Prescription ID | TCMF1921 |
Pinyin Name | Qin Lian Si Wu Tang |
Chinese Name | 芩连四物汤 |
English Name | Lung Fire Clearing Decoction |
Function Description | |
Indications | None |
Disease ICD-11 Category | |
Human Tissues Associated with Indication | |
Reference | Chinese Classical Prescriptions |
Reference Book/link | ISBN 7-5023-3930-2 |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
TCMH972 | Coptis chinensis | 黄连 | TCMH972 | ITSAO4469-14 |
TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
TCMH305 | Cnidium officinale | 川芎 | TCMH305 | ITSAP4207-14 |
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
TCMH1896 | Radix rehmanniae | 生地黄 | TCMH1896 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT232 | ABCB1 | P-glycoprotein 1 | Transporter | P08183 |
TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT27 | DRD1 | Dopamine D1 receptor | GPCR | P21728 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT283 | PTPRS | Receptor-type tyrosine-protein phosphatase S | Hydrolase | Q13332 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT332 | AOC3 | Amine oxidase, copper containing | Oxidoreductase | Q16853 |
TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
TCMT560 | F10 | Coagulation factor X | Unclassified | P00742 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT801 | TUBB3 | Tubulin beta-3 chain | Unclassified | Q13509 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Target ID | Target Name |
---|---|
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1191 | Bacillus megaterium |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1210 | Streptococcus sobrinus |
TCMT1211 | Fusobacterium nucleatum |
TCMT1214 | Enterococcus faecium |
TCMT1217 | Bacillus anthracis |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1230 | Human herpesvirus 5 |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1236 | Mycobacterium bovis |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1260 | Streptococcus agalactiae |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1305 | Salmonella enteritidis |
TCMT1318 | Human T-lymphotropic virus 1 |
TCMT1319 | Corynebacterium xerosis |
TCMT1321 | Staphylococcus hominis |
TCMT1322 | Streptococcus mitis |
TCMT1323 | Corynebacterium pseudodiphtheriticum |
TCMT1324 | Corynebacterium diphtheriae |
TCMT1343 | Staphylococcus simulans |
TCMT1344 | Staphylococcus sciuri |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1353 | Plasmodium yoelii |
TCMT1361 | Neisseria meningitidis |
TCMT1370 | Prevotella melaninogenica |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1385 | Candida shehatae |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1410 | Listeria monocytogenes |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1444 | Fusarium oxysporum |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1460 | Mycobacterium intracellulare |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 13.6719 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 12.5685 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, PPARA, XDH | 9.33743 |
[BP] GO:0015711 | organic anion transport | ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 7.97453 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.49172 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 7.33927 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, HSD17B1, PPARA | 7.24135 |
[BP] GO:0006820 | anion transport | ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 6.76776 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.02197 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.71421 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.63858 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.53563 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1 | 5.51439 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, PPARA | 4.96558 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 4.91851 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH | 4.53925 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HCAR2, MMP9, PTPN1, TNKS, TNKS2, XDH | 4.52441 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.49471 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH | 4.48228 |
[BP] GO:0065008 | regulation of biological quality | ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F10, F3, FABP3, FABP4, HCAR2, HSD17B1, PPARA, TNKS, TNKS2, XDH | 4.12415 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, F3, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PPARA, PTPN1, PTPRS, TNKS, TNKS2, XDH | 4.10737 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 4.10737 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 | 4.09758 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 | 4.03263 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1 | 3.95324 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.75035 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.75035 |
[BP] GO:0006811 | None | ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, PPARA | 3.52779 |
[BP] GO:0032787 | None | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA | 3.32831 |
[BP] GO:2001225 | regulation of chloride transport | ABCB1, CA2, CA7 | 3.27499 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.27499 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MMP1, MMP2, MMP9, XDH | 3.27499 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HCAR2, HSD17B1 | 3.15189 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, FABP3, FABP4, HSD17B1, MMP1, MMP2, PPARA, PTPN1, PTPRS, TNKS, TNKS2, XDH | 3.09659 |
[BP] GO:0042738 | exogenous drug catabolic process | CYP1A2, CYP2A6, CYP3A4 | 3.03923 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1 | 2.85113 |
[BP] GO:0071702 | None | ABCB1, ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, PPARA, TNKS | 2.80257 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 | 2.80257 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 2.68176 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9 | 2.53776 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 | 2.50013 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD17B1 | 2.42901 |
[BP] GO:0032846 | positive regulation of homeostatic process | CA2, CA7, DRD1, HCAR2, TNKS, TNKS2 | 2.41387 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.32554 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.23643 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 | 2.1971 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1 | 2.1971 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.1971 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.09555 |
[BP] GO:0070213 | None | TNKS, TNKS2 | 2.08421 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.08421 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.08421 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1 | 2.08421 |
[BP] GO:0032879 | regulation of localization | ABCB1, ACHE, ADORA1, ADORA3, ALOX15, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, HCAR2, MMP9, PPARA, PTPN1 | 2.05677 |
[BP] GO:0044070 | regulation of anion transport | ABCB1, ADORA1, CA2, CA7 | 2.02501 |
[CC] GO:0031233 | None | CA4, F10, F3 | 2.40048 |
[CC] GO:0099055 | None | ADORA1, PTPRS | 1.49846 |
[CC] GO:0099699 | None | ADORA1, PTPRS | 1.49846 |
[CC] GO:0099240 | None | ADORA1, PTPRS | 1.49846 |
[CC] GO:0098936 | None | ADORA1, PTPRS | 1.49846 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 19.0917 |
[MF] GO:0046914 | transition metal ion binding | ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, XDH | 14.4355 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 12.7331 |
[MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.4707 |
[MF] GO:0003824 | catalytic activity | ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, F3, HSD17B1, MMP1, MMP2, MMP9, PTPN1, PTPRS, TNKS, TNKS2, TUBB3, XDH | 10.1061 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 9.47597 |
[MF] GO:0043167 | ion binding | ABCB1, ACHE, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, F3, FABP3, FABP4, HSD17B1, MMP1, MMP2, MMP9, PPARA, PTPN1, PTPRS, TNKS, TNKS2, TUBB3, XDH | 8.64671 |
[MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 7.79344 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 7.79344 |
[MF] GO:0005506 | iron ion binding | ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH | 6.98407 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS | 6.76776 |
[MF] GO:0043169 | cation binding | ACHE, ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH | 6.34009 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 | 6.11105 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 5.75968 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH | 5.40407 |
[MF] GO:0046872 | metal ion binding | ALOX15, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, XDH | 5.11772 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 | 5.03028 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 4.98122 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 4.79462 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 | 4.49471 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.38962 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, XDH | 3.307 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.74226 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HSD17B1, XDH | 2.34848 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.32554 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.08421 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.08421 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 20.8955 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 8.0813 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 7.8959 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 7.2564 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | HSD17B1, CYP1A1, CYP1B1, CYP19A1 | 4.2638 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1, CYP3A4 | 3.8729 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, CYP2A6, AKR1B10, HSD17B1, ALOX15, CYP1A2, CYP1A1, AKR1B1, CYP3A4, CYP19A1, XDH | 3.371 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.8274 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 3.2046 |
Bladder cancer_Homo sapiens_hsa05219 | MMP1, MMP2, MMP9 | 3.2046 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.5367 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, CYP3A4, XDH | 3.0892 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2, CYP3A4 | 2.5986 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, ADORA1, DRD1, PPARA | 2.3533 |
Bile secretion_Homo sapiens_hsa04976 | ABCB1, CA2, CYP3A4 | 2.5921 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.828 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | ABCB1, CYP1B1, MMP9, CDC25B | 1.8392 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, ADORA1 | 1.6377 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.6131 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX15 | 1.5899 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, F3 | 1.2837 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1 | 1.46 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | MMP2, MMP9 | 1.2853 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | ADORA3, ADORA1, DRD1 | 1.256 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1, DRD1 | 1.3388 |
Complement and coagulation cascades_Homo sapiens_hsa04610 | F10, F3 | 1.423 |
Gap junction_Homo sapiens_hsa04540 | TUBB3, DRD1 | 1.3505 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 2.0839 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.9722 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PPARA | 1.25 |
Pathways in cancer_Homo sapiens_hsa05200 | MMP1, MMP2, MMP9 | 0.9314 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | ADORA3, ADORA1 | 1.1991 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | MMP2, MMP9 | 1.1996 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 2.0515 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | ADORA3, ADORA1 | 0.9516 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.2901 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | MMP2, MMP9 | 0.8386 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6002 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.5602 |
Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.6203 |
GnRH signaling pathway_Homo sapiens_hsa04912 | MMP2 | 0.5602 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | CDC25B | 0.5602 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE | 0.5402 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.6287 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.5602 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6128 |
TNF signaling pathway_Homo sapiens_hsa04668 | MMP9 | 0.5402 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5566 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1 | 0.5602 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.564 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5602 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5602 |
Serotonergic synapse_Homo sapiens_hsa04726 | ALOX15 | 0.5402 |
Dopaminergic synapse_Homo sapiens_hsa04728 | DRD1 | 0.5075 |
Measles_Homo sapiens_hsa05162 | CSNK2A1 | 0.5075 |
Hepatitis C_Homo sapiens_hsa05160 | PPARA | 0.5075 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.5088 |
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | TUBB3 | 0.6799 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1 | 0.5075 |
Hepatitis B_Homo sapiens_hsa05161 | MMP9 | 0.5039 |
Parkinson's disease_Homo sapiens_hsa05012 | DRD1 | 0.5075 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.5075 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PPARA | 0.498 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1 | 0.5075 |
Calcium signaling pathway_Homo sapiens_hsa04020 | DRD1 | 0.4657 |
Alcoholism_Homo sapiens_hsa05034 | DRD1 | 0.4657 |
Cocaine addiction_Homo sapiens_hsa05030 | DRD1 | 0.7167 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.4657 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1 | 0.4372 |
Phagosome_Homo sapiens_hsa04145 | TUBB3 | 0.4972 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.3647 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | MMP9 | 0.4657 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.4621 |
ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.7501 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.9314 |