TCM Prescription: Coptis Magnolia Decorction



Prescription Description
Prescription IDTCMF1918
Pinyin NameLian Po Yin
Chinese Name连朴饮
English NameCoptis Magnolia Decorction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH396 Semen sojae praeparata 淡豆豉 TCMH396
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH237 Acorus calamus 菖蒲 TCMH237 ITSAI4402-14
TCMH1339 Phragmites communis 芦根 TCMH1339 KT695247
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, KDR, KIT, MET, SRC, TERT, XDH 7.11961
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT 6.9913
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 6.66785
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 6.63252
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 6.35458
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC 6.10886
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.98237
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.98237
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.96556
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CYP1B1, DNMT1, F3, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH 5.96556
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, DRD1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 5.96556
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD1, F3, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, XDH 5.96556
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD1, F3, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, XDH 5.96082
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, DRD1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 5.94522
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP3, IGF1R, MMP2, MMP9, SRC 5.94522
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, KIT 5.94522
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, KIT 5.94522
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, KDR, SRC 5.94522
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 5.93127
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 5.7879
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DYRK1A, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 5.62167
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.60318
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.47166
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC 5.47166
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DYRK1A, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 5.46165
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, FABP3, KDR, SRC 5.41641
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 5.41641
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.41641
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 5.2952
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.29372
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 5.27547
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 5.27547
[BP] GO:0046777 protein autophosphorylation AURKB, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.16282
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 5.05123
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, DNMT1, DRD1, FABP3, FLT3, IGF1R, KIT, MMP2, SRC 4.99725
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, FABP3, FABP4, FLT3, MET, SRC, TERT 4.97312
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, KIT, MET 4.80589
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 4.72787
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.70838
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 4.63352
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.63352
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FUT7, PIM1, XDH 4.45004
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CYP1B1, F3, FLT3, IGF1R, KDR, MMP9, PIM1, SRC, TERT, XDH 4.43017
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 4.39745
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1B1 4.3795
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 4.33329
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DNMT1, DRD1, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 4.26751
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 4.25112
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F3, FLT3, KDR, KIT, MET, SRC, XDH 4.22584
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CYP1B1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, XDH 4.1447
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 4.1075
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DRD1, DYRK1A, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC, TERT, XDH 4.09924
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DRD1, F3, FABP4, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC 4.07314
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD1, DYRK1A, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PIM1, SRC, TERT 4.01239
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1 3.98393
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 3.92566
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, KDR, SRC 3.89418
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CNR1, CNR2, CYP19A1, DYRK1A, F3, FABP4, IGF1R, MET, MMP2, SRC, TERT, XDH 3.89418
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, FABP3, FLT3, SRC 3.85884
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CNR1, CYP1B1, F3, FABP4, FLT3, KDR, KIT, MET, MMP2, MMP9, SRC, TERT, XDH 3.85884
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1B1, DRD1, FLT3, SRC 3.84053
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DNMT1, DRD1, DYRK1A, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 3.81757
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, FABP4, KIT, MMP9, TERT 3.81403
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F3, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, XDH 3.73522
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, DRD1, FABP3, FLT3, IGF1R, MMP2, SRC 3.66171
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, DRD1, KDR, SRC 3.55714
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.53416
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, CNR1, DNMT1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 3.46231
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.46231
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.46231
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 3.40679
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, SRC 3.38817
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, DRD1, FABP3, FLT3, IGF1R, MMP2, SRC 3.38817
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, KIT, MMP2, SRC, TERT 3.38817
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.36185
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, SRC, TERT, XDH 3.31219
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 3.25933
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, IGF1R, KDR, MMP9, PIM1, SRC, TERT 3.24913
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 3.22854
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.22057
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, DRD1, KDR, SRC 3.19372
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.16255
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 3.16255
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, TERT 3.14
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CNR1, CNR2, CYP1B1, DRD1, F3, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 3.13913
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.12173
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 3.09035
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 3.05215
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.05215
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 3.05215
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, F3, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 3.05215
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CNR1, CNR2, DRD1, F3, FABP4, FLT3, IGF1R, KIT, MMP9, SRC, TERT, XDH 2.98917
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, DNMT1, DRD1, DYRK1A, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 2.9752
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.9614
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, DRD1, IGF1R, MMP2, MMP9, SRC 2.9614
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, FABP3, FABP4, MET 2.92314
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CNR1, CYP19A1, CYP1A1, DRD1, KIT, MMP2, MMP9, SRC 2.91998
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CNR1, DRD1, MMP9 2.85477
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, SRC, TERT 2.85477
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, KIT, MET 2.85477
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC, XDH 2.85477
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1 2.85477
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, SRC 2.85477
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.74761
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.71547
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.71547
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, FLT3, SRC 2.65731
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1 2.65334
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, FUT7, KDR, KIT, MET, MMP1, MMP9, SRC 2.64582
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, FUT7, KDR, KIT, MMP1, MMP9, SRC 2.63225
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, FABP3, FLT3, KIT, SRC 2.62821
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.62346
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, KIT, SRC 2.60051
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.60051
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.59197
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.58401
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CNR1, CNR2, CYP19A1, DRD1, DYRK1A, IGF1R, MET, MMP9, SRC, TERT, XDH 2.58401
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, F3, KDR, KIT, PIM1, SRC, TERT 2.58266
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, DRD1, FLT3, IGF1R, KIT, MMP2, SRC 2.54797
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, DYRK1A, IGF1R, MET, MMP9, SRC, TERT, XDH 2.51998
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD1, DYRK1A, IGF1R, MET, MMP9, SRC, TERT, XDH 2.51107
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.51107
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, DNMT1, DRD1, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, SRC, XDH 2.4756
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC 2.47023
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, SRC, TERT 2.45282
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9 2.43761
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.43761
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 2.43527
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, DRD1, FABP3, FLT3, KDR, KIT, MMP9, SRC, XDH 2.43527
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, DRD1, FABP3, FLT3, KDR, KIT, MMP9, SRC, XDH 2.43527
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.43303
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.43101
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, XDH 2.43101
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, IGF1R, MMP2, SRC 2.43046
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CNR1, CYP1A1, DRD1, KIT, SRC 2.41527
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, SRC, TERT 2.41085
[BP] GO:0038171 None CNR1, CNR2 2.40793
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.40022
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1B1, DRD1, DYRK1A, FLT3, KDR, KIT, MMP9, PIM1, SRC 2.39864
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, FUT7, KDR, KIT, MMP1, MMP9, SRC 2.38734
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CYP1A1, DRD1, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, SRC, TERT 2.37669
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC 2.35226
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.34897
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, SRC 2.34169
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1B1, DRD1, KIT, MMP2, MMP9, SRC, TERT 2.32544
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, MMP9, SRC, TERT 2.31076
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC 2.31049
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, SRC, XDH 2.2946
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.29215
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, TERT 2.25601
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, IGF1R, MMP2, SRC 2.25601
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CYP1A1, CYP3A4, DRD1, DYRK1A, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, XDH 2.25306
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, SRC, TERT 2.24868
[BP] GO:0010641 None F3, SRC 2.23986
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.23986
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, SRC 2.2213
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, DNMT1, DRD1, DYRK1A, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 2.19665
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, F3, FABP4, KDR, MET 2.19665
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.19568
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC 2.18063
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, DNMT1, DYRK1A, FLT3, KDR, KIT, MMP9, SRC, XDH 2.15703
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT 2.14549
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP2, MMP9 2.14549
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP2, MMP9 2.13985
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CYP1B1, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, XDH 2.13732
[BP] GO:0014911 positive regulation of smooth muscle cell migration BCL2, SRC, TERT 2.10351
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.10351
[BP] GO:0032229 None ADORA1, CNR2 2.10351
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.10351
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, SRC 2.09953
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, KDR, MMP2, SRC 2.05795
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, SRC, XDH 2.03717
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, F3, FLT3, KIT, MET, MMP9, SRC, TERT, XDH 2.02134
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.01396
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CNR1, CYP1B1, F3, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 2.01012
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, SRC, XDH 2.00964
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, SRC, XDH 2.00634
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, TERT, XDH 2.00634
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, DRD1, F3, FLT3, IGF1R, KDR, KIT, MET, MMP2, PIM1, SRC, TERT 4.09915
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CNR1, CNR2, DRD1, F3, FLT3, IGF1R, KDR, KIT, MET, SRC 3.32618
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CNR1, CNR2, DRD1, F3, FLT3, IGF1R, KDR, MET 3.22057
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP2, PIM1, SRC, TERT 3.12796
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, F3, MET 2.43761
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, SRC 2.32184
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CNR1, CNR2, DRD1, FLT3, IGF1R, KDR, MET 2.2386
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 7.97832
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, DYRK1A, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 7.43717
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, MMP1, MMP2, MMP9, PIM1, XDH 6.63252
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, XDH 6.60047
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.64276
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.41641
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 5.37587
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 5.15127
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.05123
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.94344
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1, CYP3A4 4.14444
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.96633
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP3A4, XDH 3.38817
[MF] GO:0004672 protein kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.38817
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, DRD1, KIT, MMP1, MMP2, MMP9, PIM1, TERT, XDH 3.29813
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.15756
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 3.12796
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.84018
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, SRC 2.74761
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 2.68789
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, SRC 2.62346
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.62346
[MF] GO:0004949 None CNR1, CNR2 2.62346
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, F3, FLT3, IGF1R, KDR, KIT, MET 2.60257
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, F3, FLT3, IGF1R, KDR, KIT, MET 2.60257
[MF] GO:0016301 kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.57786
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DNMT1, KIT, MMP1, MMP2, MMP9, PIM1, TERT, XDH 2.46616
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, F3, FLT3, IGF1R, KDR, KIT, MET 2.31049
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, DNMT1, DYRK1A, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.23986
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.23986
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.16066
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1B1, CYP3A4 2.1562
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP2, MMP9 2.10351


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.9469
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1A1, CYP1B1, CYP19A1, IGF1R 5.3285
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 4.2054
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2054
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.994
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET 4.0804
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KIT, KDR, MET, IGF1R 3.9646
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1A1, CYP1B1, CYP3A4, CYP19A1 3.9359
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 3.0349
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 3.0349
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.5875
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, FUT7, AKR1B10, ALOX5, CYP1A1, ALPL, AKR1B1, CYP3A4, CYP19A1, XDH 2.5875
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.5875
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, ADORA3, ADORA1, DRD1 2.5424
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.473
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, BCL2, MET, IGF1R 2.3295
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.4196
Adherens junction_Homo sapiens_hsa04520 SRC, MET, IGF1R 2.449
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A1, CYP1B1, CYP3A4 2.449
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.4636
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.4535
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 2.1431
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.1834
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A1, CYP1B1, CYP3A4 2.3623
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.9634
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 2.0113
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.8292
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.6336
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5865
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4944
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.3612
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.6022
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.5191
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3612
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.22
Retinol metabolism_Homo sapiens_hsa00830 CYP1A1, CYP3A4 1.5453
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.3612
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.4382
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.2696
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.3612
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.3612
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.22
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.1955
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9817
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1955
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.95
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1 1.8794
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.95
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7873
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.9289
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0504
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1 0.8658
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0113
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9555
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2283
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3609
Platelet activation_Homo sapiens_hsa04611 SRC 0.5435
Epstein-Barr virus infection_Homo sapiens_hsa05169 BCL2 0.4318
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5666
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5226
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.604
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5435
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4752
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4194
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5971
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4647
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.5226
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5971
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5971
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4305
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5442
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4645
Tight junction_Homo sapiens_hsa04530 SRC 0.5226
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5435
Alcoholism_Homo sapiens_hsa05034 DRD1 0.4645
Melanogenesis_Homo sapiens_hsa04916 KIT 0.5948
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5302
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5435
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.5226
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5156
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4957
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.5216
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6003
Axon guidance_Homo sapiens_hsa04360 MET 0.539
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2 0.5971
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.5373
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4548
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5971
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.604
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.604
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5948
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5971
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6513
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6459
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6694
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6694
Peroxisome_Homo sapiens_hsa04146 XDH 0.6112
Glioma_Homo sapiens_hsa05214 IGF1R 0.6694
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6254
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6694
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6692
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.669
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6694
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP3A4 0.6627
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6694
Shigellosis_Homo sapiens_hsa05131 SRC 0.6694
Malaria_Homo sapiens_hsa05144 MET 0.7345
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.7345
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7245
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7582
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.756
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8901
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP3A4 0.9108
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9344
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9289
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1653
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.4943


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)