TCM Prescription: He Zi Skin Powder



Prescription Description
Prescription IDTCMF1695
Pinyin NameHe Zi Pi San
Chinese Name诃子皮散
English NameHe Zi Skin Powder
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH826 Terminalia chebula 诃子 TCMH826
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.8821
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0307
[BP] GO:0042221 response to chemical AKR1B1, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, TOP1 9.34966
[BP] GO:0010033 response to organic substance AKR1B1, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK 9.34966
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK 9.01332
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, IGF1R, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK 8.63762
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F2, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRM1, SMAD3, SRC, TEK, XDH 8.13456
[BP] GO:0044281 small molecule metabolic process AKR1B1, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HSPA1A, PDE10A, PDE3A, PDE3B, PPARA, TBXAS1, XDH 7.74991
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, FLT3, GPR35, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, SMAD3, SRC, TEK, XDH 7.41526
[BP] GO:0010647 positive regulation of cell communication AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F2, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 7.39703
[BP] GO:0023056 positive regulation of signaling AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F2, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 7.37848
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, FLT3, GPR35, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, SMAD3, SRC, TEK, XDH 7.3271
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 7.11109
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, SMAD3, SRC, TEK, XDH 6.94064
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, OPRK1, OPRM1, PDE3A, SRC, TEK 6.86714
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, F2, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, SRC, TEK, XDH 6.63616
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, OPRK1, PDE3B, PPARA, SRC, TEK 6.54429
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AOX1, BACE1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 6.19561
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SMAD3, SRC 6.05177
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, GPR35, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, SMAD3, SRC, TEK, XDH 6.04687
[BP] GO:0042493 response to drug AKR1B1, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HTR2A, KDR, OPRK1, OPRM1, PDE3A, SRC, TOP1 5.93054
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AOX1, BACE1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 5.86929
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 5.79594
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK 5.7579
[BP] GO:0010648 negative regulation of cell communication ACHE, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, SMAD3, SRC, XDH 5.65734
[BP] GO:0023057 negative regulation of signaling ACHE, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, OPRK1, OPRM1, PDE3B, SMAD3, SRC, XDH 5.64707
[BP] GO:0019220 regulation of phosphate metabolic process DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 5.64707
[BP] GO:0051174 regulation of phosphorus metabolic process DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 5.59055
[BP] GO:0032879 regulation of localization ACHE, ADORA3, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F2, GPR35, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK 5.51921
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.41742
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, F2, OPRM1, PPARA, SMAD3 5.41742
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, MET, PDE3A, PPARA, TBXAS1 5.39093
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TEK 5.39093
[BP] GO:0071310 cellular response to organic substance AKR1B1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SMAD3, SRC 5.34196
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, CSNK2A1, CYP1B1, DRD2, EGFR, F2, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 5.31379
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, F2, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, TOP1 5.2984
[BP] GO:0010562 positive regulation of phosphorus metabolic process DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 5.25207
[BP] GO:0045937 positive regulation of phosphate metabolic process DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 5.25207
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, CYP1B1, DRD2, EGFR, F2, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, OPRK1, OPRM1, SRC, TEK, XDH 5.22389
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, OPRD1, OPRK1, OPRM1 5.20605
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, SMAD3, SRC, TEK, XDH 5.14924
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, DRD2, EGFR, ESR1, F2, FLT3, HTR1A, HTR2A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, TEK 5.02606
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, DRD1, DRD2, ESR1, F2, GPR35, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 5.02606
[BP] GO:0048583 regulation of response to stimulus AKR1B1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, PPARA, SMAD3, SRC, TEK, XDH 5.02606
[BP] GO:0048511 rhythmic process CSNK2A1, DRD2, EGFR, ESR1, HTR7, OPRK1, OPRM1, PPARA, SRC, TOP1 4.92308
[BP] GO:0032501 multicellular organismal process AKR1B1, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRB, F2, FABP4, HTR1A, HTR2A, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, SMAD3, SRC, TEK, TOP1 4.92308
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PPARA, SIGMAR1, SMAD3, SRC, TEK 4.80319
[BP] GO:0003018 None DRD1, EGFR, HTR1A, HTR2A, HTR7, PDE3A, SRC, TEK 4.80319
[BP] GO:0042325 regulation of phosphorylation DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, PPARA, SRC, TEK, XDH 4.73512
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSPA1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, XDH 4.73127
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, CSNK2A1, CYP1B1, DRD2, EGFR, ESRRA, F2, FABP4, FLT3, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP2, MMP9, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 4.72497
[BP] GO:0009056 catabolic process ACHE, AOX1, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 4.72497
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, FABP3, FABP4, GPR35, HTR2A, INSR, MET, SMAD3 4.71099
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HSD17B1, HTR1A, HTR2A, OPRK1 4.50121
[BP] GO:0009628 response to abiotic stimulus AKR1B1, CA2, CYP1A1, DRD1, DRD2, EGFR, HSPA1A, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK 4.37431
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, PPARA, SRC, TEK 4.30751
[BP] GO:0080134 regulation of response to stress CYP19A1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, OPRK1, PPARA, SMAD3, SRC, TEK, XDH 4.28862
[BP] GO:0009966 regulation of signal transduction AKR1B1, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRK1, OPRM1, PDE10A, PDE3B, SMAD3, SRC, TEK, XDH 4.28862
[BP] GO:0040012 regulation of locomotion ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, OPRK1, SMAD3, SRC, TEK 4.28862
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.28862
[BP] GO:0007193 None DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.28147
[BP] GO:0030334 regulation of cell migration ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.25747
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.25537
[BP] GO:0048585 negative regulation of response to stimulus CYP19A1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, PPARA, SMAD3, SRC, TEK, XDH 4.21438
[BP] GO:0048513 animal organ development ACHE, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, INSR, KDR, PPARA, SMAD3, SRC, TEK 4.20707
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, DRD2, EGFR, ESR1, F2, FABP4, KDR, MET, MMP12, OPRM1, PPARA, SMAD3, TEK 4.20707
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK 4.1584
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 4.13229
[BP] GO:0042592 homeostatic process AKR1B1, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, HTR2A, INSR, MET, SMAD3, SRC 4.1021
[BP] GO:0010035 response to inorganic substance AKR1B1, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 4.08798
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SMAD3, SRC 4.08552
[BP] GO:0051049 regulation of transport ACHE, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, F2, GPR35, HSPA1A, HTR1A, HTR2A, INSR, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC 4.0745
[BP] GO:0003013 None DRD1, EGFR, HTR1A, HTR2A, HTR7, PDE3A, SRC, TEK 4.04539
[BP] GO:0001932 regulation of protein phosphorylation DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, TEK, XDH 4.04404
[BP] GO:0030534 None DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 4.03262
[BP] GO:2000021 regulation of ion homeostasis CA2, CA7, DRD1, DRD2, F2, HTR2A, KDR, SRC 4.01006
[BP] GO:2000145 regulation of cell motility ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.00338
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.98608
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.9642
[BP] GO:0051716 cellular response to stimulus AKR1B1, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SMAD3, SRC 3.9642
[BP] GO:0044255 cellular lipid metabolic process ACHE, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PDE3A, PPARA, TBXAS1 3.96305
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSPA1A, HTR2A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, XDH 3.94038
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, OPRK1, SMAD3, SRC, TEK 3.93262
[BP] GO:0043408 regulation of MAPK cascade DRD2, DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, OPRK1, OPRM1, SRC, TEK, XDH 3.92096
[BP] GO:0033993 response to lipid CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, OPRK1, OPRM1, SRC 3.90504
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, CA2, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F2, GPR35, HSPA1A, HTR2A, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SMAD3, SRC, TEK, XDH 3.90504
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 3.90258
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SRC 3.88193
[BP] GO:0043269 regulation of ion transport CA2, CA7, DRD1, DRD2, F2, GPR35, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 3.88193
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, BACE1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, HSPA1A, HTR1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SMAD3, SRC, TEK, TOP1, XDH 3.88193
[BP] GO:0042327 positive regulation of phosphorylation DRD2, EGFR, ESRRB, F2, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, TEK, XDH 3.88193
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.87991
[BP] GO:0031399 regulation of protein modification process DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, SRC, TEK, XDH 3.86365
[BP] GO:0009636 response to toxic substance AKR1B1, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, SRC 3.8316
[BP] GO:0007188 None DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 3.81529
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, CA3, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, SRC, TEK, TOP1, XDH 3.81179
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, HTR2A, OPRM1, PPARA 3.79872
[BP] GO:0043410 positive regulation of MAPK cascade DRD2, EGFR, FLT3, HTR2A, INSR, KDR, OPRK1, OPRM1, SRC, TEK, XDH 3.79708
[BP] GO:0051701 interaction with host EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.79115
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.78388
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 3.75722
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, OPRK1, PDE3A, PDE3B, SRC 3.75098
[BP] GO:0065009 regulation of molecular function ADORA3, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GPR35, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP9, NUAK1, OPRD1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 3.73376
[BP] GO:0051270 regulation of cellular component movement ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.69691
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, HSPA1A 3.68055
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, EGFR, IGF1R, INSR, MMP2, OPRM1, PDE3A, PDE3B, SRC 3.62434
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, PDE3A 3.61619
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.59853
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, F2, MMP12, PPARA, SMAD3, TEK 3.59515
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, HSD17B1 3.59429
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AOX1, BACE1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 3.58909
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 3.57449
[BP] GO:0006793 phosphorus metabolic process ACHE, CA3, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PDE3A, PDE3B, SRC, TEK, TOP1, XDH 3.54589
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, FABP3, GPR35, HTR2A, SMAD3 3.53424
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.53424
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, HTR1A, INSR, SMAD3 3.51414
[BP] GO:0031325 positive regulation of cellular metabolic process DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 3.4989
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, OPRK1, PDE3B, PPARA, SRC, TEK 3.47264
[BP] GO:0001666 response to hypoxia CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 3.47222
[BP] GO:0010604 positive regulation of macromolecule metabolic process CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 3.46354
[BP] GO:0001934 positive regulation of protein phosphorylation DRD2, EGFR, F2, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, TEK, XDH 3.46326
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, OPRM1, PDE3A, SRC 3.46326
[BP] GO:0007187 None DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 3.44427
[BP] GO:0009893 positive regulation of metabolic process CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 3.42641
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.42641
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.42355
[BP] GO:0036293 response to decreased oxygen levels CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 3.4009
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 3.37596
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, F2, FABP3, FLT3, HTR2A, PDE3B, PPARA, SRC, TEK 3.3677
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.33397
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, HTR2A, KDR, OPRM1, SRC, TEK 3.32814
[BP] GO:0032844 regulation of homeostatic process CA2, CA7, DRD1, DRD2, EGFR, F2, HTR2A, KDR, OPRK1, SRC 3.31015
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR, PDE3A 3.31015
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, OPRD1, OPRM1, PDE3A, SMAD3, SRC 3.28256
[BP] GO:0051247 positive regulation of protein metabolic process CSNK2A1, DRD2, EGFR, ESR1, F2, FLT3, HSPA1A, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 3.28229
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28229
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC, TEK 3.28071
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, HTR2A, KDR, OPRM1, SRC, TEK 3.28071
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.2771
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.2771
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F2, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK 3.24599
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.23805
[BP] GO:0010941 regulation of cell death AKR1B1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PPARA, SIGMAR1, SMAD3, SRC, TEK, XDH 3.22656
[BP] GO:0070482 response to oxygen levels CYP1A1, DRD2, MMP2, OPRD1, PPARA, SMAD3, SRC, TEK 3.17434
[BP] GO:0044092 negative regulation of molecular function ADORA3, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, OPRM1, PPARA, SRC 3.17321
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.16494
[BP] GO:0018193 peptidyl-amino acid modification CSNK2A1, DRD1, EGFR, F2, FLT3, IGF1R, INSR, KDR, MET, SENP6, SRC, TEK, TOP1 3.16494
[BP] GO:0051896 regulation of protein kinase B signaling DRD2, EGFR, INSR, MET, SRC, TEK, XDH 3.11498
[BP] GO:0032868 None FABP3, INSR, OPRK1, PDE3B, PPARA, SRC 3.09104
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HTR2A 3.08729
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, BACE1, CA2, CA7, DRD1, DRD2, EGFR, HTR2A 3.08729
[BP] GO:0043067 regulation of programmed cell death AKR1B1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, SIGMAR1, SMAD3, SRC, TEK, XDH 3.06489
[BP] GO:0032502 developmental process ACHE, AKR1B1, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HTR2A, INSR, KDR, MET, MMP2, MMP9, PDE3A, PDE3B, PPARA, SIGMAR1, SMAD3, SRC, TEK 3.06489
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PDE3B, SRC, XDH 3.04813
[BP] GO:0032270 positive regulation of cellular protein metabolic process DRD2, EGFR, ESR1, F2, FLT3, HSPA1A, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 3.02833
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, GPR35, HTR2A, SMAD3 3.02138
[BP] GO:0051240 positive regulation of multicellular organismal process CA2, CYP1B1, DRD2, EGFR, ESRRB, F2, HSPA1A, HTR2A, KDR, MET, MMP12, MMP9, OPRM1, PDE3A, SMAD3, SRC, TEK 3.02138
[BP] GO:0031635 None OPRK1, OPRM1 2.9411
[BP] GO:0009115 None AOX1, XDH 2.9411
[BP] GO:0032268 regulation of cellular protein metabolic process CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 2.93038
[BP] GO:0050790 regulation of catalytic activity ADORA3, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, MMP9, NUAK1, OPRM1, SMAD3, SRC, TEK, XDH 2.91864
[BP] GO:0007610 None DRD1, DRD2, EGFR, HTR1A, HTR2A, INSR, OPRD1, OPRK1, OPRM1, PPARA 2.91292
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.90603
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.89412
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.89412
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, SMAD3, XDH 2.89255
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.89255
[BP] GO:1900542 None DRD1, DRD2, ESRRB, HTR2A, INSR, OPRM1, PPARA 2.88291
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.86675
[BP] GO:0060548 negative regulation of cell death AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, PPARA, SMAD3, SRC, TEK 2.85758
[BP] GO:0006140 None DRD1, DRD2, ESRRB, HTR2A, INSR, OPRM1, PPARA 2.80979
[BP] GO:0007631 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.79329
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, OPRD1, PDE3A, SMAD3, SRC 2.76748
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.75498
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.75498
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PPARA, SMAD3, SRC, TEK, TOP1, XDH 2.75147
[BP] GO:0016477 cell migration CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.73881
[BP] GO:0009891 positive regulation of biosynthetic process DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC 2.73881
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.7311
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.72868
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.72315
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.70373
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, INSR, SMAD3, XDH 2.69756
[BP] GO:0051828 entry into other organism involved in symbiotic interaction EGFR, HSPA1A, HTR2A, MET, SRC 2.69179
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction EGFR, HSPA1A, HTR2A, MET, SRC 2.69179
[BP] GO:0030260 entry into host cell EGFR, HSPA1A, HTR2A, MET, SRC 2.69179
[BP] GO:0044409 entry into host EGFR, HSPA1A, HTR2A, MET, SRC 2.69179
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.67259
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.63387
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.62461
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.61283
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.61283
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, INSR, KDR, MMP9, PPARA, SIGMAR1, SMAD3, SRC, TEK 2.60669
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.60669
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PDE3A, SMAD3, SRC, TEK 2.60191
[BP] GO:0042981 regulation of apoptotic process AKR1B1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MMP9, PDE3A, SIGMAR1, SMAD3, SRC, TEK, XDH 2.60101
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, BACE1, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP1, XDH 2.58614
[BP] GO:0040011 locomotion CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.5755
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.5755
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.56783
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.56783
[BP] GO:0009968 negative regulation of signal transduction DRD2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PDE3B, SMAD3, SRC, XDH 2.56783
[BP] GO:0046110 None AOX1, XDH 2.56019
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56019
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, HTR1A 2.55945
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.55659
[BP] GO:0044419 interspecies interaction between organisms EGFR, F2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.49998
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.48866
[BP] GO:0043434 None FABP3, INSR, OPRK1, PDE3B, PPARA, SRC, TEK 2.48866
[BP] GO:0031401 positive regulation of protein modification process DRD2, EGFR, F2, FLT3, HTR2A, INSR, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, TEK, XDH 2.48866
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD1, DRD2, F2, PPARA, SMAD3, TEK 2.4841
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F2, FABP4, KDR, MET, OPRM1, SMAD3 2.4841
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, BACE1, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SIGMAR1, SMAD3, SRC, TEK, TOP1, XDH 2.4841
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, F2, PPARA, SMAD3, TEK 2.47532
[BP] GO:1901575 None ACHE, AOX1, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, PDE10A, PDE3A, PDE3B, XDH 2.4711
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.46299
[BP] GO:0035690 cellular response to drug AKR1B1, CYP1B1, DRD1, EGFR, KDR, OPRM1, SRC 2.46299
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, EGFR, ESR1, F2, GPR35, HTR2A, SMAD3 2.46299
[BP] GO:0003008 None AKR1B1, CYP1B1, DRD1, DRD2, EGFR, HTR1A, HTR2A, HTR7, INSR, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TEK 2.46029
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, SMAD3, TEK 2.45292
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD1, DRD2, EGFR, HTR2A 2.45111
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.45111
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, F2, GPR35, HTR2A, SMAD3 2.44278
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.43908
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, DRD1, DRD2, HTR2A, MET 2.4387
[BP] GO:0048870 cell motility CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.42961
[BP] GO:1904062 None DRD1, DRD2, F2, GPR35, MMP9, OPRK1, OPRM1 2.42961
[BP] GO:0042698 ovulation cycle EGFR, OPRK1, OPRM1 2.40199
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.40199
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40199
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, DRD1, DRD2, EGFR 2.39704
[BP] GO:0007268 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.39263
[BP] GO:0098916 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.39263
[BP] GO:0043467 regulation of generation of precursor metabolites and energy ESRRB, HTR2A, INSR, OPRK1, PPARA 2.38438
[BP] GO:0044057 None ADORA3, DRD2, EGFR, GPR35, HTR2A, OPRD1, OPRK1, OPRM1, SMAD3 2.38233
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.36447
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, TBXAS1 2.36447
[BP] GO:0006468 protein phosphorylation CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TOP1 2.36447
[BP] GO:0097746 None DRD1, EGFR, HTR1A, HTR2A, HTR7 2.36223
[BP] GO:0035296 None DRD1, EGFR, HTR1A, HTR2A, HTR7 2.36223
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.36113
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.34845
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, DRD1, DRD2, HTR2A 2.34787
[BP] GO:0099536 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.34787
[BP] GO:0099537 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.34787
[BP] GO:0007198 None HTR1A, HTR7 2.33931
[BP] GO:0006145 None AOX1, XDH 2.33931
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33931
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33931
[BP] GO:0051246 regulation of protein metabolic process CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, SMAD3, SRC, TEK, XDH 2.33931
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.33346
[BP] GO:0009892 negative regulation of metabolic process CSNK2A1, CYP2D6, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, OPRD1, OPRM1, PDE3B, PPARA, SMAD3, SRC, XDH 2.33303
[BP] GO:0051894 None KDR, SMAD3, TEK 2.33159
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.33159
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.33159
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.33159
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.33159
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.32217
[BP] GO:0006110 None ESRRB, HTR2A, INSR, PPARA 2.29927
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, BACE1, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SIGMAR1, SMAD3, SRC, TEK, XDH 2.29927
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, EGFR, ESR1, F2, GPR35, HTR2A, SMAD3 2.29692
[BP] GO:0071702 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MMP12, OPRD1, PPARA, SIGMAR1 2.29504
[BP] GO:0051050 positive regulation of transport ACHE, CA2, CYP19A1, DRD1, DRD2, EGFR, F2, INSR, MMP12, OPRK1, SMAD3, SRC 2.2902
[BP] GO:0050880 None DRD1, EGFR, HTR1A, HTR2A, HTR7 2.27775
[BP] GO:0035150 None DRD1, EGFR, HTR1A, HTR2A, HTR7 2.2635
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.26202
[BP] GO:1903530 regulation of secretion by cell ACHE, CYP19A1, DRD2, EGFR, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC 2.24982
[BP] GO:1903393 None KDR, SMAD3, TEK 2.24566
[BP] GO:0031644 None GPR35, OPRD1, OPRK1, OPRM1 2.24136
[BP] GO:0007623 circadian rhythm DRD2, EGFR, HTR7, PPARA, TOP1 2.22403
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 2.21827
[BP] GO:0050793 regulation of developmental process CA2, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F2, HTR2A, INSR, KDR, NUAK1, OPRM1, PDE3A, PDE3B, PPARA, SMAD3, SRC, TEK, XDH 2.19753
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.17643
[BP] GO:0043627 response to estrogen CA2, ESR1, OPRK1, TEK 2.17643
[BP] GO:0034762 None CA2, DRD1, DRD2, F2, GPR35, MMP9, OPRK1, OPRM1 2.17089
[BP] GO:0021853 None DRD1, DRD2 2.16782
[BP] GO:1904936 None DRD1, DRD2 2.16782
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, DRD1, DRD2, EGFR, F2 2.16696
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.16696
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.16696
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD1, DRD2, ESR1, F2, GPR35, HTR2A, SMAD3 2.16696
[BP] GO:0043549 regulation of kinase activity DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, IGF1R, INSR, SRC, TEK 2.1568
[BP] GO:0043470 None ESRRB, HTR2A, INSR, PPARA 2.14536
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PDE3A, SMAD3, SRC, TEK 2.13228
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.12813
[BP] GO:0051952 None DRD1, DRD2, HTR2A, OPRK1 2.12813
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.12813
[BP] GO:0042060 None EGFR, OPRM1, PPARA, SMAD3 2.10924
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.10924
[BP] GO:0009410 None DRD1, DRD2, EGFR, OPRK1, OPRM1 2.10814
[BP] GO:0035556 intracellular signal transduction AKR1B1, CYP1B1, DRD1, DRD2, EGFR, HTR2A, IGF1R, INSR, KDR, MET, NUAK1, OPRM1, PDE3A, SRC, TEK 2.10289
[BP] GO:0006873 cellular ion homeostasis CA2, CA7, DRD1, DRD2, ESR1, F2, GPR35, HTR2A, SMAD3 2.10127
[BP] GO:0019932 second-messenger-mediated signaling DRD1, DRD2, EGFR, KDR, OPRM1, PDE3A 2.09733
[BP] GO:0007611 None DRD1, DRD2, EGFR, HTR2A, INSR, OPRK1 2.09733
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A 2.09733
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B 2.09733
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.09733
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09733
[BP] GO:0022414 reproductive process AKR1B1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, INSR, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC 2.09343
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.09204
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HTR2A, IGF1R, INSR, SRC 2.08737
[BP] GO:0044248 cellular catabolic process ACHE, AOX1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, HSPA1A, PDE10A, PDE3A, PDE3B, SRC, XDH 2.08731
[BP] GO:0080090 regulation of primary metabolic process ADORA3, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PDE3B, PPARA, SMAD3, SRC, TEK, XDH 2.08674
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC 2.08674
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.08674
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.08674
[BP] GO:0006979 response to oxidative stress AKR1B1, CA3, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.07222
[BP] GO:1901890 None KDR, SMAD3, TEK 2.07222
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.07222
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B 2.07222
[BP] GO:0001659 None DRD1, DRD2, HTR2A 2.07222
[BP] GO:0043114 None PDE3A, SRC, TEK 2.07222
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AOX1, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PPARA, SENP6, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 2.05831
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, INSR, MET, SRC, TEK 2.05579
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.05576
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, CA9, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, OPRD1, OPRK1, OPRM1, PPARA, SMAD3, SRC, TEK, XDH 2.05453
[BP] GO:0051046 None ACHE, CYP19A1, DRD2, EGFR, HTR1A, HTR2A, MMP12, OPRK1, OPRM1, SRC 2.05444
[BP] GO:0051128 regulation of cellular component organization CSNK2A1, DRD2, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, OPRD1, PDE3A, SENP6, SMAD3, SRC, TEK 2.05098
[BP] GO:0021843 None DRD1, DRD2 2.05098
[BP] GO:0046113 None AOX1, XDH 2.05098
[BP] GO:0021830 None DRD1, DRD2 2.05098
[BP] GO:0021826 None DRD1, DRD2 2.05098
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.05098
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.04996
[BP] GO:0022029 None DRD1, DRD2, EGFR 2.04996
[BP] GO:0043278 None DRD2, OPRK1, OPRM1 2.04996
[BP] GO:0014072 None DRD2, OPRK1, OPRM1 2.04996
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.04996
[BP] GO:0044093 positive regulation of molecular function DRD2, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, HTR2A, INSR, MET, MMP9, OPRD1, SMAD3, SRC, TEK, XDH 2.04907
[BP] GO:0051704 multi-organism process CYP1A1, EGFR, F2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, MMP12, OPRK1, SMAD3, SRC, TOP1 2.03655
[BP] GO:1901568 fatty acid derivative metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.03655
[BP] GO:0046058 None PDE10A, PDE3A, PDE3B 2.01532
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A 2.01532
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, F2, GPR35, HTR2A 2.01532
[BP] GO:0048729 tissue morphogenesis CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.01455
[BP] GO:0010959 None DRD1, DRD2, F2, GPR35, HTR2A, OPRD1, OPRK1 2.01455
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, MMP12, OPRK1, SRC 2.01017
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, BACE1, CA4, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 4.28147
[CC] GO:0005887 integral component of plasma membrane ADORA3, BACE1, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 3.95768
[CC] GO:0045121 membrane raft BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.95436
[CC] GO:0098857 membrane microdomain BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.93737
[CC] GO:0044459 plasma membrane part ADORA3, BACE1, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, F2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TEK 3.89447
[CC] GO:0098589 membrane region BACE1, EGFR, HTR2A, INSR, KDR, OPRD1, OPRM1, SRC, TEK 3.4384
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, DRD1, DRD2, EGFR, HTR2A, INSR, MET, OPRD1, OPRM1, SIGMAR1, SRC, TEK 3.32814
[CC] GO:0031253 None CA4, CA9, DRD1, DRD2, INSR, OPRD1, OPRM1, SRC 2.96294
[CC] GO:0032590 None INSR, OPRD1, OPRM1 2.89412
[CC] GO:0005886 plasma membrane ACHE, ADORA3, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, SMAD3, SRC, TEK 2.51971
[CC] GO:0043204 None DRD2, OPRK1, OPRM1, PDE10A, TOP1 2.47532
[CC] GO:0044425 membrane part ACHE, ADORA3, BACE1, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, FLT3, FUT7, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SRC, TBXAS1, TEK 2.16782
[CC] GO:0044463 None AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.01179
[CC] GO:0120038 None AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, INSR, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.01179
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.1222
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3, TBXAS1, XDH 13.8821
[MF] GO:0043167 ion binding ACHE, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PPARA, SMAD3, SRC, TBXAS1, TEK, TOP1, XDH 13.033
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0022
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4794
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3 8.64506
[MF] GO:0043169 cation binding ACHE, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PPARA, SMAD3, TBXAS1, XDH 8.08706
[MF] GO:0038023 signaling receptor activity ADORA3, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, TEK 8.08706
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.49723
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AOX1, BACE1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, F2, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, SENP6, SRC, TBXAS1, TEK, TOP1, XDH 7.41526
[MF] GO:0004872 receptor activity ADORA3, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, TEK 7.16458
[MF] GO:0004871 signal transducer activity ADORA3, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, SMAD3, TEK 7.11471
[MF] GO:0060089 molecular transducer activity ADORA3, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1, TEK 6.94064
[MF] GO:0008144 drug binding ACHE, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR2A, IGF1R, INSR, KDR, MET, NUAK1, PDE10A, PPARA, SIGMAR1, SRC, TEK, TOP1 6.34752
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.03298
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.41742
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.41742
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.31281
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.07894
[MF] GO:0046872 metal ion binding AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE10A, PDE3A, PDE3B, PPARA, SMAD3, TBXAS1, XDH 4.90195
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 4.72497
[MF] GO:0099600 transmembrane receptor activity ADORA3, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 4.54047
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, DRD1, DRD2, EGFR, FLT3, GPR35, HTR1A, HTR2A, HTR7, IGF1R, INSR, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, TEK 4.54047
[MF] GO:0004713 protein tyrosine kinase activity EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.35123
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 4.35123
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.23485
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.05802
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.05759
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.93262
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.93262
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 3.87235
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.61484
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRM1 3.5869
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.54384
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.40601
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.2897
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, SRC, TBXAS1, XDH 3.26915
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.17321
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.17321
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 3.06489
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.98107
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.96093
[MF] GO:0004672 protein kinase activity CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TOP1 2.96093
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.9411
[MF] GO:0004119 None PDE3A, PDE3B 2.9411
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.89412
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 2.88058
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.81186
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.61283
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.5755
[MF] GO:0042277 peptide binding ACHE, BACE1, IGF1R, INSR, OPRD1, OPRK1, OPRM1 2.56931
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.48866
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.40199
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TOP1 2.38406
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.36447
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.33931
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.33159
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.33159
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.33159
[MF] GO:0033218 amide binding ACHE, BACE1, IGF1R, INSR, OPRD1, OPRK1, OPRM1 2.32578
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.29927
[MF] GO:0008528 None GPR35, OPRD1, OPRK1, OPRM1, SIGMAR1 2.2902
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.2902
[MF] GO:0001653 None GPR35, OPRD1, OPRK1, OPRM1, SIGMAR1 2.27775
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.16782
[MF] GO:0043559 insulin binding IGF1R, INSR 2.16782
[MF] GO:0016301 kinase activity CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TOP1 2.12813
[MF] GO:0004930 None ADORA3, DRD1, DRD2, GPR35, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 2.08674
[MF] GO:0016491 oxidoreductase activity AKR1B1, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, TBXAS1, XDH 2.07222
[MF] GO:0004064 arylesterase activity CA1, CA2 2.05098
[MF] GO:0043546 None AOX1, XDH 2.05098


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.5187
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.1907
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR7, GPR35, ADORA3, HTR1A, OPRK1, OPRM1, HTR2A, DRD1, F2, DRD2 7.1907
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.83
Ovarian steroidogenesis_Homo sapiens_hsa04913 INSR, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.4255
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.2132
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.1435
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.299
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.9442
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.7073
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6786
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.3985
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9442
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, PDE3A, OPRM1, DRD1 3.8962
Gap junction_Homo sapiens_hsa04540 SRC, HTR2A, DRD1, DRD2, EGFR 3.9329
cAMP signaling pathway_Homo sapiens_hsa04024 PDE3B, PDE3A, HTR1A, DRD1, DRD2, PPARA 3.3927
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, INSR, PDE3B, PDE3A 2.8251
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.1324
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2034
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5058
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6223
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.3249
Serotonergic synapse_Homo sapiens_hsa04726 HTR7, CYP2D6, HTR1A, HTR2A 2.5058
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2968
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, PDE3B 2.3249
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2054
Calcium signaling pathway_Homo sapiens_hsa04020 HTR7, HTR2A, DRD1, EGFR 1.9801
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1788
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1489
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1749
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2016
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1448
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 1.9918
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.1709
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9801
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9274
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4254
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 1.9961
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4032
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4254
MicroRNAs in cancer_Homo sapiens_hsa05206 CYP1B1, MMP9, MET, EGFR 1.2902
Metabolic pathways_Homo sapiens_hsa01100 FUT7, HSD17B1, TBXAS1, CYP1A2, CYP1A1, AOX1, AKR1B1, CYP19A1, XDH 1.2562
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 1.0588
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2749
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9393
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2 0.9948
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0489
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0588
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2562
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2A 1.0038
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, IGF1R 1.0038
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0214
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 0.9948
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9427
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1295
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2562
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.048
Renin secretion_Homo sapiens_hsa04924 PDE3B, PDE3A 1.2562
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8901
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9024
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9024
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3 0.8962
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8333
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8844
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8608
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8441
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4254
Insulin signaling pathway_Homo sapiens_hsa04910 INSR, PDE3B 0.8292
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8251
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8251
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8204
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8292
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.808
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7962
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6653
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7361
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2437
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3079
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3338
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3534
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3429
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3452
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.3534
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3335
Jak-STAT signaling pathway_Homo sapiens_hsa04630 AOX1 0.3692
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3766
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4187
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4393
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4393
Axon guidance_Homo sapiens_hsa04360 MET 0.4342
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4686
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4686
Toxoplasmosis_Homo sapiens_hsa05145 HSPA1A 0.4501
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4855
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4927
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5084
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5079
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5126
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.537
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5261
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5261
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5363
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5255
Peroxisome_Homo sapiens_hsa04146 XDH 0.537
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.567
Complement and coagulation cascades_Homo sapiens_hsa04610 F2 0.5484
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5656
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5542
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5753
Bile secretion_Homo sapiens_hsa04976 CA2 0.5738
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5901
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5884
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6068
Shigellosis_Homo sapiens_hsa05131 SRC 0.5921
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5921
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6022
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3 0.6183
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6211
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6091
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6238
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6417
Arachidonic acid metabolism_Homo sapiens_hsa00590 TBXAS1 0.6022
Malaria_Homo sapiens_hsa05144 MET 0.6609
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6645
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6645
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6645
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6653
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9918
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7251
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7547
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7962
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8145
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.7547
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7894
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8013
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7815
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7481
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8013
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.819
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8145
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1122
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2562


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)