TCM Prescription: Cock-Crowing Powder



Prescription Description
Prescription IDTCMF1892
Pinyin NameJi Ming San
Chinese Name鸡鸣散
English NameCock-Crowing Powder
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1184 Citrus reticulata 橘皮 TCMH1184 ITSAA1245-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH2216 Evodia rutaecarpa 吴茱萸 TCMH2216
TCMH2046 folium perillae 苏叶 TCMH2046
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH78 Platycodon grandiflorum 白桔梗 TCMH78 ITSAJ4293-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MCL1, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SRC, TRPV1, TYR 10.3925
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR2C, KDR, MAOA, MCL1, MET, MTNR1B, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TRPV1, XDH 10.3515
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SRC, TRPV1, TYR 10.0941
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTGES, PTGS2, RORC, SRC, TRPV1, TYR 9.85614
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH 8.40639
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH 8.37975
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH 7.70918
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HTR2A, HTR2B, HTR2C, KDR, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 7.58061
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, SRC 7.34475
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.33879
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MCL1, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, XDH 7.33879
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, XDH 7.097
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.02531
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 7.02531
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, PRKCE, PTGES, PTGS2, RORC, SRC, TYR 6.9929
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, PRKCE, PRKCG, PTGES, PTGS2, RORC, SRC, TRPV1, TYR 6.96354
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, PTGES, PTGS2, SRC 6.93876
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC 6.83986
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC 6.74524
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TRPV1 6.70345
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.70345
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC 6.6949
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.6949
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 6.6949
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 6.64196
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MCL1, MET, MTNR1B, PIK3CA, PIK3CB, PRKCB, PRKCE, SRC, TRPV1 6.61759
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 6.38847
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.36486
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 6.19538
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, XDH 6.09727
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, GLO1, HTR2B, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SRC 6.07971
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 6.06837
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 6.03299
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TRPV1 6.03299
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 5.90954
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.88414
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SRC, TBXAS1, TOP2A, TYR, XDH 5.88414
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 5.84147
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.79904
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.76875
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1 5.74708
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 5.72553
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MCL1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, TYR 5.72105
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC, TRPV1 5.72105
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.60416
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2A, HTR2B, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SRC, TOP2A, TYR 5.58655
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.58655
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, MTNR1B, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 5.56835
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC 5.53058
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, FLT3, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 5.53058
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC 5.53058
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SRC, TBXAS1, TOP2A, TRPV1, TYR, XDH 5.53058
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.36336
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 5.36336
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.35214
[BP] GO:0032879 regulation of localization ACHE, APEX1, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CYP19A1, CYP1B1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1B, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TRPV1 5.20733
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.18802
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.10195
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CYP1B1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 5.07979
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C 5.03123
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2, HTR2A, HTR2C, MTNR1B, PRKCA, PRKCE, SLC22A1 4.93203
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.86709
[BP] GO:0019371 None PTGES, PTGS1, PTGS2, TBXAS1 4.83252
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CYP1B1, ESR1, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, PTGES, PTGS1, PTGS2, SRC, XDH 4.78201
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 4.76951
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 4.65652
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 4.6373
[BP] GO:0048511 rhythmic process AXL, BCL2, ESR1, MTNR1A, MTNR1B, PPARA, PRKCG, RORC, SRC, TOP2A 4.6373
[BP] GO:0042327 positive regulation of phosphorylation BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.6373
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.6373
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 4.59401
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TYR 4.59375
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, ESR1, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, PTGS2 4.55066
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, HTR2A, HTR2B, HTR2C, MMP9, MTNR1B, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TRPV1 4.52504
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 4.52504
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 4.5133
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 4.49963
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.49339
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 4.49339
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, HTR2A, HTR2B, HTR2C, IGF1R, MCL1, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SRC, TRPV1, TYR 4.45375
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.43637
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, CDC25B, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.41433
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 4.41227
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.41047
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, CDC25B, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.36945
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, PRKCD, PRKCE, SRC 4.28718
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 4.28699
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 4.25856
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, PIK3CA, SRC 4.23585
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.23585
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 4.23453
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP9, MTNR1B, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.16735
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, FLT3, FUT7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SRC, TRPV1 4.16722
[BP] GO:0042325 regulation of phosphorylation BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.16722
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GLO1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, XDH 4.15159
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.13522
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 4.13522
[BP] GO:0001932 regulation of protein phosphorylation BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.08825
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP9, MTNR1B, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 4.07896
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.07896
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.07896
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PRKCD, PTGS1, PTGS2, SRC 4.03374
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.95242
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.95242
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 3.95242
[BP] GO:0007165 signal transduction AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RORC, SRC, TRPV1 3.9469
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1, TYR 3.9469
[BP] GO:0040012 regulation of locomotion APEX1, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 3.88545
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.81152
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, HTR2A, HTR2B, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 3.80915
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.80732
[BP] GO:0006950 response to stress ACHE, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, HTR2C, MCL1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1 3.80621
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, MCL1, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 3.79872
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, PRKCE, SRC, TRPV1 3.78437
[BP] GO:0009894 regulation of catabolic process APEX1, BCL2, HTR2A, HTR2B, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1 3.76582
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MMP9, PTGS2, PTPN1, SRC 3.67059
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, PIK3CA, SRC 3.6652
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 3.66423
[BP] GO:0031401 positive regulation of protein modification process BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.63415
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.61415
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1, TYR 3.61255
[BP] GO:0007210 None HTR2A, HTR2B, HTR2C, HTR6 3.61255
[BP] GO:0098664 None HTR2A, HTR2B, HTR2C, HTR6 3.61255
[BP] GO:0031325 positive regulation of cellular metabolic process AURKB, BCL2, CDC25B, ESR1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, XDH 3.60391
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, HTR2A, HTR2B, IGF1R, KDR, MCL1, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC 3.53513
[BP] GO:0043408 regulation of MAPK cascade FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, XDH 3.53276
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.52725
[BP] GO:0043410 positive regulation of MAPK cascade FLT3, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, XDH 3.43667
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGES, PTGS2, SRC 3.41143
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, XDH 3.4108
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.40709
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MCL1, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.40279
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.40279
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.40279
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.37423
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, HTR2A, HTR2B, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC, TRPV1, TYR 3.35544
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B2 3.33583
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, FLT3, IGF1R, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A 3.33494
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.31832
[BP] GO:0006855 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.31832
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.31832
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.31326
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.30707
[BP] GO:0031399 regulation of protein modification process BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 3.25769
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, TRPV1 3.24737
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, GLO1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, XDH 3.23432
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC 3.21697
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.19022
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, PPARA, PRKCD, PTGS2, SRC, TRPV1 3.18968
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.18727
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.18151
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CYP1A1, CYP1A2, ESR1, FLT3, FUT7, GLO1, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 3.15045
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.1403
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC 3.13784
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MCL1, MET, PIK3CA 3.13783
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.13685
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.11213
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.09359
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, BCL2, CDK6, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 3.08363
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.08316
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, PIM1, PRKCG, SRC 3.06312
[BP] GO:0060401 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.01731
[BP] GO:0032270 positive regulation of cellular protein metabolic process BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 3.01673
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 3.01673
[BP] GO:2000145 regulation of cell motility APEX1, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 3.00381
[BP] GO:0009893 positive regulation of metabolic process AURKB, BCL2, CDC25B, ESR1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TOP2A, TRPV1, XDH 2.99895
[BP] GO:0034097 response to cytokine AXL, BCL2, FABP4, FLT3, MCL1, PRKCA, PTGES, PTGS2, SRC, TRPV1 2.97993
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.97993
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.97993
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, PTGES, PTGS1, PTGS2 2.97993
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.96048
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.95003
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.94443
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SRC 2.92458
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2C, HTR6, MTNR1B, PRKCG 2.91757
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2C, HTR6, MTNR1B, PRKCG 2.91757
[BP] GO:0007208 None HTR2A, HTR2C 2.89971
[BP] GO:0035408 None PRKCA, PRKCB 2.89971
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.89971
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.89971
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.89971
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, MCL1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.88015
[BP] GO:0055074 calcium ion homeostasis BCL2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.86895
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2C, HTR6, MTNR1B, PRKCG 2.86525
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2C, HTR6, MTNR1B, PRKCG 2.86525
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.86431
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.86125
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, MCL1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.85124
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.83613
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.8122
[BP] GO:0015893 None CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.78332
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.76118
[BP] GO:0051247 positive regulation of protein metabolic process BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.75547
[BP] GO:0080134 regulation of response to stress CDK6, CYP19A1, ESR1, FABP4, IGF1R, MCL1, MET, MMP2, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, XDH 2.75076
[BP] GO:0044092 negative regulation of molecular function AURKB, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.72854
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.72854
[BP] GO:0051270 regulation of cellular component movement APEX1, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.69987
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TOP2A, TRPV1, TYR, XDH 2.69289
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2 2.69221
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HTR2A, PRKCD, PTGS2 2.69221
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.69221
[BP] GO:0030334 regulation of cell migration APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.66018
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 2.65969
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.6595
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6595
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MMP9, PTGS2, PTPN1, SRC 2.65474
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, BCL2, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, XDH 2.62571
[BP] GO:0007610 None BCL2, HTR2A, HTR2B, HTR2C, MTNR1A, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 2.61137
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, MCL1, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TOP2A, TRPV1, XDH 2.59223
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.58599
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.57974
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, KDR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SRC 2.55101
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CYP19A1, CYP1A1, HSD17B2, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 2.53389
[BP] GO:0046890 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.53389
[BP] GO:0030335 positive regulation of cell migration BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.53017
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, PIK3CB, PRKCD, PTPN1, SRC 2.52644
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.52052
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, PRKCD, PTGS2, TRPV1, XDH 2.5127
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51159
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.51103
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, ESR1, FLT3, IGF1R, MMP2, PRKCD, PRKCE, PTGS2, SRC, TRPV1 2.49693
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TOP2A, TRPV1, TYR, XDH 2.4965
[BP] GO:0090087 None ACHE, CA2, CHRM1, HTR2B, HTR2C, MTNR1B, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 2.49517
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.49395
[BP] GO:0065007 biological regulation ACHE, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAOA, MCL1, MET, MMP1, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SRC, TOP2A, TRPV1, XDH 2.49395
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, MAOA, PTGS2, SLC22A2, SLC22A3, TRPV1 2.47829
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.47546
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 2.47043
[BP] GO:2000147 positive regulation of cell motility BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.45074
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.42928
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.42731
[BP] GO:0009895 negative regulation of catabolic process BCL2, HTR2B, MCL1, MET, PIK3CA, PPARA, PRKCG 2.4078
[BP] GO:0016477 cell migration AXL, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 2.39987
[BP] GO:0051272 positive regulation of cellular component movement BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.36972
[BP] GO:0007187 None CHRM1, CHRM2, CHRM4, HTR6, MTNR1A, MTNR1B 2.36815
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.36556
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.36556
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.36556
[BP] GO:0051282 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.3584
[BP] GO:0010604 positive regulation of macromolecule metabolic process AURKB, BCL2, CDC25B, ESR1, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 2.31547
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade HTR2A, HTR2B, HTR2C, KDR, PRKCA, PTPN1, SRC 2.31283
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, PIK3CB, PRKCE, SRC 2.31283
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.30983
[BP] GO:0051239 regulation of multicellular organismal process AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CYP1B1, ESR1, HTR2A, HTR2B, HTR2C, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SRC, TRPV1, XDH 2.29485
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.28854
[BP] GO:0006875 cellular metal ion homeostasis BCL2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, TRPV1 2.28854
[BP] GO:0043434 None APEX1, FABP3, PPARA, PRKCD, PTGS2, SRC, TRPV1 2.28237
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, MCL1, MET, MMP2, MMP9, PRKCD, PTGS2, RORC, SRC, TOP2A 2.28237
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, HTR2A, MET, PIK3CA, TRPV1 2.28237
[BP] GO:0040017 positive regulation of locomotion BCL2, IGF1R, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC 2.27339
[BP] GO:0015874 None SLC22A1, SLC22A2 2.27166
[BP] GO:1901374 None SLC22A1, SLC22A2 2.27166
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27166
[BP] GO:0007154 None AXL, BCL2, CHRM1, CHRM2, CHRM4, HTR2A, HTR2C, HTR6, MTNR1B, PRKCG, PTGS2, TRPV1 2.27001
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD17B2, KDR, MCL1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 2.27001
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.27001
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.27001
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.27001
[BP] GO:0007166 cell surface receptor signaling pathway AXL, BCL2, CA1, CHRM4, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TRPV1 2.24816
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade HTR2A, HTR2B, HTR2C, KDR, PRKCA, SRC 2.22569
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.22208
[BP] GO:0032098 None HTR2C, PPARA, SLC22A3 2.22208
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.22208
[BP] GO:0040011 locomotion AXL, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 2.22019
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, IGF1R, MMP2, PRKCD, PTGS2, SRC, TRPV1 2.16704
[BP] GO:1900076 regulation of cellular response to insulin stimulus PRKCB, PRKCD, PTPN1, SRC 2.14836
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.14085
[BP] GO:0050878 regulation of body fluid levels AKR1B1, CHRM1, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.13433
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.13154
[BP] GO:0045913 None HTR2A, PPARA, PRKCE, SRC 2.12943
[BP] GO:0006693 None PTGES, PTGS1, PTGS2 2.12927
[BP] GO:0006692 None PTGES, PTGS1, PTGS2 2.12927
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, HSD17B2, MMP2, MMP9, MTNR1A, PTGS2, SRC, TOP2A 2.12839
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.1215
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.1215
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.11201
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, MCL1, MMP9, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TOP2A, TRPV1 2.10804
[BP] GO:0002431 Fc receptor mediated stimulatory signaling pathway PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.09634
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.09603
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, MCL1, MMP9, PTGS2, PTPN1, SRC 2.09603
[BP] GO:0071502 None HTR2B, TRPV1 2.09603
[BP] GO:0046618 None SLC47A1, SLC47A2 2.09603
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.09603
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SRC, TRPV1 2.09234
[BP] GO:0048870 cell motility AXL, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 2.09008
[BP] GO:0031330 negative regulation of cellular catabolic process BCL2, HTR2B, MCL1, MET, PIK3CA, PRKCG 2.09008
[BP] GO:0038094 Fc-gamma receptor signaling pathway PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.07745
[BP] GO:0010506 regulation of autophagy BCL2, HTR2B, KDR, MCL1, MET, PIK3CA, PIK3CB 2.07283
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, MAOA, TYR 2.06039
[BP] GO:0045859 regulation of protein kinase activity CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.04441
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, PTGS2, SRC 2.02024
[BP] GO:0006636 unsaturated fatty acid biosynthetic process PTGES, PTGS1, PTGS2 2.01444
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.01444
[CC] GO:0016020 membrane ACHE, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, GLO1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAOA, MCL1, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TRPV1, TYR 6.41491
[CC] GO:0005886 plasma membrane ACHE, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, ESR1, FLT3, GLO1, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1 6.06837
[CC] GO:0044425 membrane part ACHE, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAOA, MCL1, MET, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TRPV1, TYR 4.52689
[CC] GO:0031226 intrinsic component of plasma membrane AXL, CA4, CHRM1, CHRM2, CHRM4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, SLC22A1, SLC22A2, SLC22A3, TRPV1 3.74939
[CC] GO:0005887 integral component of plasma membrane AXL, CHRM1, CHRM2, CHRM4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, SLC22A1, SLC22A2, SLC22A3, TRPV1 3.43051
[CC] GO:0044459 plasma membrane part AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TRPV1 2.74348
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, PRKCA, PRKCD, PRKCE, PRKCG, PTGES, SRC, TYR 2.66871
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, HTR2A, MET, PRKCG, PTGS2, SLC22A1, SRC, TRPV1 2.37842
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, TBXAS1, TYR, XDH 11.0879
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.77218
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 9.4587
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLO1, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SRC, TBXAS1, TOP2A, TRPV1, TYR, XDH 9.00118
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TOP2A, TYR, XDH 8.27837
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 7.02531
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, HTR2A, HTR2B, HTR2C, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TOP2A, TRPV1, TYR, XDH 7.00306
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.64196
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC 6.38847
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.14853
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 6.06837
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.92114
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.53742
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.35214
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TOP2A, TRPV1, TYR, XDH 5.26519
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.16283
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.1446
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.11778
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.92192
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.83252
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.69883
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.59401
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 4.47001
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.41047
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.07896
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.91646
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.81152
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.67059
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.6652
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, NQO2, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 3.63415
[MF] GO:0004993 None HTR2A, HTR2B, HTR2C, HTR6 3.61255
[MF] GO:0099589 None HTR2A, HTR2B, HTR2C, HTR6 3.61255
[MF] GO:0038023 signaling receptor activity AXL, CHRM1, CHRM2, CHRM4, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TRPV1 3.5537
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.53276
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.48544
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.37249
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.31356
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.31356
[MF] GO:0060089 molecular transducer activity AXL, CDK6, CHRM1, CHRM2, CHRM4, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TRPV1 3.29532
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.24362
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.2032
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.08811
[MF] GO:0043176 None HTR2A, HTR2B, HTR2C 3.08009
[MF] GO:0051378 None HTR2A, HTR2B, HTR2C 3.08009
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 3.08009
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 3.06312
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.97993
[MF] GO:0004872 receptor activity AXL, CHRM1, CHRM2, CHRM4, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TRPV1 2.96048
[MF] GO:0004871 signal transducer activity AXL, CHRM1, CHRM2, CHRM4, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, PRKCE, RORC, TRPV1 2.96048
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.96048
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.89971
[MF] GO:0035403 None PRKCA, PRKCB 2.89971
[MF] GO:0071886 None HTR2A, HTR2C 2.89971
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.69987
[MF] GO:0015238 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.66018
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.58599
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.52052
[MF] GO:0008502 None MTNR1A, MTNR1B 2.51159
[MF] GO:0015307 None SLC47A1, SLC47A2 2.51159
[MF] GO:1901375 None SLC22A1, SLC22A2 2.51159
[MF] GO:0005333 None SLC22A1, SLC22A2 2.51159
[MF] GO:0005277 None SLC22A1, SLC22A2 2.51159
[MF] GO:0008513 None SLC22A1, SLC22A2 2.51159
[MF] GO:0004699 None PRKCD, PRKCE 2.51159
[MF] GO:0042165 neurotransmitter binding ACHE, HTR2A, HTR2B, HTR2C 2.50459
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.47829
[MF] GO:0036094 small molecule binding AURKB, AXL, CDK6, FABP3, FABP4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.45735
[MF] GO:0099600 transmembrane receptor activity AXL, CHRM1, CHRM2, CHRM4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 2.45255
[MF] GO:0004888 transmembrane signaling receptor activity AXL, CHRM1, CHRM2, CHRM4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 2.45255
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.43417
[MF] GO:0000166 nucleotide binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.39293
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1, XDH 2.3914
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.25084
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.22208
[MF] GO:0043168 anion binding AURKB, AXL, CDK6, FABP3, FABP4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, SRC, TOP2A, TRPV1, XDH 2.17372
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.13517
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.11165
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CDK6, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP2A, TRPV1 2.10518
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.09603
[MF] GO:0070405 ammonium ion binding ACHE, HTR2A, HTR2B, HTR2C 2.03804


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, TRPV1, HTR2A 12.7206
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, HTR6, PRKCB, MAOA, ALOX5, HTR2B, HTR2C, PRKCA, HTR2A, PTGS2, PTGS1 10.8914
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM1, PIK3CA, PRKCB, CHRM4, BCL2, PRKCA, PIK3CB 9.67
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET, MCL1 9.9731
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PIK3CA, PRKCB, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 9.67
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, IGF1R, CDK6, PIK3CA, BCL2, MET 8.6455
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB 8.6981
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 8.9481
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0431
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.0723
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 7.43
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 7.43
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, IGF1R 7.3937
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB 7.43
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, HTR6, CHRM1, PRKCB, HTR2B, HTR2C, PRKCA, HTR2A 6.7392
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, PIK3CA, KDR, BCL2, PRKCA, PIK3CB, MET, MCL1, IGF1R 6.4564
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, MET, IGF1R 6.3021
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, MTNR1A, CHRM1, MTNR1B, CHRM4, HTR2B, HTR2C, TRPV1, HTR2A 6.3385
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, HTR2B, HTR2C, PRKCA, HTR2A 6.5203
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 6.4037
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB 6.366
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1 6.3021
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB, IGF1R 6.2021
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, PRKCE, PRKCD, PIK3CB, PPARA 6.0509
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 5.8489
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 5.8489
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, PRKCE, BCL2, PRKCA, PIK3CB 5.8153
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, KDR, PRKCA, PIK3CB, MET, IGF1R 5.0671
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2 5.0671
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB 5.396
Metabolic pathways_Homo sapiens_hsa01100 MAOA, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, FUT7, AKR1B10, ALOX5, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 4.5382
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 5.0474
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.9234
Tight junction_Homo sapiens_hsa04530 PRKCG, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.3273
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.5842
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA 4.1224
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, MTNR1A, PRKCB, MTNR1B, PRKCA 4.042
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2, PTGES, PTGS1 4.8645
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.2315
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 5.7905
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.9842
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.0059
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.9731
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, CHRM1, PIK3CA, PIK3CB, PPARA 3.5875
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.5952
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.6207
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB 3.4465
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.4425
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB, MCL1 3.1742
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.6621
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.7411
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, MAOA, PRKCA 3.5163
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.5163
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.8952
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.4327
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.9923
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.263
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.965
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.401
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.1391
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.8324
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB, MCL1 2.477
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA, PTGS2 2.9547
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.7025
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2343
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.401
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4743
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.3194
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, MAOA, PRKCA 2.5914
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 4.0369
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.724
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 3.1514
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 3.0199
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCE, PRKCD, PIK3CB 4.0101
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3239
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.334
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3214
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.4148
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.2493
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.2666
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB 2.1865
Axon guidance_Homo sapiens_hsa04360 MET 0.4257
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.434
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1506
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5965
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.9801
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.501
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6751
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5206
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 1.6897
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8083
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0517
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5376
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5432
Measles_Homo sapiens_hsa05162 CDK6, PIK3CA, PIK3CB 1.7007
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.3181
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7226
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7226
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9927
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6834
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.6704
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7964
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, PRKCB, PRKCA 1.6704
Peroxisome_Homo sapiens_hsa04146 XDH 0.5621
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.611
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0361
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, PRKCE, PIK3CB 1.504
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB 1.6619
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 1.8918
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1452
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1565
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1565
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0976
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 2.128
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6209
NF-kappa B signaling pathway_Homo sapiens_hsa04064 PRKCB, BCL2, PTGS2 2.1061
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.1928
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 2.1506
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6236
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 2.3707
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.3707
Shigellosis_Homo sapiens_hsa05131 SRC 0.6436
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.4342
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6436
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.4662
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.4836
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.4662
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4662
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.5178
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.3905
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.3707
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.7029
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.4211
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1 1.44
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.44
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7298
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.7298
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.7319
Malaria_Homo sapiens_hsa05144 MET 0.7368
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.7368
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.4558
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4639
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4969
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7562
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5683
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6619
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.8952
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.8083
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.8083
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9007
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8784
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 3.1714
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9219
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9606
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9112
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0614
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9485
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.9435
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0108
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9237
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9905
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2531
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.122
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1904
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4425


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)