TCM Prescription: Lung Fire Clearing Decoction



Prescription Description
Prescription IDTCMF1921
Pinyin NameQin Lian Si Wu Tang
Chinese Name芩连四物汤
English NameLung Fire Clearing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 13.6719
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.5685
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, PPARA, XDH 9.33743
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 7.97453
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.49172
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.33927
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, HSD17B1, PPARA 7.24135
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.76776
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.02197
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.71421
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.63858
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.53563
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1 5.51439
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, PPARA 4.96558
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 4.91851
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH 4.53925
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH 4.52441
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.49471
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH 4.48228
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F10, F3, FABP3, FABP4, HCAR2, HSD17B1, PPARA, TNKS, TNKS2, XDH 4.12415
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, F3, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PPARA, PTPN1, PTPRS, TNKS, TNKS2, XDH 4.10737
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 4.10737
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 4.09758
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 4.03263
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1 3.95324
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.75035
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.75035
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, PPARA 3.52779
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.32831
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.27499
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27499
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MMP1, MMP2, MMP9, XDH 3.27499
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HCAR2, HSD17B1 3.15189
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, FABP3, FABP4, HSD17B1, MMP1, MMP2, PPARA, PTPN1, PTPRS, TNKS, TNKS2, XDH 3.09659
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.03923
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1 2.85113
[BP] GO:0071702 None ABCB1, ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, PPARA, TNKS 2.80257
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.80257
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.68176
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9 2.53776
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.50013
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.42901
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, HCAR2, TNKS, TNKS2 2.41387
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.32554
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23643
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.1971
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.1971
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1971
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.09555
[BP] GO:0070213 None TNKS, TNKS2 2.08421
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.08421
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.08421
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1 2.08421
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HCAR2, MMP9, PPARA, PTPN1 2.05677
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.02501
[CC] GO:0031233 None CA4, F10, F3 2.40048
[CC] GO:0099055 None ADORA1, PTPRS 1.49846
[CC] GO:0099699 None ADORA1, PTPRS 1.49846
[CC] GO:0099240 None ADORA1, PTPRS 1.49846
[CC] GO:0098936 None ADORA1, PTPRS 1.49846
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 19.0917
[MF] GO:0046914 transition metal ion binding ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, XDH 14.4355
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.7331
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4707
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F3, HSD17B1, MMP1, MMP2, MMP9, PTPN1, PTPRS, TNKS, TNKS2, TUBB3, XDH 10.1061
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 9.47597
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, F3, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PPARA, PTPN1, PTPRS, TNKS, TNKS2, TUBB3, XDH 8.64671
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 7.79344
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.79344
[MF] GO:0005506 iron ion binding ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 6.98407
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 6.76776
[MF] GO:0043169 cation binding ACHE, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH 6.34009
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.11105
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.75968
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH 5.40407
[MF] GO:0046872 metal ion binding ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH 5.11772
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 5.03028
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.98122
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.79462
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.49471
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.38962
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH 3.307
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74226
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, XDH 2.34848
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.32554
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.08421
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.08421


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.8955
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.0813
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.8959
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.2564
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, CYP19A1 4.2638
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.8729
Metabolic pathways_Homo sapiens_hsa01100 CBR1, CYP2A6, AKR1B10, HSD17B1, ALOX15, CYP1A2, CYP1A1, AKR1B1, CYP3A4, CYP19A1, XDH 3.371
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.8274
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.2046
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.2046
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.5367
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 3.0892
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.5986
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, PPARA 2.3533
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.5921
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.828
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, CYP1B1, MMP9, CDC25B 1.8392
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.6377
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.6131
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15 1.5899
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, F3 1.2837
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.46
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9 1.2853
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1 1.256
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.3388
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.423
Gap junction_Homo sapiens_hsa04540 TUBB3, DRD1 1.3505
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0839
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9722
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.25
Pathways in cancer_Homo sapiens_hsa05200 MMP1, MMP2, MMP9 0.9314
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1991
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1996
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0515
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9516
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2901
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9 0.8386
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6002
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5602
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6203
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.5602
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5602
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5402
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6287
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5602
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6128
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5402
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5566
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5602
Peroxisome_Homo sapiens_hsa04146 XDH 0.564
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5602
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5602
Serotonergic synapse_Homo sapiens_hsa04726 ALOX15 0.5402
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.5075
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5075
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5075
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5088
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6799
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5075
Hepatitis B_Homo sapiens_hsa05161 MMP9 0.5039
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.5075
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5075
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.498
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.5075
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4657
Alcoholism_Homo sapiens_hsa05034 DRD1 0.4657
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.7167
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4657
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.4372
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4972
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3647
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.4657
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4621
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7501
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9314


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)