TCM Prescription: Radix Bupleuri Liver Clearing Decoction



Prescription Description
Prescription IDTCMF1897
Pinyin NameCai Hu Qing Gan Yin
Chinese Name柴胡清肝饮
English NameRadix Bupleuri Liver Clearing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH2039 Caulis perillae frutescentis 苏梗 TCMH2039
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1297 Punta Toro virus
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.9792
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1883
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 8.58015
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 8.53214
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, RORC, SRC, TERT, TOP1 8.36161
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 8.06131
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, SRC, TERT 8.06131
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 7.19595
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, PPARA, RORC, SRC 7.018
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, FABP3, IGF1R, MMP2, MMP9, PPARA, RORC, SRC 6.92557
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, TNKS, TNKS2, XDH 6.87898
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, TNKS, TNKS2, XDH 6.86588
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, FABP3, FUT7, PIM1, PPARA, XDH 6.5895
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, F10, FABP3, FABP4, FLT3, KDR, KIT, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH 6.42594
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F10, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.98423
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC, TERT 5.95729
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F10, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.95729
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, SRC, TOP1 5.72972
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RORC, SRC 5.59074
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 5.54081
[BP] GO:0030334 regulation of cell migration APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.50156
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1 5.39135
[BP] GO:2000145 regulation of cell motility APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.17627
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.17609
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, DNMT1, DRD1, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, SRC 5.15711
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.05761
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, TNKS, TNKS2, XDH 5.03388
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1, XDH 4.98458
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.98458
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.98458
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, TNKS, TNKS2, XDH 4.96309
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, DRD1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP1 4.95968
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.95968
[BP] GO:0040012 regulation of locomotion APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.89638
[BP] GO:0051270 regulation of cellular component movement APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.88726
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.88558
[BP] GO:0046777 protein autophosphorylation AURKB, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.87295
[BP] GO:0048511 rhythmic process AXL, BCL2, DRD2, DYRK1A, KIT, PPARA, RORC, SRC, TOP1 4.82885
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1, XDH 4.7498
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 4.74689
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.61527
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, F10, FLT3, KDR, KIT, MET, MMP9, SRC, TERT, TNKS, TNKS2, XDH 4.4689
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, DRD2, FABP4, KIT, MMP9, TERT 4.44874
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS, TOP1 4.44874
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC, TERT 4.42041
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, DRD2, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 4.37094
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, FABP4, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2, TOP1 4.29626
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, CYP19A1, CYP1A1, CYP1B1, DRD2, FABP3, FABP4, FUT7, KIT, MET, PPARA 4.22141
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 4.22141
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1B1 4.20641
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS, TOP1 4.20641
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FLT3, RORC, SRC 4.20452
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC, TNKS, TNKS2 4.07993
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CYP1B1, DNMT1, DRD2, FABP3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, SRC, TERT, XDH 4.07621
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS2 3.9899
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, F10, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, RORC, SRC, TERT, TOP1 3.98219
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS, TOP1 3.92332
[BP] GO:0006811 None ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 3.85663
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, SRC, TERT 3.84428
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, F10, FABP4, FLT3, KDR, KIT, MET, MMP2, MMP9, SRC, TERT, TNKS, TNKS2, XDH 3.7561
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, DRD2, F10, FLT3, KDR, KIT, MET, SRC, XDH 3.73434
[BP] GO:0051179 None ABCB1, ACHE, ALOX5, APP, AURKB, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, FABP3, KIT, MMP9, PPARA, SRC, TERT, TNKS, TNKS2, XDH 3.70312
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, FLT3, MET, SRC, TERT 3.65647
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, APP, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F10, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, SRC, TERT, TNKS, TNKS2, XDH 3.65647
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT 3.65647
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT 3.65647
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2 3.65072
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, KIT, MMP2, PPARA, SRC, TERT 3.63918
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.63769
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, KIT, MET, SRC, XDH 3.60115
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CYP1B1, DRD2, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, XDH 3.52375
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 3.49009
[BP] GO:0051234 None ABCB1, ACHE, ALOX5, APP, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, FABP3, KIT, MMP9, PPARA, SRC, TERT, TNKS, XDH 3.43635
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, TNKS, TNKS2 3.4243
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, SRC, TERT, XDH 3.4243
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.36149
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.29746
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 3.29232
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, DRD1, IGF1R, MMP2, MMP9, RORC, SRC 3.28002
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.25125
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.25125
[BP] GO:0032879 regulation of localization ABCB1, ACHE, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, DRD1, DRD2, F10, IGF1R, KDR, KIT, MET, MMP9, PPARA, SRC, TERT 3.25125
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, FLT3, RORC, SRC 3.24075
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CYP1A1, DRD1, DRD2, DYRK1A, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TNKS, TNKS2, TOP1, XDH 3.22531
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIM1, SRC, TERT, XDH 3.15462
[BP] GO:0006810 None ABCB1, ACHE, ALOX5, APP, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, F10, FABP3, KIT, MMP9, PPARA, SRC, TNKS, XDH 3.11847
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 3.09572
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1A1, CYP1B1, DRD2, FABP3, FABP4, FUT7, KIT, MET, PPARA 3.09572
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 3.0914
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 3.08359
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.0689
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 3.03053
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, SRC 3.03053
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 3.00924
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, FABP3, FLT3, KIT, PPARA, SRC 3.00924
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.99624
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AURKB, BCL2, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.95082
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, DRD1, DYRK1A, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TNKS, TNKS2, TOP1 2.92068
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.91027
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.89568
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.8525
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.8525
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.8525
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 2.83513
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.80836
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.76926
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.76926
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.75492
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, DRD2, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, TERT 2.7426
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, DRD1, DYRK1A, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, SRC, TNKS, TNKS2, TOP1 2.7359
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CYP1A1, DRD1, DRD2, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, RORC, SRC, TERT 2.7359
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CYP1A1, FABP3, FLT3, RORC, SRC 2.7359
[BP] GO:0032922 None DRD2, PPARA, RORC, TOP1 2.72502
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, BCL2, DNMT1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.66393
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2 2.65303
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, KDR, KIT, MMP9, PIM1, PPARA, RORC, SRC 2.64318
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.63262
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.62817
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.6224
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.60386
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.59954
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53522
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, MET 2.52518
[BP] GO:0009893 positive regulation of metabolic process APP, AURKB, BCL2, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.51577
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.50506
[BP] GO:0071702 None ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA, TNKS 2.50506
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.50143
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.48521
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.47368
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, SRC, TERT 2.46606
[BP] GO:0007623 circadian rhythm DRD2, DYRK1A, PPARA, RORC, TOP1 2.45981
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.44526
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, BCL2, DNMT1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP9, PPARA, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.44526
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CYP1B1, DRD2, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS 2.43012
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CYP1B1, DRD2, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT, TNKS, TNKS2, XDH 2.39886
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.38351
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 2.36946
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.36578
[BP] GO:0032845 None BCL2, DRD2, SRC, TNKS, TNKS2 2.36578
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.34611
[BP] GO:0048169 None APP, DRD2, KIT 2.33972
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, KIT, PPARA, RORC, SRC 2.33972
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1 2.31422
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.30316
[BP] GO:0070213 None TNKS, TNKS2 2.30316
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.30178
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MMP1, MMP9, SRC 2.29558
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, KIT, MET, SRC 2.28131
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.28131
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MET, MMP1, MMP9, SRC 2.28131
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, IGF1R, MET, MMP9, SRC, XDH 2.26899
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.26899
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.26899
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.26899
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.25289
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2 2.25289
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, IGF1R, KDR, MMP9, PIM1, SRC, TERT 2.23656
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.23656
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, DRD1, FLT3, IGF1R, KIT, MMP2, SRC 2.23656
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, DRD2, DYRK1A, FABP4, IGF1R, MET, MMP2, PPARA, SRC, TERT, XDH 2.20577
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, IGF1R, MMP2, SRC 2.16037
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.15343
[BP] GO:0021853 None DRD1, DRD2 2.13637
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.13637
[BP] GO:1904936 None DRD1, DRD2 2.13637
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.11934
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, SRC, XDH 2.09849
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CYP1B1, FLT3, IGF1R, KDR, MMP9, PIM1, SRC, TERT, XDH 2.09781
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.0865
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, SRC, XDH 2.08637
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC 2.07026
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, SRC, XDH 2.05697
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.05697
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, DRD1, DRD2, FABP3, FLT3, KDR, KIT, MMP9, SRC, XDH 2.05697
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, DRD1, DRD2, FABP3, FLT3, KDR, KIT, MMP9, SRC, XDH 2.05697
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, KIT 2.05598
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, DRD2, KDR, KIT, MET, MMP9, PIM1, SRC, TERT 2.03303
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MMP1, MMP9, SRC 2.02872
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.02859
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, DRD2, PPARA 2.02225
[BP] GO:0031399 regulation of protein modification process APP, BCL2, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, SRC, XDH 2.02188
[BP] GO:0021843 None DRD1, DRD2 2.00721
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00721
[BP] GO:0021830 None DRD1, DRD2 2.00721
[BP] GO:0021826 None DRD1, DRD2 2.00721
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2 2.00525
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, DRD1, DRD2 2.00392
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, IGF1R, MMP2, SRC 2.00392
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA5A, CA5B, CA6, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.53822
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA5A, CA5B, CA6, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 2.10242
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.81553
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, DRD1, DRD2, F10, FLT3, IGF1R, KDR, KIT, MET, MMP2, PIM1, SRC, TERT 1.74452
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, MET 1.53847
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.5721
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F10, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS, TNKS2, TOP1, XDH 12.6087
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2176
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, TNKS, XDH 12.1883
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0242
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, SRC, TERT, TNKS, TNKS2, TOP1, XDH 10.2124
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, F10, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, TERT, TNKS, TNKS2, XDH 7.78554
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.38074
[MF] GO:0008270 zinc ion binding CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, MMP1, MMP2, MMP9, PPARA, RORC, TNKS 7.018
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, DNMT1, F10, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, TERT, TNKS, TNKS2, XDH 5.8729
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.17609
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP1 5.05761
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 5.03459
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.72324
[MF] GO:0004672 protein kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.78601
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.14267
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT, TOP1 2.92432
[MF] GO:0016301 kinase activity AURKB, AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 2.8525
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1 2.43012
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1 2.30178
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1B1, XDH 2.20577


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.1758
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1A1, CYP1B1, CYP19A1, IGF1R 5.0807
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 3.83
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9226
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7082
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET 3.7501
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, DRD2, MET, IGF1R 3.6796
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4393
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.755
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.3808
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.3808
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.2654
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1A1, CYP1B1, CYP19A1 2.3808
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, BCL2, MET, IGF1R 2.0206
Adherens junction_Homo sapiens_hsa04520 SRC, MET, IGF1R 2.1714
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1092
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.9363
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.8857
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 2.0206
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9389
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, FUT7, AKR1B10, ALOX5, CYP1A1, ALPL, AKR1B1, CYP19A1, XDH 1.8526
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.7375
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.6319
cAMP signaling pathway_Homo sapiens_hsa04024 DRD1, DRD2, PPARA 1.3628
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.424
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4376
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3628
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3628
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5789
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2338
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.089
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2262
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1 1.7201
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0206
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3628
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A1, CYP1B1 1.3517
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3087
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1363
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8781
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2338
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.089
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A1, CYP1B1 1.279
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0755
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 1.0141
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7768
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8739
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0755
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9477
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8526
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.8499
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8274
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8274
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 DRD1, DRD2 0.6187
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3269
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5546
Epstein-Barr virus infection_Homo sapiens_hsa05169 BCL2 0.3953
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3834
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5274
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5274
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5528
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3942
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4415
Platelet activation_Homo sapiens_hsa04611 SRC 0.5089
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5089
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5528
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4851
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5528
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.4272
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4312
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.5528
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5089
Melanogenesis_Homo sapiens_hsa04916 KIT 0.5507
Tight junction_Homo sapiens_hsa04530 SRC 0.4851
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5528
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.5089
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4957
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5089
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.477
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.484
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4738
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5507
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6187
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4829
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5546
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6187
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5546
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4614
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5089
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4178
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4957
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2 0.5528
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5528
Glioma_Homo sapiens_hsa05214 IGF1R 0.6187
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6216
Axon guidance_Homo sapiens_hsa04360 MET 0.5043
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.601
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5528
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5957
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6187
Peroxisome_Homo sapiens_hsa04146 XDH 0.5615
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5754
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6066
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6185
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6183
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6187
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6187
Retinol metabolism_Homo sapiens_hsa00830 CYP1A1 0.6187
Shigellosis_Homo sapiens_hsa05131 SRC 0.6187
Malaria_Homo sapiens_hsa05144 MET 0.6623
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6529
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6811
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.683
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6849
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.823
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8499
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8274
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8499
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0755
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.3628


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)