TCM Prescription: Gallbladder Calming Decoction



Prescription Description
Prescription IDTCMF1764
Pinyin NameAn Dan Tang
Chinese Name安胆汤
English NameGallbladder Calming Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH767 Herba lysimachiae 过路黄 TCMH767
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 14.4611
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TOP1 12.0232
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, F10, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TOP1 9.51891
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.41389
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH 9.26464
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PTGS2, SRC 9.22252
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC 8.95126
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 8.51125
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 8.51125
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC, TOP1 8.47116
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 8.27693
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.67813
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CYP1B1, ESR1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.67813
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TOP1 7.65028
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC 7.65028
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, F10, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.63583
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, F10, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.51919
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 7.48854
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 7.47484
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, XDH 7.47445
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.31878
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PPARA, PTGS2, SRC 7.31878
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 7.31878
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 7.17308
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, BCL2, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 7.12907
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.00459
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.95581
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, SRC 6.95581
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.87568
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC 6.82047
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 6.65811
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 6.49671
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 6.41057
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, SRC 6.38184
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CNR1, CYP1B1, F10, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.36923
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 6.2139
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 6.11132
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 6.06037
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, SRC 6.06037
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HTR1A, HTR2A, HTR2C 5.95742
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2 5.94628
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.89508
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2 5.84657
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2 5.75195
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 5.75152
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.54105
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1B1 5.5317
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 5.50604
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, CYP1B1, F10, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CB, PPARA, PTGS2, SRC 5.474
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1B1, PTGS1, PTGS2 5.39589
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 5.39589
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 5.39589
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 5.35287
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGS1, PTGS2 5.33016
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 5.32953
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, PIK3CA, PIK3CB, SRC 5.30609
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 5.29146
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 5.2837
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, F10, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 5.26448
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 5.26448
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.26448
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 5.25889
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 5.25889
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGS1, PTGS2 5.1683
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 5.09558
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, FABP4, KIT, MMP9, PTGS2 5.04855
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.04615
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 5.03604
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CYP1B1, ESR1, FLT3, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, XDH 4.92289
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.77636
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 4.77505
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CYP19A1, CYP1A1, HSD11B1, HSD11B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.73259
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PTGS2, SRC 4.726
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.70028
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.70028
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.66588
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.66243
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.64334
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC 4.64059
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.61972
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.61972
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC 4.61966
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, SRC 4.58726
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.58723
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP1, XDH 4.57233
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.5636
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.54475
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.46025
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.46025
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 4.41549
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PTGS2, SRC 4.39025
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC 4.34892
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 4.34541
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, SRC 4.34541
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.34541
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 4.33256
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.32575
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.32575
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.30109
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP1, XDH 4.29172
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.2508
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, PIK3CB, SRC, XDH 4.24942
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2, XDH 4.22784
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC 4.22279
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGS1, PTGS2 4.15636
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A 4.15636
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.15501
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.14555
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.14034
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, SRC 4.08821
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1B1, HSD11B2, HTR1A, HTR2C, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC 4.06796
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1B1, PTGS1, PTGS2 4.05326
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2 4.0459
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TOP1 4.02789
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.92438
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC 3.88098
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.87891
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.87891
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1 3.87891
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.87891
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.86362
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 3.8186
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 3.8186
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.80993
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2 3.80177
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.80177
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CYP1B1, ESR1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.76413
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP1, XDH 3.75133
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.74486
[BP] GO:0051049 regulation of transport ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2, SRC 3.72666
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, PIK3CB, SRC, XDH 3.72666
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.72666
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.72666
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.72666
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.72666
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.72666
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.72666
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.72666
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.71963
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.7076
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, XDH 3.69721
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.68065
[BP] GO:0007154 None AKR1C3, AXL, BCL2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.6801
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC 3.64801
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CYP19A1, CYP1A1, ESR1, FLT3, HSD11B1, KDR, KIT, PIK3CA, PPARA, SRC 3.62814
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.62086
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, KIT, MMP2, MMP9, PTGS2, SRC 3.61789
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.5899
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.57991
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, SRC 3.57991
[BP] GO:0048511 rhythmic process AXL, BCL2, ESR1, HTR7, KIT, PPARA, SRC, TOP1 3.57376
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.56535
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.55695
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.5506
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.51797
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP1, XDH 3.50245
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.50245
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.50245
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.488
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.47847
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 3.46146
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.41685
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.33838
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.33562
[BP] GO:0019371 None AKR1C3, PTGS1, PTGS2 3.33562
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.33105
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, XDH 3.32959
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.30227
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 3.29189
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.26321
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 3.22462
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, FABP4, MMP9, PTGS2 3.22206
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC 3.21668
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, SRC 3.21668
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2 3.19527
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC 3.0613
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 3.0613
[BP] GO:0007208 None HTR2A, HTR2C 3.0613
[BP] GO:0016488 None AKR1B10, AKR1C3 3.0613
[BP] GO:0016487 None AKR1B10, AKR1C3 3.0613
[BP] GO:0016107 None AKR1B10, AKR1C3 3.0613
[BP] GO:0006714 None AKR1B10, AKR1C3 3.0613
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.04622
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 3.04622
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CYP19A1, CYP1A1, CYP1B1, ESR1, FLT3, HSD11B1, HTR5A, KDR, KIT, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC 3.02045
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 3.01733
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 3.00117
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.96778
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.93787
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.91108
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 2.90588
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.90549
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, FABP4, MMP9, PTGS2 2.90389
[BP] GO:0043269 regulation of ion transport APP, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.90125
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.89665
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.88987
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.88987
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.88987
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.88362
[BP] GO:0090066 None ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.86909
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.84693
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.8231
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, KIT, SRC 2.81909
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP1, XDH 2.80533
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, ESR1, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.78359
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.78308
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.78308
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.78308
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, PTGS2, SRC 2.7594
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.75035
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.73081
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KDR, PTGS2, SRC 2.71451
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.68161
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.68114
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.6744
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.6589
[BP] GO:0016095 None AKR1B10, AKR1C3 2.6589
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.6589
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.64337
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.62694
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC 2.62245
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.61066
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.61066
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, PTGS2, SRC 2.60713
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AURKB, BCL2, CNR1, CNR2, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.60539
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.57451
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.53592
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.53293
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.52027
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.51788
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CNR1, CYP1A1, ESR1, KIT, PTGS2, SRC 2.51145
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2 2.50823
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2B, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC 2.49387
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.47999
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.46859
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, ESR1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.44454
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.42385
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.41887
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, PTGS1, PTGS2 2.40957
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, KDR, MMP2, PTGS2, SRC 2.4052
[BP] GO:0038171 None CNR1, CNR2 2.40458
[BP] GO:0014827 None HTR1D, HTR2B 2.40458
[BP] GO:0001667 ameboidal-type cell migration CYP1B1, HTR2B, KDR, KIT, PIK3CA 2.38713
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, XDH 2.3866
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.38189
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TOP1 2.35793
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.35793
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2 2.34411
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.33874
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.3381
[BP] GO:0006693 None AKR1C3, PTGS1, PTGS2 2.33738
[BP] GO:0006692 None AKR1C3, PTGS1, PTGS2 2.33738
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, PTGS2 2.30262
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CB, SRC 2.28473
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC 2.28035
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CYP19A1, ESR1, KIT, PTGS2, SRC 2.27136
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.26624
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.26592
[BP] GO:0065009 regulation of molecular function ADORA3, APP, AURKB, BCL2, CNR1, CNR2, CYP1B1, ESR1, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, XDH 2.25503
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.25503
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.25503
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, SRC 2.24872
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AURKB, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.24121
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.23935
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, KIT, PIK3CA 2.23307
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.23307
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.23124
[BP] GO:0071502 None HTR1B, HTR2B 2.23124
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.23124
[BP] GO:0008217 None CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.23124
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2C, KDR, KIT, PIM1, PTGS2, SRC 2.22943
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.22538
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.21972
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP1, XDH 2.20498
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.20239
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.19061
[BP] GO:0002209 None BCL2, HTR1A, HTR2C 2.19061
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.19061
[BP] GO:0001662 None BCL2, HTR1A, HTR2C 2.19061
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.19061
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.18982
[BP] GO:1901570 None ALOX15, ALOX5, PTGS1, PTGS2 2.18982
[BP] GO:0007267 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.16434
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.15508
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PTGS2 2.13252
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.12279
[BP] GO:0042596 None BCL2, HTR1A, HTR2C 2.11717
[BP] GO:0019217 None CNR1, FABP3, PPARA, PTGS2 2.11717
[BP] GO:0045859 regulation of protein kinase activity APP, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CA, PIK3CB, SRC 2.1141
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 2.11387
[BP] GO:0060191 regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.10083
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.09275
[BP] GO:0014831 None HTR1D, HTR2B 2.09275
[BP] GO:0032229 None CNR2, HTR1B 2.09275
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.09275
[BP] GO:0016115 None AKR1B10, AKR1C3 2.09275
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, FLT3, FUT7, KIT, MMP9, PIK3CA, PIK3CB, SRC 2.09184
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP2, MMP9 2.09039
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.09039
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9 2.07991
[BP] GO:0007200 None ESR1, HTR2A, HTR2B, HTR2C 2.07348
[BP] GO:0010565 None AKR1C3, CNR1, FABP3, PPARA, PTGS2 2.06569
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA 2.06536
[BP] GO:0043406 positive regulation of MAP kinase activity FLT3, HTR2A, HTR2B, KIT, PIK3CB, SRC 2.05755
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.0476
[BP] GO:2001023 None CNR1, HTR1B, HTR2A, MET 2.04106
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, SRC 2.03067
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, KIT, MMP2, PIK3CA, PIK3CB, SRC 2.02882
[BP] GO:0001523 None AKR1B10, AKR1C3, CYP1A1, CYP1B1 2.0274
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, PTGS2, XDH 2.0274
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AURKB, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP1, XDH 2.02561
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.02561
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CNR1, CYP1B1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.02419
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1B1, FABP3, FABP4 2.01708
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PTGS2 2.01149
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, ESR1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.006
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 7.17308
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, ESR1, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, SRC 6.82542
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTGS2, SRC 6.65811
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FLT3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 6.07362
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 6.02972
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FLT3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC 5.85324
[CC] GO:0031224 None ACHE, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CNR1, CNR2, ESR1, F10, FLT3, FUT7, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 2.49338
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9755
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.6154
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.6154
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.5493
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.4916
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 12.0232
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.5114
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.385
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP1, XDH 10.1346
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.51125
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 7.60371
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, XDH 7.29819
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, XDH 7.00459
[MF] GO:0004872 receptor activity ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.79875
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 6.79354
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 6.79354
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CYP19A1, CYP1A1, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1 6.76524
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.58742
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.0968
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.36247
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2, XDH 5.16685
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, F10, FLT3, FUT7, HSD11B1, HSD11B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TOP1, XDH 5.12828
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.11696
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.66613
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.57233
[MF] GO:0004930 None ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.34541
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.7652
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, PTGS1, PTGS2, SRC 3.53761
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, XDH 3.40473
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.40353
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TOP1 3.37449
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, PTGS1, PTGS2, SRC 3.37449
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.33562
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1B1, PTGS1, PTGS2 3.1148
[MF] GO:0016301 kinase activity AURKB, AXL, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 3.0613
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.0613
[MF] GO:0045550 None AKR1B10, AKR1C3 3.0613
[MF] GO:0003845 None HSD11B1, HSD11B2 3.0613
[MF] GO:0071886 None HTR2A, HTR2C 3.0613
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1B1, XDH 3.06099
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 3.04329
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1B1, HSD11B2, NQO2, PTGS1, PTGS2, SRC, XDH 2.88987
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.76726
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.6589
[MF] GO:0047718 None AKR1B10, AKR1C3 2.6589
[MF] GO:0004949 None CNR1, CNR2 2.6589
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA 2.6228
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2 2.61066
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1 2.46859
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.46381
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.44354
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.38189
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1 2.33738
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.33738
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.33738
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2 2.29126
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.29126
[MF] GO:0035004 phosphatidylinositol 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.28337
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, XDH 2.24609
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2 2.22538
[MF] GO:1901363 heterocyclic compound binding APP, AURKB, AXL, BCL2, CYP19A1, CYP1A1, CYP1B1, ESR1, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP1, XDH 2.18386
[MF] GO:0097159 organic cyclic compound binding APP, AURKB, AXL, BCL2, CYP19A1, CYP1A1, CYP1B1, ESR1, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TOP1, XDH 2.11742
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, PTGS1, PTGS2 2.0274


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 20.4193
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 11.4415
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 8.3766
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.7486
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 6.7486
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, KIT, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 6.472
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.5502
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 6.472
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 5.5406
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 5.2387
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.2387
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 5.0427
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 5.1292
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 5.1334
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.0427
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.7905
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 4.4789
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, PTGS2, PTGS1 5.0352
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.8925
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.1036
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.7852
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1C3, AKR1B1, PTGS2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, CYP1A1, ALPL, XDH 3.5258
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 3.4938
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.4587
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3566
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.5002
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.4938
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5258
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.3283
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.2507
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.4046
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.2822
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.9303
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.9337
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 3.2567
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A1, CYP1B1, PTGS2 3.3345
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 3.031
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.8623
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.8623
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.828
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.8623
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.845
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.5449
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.4737
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.4737
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2913
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.5519
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.5619
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.5924
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.1331
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.1767
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.5449
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.2645
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 2.0253
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.8002
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.923
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.8908
Adherens junction_Homo sapiens_hsa04520 SRC, MET, IGF1R 2.4419
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.7852
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.8268
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A1, CYP1B1 2.4505
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.8268
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 3.0889
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.7747
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PIK3CB 1.7703
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.7263
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.744
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.6313
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.4658
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.5333
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.4541
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.4107
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3906
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.401
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.401
Tight junction_Homo sapiens_hsa04530 SRC 0.4619
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6923
Axon guidance_Homo sapiens_hsa04360 MET 0.4908
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4991
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.9311
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.9226
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB 1.0954
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0969
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1099
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.0829
Melanogenesis_Homo sapiens_hsa04916 KIT 0.5686
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5682
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5812
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5805
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2968
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3522
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3443
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2717
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2968
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5983
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2824
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.3072
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2824
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.2968
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.6035
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.3744
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.3443
Peroxisome_Homo sapiens_hsa04146 XDH 0.6223
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.506
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.506
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.6379
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5436
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6615
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6598
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6708
Bile secretion_Homo sapiens_hsa04976 CA2 0.6688
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.5575
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5186
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.5436
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.6253
Retinol metabolism_Homo sapiens_hsa00830 CYP1A1 0.6927
Shigellosis_Homo sapiens_hsa05131 SRC 0.6927
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.7169
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.6655
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.6313
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.7215
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7783
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7703
Malaria_Homo sapiens_hsa05144 MET 0.7908
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.8002
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8038
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8088
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1 1.8732
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0759
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.942
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0279
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.959
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15 0.983
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2745
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0204
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0086
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2609
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.5969


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)