TCM Prescription: Tong Jing Pills



Prescription Description
Prescription IDTCMF166
Pinyin NameTong Jing Wan
Chinese Name痛经丸
English NameTong Jing Pills
Function Description妇人经血凝滞不行, 脐腹腰背疼痛, 渐成血瘕
IndicationsDysmenorrhea
Disease ICD-11 Category GA34.3 [Dysmenorrhoea, 痛经 ];
Human Tissues Associated with IndicationUterus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH263 Fructus leonuri 茺蔚子 TCMH263
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.8861
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0975
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.5541
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F2, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 10.2588
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F2, F3, FLT3, HCAR2, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 10.2453
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 9.96292
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, HTR2B, PIM1, PPARA, TYR, XDH 9.12661
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 8.90716
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, KDR, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 8.82193
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, RORC, SLC6A4, SRC, TYR 8.2314
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, DRD1, DRD2, DRD3, F2, HCAR2, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 8.06031
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 8.06031
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 8.04696
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F2, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TYR 7.79561
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, RORC, SLC6A4, SRC, TYR 7.67652
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, HSD17B1, HSD17B2 7.67652
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.54962
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 7.40172
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, SRC 7.40172
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 7.32444
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HTR5A, RORC, SLC6A4, SRC, TYR 7.18919
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, KDR, SLC6A2, SLC6A4, SRC 7.09972
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 7.00914
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.95732
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.94903
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.94178
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 6.90795
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 6.90795
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 6.90778
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.88993
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.87528
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 6.82639
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 6.70341
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69097
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69097
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, RORC, SLC6A4, SRC, TYR 6.55134
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC 6.49593
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM2, DRD2, DRD3, HTR1A, HTR5A, HTR7 6.48178
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 6.48178
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, RORC 6.43249
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SLC6A4, SRC 6.43144
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F10, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.38638
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HTR5A, PPARA, SLC6A4, SRC 6.3071
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.22253
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.14356
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.14356
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 6.13045
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 6.12047
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HTR5A, IGF1R, MMP2, PPARA, SLC6A4, SRC 6.08893
[BP] GO:0007200 None ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, ESR1, HTR2A, HTR2B 6.0768
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, F2, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, RORC, SRC 6.02216
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA 6.00231
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 5.95274
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 5.92897
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, KCNH2, MET, SRC, TERT 5.89441
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F2, F3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 5.78115
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.78115
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 5.6646
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.6375
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.6375
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, PPARA, SLC6A2, SLC6A4 5.56137
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 5.55763
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, FABP3, FABP4, FUT7, MET, PPARA 5.53486
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC 5.50106
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CES1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SIGMAR1, SLC6A4, SRC, TERT, TNKS2, TYR 5.49174
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.42549
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A 5.2982
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA, RORC, SLC6A4, SRC 5.22973
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.19422
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, F2, HCAR2, TNKS, TNKS2 5.129
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.12626
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.01393
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP3, FABP4, HTR2A, HTR2B, KCNH2, MET 4.96422
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.94346
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC, TERT 4.93657
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.88211
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, F2, HCAR2, HTR2B, KCNH2, MMP12, SLC6A4, SRC, TERT 4.8493
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2 4.81166
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.76973
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.69476
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.6938
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.62012
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, HTR2A, KCNH2, MMP9 4.62012
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.62012
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.58492
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TERT, XDH 4.56958
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TERT, XDH 4.50972
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 4.47119
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.46195
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR1A, HTR2A, KCNH2, MMP9, SLC6A4 4.45658
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.44088
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.41522
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.39677
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, CA2, CHRM2, DRD1, DRD2, DRD3, ESR1, F2, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 4.39454
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.38332
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, SLC6A4 4.36814
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.36814
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3 4.36814
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.36814
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36814
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.28263
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, F2, HCAR2, HTR1A, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 4.27375
[BP] GO:0032225 None DRD1, DRD2, DRD3, SLC6A4 4.12817
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, SLC6A4 4.12389
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, SLC6A4 4.12389
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.09877
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.09877
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SRC, TERT 4.09672
[BP] GO:0050801 ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP3, HTR2A, HTR2B, KCNH2 4.0183
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TERT, XDH 4.01282
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, BCL2, CA2, CHRM2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, HTR2A, HTR2B, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SRC, TERT, TNKS2, XDH 4.01282
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA 4.01282
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.01282
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.01282
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HTR2A, HTR2B, MMP2, PPARA, SLC6A4, SRC, TERT, TYR 4.00309
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A 3.98072
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.98072
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.97734
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 3.96721
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.95715
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F2, F3, HCAR2, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT 3.90831
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.90831
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.90222
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.85992
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.83927
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.81037
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.79901
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.78421
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT 3.77041
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.76142
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.70607
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT 3.67113
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.66893
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.66855
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.66816
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.61552
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.5749
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.57282
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, BCL2, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.554
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, KCNH2 3.52811
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, ESR1, F10, F2, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.52376
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.48936
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 3.48936
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.48936
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.48936
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.47942
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, HTR5A, KDR, MMP9, PIM1, PPARA, RORC, SIGMAR1, SRC, TYR 3.47942
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.45153
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2 3.42067
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 3.42045
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SLC6A4, SRC, TERT 3.41282
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.37791
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.37791
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.37791
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.35042
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HCAR2, HTR2B, MMP12, SLC6A4, SRC 3.33402
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PTPN1, SRC, TERT, TNKS, XDH 3.31948
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, F2, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, XDH 3.31718
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.30325
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 3.29237
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.22808
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.22677
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.22677
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 3.19555
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.19175
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 3.14863
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.14863
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, F2, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TNKS, XDH 3.14863
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR2A, HTR2B, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 3.14863
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.10083
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.09798
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.09798
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.0597
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SLC6A4, SRC 3.02632
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, XDH 3.02612
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.01819
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, F2, PPARA 3.01819
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.01819
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.99989
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 2.99496
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.97464
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, SLC6A2, SLC6A4 2.97155
[BP] GO:0055080 cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, KCNH2 2.97155
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 2.96859
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 2.96859
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, TYR 2.94836
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 2.93699
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 2.93699
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.93121
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 2.92259
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.92259
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.91917
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.90214
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.88386
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.87986
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.87986
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.87986
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SLC6A4, SRC 2.85853
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.83499
[BP] GO:0009115 None AOX1, XDH 2.83221
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, F2, HTR2A, KCNH2 2.82809
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, MMP12, PPARA, SIGMAR1, SLC6A2, SLC6A4, TNKS 2.81681
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.81681
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.81511
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, PTPN1, SRC, TERT, TNKS, XDH 2.7922
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7922
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.7922
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.7922
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, KDR, MET, MMP12, PPARA 2.752
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, RORC, SLC6A4 2.73257
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 2.71864
[BP] GO:0030003 cellular cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.71864
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.71033
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.70638
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.70638
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.70638
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.69633
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM2, DRD2, HTR2A, KCNH2 2.69633
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.67369
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, PTPN1, SRC, TNKS 2.67272
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.67052
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.66129
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.66129
[BP] GO:0006873 cellular ion homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.64184
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.63613
[BP] GO:0007268 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 2.63613
[BP] GO:0098916 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 2.63613
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.63613
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.63529
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.63529
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.63529
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.63529
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.63529
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.62339
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, KCNH2, SLC6A2 2.61566
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2 2.59813
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.58112
[BP] GO:0099536 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 2.58112
[BP] GO:0099537 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, SLC6A2 2.58112
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, TYR 2.56965
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, SLC6A4 2.56517
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.56517
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56517
[BP] GO:0055074 calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.55746
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.52333
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.52333
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.51909
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 2.51815
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.50667
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, TYR 2.50139
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.4975
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.49322
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MET, PTPN1, SRC 2.46042
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2 2.45823
[BP] GO:0046110 None AOX1, XDH 2.45823
[BP] GO:0060160 None DRD2, DRD3 2.45823
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45823
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, SLC6A4, SRC, TYR 2.45541
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.45506
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, PTPN1, RORC, SLC6A4, SRC, TERT 2.4365
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.43577
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.42648
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.42648
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, TERT 2.42648
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.42648
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, SLC6A2 2.411
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM2, DRD2, DRD3, HCAR2, HTR2A, KCNH2 2.40107
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, FABP4, HTR2B, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.39817
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.39116
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.39116
[BP] GO:0043270 None ADORA1, ADRA2A, DRD1, DRD2, F2, KCNH2, SLC6A4 2.39116
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, BCL2, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, SLC6A2 2.38929
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.37928
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37928
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.3735
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.36332
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, F2, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.3503
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.34458
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2 2.34012
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 2.3248
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, FUT7, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.32436
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.32376
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.32376
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, SLC6A2 2.32247
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS 2.32043
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 2.30672
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, HTR2A, HTR2B 2.3027
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, F2, MMP12, PPARA 2.30076
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.30076
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.30076
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.30076
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 2.28932
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.28488
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TYR 2.28051
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, HTR2A, PTPN1, SRC 2.28051
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.27738
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.27738
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.27738
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.27472
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.27472
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.27472
[BP] GO:0034762 None ADRA2A, BCL2, CA2, DRD1, DRD2, DRD3, F2, KCNH2, MMP9 2.27405
[BP] GO:0055065 metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, KCNH2 2.27405
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.25557
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, HTR2B, MMP12, SRC 2.24969
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, DRD2, ESR1, F2, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.23347
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.23309
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.23309
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.23309
[BP] GO:0070213 None TNKS, TNKS2 2.23309
[BP] GO:0006145 None AOX1, XDH 2.23309
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23309
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.21705
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, BCL2, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.21333
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.21333
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.21333
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.21032
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2B 2.20345
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, HCAR2, HTR2B, MMP12, SRC 2.20138
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.19284
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6 2.19284
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, HCAR2, HTR2B, MET, PPARA 2.19284
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A 2.19284
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.19284
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.19284
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19284
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.18505
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, HCAR2, HTR2B, MMP12, SLC6A4, SRC 2.17941
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.17307
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.1528
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.14762
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.14472
[BP] GO:0071875 None ADRA1A, ADRA2A, DRD2 2.14472
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.14472
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.14023
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.13427
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, DRD2, DRD3, F2, HCAR2, HTR2B, MMP12, PTPN1, SRC 2.12874
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.12438
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2 2.10778
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.10545
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.10545
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 2.10219
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 2.09151
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.08539
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.08441
[BP] GO:0006940 None ADORA1, ADRA1A, ADRA2A, CHRM2 2.08441
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DRD3, SLC6A4, SRC, TERT 2.07752
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F2, PPARA 2.06529
[BP] GO:0021853 None DRD1, DRD2 2.06529
[BP] GO:0010641 None F3, SRC 2.06529
[BP] GO:0090325 None DRD2, DRD3 2.06529
[BP] GO:0007598 None F10, F3 2.06529
[BP] GO:1904936 None DRD1, DRD2 2.06529
[BP] GO:0042321 None ADORA1, DRD2 2.06529
[BP] GO:0010513 None HTR2A, HTR2B 2.06529
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.06529
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.06529
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, SLC6A4 2.06087
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.05529
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, SRC 2.05138
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, TNKS2 2.05138
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.05138
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KCNH2, KDR, SRC 2.04858
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD17B1, HSD17B2 2.03431
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.03035
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.03035
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.02725
[BP] GO:0045745 None DRD2, DRD3, F2 2.02725
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.02725
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, HTR2A, HTR2B 2.02725
[BP] GO:1904062 None ADRA2A, DRD1, DRD2, DRD3, F2, KCNH2, MMP9 2.01017
[BP] GO:0008277 regulation of G-protein coupled receptor protein signaling pathway ADRA2A, DRD2, DRD3, F2, MET 2.01017
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA4, CHRM2, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC6A2, SLC6A4 6.59582
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC6A2, SLC6A4 5.02101
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA2, CA4, CA9, CHRM2, DRD1, DRD2, DRD3, F10, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, SIGMAR1, SLC6A2, SLC6A4, SRC 4.5783
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 4.56401
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, FUT7, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR 4.55562
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, FUT7, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TYR 3.48936
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, F10, F2, FLT3, HSD17B2, PTPN1, SIGMAR1 3.27128
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2A, HTR5A, KCNH2, KDR, MMP2, MMP9, PIM1, PTPN1, SIGMAR1, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.4975
[CC] GO:0031233 None CA4, F10, F3 2.32376
[CC] GO:0005783 None ADORA1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.12438
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.9917
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 18.2217
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 13.73
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 12.7645
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9519
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 10.5541
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5237
[MF] GO:0008227 None ADRA1A, ADRA2A, CHRM2, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 10.2337
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 9.38854
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, SLC6A4 9.18914
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 9.11156
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.82193
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 8.45995
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, F10, F2, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 8.06031
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.06031
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.67814
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 7.40172
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 7.34585
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.98673
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 6.95732
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.89123
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.76152
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.70341
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.70341
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69097
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69097
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.61028
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, SRC 6.04959
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SLC6A4, SRC 5.96442
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.85495
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.8433
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CHRM2, DRD1, DRD2, DRD3, F3, FLT3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.8433
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, SRC 5.8127
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 5.42549
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 5.0015
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.97055
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.97055
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.83463
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.54549
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, CHRM2, DRD1, DRD2, DRD3, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.09672
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD17B1, SRC, XDH 3.98158
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.78421
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.70496
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.48771
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD17B1, PPARA, RORC 3.32562
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.28784
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.21031
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.87986
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.83221
[MF] GO:0008389 None CYP2A13, CYP2A6 2.83221
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.7922
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.7826
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 2.73257
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.71033
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.59969
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.56517
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.4975
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.4975
[MF] GO:0005330 None SLC6A2, SLC6A4 2.45823
[MF] GO:0047374 None CES1, CES2 2.45823
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.32376
[MF] GO:0004252 None F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.3027
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.27472
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.23309
[MF] GO:0032795 None ADORA1, ADRA2A 2.23309
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.20345
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, TERT, TYR, XDH 2.20138
[MF] GO:0008236 None F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.06963
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06529


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.414
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR2B, HTR1A, HTR2A, F2, HTR5A, ADRA1A, ADRA2A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 10.6611
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A, CYP2C19, SLC6A4 8.9165
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.3991
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.4746
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 4.9454
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.9508
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 4.714
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19 4.8262
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.7212
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 3.9686
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.857
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP2C19, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 3.6078
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 3.6153
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.4436
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7091
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6957
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.3365
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.5743
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.1798
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.0275
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9481
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.1385
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.1321
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.0658
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A, ADRA2A 1.6745
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8099
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5884
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.5462
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.7272
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, BCL2, MET, IGF1R 1.3678
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.4368
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.3516
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3677
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.3052
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.2
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1679
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, F2 0.9158
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9248
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9226
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9454
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8941
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1949
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9226
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.751
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1679
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8271
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.0866
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.863
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1168
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9158
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7873
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.02
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7873
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7873
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.757
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1818
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7007
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1131
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7007
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7007
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5669
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.688
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5669
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2798
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5124
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.1679
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1862
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1862
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2402
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.263
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2743
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2831
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.263
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.311
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3003
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3283
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3306
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3283
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3272
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3343
Platelet activation_Homo sapiens_hsa04611 SRC 0.3467
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3467
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3343
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3467
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3687
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3467
Axon guidance_Homo sapiens_hsa04360 MET 0.3424
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5753
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3467
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.5884
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3946
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3946
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4158
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4047
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4158
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.4828
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4047
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4047
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4158
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4158
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4158
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4158
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4158
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4158
Peroxisome_Homo sapiens_hsa04146 XDH 0.4158
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4494
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4613
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4756
Glioma_Homo sapiens_hsa05214 IGF1R 0.4756
Bile secretion_Homo sapiens_hsa04976 CA2 0.4604
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4744
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4772
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4756
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4733
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4756
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.471
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4756
Shigellosis_Homo sapiens_hsa05131 SRC 0.4756
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7314
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5462
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.53
Malaria_Homo sapiens_hsa05144 MET 0.5406
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5465
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5435
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6921
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7007
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7233
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6998
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7138
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9158
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1818


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)