TCM Prescription: Coughing of Blood Formula



Prescription Description
Prescription IDTCMF1916
Pinyin NameKe Xue Fang
Chinese Name咳血方
English NameCoughing of Blood Formula
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1678 Indigo naturalis 青黛 TCMH1678
TCMH705 Trichosanthes kirilowii 瓜蒌 TCMH705 ITSAO4359-14
TCMH777 Pumex 海浮石 TCMH777
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH583 Apis cerana 蜂蜜 TCMH583 AGIRI284-17
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT242 HRH3 Histamine H3 receptor GPCR Q9Y5N1
TCMT245 HRH2 Histamine H2 receptor GPCR P25021
TCMT246 HRH4 Histamine H4 receptor GPCR Q9H3N8
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PPARA, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, TYR 11.1807
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, PPARA, PTGES, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR 10.6482
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, XDH 10.442
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, PPARA, PTGES, PTGS2, SRC, TEK, TRPV1, TYR 10.3953
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HRH3, HRH4, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MET, MTNR1B, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 9.24601
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, SRC, TERT 9.07141
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, PPARA, PTGES, PTGS2, TBXAS1, TRPV1 8.56792
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TRPV1 8.55886
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.18328
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 7.94416
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 7.77527
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, FABP4, FLT3, HRH4, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, TYR 7.70528
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PTGS2, SMAD3, SRC, TERT, TRPV1 7.69723
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, XDH 7.57168
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, XDH 7.55078
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, IDO1, PTGES, PTGS2, SRC, TYR 7.39453
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.39453
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HRH3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, MTNR1B, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 7.39453
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.35265
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.2935
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, KIT, PPARA, PTGS2, SRC, TEK, TRPV1 7.10008
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.9856
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.98252
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.92084
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.92084
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.91581
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.91167
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 6.86416
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TRPV1, TYR, XDH 6.83335
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, MTNR1B, NUAK1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 6.7767
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, IDO1, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR, XDH 6.66335
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, MTNR1B, NUAK1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 6.66035
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 6.66035
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.66035
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTGES, PTGS2, SRC, TEK, TRPV1, TYR 6.6204
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.57094
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, XDH 6.55169
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.49839
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 6.46416
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, PTGS2, SMAD3, SRC, TRPV1 6.45418
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FLT3, GPR35, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.41337
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.38497
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, XDH 6.31775
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2, TERT 6.28984
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR 6.26997
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.21858
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HRH3, HSD17B2, IDO1, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 5.99604
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA6, CA7, CA9 5.96175
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, NQO2, NUAK1, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TYR, XDH 5.96175
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GPR35, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.85859
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, GPR35, HRH3, HRH4, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.79701
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, KIT, MTNR1A, MTNR1B, PPARA, SRC, TOP1 5.77797
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, HRH4, INSR, MET, MTNR1B, SMAD3, SRC, TERT, TRPV1 5.70878
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.70313
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, PTGS2, SRC, TEK, XDH 5.70313
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTGS2, SRC, TEK, TOP1, XDH 5.69957
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NUAK1, PTGS2, SMAD3, SRC, TERT, TRPV1 5.69957
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 5.53364
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, XDH 5.49856
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GPR35, HRH4, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, XDH 5.4694
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.42194
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTGS2, SRC, TEK, TOP1, XDH 5.3458
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, MTNR1A, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 5.3458
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, MTNR1A, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 5.29675
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, PPARA, SMAD3, SRC, TEK, TYR 5.25213
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.16322
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGES, PTGS2, TBXAS1 5.06455
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.05561
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.05561
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2, TBXAS1 5.04166
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PTGS2, SRC, TOP1, TRPV1 5.03911
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2, TBXAS1 4.89256
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HRH3, HSPA1A, INSR, MMP12, MMP9, MTNR1B, PPARA, PTGS2, SMAD3, SRC, TERT, TRPV1 4.88177
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TRPV1, TYR 4.86314
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 4.75966
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MAOA, NQO2, PTGS2, TBXAS1, TYR, XDH 4.74917
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.74505
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2, TBXAS1 4.71011
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HRH3, HRH4, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.65764
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, GPR35, HRH3, HRH4, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.63517
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 4.49734
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, IDO1, PTGES, PTGS2, SMAD3, TERT, XDH 4.49734
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TRPV1, TYR 4.48516
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, HRH4, INSR, MET, MTNR1B, SMAD3, TRPV1 4.48516
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.45877
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, SRC, TEK 4.45001
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, SRC 4.40283
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.39921
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, MMP12, PTGS2, SMAD3, SRC, TERT, TRPV1 4.39921
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 4.3716
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 4.3716
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, HSPA1A, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 4.35412
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.33897
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 4.31133
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 4.2845
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HRH3, INSR, MAOA, PTGS2, SMAD3, TRPV1 4.2845
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.23722
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.23722
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, IGF1R, INSR, MMP2, MMP9, PTGS2, SRC, TRPV1 4.21643
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HRH4, HSPA1A, IDO1, KIT, MMP2, MMP9, NUAK1, PPARA, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 4.21643
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS2, SRC 4.21441
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, DUSP3, DYRK1A, EGFR, FLT3, FUT7, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TOP1, TYR, XDH 4.21068
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TOP1 4.20652
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 4.15523
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 4.15401
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, KIT, MET, PIM1, SRC, TEK, TYR 4.12473
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, HRH3, HRH4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 4.08481
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 4.08323
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HRH3, HRH4, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 4.00704
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.99605
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.98867
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.98631
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC, TRPV1 3.98209
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, EGFR, GPR35, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.98054
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, XDH 3.98054
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TRPV1, TYR, XDH 3.9747
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA6, CA7, CA9, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, HRH3, HRH4, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TRPV1, TYR, XDH 3.9747
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, EGFR, FLT3, IGF1R, INSR, KIT, MMP2, PTGS2, SMAD3, SRC, TRPV1 3.95807
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.93086
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, SRC, TEK, XDH 3.92341
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, KDR, PTGS2, SRC, TRPV1 3.90152
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS2, TBXAS1 3.83869
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.80452
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, SRC, TEK 3.79927
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, DYRK1A, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC, TOP1 3.79472
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.79472
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.79472
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, EGFR, FABP3, FLT3, INSR, KDR, KIT, MMP9, MTNR1A, PTGS2, SMAD3, SRC, TEK, XDH 3.77637
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, EGFR, FABP3, FLT3, INSR, KDR, KIT, MMP9, MTNR1A, PTGS2, SMAD3, SRC, TEK, XDH 3.77637
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC, TRPV1 3.76729
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2, TBXAS1 3.76729
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, HRH4, IGF1R, INSR, KDR, KIT, SRC, TEK, XDH 3.76729
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TRPV1, TYR, XDH 3.76523
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, EGFR, IDO1, KIT, MMP12, PTGES, PTGS2, SMAD3, SRC, TRPV1, TYR 3.75778
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.72867
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.72796
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2, TBXAS1 3.72706
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.69594
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.66207
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.66207
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TERT, XDH 3.63187
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TERT, XDH 3.61584
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.55742
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.55742
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC, TRPV1 3.50872
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.49434
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.4911
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, TERT, XDH 3.48938
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.44084
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, TRPV1 3.43221
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 3.43221
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.42497
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT 3.42221
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.40172
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.39294
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, PPARA, PTGS2, SRC, TEK, XDH 3.38937
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, MTNR1A, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.36493
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A1, EGFR, HSD17B2, IDO1, INSR, KIT, MMP2, MMP9, MTNR1A, PTGS2, SRC 3.36493
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, FLT3, PTGS2, SRC, TRPV1 3.35975
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.35352
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.32659
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, PTGES, PTGS2, SMAD3, SRC 3.30033
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.28937
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28937
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, HRH4, IGF1R, INSR, KDR, KIT, MMP9, PTGS2, SRC, TEK, XDH 3.28749
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 3.26165
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.26086
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.25889
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.24627
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.24361
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, SRC 3.214
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.21112
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 3.17733
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.17733
[BP] GO:0019371 None PTGES, PTGS2, TBXAS1 3.17733
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGES, PTGS2, TBXAS1 3.16153
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, PTGES, PTGS2, SMAD3, SRC 3.13676
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, DNMT1, DYRK1A, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, MTNR1A, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.11032
[BP] GO:0007623 circadian rhythm DYRK1A, EGFR, MTNR1A, MTNR1B, PPARA, TOP1 3.07666
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 3.06821
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.06127
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, SRC 3.0336
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 3.01692
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.01639
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, HRH3 3.01064
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.01064
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 3.01064
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, GPR35, HRH3, MMP9, PTGS2 3.00844
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.98835
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97501
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD17B1, HSD17B2, MTNR1B 2.96608
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT 2.95885
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, INSR, KDR, KIT, SRC, TEK, XDH 2.95479
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 2.95282
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, MTNR1A, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.94591
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, HRH3, HRH4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TERT, TRPV1, XDH 2.93781
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, HSPA1A, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.91778
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.90561
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, MAOA, TYR 2.87373
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.85783
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, DNMT1, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, SMAD3, SRC, TEK, TRPV1 2.85507
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MAOA 2.84735
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 2.79998
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, DNMT1, DYRK1A, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTGS2, SRC, TEK, XDH 2.79794
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 2.7948
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.78988
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, DNMT1, DYRK1A, EGFR, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 2.77921
[BP] GO:0007610 None APP, BCL2, EGFR, IDO1, INSR, KIT, MTNR1A, PPARA, PTGS2, TRPV1 2.77503
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, PTGS2, SRC, TRPV1, TYR 2.74749
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, SRC 2.74102
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, GPR35, HRH4, SMAD3, TRPV1 2.72946
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.72946
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.71247
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.71092
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.70668
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTGS2, SRC, TEK, XDH 2.68134
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.68134
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, SRC 2.66546
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TEK, TYR 2.64743
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA7, CA9, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GPR35, HRH3, HRH4, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, XDH 2.63573
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.63573
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.63573
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.63573
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.63573
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, SMAD3, SRC, TRPV1 2.63275
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.61811
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, IDO1, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.61755
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.60332
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.5906
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 2.58851
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.58053
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56015
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, KIT, PTGS2, TEK, TERT 2.56015
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, HRH3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, MTNR1A, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, XDH 2.56015
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.55538
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.53724
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.53523
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.53131
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.53131
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.52356
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTGS2, SRC, TEK, XDH 2.52228
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, SMAD3, SRC, TEK, TRPV1 2.49285
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR 2.46886
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, HSD17B2, INSR, KIT, SRC 2.45858
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.45858
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CYP19A1, EGFR, HSD17B2, INSR, KIT, PTGS2, SRC 2.45154
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.44948
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 2.44545
[BP] GO:0050890 None ADORA1, APP, EGFR, HRH3, INSR, KIT, PTGS2 2.44388
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP1 2.43891
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.42227
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.42227
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.4147
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.41383
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, GPR35, HRH3, MMP9, PTGS2 2.4111
[BP] GO:0043434 None FABP3, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 2.39504
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.3879
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.3879
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.36914
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.3628
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, TRPV1, TYR 2.3628
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, SMAD3, SRC, TERT, XDH 2.3628
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.35618
[BP] GO:0044419 interspecies interaction between organisms AXL, DYRK1A, EGFR, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.34538
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, KIT, PTGS2, TYR 2.34041
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32008
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31279
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, IDO1, INSR, KDR, KIT, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.28005
[BP] GO:0051894 None KDR, SMAD3, TEK 2.27348
[BP] GO:0061900 None APP, EGFR, TRPV1 2.27348
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27348
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.27042
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.26708
[BP] GO:0006940 None ADORA1, CHRM2, KIT, PTGS2 2.26708
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, GPR35, HRH4, SMAD3, TRPV1 2.24626
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.24549
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.24549
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, IDO1, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 2.24549
[BP] GO:0044057 None ADORA1, ADORA3, CHRM2, EGFR, GPR35, KIT, PTGS2, SMAD3, TRPV1 2.24185
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, IDO1, MAOA, XDH 2.23657
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.23657
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, PTGS2, SRC, TRPV1, TYR 2.2305
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, SMAD3, SRC, TEK, TOP1 2.22796
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, XDH 2.22583
[BP] GO:0046683 response to organophosphorus APP, PTGS2, TEK, TRPV1, TYR 2.20724
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, EGFR, FLT3, HSPA1A, INSR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT, XDH 2.19222
[BP] GO:1903393 None KDR, SMAD3, TEK 2.19034
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, SRC, TERT 2.19034
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.18648
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC 2.17029
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.16997
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.16997
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.16242
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.15378
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, SRC 2.15378
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR 2.13825
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.13825
[BP] GO:0014050 None ADORA1, HRH3 2.13825
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, FABP4, HRH3, HRH4, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TERT, TRPV1, XDH 2.13825
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.13744
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, APP, AXL, BCL2, CDK6, EGFR, GPR35, IDO1, PTGS2, SMAD3, TEK, TERT, XDH 2.13268
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.11104
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HRH4, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 2.10464
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.1038
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTGS2 2.09982
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, EGFR, KIT, MTNR1A, PTGS2, SRC 2.0905
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR 2.07917
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGES, PTGS2 2.07617
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.07617
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, HRH4, KIT, PTGES, PTGS2, TRPV1 2.05793
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.05443
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CYP1A1, DUSP3, INSR, TERT 2.03694
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.03599
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.03576
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MMP1, MMP12, MMP9, SRC, TEK 2.01828
[BP] GO:0050678 None CDK6, EGFR, KDR, MMP12, SMAD3, TEK, XDH 2.01828
[BP] GO:0018958 None AKR1B1, BCL2, MAOA, TYR 2.01737
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, SRC 2.01669
[BP] GO:0014074 response to purine-containing compound APP, PTGS2, TEK, TRPV1, TYR 2.01669
[BP] GO:1901342 regulation of vasculature development CYP1B1, KDR, KIT, PTGS2, TEK, TERT, XDH 2.0146
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, HRH3, HRH4, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TERT, TRPV1, XDH 2.00983
[BP] GO:1901890 None KDR, SMAD3, TEK 2.00576
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.00576
[BP] GO:2000352 None KDR, TEK, TERT 2.00576
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.00576
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.00576
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00002
[BP] GO:1990535 None APP, INSR 2.00002
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CHRM2, DUSP3, EGFR, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PTGS2, SRC, TEK, TRPV1 3.98631
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MMP2, MTNR1A, MTNR1B, PIM1, SMAD3, SRC, TEK, TERT, TRPV1 3.69769
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.55614
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CHRM2, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 3.50872
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, FUT7, GPR35, HRH3, HRH4, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR 3.43763
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CHRM2, FLT3, GPR35, HRH3, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 3.19708
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 3.06033
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GPR35, HRH3, HRH4, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTGS2, SRC, TBXAS1, TEK, TRPV1, TYR 3.04664
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 3.04248
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.56209
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRM2, EGFR, INSR, MET, PTGS2, SRC, TEK, TRPV1 2.56015
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.43643
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, MET, TEK 2.13268
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGES, PTGS2, SRC, TBXAS1, TEK, TERT, TOP1, TYR, XDH 11.9229
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TRPV1, TYR, XDH 10.183
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 9.9739
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, SMAD3, TBXAS1, TYR, XDH 9.5006
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.72004
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TOP1, TRPV1 8.56792
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.92354
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.41087
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 7.1468
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 6.38646
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 6.21782
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MAOA, NQO2, PTGS2, TBXAS1, TYR, XDH 5.81727
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.70313
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 5.56421
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TERT, TOP1 5.49856
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC, TBXAS1 5.30998
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.29717
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2 5.24861
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1, XDH 5.20507
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC, TBXAS1 5.09057
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1, XDH 4.599
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1, XDH 4.599
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 4.57818
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, NQO2, PTGES, PTGS2, SRC, TBXAS1, XDH 4.57818
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 4.44371
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 4.40283
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 4.39921
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, PTGES, SRC, TEK, TOP1, TRPV1, XDH 4.33492
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK, TRPV1 4.31852
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK, TRPV1 4.31852
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS2, SMAD3, TBXAS1, TERT, TRPV1, TYR, XDH 4.12124
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM2, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 4.12124
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA6, CA7, CA9, DNMT1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, SMAD3 3.90609
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS2, SMAD3, TBXAS1, TERT, TRPV1, TYR, XDH 3.8725
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.80889
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.77849
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1, TYR 3.76729
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 3.76523
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, HRH3, HRH4, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, SMAD3, TEK, TRPV1 3.76459
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.69769
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.60687
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.55742
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, KDR, KIT, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TRPV1, TYR, XDH 3.50828
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 3.44473
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 3.41533
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK, TOP1 3.38076
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA6, CA7, CA9 3.36493
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 3.32659
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 3.28937
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TRPV1 3.286
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 3.09435
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.78988
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 2.74861
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MTNR1A, NQO2, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TRPV1, XDH 2.72946
[MF] GO:0008502 None MTNR1A, MTNR1B 2.56015
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TRPV1, XDH 2.35382
[MF] GO:0051425 None APP, INSR 2.31279
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.31279
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.31146
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.20724
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.19034
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.1499
[MF] GO:0043559 insulin binding IGF1R, INSR 2.13825
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.13744
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.07617
[MF] GO:0004969 None HRH3, HRH4 2.00002


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.161
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA6, CA9, CA14 11.161
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, EGFR, IGF1R 6.4138
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.4877
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, AKR1B1, PTGS2, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES, IDO1 5.5339
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 5.7462
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 5.3653
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.838
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1, IDO1 5.3653
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, MTNR1A, HRH3, GPR35, MTNR1B, ADORA3, HRH4, ADORA1, TRPV1 5.202
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 5.0836
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.3573
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.452
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.1595
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.8732
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.649
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.5921
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.2738
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.4512
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGES 3.3
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 3.0389
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.2111
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.1521
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.6321
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1813
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5, PTGS2 2.4779
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 2.9626
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2292
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.0381
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.275
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.2183
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.1656
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1717
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.1595
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8758
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1347
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8706
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8539
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0584
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.8908
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6625
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8374
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.6077
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.4575
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.3995
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5964
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.3089
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.2692
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.107
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1, PPARA 1.1166
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.0703
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9431
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0717
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.1801
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.0185
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0389
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9539
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0101
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9523
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.0367
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1339
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0717
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8959
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0717
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.3349
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0668
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2753
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8468
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8941
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8242
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9158
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8236
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.2111
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8236
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1952
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3 0.8941
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7978
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.252
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7742
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.308
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7438
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, EGFR 0.7126
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7142
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7438
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3215
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3313
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6556
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3289
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3313
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3209
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3708
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3789
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3946
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.5594
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3946
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4035
Axon guidance_Homo sapiens_hsa04360 MET 0.416
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.424
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.4136
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4296
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4324
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4832
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4743
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4819
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4819
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4881
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4874
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4819
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5006
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5064
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5204
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5056
Peroxisome_Homo sapiens_hsa04146 XDH 0.5214
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5594
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5594
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5464
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5581
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5653
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5771
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5672
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.575
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5792
Shigellosis_Homo sapiens_hsa05131 SRC 0.5792
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5991
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5792
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7781
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6661
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6295
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6478
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6517
Malaria_Homo sapiens_hsa05144 MET 0.6558
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6558
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6556
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6558
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7328
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6607
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6688
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6782
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6735
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7142
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9431
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7438
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7438
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7126
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8196
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7765
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7978
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8236
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8196
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8383
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9454
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0101
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1291


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)