS, TOP2A 3.7945
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DRD2, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.7945
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, CYP19A1, DRD1, DRD2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 3.76463
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 3.75886
[BP] GO:0043412 macromolecule modification ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A 3.75886
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 3.73309
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.72816
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, HSPA1A 3.71508
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.7094
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.63758
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPI, APEX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.6313
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, EGFR, F3, FABP4, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 3.6313
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.6313
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FLT3, INSR, PPARA, SRC, TEK 3.62579
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 3.61565
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.57738
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.57275
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.56672
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.56563
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.5529
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.5529
[BP] GO:0009611 response to wounding ACHE, ALOX15, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.50896
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.46377
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, CDC25B, DRD1, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.4619
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, CDC25B, DRD1, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.4619
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.39511
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, CSNK2A1, DRD2, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.3907
[BP] GO:0065009 regulation of molecular function APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.38206
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2, EGFR 3.38206
[BP] GO:0010648 negative regulation of cell communication ACHE, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, XDH 3.35557
[BP] GO:0023057 negative regulation of signaling ACHE, DRD1, DRD2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, XDH 3.34092
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, KDR, SRC, TNKS, TNKS2 3.33287
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.32922
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.31371
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, KDR, SRC, TEK 3.27829
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 3.26468
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26468
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, EGFR, PPARA, SRC, TOP1, TOP2A 3.24944
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, KDR, SRC, TOP1 3.2231
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.2231
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK, TNKS 3.21903
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.20925
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.17485
[BP] GO:0051049 regulation of transport ACHE, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.15317
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 3.14001
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, CDC25B, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.13936
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, SRC 3.13883
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, HSD17B1, HSD17B2 3.11689
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.10108
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 3.09315
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.07476
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR 3.01479
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, PPARA 2.96655
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.95367
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94758
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.89378
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, EGFR, FABP4, GPR35, INSR, MET, SMAD3 2.8934
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.88589
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.85508
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2 2.84036
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, EGFR, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.81765
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.79395
[BP] GO:0015758 None DRD1, SLC5A1, SLC5A2, SLC5A4 2.74945
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.73726
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC, TNKS 2.73127
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 2.72356
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.70582
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, PPARA, SRC, TEK 2.6858
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.67873
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, SRC 2.67225
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, INSR, SMAD3 2.65959
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.65959
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.65959
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.65959
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.65959
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.65168
[BP] GO:0048869 cellular developmental process ACHE, APP, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MET, MMP2, MMP9, PTPRS, SMAD3, SRC, TEK, TOP2A 2.65115
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, EGFR, HSPA1A, INSR, TNKS 2.64934
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.64351
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, SRC, TYR 2.64228
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.63817
[BP] GO:0001666 response to hypoxia CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.63177
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 2.61629
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.58702
[BP] GO:0008645 None DRD1, SLC5A1, SLC5A2, SLC5A4 2.58702
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.57387
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.561
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.56079
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.55134
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.55134
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.54634
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, DRD2, EGFR, F3, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK 2.54595
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP4, GBA2 2.54595
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.54595
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1 2.54595
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.54595
[BP] GO:0015749 None DRD1, SLC5A1, SLC5A2, SLC5A4 2.54595
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.54595
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, EGFR, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.53159
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52872
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, INSR 2.51745
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD1, DRD2, PPARA, PTPRS, SMAD3, TEK 2.46979
[BP] GO:0044093 positive regulation of molecular function APP, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.46979
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.46979
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.46979
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, XDH 2.46837
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.42957
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.41974
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41616
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.39606
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.38016
[BP] GO:0070482 response to oxygen levels CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.37969
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.37969
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.37969
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.3779
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, PTPRS, XDH 2.3738
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.3738
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.3738
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.3738
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.36955
[BP] GO:0040008 regulation of growth APP, CSNK2A1, DRD2, EGFR, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 2.35497
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, EGFR, FABP4, MET 2.35268
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 2.35268
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32714
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.32699
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.32255
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.32178
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, DRD1, DRD2, EGFR 2.32156
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, DRD1, DRD2, EGFR 2.32156
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.31871
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.31871
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3093
[BP] GO:0070213 None TNKS, TNKS2 2.3093
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3093
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3093
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, SRC 2.3093
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD1, DRD2, KDR, SRC 2.3093
[BP] GO:0051894 None KDR, SMAD3, TEK 2.29961
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.29961
[BP] GO:0051050 positive regulation of transport ACHE, APP, AXL, CA2, CYP19A1, DRD1, DRD2, EGFR, INSR, MMP12, SMAD3, SRC 2.29616
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.28331
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.27745
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, PPARA 2.26618
[BP] GO:0050927 None F3, KDR, SMAD3 2.25401
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.2447
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.2365
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PTPN1, SRC, TEK, TNKS 2.23589
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.23425
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.21622
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.21622
[BP] GO:0050926 None F3, KDR, SMAD3 2.21622
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.21622
[BP] GO:1903393 None KDR, SMAD3, TEK 2.21622
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PTPN1, SRC 2.21495
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.17033
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.15131
[BP] GO:0019222 regulation of metabolic process ACHE, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, XDH 2.15105
[BP] GO:0034219 None SLC5A1, SLC5A2, SLC5A4 2.13469
[BP] GO:0021853 None DRD1, DRD2 2.13469
[BP] GO:0010641 None F3, SRC 2.13469
[BP] GO:0007598 None F10, F3 2.13469
[BP] GO:1904936 None DRD1, DRD2 2.13469
[BP] GO:0050678 None EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.13469
[BP] GO:0009968 negative regulation of signal transduction DRD2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, XDH 2.10364
[BP] GO:0022414 reproductive process AKR1B1, APP, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, INSR, MMP2, MMP9, SRC, TOP2A 2.10364
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.10364
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.10364
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, EGFR, MET 2.09691
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.08554
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.06902
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, SMAD3, SRC, XDH 2.06902
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.06902
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, TYR 2.06902
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.0661
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.0661
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.0661
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.05402
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.03684
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.03684
[BP] GO:1901890 None KDR, SMAD3, TEK 2.0319
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.0319
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.02568
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.02083
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.00985
[BP] GO:0008643 None DRD1, SLC5A1, SLC5A2, SLC5A4 2.00985
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.00985
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.00985
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.00985
[BP] GO:0021843 None DRD1, DRD2 2.00985
[BP] GO:1990535 None APP, INSR 2.00985
[BP] GO:0021830 None DRD1, DRD2 2.00985
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.00985
[BP] GO:0021826 None DRD1, DRD2 2.00985
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.00985
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.00985
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 2.00661
[CC] GO:0005886 plasma membrane ACHE, ALOX15, ALPI, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, F10, F3, FLT3, GBA2, GLO1, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TEK 3.95793
[CC] GO:0031226 intrinsic component of plasma membrane APP, AXL, CA4, DRD1, DRD2, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK 3.82795
[CC] GO:0044459 plasma membrane part ALOX15, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TEK 3.51781
[CC] GO:0016020 membrane ACHE, ALOX15, ALOX5, ALPI, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 3.21626
[CC] GO:0009330 None TOP1, TOP2A 2.90249
[CC] GO:0031233 None CA4, F10, F3 2.46979
[CC] GO:0005887 integral component of plasma membrane APP, AXL, DRD1, DRD2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK 2.42069
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, SRC, TNKS2, TYR 2.37969
[CC] GO:0044425 membrane part ACHE, ALOX15, ALPI, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TYR 2.34285
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, PIM1, PTPN1, PTPRS, SMAD3, SRC, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.24208
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, FUT7, GBA2, GLO1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.06585
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00985
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 13.798
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, ALPI, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 12.9474
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, F10, F3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 12.4877
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1459
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.48398
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1, TOP2A 7.13228
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.88763
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.79122
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 6.55679
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.4702
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, SMAD3, TNKS 5.62075
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.52612
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.47825
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.44251
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.19249
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.17961
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPI, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 5.17961
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.82604
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TYR, XDH 4.64813
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TOP1 4.31615
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.29396
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.09588
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.92309
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.90478
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.87695
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.86994
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.58229
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.3907
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.3907
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TOP1, TOP2A, XDH 3.3907
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.26466
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.23103
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.1114
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.9674
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.85508
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.70582
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.61629
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A 2.58702
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.52872
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.44078
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.41616
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.3738
[MF] GO:0019899 enzyme binding ALPI, APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, F3, HSPA1A, MET, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 2.34543
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.34235
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3093
[MF] GO:0051425 None APP, INSR 2.3093
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3093
[MF] GO:0015145 None SLC5A1, SLC5A2, SLC5A4 2.29961
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.27827
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.20708
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13469
[MF] GO:0043559 insulin binding IGF1R, INSR 2.13469
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.11757
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, XDH 2.11626
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.099
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0319
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00985


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.6174
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1777
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.3712
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.6351
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.0685
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.251
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.1089
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, TYR, CYP3A4, GBA2, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPI, XDH 3.9504
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.574
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.3102
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.5884
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.0144
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.0144
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.6341
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.8156
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.5974
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 2.908
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3215
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5147
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.624
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2843
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.647
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1884
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9889
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1642
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1614
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.186
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1514
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9404
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8837
Bile secretion_Homo sapiens_hsa04976 CA2, SLC5A1, CYP3A4 2.1514
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1, PPARA 2.1583
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7007
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4916
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.6794
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4559
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4284
cAMP signaling pathway_Homo sapiens_hsa04024 DRD1, DRD2, PPARA 1.163
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, DRD1, DRD2 0.8931
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3551
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0817
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0277
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0921
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2783
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3126
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.35
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0533
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2744
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.163
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9045
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0803
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9045
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8931
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8419
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8693
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.331
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8526
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1615
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8931
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.2466
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8395
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8395
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8395
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8395
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8395
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8348
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15 1.3082
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8219
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4462
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7937
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1, EGFR 0.7303
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7303
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6684
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4783
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.648
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.248
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3126
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3555
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3485
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3388
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3479
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3485
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.368
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3555
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.3555
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3755
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3384
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4177
Platelet activation_Homo sapiens_hsa04611 SRC 0.4412
Axon guidance_Homo sapiens_hsa04360 MET 0.4332
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4412
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4679
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4493
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4679
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4919
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4847
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4919
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7719
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4923
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4919
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4965
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.5051
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4963
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5007
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5102
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5102
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5201
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5098
Peroxisome_Homo sapiens_hsa04146 XDH 0.5207
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.558
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5594
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5567
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5455
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5662
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5809
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5791
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7289
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6633
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6012
Shigellosis_Homo sapiens_hsa05131 SRC 0.5825
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5825
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5926
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6242
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6269
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6447
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9622
Malaria_Homo sapiens_hsa05144 MET 0.655
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.648
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6586
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 SLC5A1 0.6704
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6623
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7187
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7479
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7133
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8233
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7479
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7823
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7617
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.828
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8233
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9901
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.902
Folate biosynthesis_Homo sapiens_hsa00790 ALPI 0.9876


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)