TCM Prescription: Yellow Earth Decoction



Prescription Description
Prescription IDTCMF1915
Pinyin NameHuang Tu Tang
Chinese Name黄土汤
English NameYellow Earth Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2575 Terra flava usta 灶心土 TCMH2575
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 9.58388
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.69543
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 8.28631
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 8.28631
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 8.28631
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 8.25094
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.25094
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.24801
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, SRC, TEK 7.93075
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 7.86731
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.85472
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 7.40725
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, SRC, TEK, TYR 7.38666
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 7.23866
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.16085
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 6.81732
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 6.7761
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.7657
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.7657
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.71402
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.70649
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.67965
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.16531
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.09861
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HSPA1A, PPARA, TYR, XDH 5.79062
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.74581
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, MET, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, TYR 5.62579
[BP] GO:0080134 regulation of response to stress ABCB1, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.49408
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.47927
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.44101
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK, XDH 5.42813
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CDK6, CYP19A1, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 5.41705
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.39708
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.13701
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 4.95315
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.92764
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 4.89923
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.86807
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.78477
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP12, TEK 4.71243
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA 4.70551
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.69624
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.66691
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 4.6332
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 4.60707
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.47319
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.44473
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.43385
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4278
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.42483
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.41504
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 4.36958
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK 4.3476
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PPARA 4.3476
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 4.26446
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 4.25143
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, BCL2, CDC25B, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.13852
[BP] GO:0051896 regulation of protein kinase B signaling DRD3, EGFR, F3, INSR, MET, SRC, TEK, XDH 4.13786
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, SMAD3, SRC 4.12517
[BP] GO:0042493 response to drug ABCB1, AKR1B1, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, HSD11B2, KDR, SRC 4.12206
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.12206
[BP] GO:0009893 positive regulation of metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.11162
[BP] GO:0010638 positive regulation of organelle organization ALOX15, BCL2, DRD3, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 4.10276
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.06705
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.0327
[BP] GO:0040012 regulation of locomotion BCL2, CDK6, CYP19A1, CYP1B1, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.02575
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.00121
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD3, GBA2, TYR 3.93656
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TYR 3.93281
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, SMAD3, SRC 3.91978
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, HSPA1A 3.91642
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 3.8827
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.82133
[BP] GO:0006468 protein phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 3.81849
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA 3.80936
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.79229
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.79229
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 3.7676
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.75189
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.74392
[BP] GO:2000145 regulation of cell motility BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.69018
[BP] GO:0010941 regulation of cell death AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, MET, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.63511
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.62556
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.60918
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.5324
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, DRD3, EGFR, KDR, SRC, TNKS, TNKS2 3.50339
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.49092
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.49092
[BP] GO:0065009 regulation of molecular function ABCB1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.48901
[BP] GO:0043067 regulation of programmed cell death AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, MET, PTPN1, SMAD3, SRC, TEK, XDH 3.45203
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PTPN1, PTPRS, SMAD3, SRC, XDH 3.44024
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.42525
[BP] GO:0042592 homeostatic process AKR1B1, BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.40695
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.39662
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.37558
[BP] GO:0051270 regulation of cellular component movement BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.37398
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 3.32541
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.30732
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.27743
[BP] GO:0030334 regulation of cell migration BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.26596
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.26081
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26081
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, PTPN1, SRC, XDH 3.24449
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 3.19729
[BP] GO:0008283 cell proliferation ABCB1, ACHE, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, SRC, TEK, TYR 3.18202
[BP] GO:0007346 regulation of mitotic cell cycle BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, SMAD3, TNKS 3.15699
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.15521
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 3.15521
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.14625
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC 3.14625
[BP] GO:0060548 negative regulation of cell death AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PPARA, PTPN1, SMAD3, SRC, TEK 3.13635
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SMAD3, SRC 3.13635
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 3.11682
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD3, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 3.05139
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.03915
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F3, INSR, MET, SRC, TEK 2.98941
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.98878
[BP] GO:0016310 phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 2.96924
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.95875
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, PPARA, PTPN1, SRC, TEK, XDH 2.95818
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.95818
[BP] GO:0042981 regulation of apoptotic process AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.95785
[BP] GO:0009628 response to abiotic stimulus AKR1B1, BCL2, CA2, CYP1A1, DRD3, EGFR, HSD11B2, HSPA1A, PPARA, SMAD3, SRC, TEK, TYR 2.93298
[BP] GO:0050790 regulation of catalytic activity BCL2, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.92915
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.92454
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.921
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, BCL2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 2.9186
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.9186
[BP] GO:0009115 None AOX1, XDH 2.91176
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.89499
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.89499
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, SMAD3, SRC, TNKS, TNKS2 2.89085
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.87268
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK 2.87268
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.87268
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.84118
[BP] GO:0044093 positive regulation of molecular function ABCB1, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.84118
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.84118
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.84118
[BP] GO:0003006 developmental process involved in reproduction ALPL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.82269
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.81703
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.79094
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.79094
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.75508
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.7428
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.71879
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.71737
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.69072
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.68788
[BP] GO:0051239 regulation of multicellular organismal process BCL2, CA2, CDK6, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 2.67774
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.67265
[BP] GO:0009891 positive regulation of biosynthetic process DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.67246
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 2.67223
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.67223
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.66762
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.66762
[BP] GO:0050793 regulation of developmental process BCL2, CA2, CDK6, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, INSR, KDR, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 2.63683
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.63525
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.6263
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.6263
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.61353
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, DRD3, EGFR, ESR1, PPARA, SRC 2.58711
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, PTPRS, XDH 2.58661
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.57643
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, TEK 2.5764
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD3, EGFR, ESR2, HSPA1A, INSR, PTPRS, SMAD3, TNKS2 2.57011
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.56264
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, BCL2, CA2, CA7, CYP19A1, DRD3, EGFR, GPR35, HSPA1A, INSR, MMP12, PPARA, PTPN1, SMAD3, SRC 2.56264
[BP] GO:0046110 None AOX1, XDH 2.55549
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55549
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.55549
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, PPARA, SMAD3, SRC, TEK 2.54008
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CYP1A1, CYP1B1, DRD3, KDR, SRC 2.53941
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, GPR35, SMAD3 2.49887
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.49887
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 2.47353
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47103
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.4516
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.44277
[BP] GO:0051128 regulation of cellular component organization ALOX15, BCL2, CSNK2A1, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.44002
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.42564
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.42361
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD3, KDR, SRC 2.41866
[BP] GO:0051726 regulation of cell cycle BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, SMAD3, SRC, TNKS 2.4183
[BP] GO:0044092 negative regulation of molecular function CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PPARA, PTPN1, SRC, TNKS 2.4183
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, PTPN1, SMAD3, SRC, TEK, XDH 2.41236
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37499
[BP] GO:0051054 positive regulation of DNA metabolic process EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.37221
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PTPN1, SMAD3, SRC, TEK 2.35685
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.35685
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4 2.33967
[BP] GO:0019222 regulation of metabolic process ACHE, ALOX15, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.33861
[BP] GO:0051894 None KDR, SMAD3, TEK 2.33589
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.33589
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.32453
[BP] GO:0070213 None TNKS, TNKS2 2.32453
[BP] GO:0006145 None AOX1, XDH 2.32453
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32453
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.32282
[BP] GO:0031399 regulation of protein modification process ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SRC, TEK, XDH 2.30666
[BP] GO:0010564 regulation of cell cycle process BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, EGFR, HSPA1A, INSR, TNKS 2.30317
[BP] GO:0050927 None F3, KDR, SMAD3 2.29855
[BP] GO:0031328 positive regulation of cellular biosynthetic process DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.28694
[BP] GO:0018193 peptidyl-amino acid modification BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 2.28265
[BP] GO:0048869 cellular developmental process ACHE, ALPL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, PTPRS, SMAD3, SRC, TEK 2.27607
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD3, EGFR, TNKS, TNKS2 2.2727
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.26719
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2 2.26719
[BP] GO:0050926 None F3, KDR, SMAD3 2.26283
[BP] GO:1903393 None KDR, SMAD3, TEK 2.26283
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ALOX15, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.25743
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.2519
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.21747
[BP] GO:0043085 positive regulation of catalytic activity BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.21735
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.21279
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.20731
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.17229
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP12, SRC, XDH 2.1594
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4 2.15576
[BP] GO:0009894 regulation of catabolic process BCL2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.15393
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.15393
[BP] GO:0043696 None CDK6, ESRRB 2.15393
[BP] GO:0043697 None CDK6, ESRRB 2.15393
[BP] GO:0010641 None F3, SRC 2.15393
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, SRC 2.14518
[BP] GO:0018958 None AKR1B1, BCL2, DRD3, TYR 2.14099
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA 2.1263
[BP] GO:0006464 cellular protein modification process ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.1263
[BP] GO:0036211 protein modification process ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.1263
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.11043
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.11043
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.11043
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, SMAD3, SRC, TEK 2.09003
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.08856
[BP] GO:1901890 None KDR, SMAD3, TEK 2.07679
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.07679
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.07679
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, DRD3, FABP3, FLT3, PPARA, SRC, TEK 2.07679
[BP] GO:0051254 None DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, SMAD3, SRC, TNKS 2.06635
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.05549
[BP] GO:0030308 None BCL2, ESR2, HSPA1A, PTPRS, SMAD3 2.04822
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, INSR, SMAD3 2.04588
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.0383
[BP] GO:0045787 positive regulation of cell cycle CDC25B, CYP1A1, DRD3, DUSP3, EGFR, INSR, SRC 2.02681
[BP] GO:2000026 regulation of multicellular organismal development BCL2, CA2, CDK6, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F3, INSR, KDR, PTPRS, SMAD3, SRC, TEK, XDH 2.02245
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, GPR35, SMAD3 2.02245
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.02245
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02245
[BP] GO:0046113 None AOX1, XDH 2.02245
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.01795
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, BCL2, CA2, CYP19A1, DRD3, EGFR, INSR, MMP12, SMAD3, SRC 2.00727
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.46736
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, BCL2, CA1, CA2, CA4, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 2.28067
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.02245
[CC] GO:0044425 membrane part ABCB1, ACHE, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, PTPRS, SRC, TEK, TYR 1.97607
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, AOX1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, PTPN1, PTPRS, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 1.87847
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPN1, PTPRS, SRC, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 10.5891
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.92829
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 9.80381
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 9.59054
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.61662
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.61662
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.25459
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.73106
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.67858
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.6074
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PTPN1, SMAD3, TNKS 5.14947
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.54997
[MF] GO:0004713 protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.54988
[MF] GO:0008144 drug binding ABCB1, ACHE, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, SRC, TEK 4.4798
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.13786
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.00121
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.00121
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.87009
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.80936
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.67217
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.62721
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.57103
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.53733
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.46938
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.38651
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, ESR1, ESR2, ESRRA, ESRRB, MMP12, NUAK1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TYR, XDH 3.20112
[MF] GO:0004672 protein kinase activity CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 3.18506
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 3.17345
[MF] GO:0008289 lipid binding ALOX15, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.07694
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.03915
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 2.98804
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, CDK6, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PTPRS, SRC, TEK, TUBB3, XDH 2.93454
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91176
[MF] GO:0003845 None HSD11B1, HSD11B2 2.91176
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.89418
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.87268
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.87268
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.87268
[MF] GO:0038023 signaling receptor activity DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.84118
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, SRC, XDH 2.75763
[MF] GO:0060089 molecular transducer activity CDK6, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.70985
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.66644
[MF] GO:0036094 small molecule binding ABCB1, AOX1, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TUBB3, XDH 2.66629
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.6263
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TUBB3, XDH 2.47145
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TUBB3, XDH 2.47103
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP12, NUAK1, PPARA, PTPN1, SMAD3, TNKS, TNKS2, TYR, XDH 2.46173
[MF] GO:0004871 signal transducer activity DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 2.44002
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.38752
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.36082
[MF] GO:0004872 receptor activity DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 2.35685
[MF] GO:0016301 kinase activity CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.34967
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32453
[MF] GO:0019899 enzyme binding BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, MET, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS2 2.30403
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.27607
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.15393
[MF] GO:0043559 insulin binding IGF1R, INSR 2.15393
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.08856
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.07679
[MF] GO:0004064 arylesterase activity CA1, CA2 2.02245
[MF] GO:0043546 None AOX1, XDH 2.02245


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.431
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.3626
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.3552
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.659
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.9678
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.2332
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.0034
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.2332
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8814
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.032
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.8814
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.1073
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.8324
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.5768
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, CYP1B1, MET, EGFR, CDC25B 3.5768
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.5768
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.336
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, BCL2, MET, EGFR, IGF1R 2.9314
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.336
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3541
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2 2.2656
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.2656
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2656
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.2634
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2607
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2656
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2159
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2578
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, F3 1.8626
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.9931
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.9935
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2547
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8055
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6505
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6121
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.6904
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.6124
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.58
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3636
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.2708
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0422
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.1663
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.4535
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4033
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1275
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1954
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.4535
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.3084
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.154
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0071
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1976
Toxoplasmosis_Homo sapiens_hsa05145 BCL2, HSPA1A 1.0071
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9329
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9112
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8671
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9007
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9809
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1558
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8959
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9112
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4033
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2693
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.419
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8589
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3392
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8589
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3236
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8242
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.7044
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15 1.4033
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7913
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6992
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2711
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, DRD3 0.586
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6582
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3753
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.365
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.371
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.6904
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.3476
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3753
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3646
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.3867
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4111
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4185
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4111
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4346
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4468
Platelet activation_Homo sapiens_hsa04611 SRC 0.4676
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4698
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4698
Axon guidance_Homo sapiens_hsa04360 MET 0.4594
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4676
Dopaminergic synapse_Homo sapiens_hsa04728 DRD3 0.4572
Serotonergic synapse_Homo sapiens_hsa04726 ALOX15 0.4881
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5196
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5122
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5196
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5201
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5196
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5246
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5243
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5414
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8474
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5426
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5426
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5528
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.542
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8626
Peroxisome_Homo sapiens_hsa04146 XDH 0.5535
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7501
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.586
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5686
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5748
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6149
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6015
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8055
Shigellosis_Homo sapiens_hsa05131 SRC 0.6169
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7371
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6169
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6402
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3 0.6564
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0119
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6664
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6803
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6664
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6836
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6992
Malaria_Homo sapiens_hsa05144 MET 0.6953
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6992
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6992
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6992
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6992
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7044
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7905
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8623
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8256
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8483
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8671
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8623
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9809
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.057
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1876
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3392


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)