TCM Prescription: Aconitum Heart Clearing Decoction



Prescription Description
Prescription IDTCMF1652
Pinyin NameFu Zi Xie Xin Tang
Chinese Name附子泻心汤
English NameAconitum Heart Clearing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.2487
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.2487
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA12, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD3, ESR1, F3, FABP3, FABP4, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TNKS, TNKS2, XDH 12.7872
[BP] GO:0007187 None CNR1, CNR2, DRD1, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 9.65825
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.94948
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD3, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2 8.46298
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD3, ESR1, FABP3, FABP4, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2 8.45555
[BP] GO:0042493 response to drug ABCB1, AKR1B1, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD3, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 7.72418
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.7179
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.18257
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1 6.91209
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2C 6.88637
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.7726
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.75184
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PTGS1, PTGS2 6.46887
[BP] GO:0007188 None CNR1, DRD1, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.33415
[BP] GO:0050795 None CNR1, DRD3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 6.33415
[BP] GO:0099536 None CNR1, DRD1, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.25539
[BP] GO:0099537 None CNR1, DRD1, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.25539
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD3, ESR1, HSD11B2, HTR1B, HTR5A, PTGS2 6.02157
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CNR1, CNR2, DRD1, DRD3, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 5.98787
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1 5.92047
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD3, ESR1, FABP3, FABP4, HSD11B2, HTR1B, HTR5A, MMP2, PIK3CA, PPARA, PTGS2 5.92047
[BP] GO:0007193 None DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.91324
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, BCL2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD3, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 5.8965
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, BCL2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD3, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 5.89408
[BP] GO:0097746 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.89408
[BP] GO:0035296 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.89408
[BP] GO:0050880 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.68836
[BP] GO:0035150 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.67214
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, CA12, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PPARA, PTGS1, PTGS2, XDH 5.64682
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.45486
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.43209
[BP] GO:0032844 regulation of homeostatic process BCL2, CA7, CNR1, DRD1, DRD3, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2, TNKS, TNKS2 5.42811
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX15, ALPL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD3, ESR1, F3, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, TNKS2 5.42142
[BP] GO:0007268 None DRD1, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.38951
[BP] GO:0098916 None DRD1, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.38951
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.33186
[BP] GO:0033993 response to lipid ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, PTGS2 5.33186
[BP] GO:0003018 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.27298
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.26606
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD3, HTR1B, HTR1D 5.20436
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.16103
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1 5.12991
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 5.08729
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.07351
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, BCL2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, TNKS, TNKS2, XDH 5.06766
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, DRD1, HTR1B, HTR2A, PTGS2 5.02832
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, BCL2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, TNKS, TNKS2, XDH 4.96907
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2 4.94457
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA7, CNR1, DRD1, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 4.82882
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD3, ESR1, F3, FABP3, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 4.71936
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2 4.63088
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.51461
[BP] GO:0003013 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.46575
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD3, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 4.44162
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, DRD3, HTR1B, HTR2A, MMP9, PTGS2 4.38779
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 4.38556
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA4, CA7, CA9 4.38104
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA7, CNR1, CNR2, DRD1, DRD3, HTR1B, HTR2A, PTGS2 4.34799
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA7, CNR1, CNR2, DRD1, DRD3, HTR1B, HTR2A, PTGS2 4.34799
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.2737
[BP] GO:0006939 None DRD1, HTR1D, HTR2A, HTR2B, HTR7 4.21894
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD3, HTR1A 4.21894
[BP] GO:0032846 positive regulation of homeostatic process CA7, CNR1, DRD1, DRD3, PIK3CB, PTGS2, TNKS, TNKS2 4.21894
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, DRD3, F3, FABP4, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, TNKS2, XDH 4.17557
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.17232
[BP] GO:0007610 None BCL2, CNR1, DRD1, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 4.12538
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1 4.11612
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD3, ESR1, F3, FABP4, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, TNKS, TNKS2, XDH 4.10393
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, DRD3, ESR1, F3, FABP3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS1, PTGS2, XDH 4.04837
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, DRD1, HTR1B, HTR2A, PTGS2 3.81973
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.79968
[BP] GO:0007154 None BCL2, CNR1, DRD1, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.74888
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, DRD3, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.74714
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 3.73969
[BP] GO:0090066 None ALOX15, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.6958
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS2 3.67562
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.67068
[BP] GO:0043269 regulation of ion transport ABCB1, BCL2, CA7, CNR1, DRD1, DRD3, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.67068
[BP] GO:0014059 None CNR1, DRD3, HTR1B, HTR2A 3.64348
[BP] GO:0003008 None AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2 3.64024
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.57576
[BP] GO:0007267 None CNR1, DRD1, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.5656
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.54028
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.54028
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1 3.52868
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, BCL2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD3, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 3.52776
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.4916
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA7, CNR1, CNR2, HTR1B 3.44468
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 3.44468
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA7, DRD1, DRD3, HTR2A, HTR2B, HTR2C 3.42703
[BP] GO:0051952 None CNR1, DRD1, DRD3, HTR1B, HTR2A 3.36182
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.36182
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.3594
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, BCL2, CA7, CNR1, CYP19A1, DRD1, DRD3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 3.35233
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA7, DRD1, DRD3, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 3.34051
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA4, CA7, CA9, DRD3, FABP3, PPARA 3.33661
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD3, HTR1A 3.3216
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, F3, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PTGS2, XDH 3.28891
[BP] GO:0006730 one-carbon metabolic process CA12, CA4, CA7, CA9 3.27244
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, BCL2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD3, ESR1, F3, FABP3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, TNKS, TNKS2, XDH 3.25744
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, TNKS, TNKS2 3.2529
[BP] GO:0002031 None DRD3, HTR1B, HTR2B 3.25281
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.25281
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.19448
[BP] GO:0023052 None CNR1, DRD1, DRD3, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.19448
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, BCL2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD3, ESR1, F3, FABP3, FABP4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, TNKS, TNKS2, XDH 3.18534
[BP] GO:0008217 None CNR1, DRD3, HSD11B2, PPARA, PTGS1, PTGS2 3.18496
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, DRD1, DRD3, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 3.13263
[BP] GO:0042592 homeostatic process AKR1B1, BCL2, CA12, CA7, CNR1, DRD1, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.131
[BP] GO:0007200 None DRD1, ESR1, HTR2A, HTR2B, HTR2C 3.12566
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, DRD1, DRD3, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 3.09429
[BP] GO:2001023 None CNR1, DRD1, DRD3, HTR1B, HTR2A 3.08269
[BP] GO:0051588 None DRD1, DRD3, HTR1A, HTR1B, HTR2C 3.06162
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PTGS2 3.03702
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, HTR2C 3.00415
[BP] GO:0007208 None HTR2A, HTR2C 2.95749
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 2.92987
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, DRD3, ESR1, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.90637
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD3, FABP3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2 2.88906
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.87459
[BP] GO:0050433 None CNR1, DRD3, HTR1B, HTR2A 2.87459
[BP] GO:0032225 None DRD1, DRD3, PTGS2 2.79011
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.78275
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, DRD1, DRD3, ESR1, F3, FABP4, PPARA, PTGS2, PTPRS 2.78083
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.77608
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA7, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.75655
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD3, HTR1A 2.75182
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, HTR1B, MMP2, MMP9, PIK3CA, PTGS2 2.73267
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA9, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, TNKS2 2.73186
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA7, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.70527
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.69628
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, TNKS, TNKS2 2.68913
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C 2.6664
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.6664
[BP] GO:0014821 None DRD1, HTR1D, HTR2B 2.66532
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3 2.64564
[BP] GO:0031623 None ACHE, DRD3, HTR1B, HTR2B 2.64475
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.63947
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD3, FABP3, HSD11B2, HTR1B, MMP2, PPARA, PTGS2 2.63091
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA4, CA7, CA9, DRD3, FABP3, PPARA 2.55473
[BP] GO:0009628 response to abiotic stimulus AKR1B1, BCL2, CYP1A1, DRD1, DRD3, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2 2.55473
[BP] GO:0048148 None DRD1, DRD3, HTR2A 2.54711
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.54371
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.49058
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.48769
[BP] GO:0030003 cellular cation homeostasis BCL2, CA7, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.43432
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.42928
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.42839
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, HTR1B, MMP2, PIK3CA, PTGS2 2.42307
[BP] GO:0006936 None DRD1, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.42307
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.42307
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.41328
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38231
[BP] GO:0006873 cellular ion homeostasis BCL2, CA7, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.36893
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD3, PIK3CA, TNKS2 2.35393
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, BCL2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 2.35393
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, BCL2, CA12, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3, ESR1, F3, FABP3, FABP4, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, XDH 2.34962
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.33972
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.33972
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.33972
[BP] GO:0070213 None TNKS, TNKS2 2.31119
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA7 2.31119
[BP] GO:0038171 None CNR1, CNR2 2.31119
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31119
[BP] GO:0014827 None HTR1D, HTR2B 2.31119
[BP] GO:0050790 regulation of catalytic activity ADORA3, BCL2, CNR1, CNR2, CSNK2A1, DRD1, DRD3, ESR1, F3, FABP4, HTR2A, HTR2B, MMP9, PIK3CA, PIK3CB, PTGS2, TNKS, XDH 2.28238
[BP] GO:1900543 None DRD3, HTR1B, HTR1E, PPARA 2.28185
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, HTR2A, HTR2B, HTR2C 2.26186
[BP] GO:0045980 None DRD3, HTR1B, HTR1E, PPARA 2.26186
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.26039
[BP] GO:0001975 None CNR2, DRD1, DRD3 2.26039
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD3, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PPARA, PTGS2, PTPRS, TNKS, TNKS2, XDH 2.25828
[BP] GO:1900542 None DRD1, DRD3, HTR1B, HTR1E, HTR2A, PPARA 2.25828
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, DRD1, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.23256
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, DRD1, FABP3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.23256
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD3, HTR1B 2.21973
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.21122
[BP] GO:0006140 None DRD1, DRD3, HTR1B, HTR1E, HTR2A, PPARA 2.19863
[BP] GO:0006811 None ABCB1, CA12, CA14, CA4, CA7, CA9, DRD1, DRD3, FABP3, HTR2A, HTR2B, HTR2C, PPARA 2.18305
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.18236
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.18236
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.17409
[BP] GO:0055080 cation homeostasis BCL2, CA7, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.16714
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA12, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3, ESR1, F3, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, XDH 2.15756
[BP] GO:0019725 cellular homeostasis BCL2, CA7, DRD1, DRD3, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.15266
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.14664
[BP] GO:0071502 None HTR1B, HTR2B 2.13867
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, CSNK2A1, HTR2B, HTR2C, PIK3CA, PIK3CB, PTGS2 2.13276
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, HSD11B2, HTR1B, PTGS2 2.12376
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.11058
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD3, HTR1A, PTGS2 2.09035
[BP] GO:0042220 None CNR1, DRD3, HTR1B 2.07075
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2 2.05671
[BP] GO:0019217 None CNR1, FABP3, PPARA, PTGS2 2.05281
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.04537
[BP] GO:0044092 negative regulation of molecular function ADORA3, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, ESR1, FABP4, MMP9, PPARA, PTGS2, TNKS 2.03956
[BP] GO:0003012 None DRD1, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.02144
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.00369
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B 2.00369
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3, ESR1, F3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, TNKS, TNKS2 5.45267
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, CA4, CNR1, CNR2, DRD1, DRD3, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTPRS 5.28769
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3, ESR1, F3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS 5.1565
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, CA12, CA14, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTPRS 4.4627
[CC] GO:0005887 integral component of plasma membrane ADORA3, CNR1, CNR2, DRD1, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTPRS 4.21894
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, CA4, CA9, CNR1, CNR2, DRD1, DRD3, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2, PTPRS 3.99257
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, HSD11B1, HSD11B2, PTGS1, PTGS2 2.26182
[CC] GO:0031224 None ABCB1, ACHE, ADORA3, ALPL, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD3, ESR1, F3, FUT7, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTPRS 2.04988
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.2487
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.2487
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.835
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.835
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.8216
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 14.3588
[MF] GO:0030594 None DRD1, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.9783
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.8086
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 12.3285
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALPL, CA12, CA14, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3, ESR1, F3, FABP3, FABP4, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, TUBB3, XDH 9.81637
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, CA12, CA14, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2, TNKS, TNKS2, XDH 7.18257
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA4, CA7, CA9 6.39356
[MF] GO:0046914 transition metal ion binding ALOX15, CA12, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, TNKS, XDH 6.33415
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 6.01012
[MF] GO:0004930 None ADORA3, CNR1, CNR2, DRD1, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.92047
[MF] GO:0038023 signaling receptor activity ADORA3, CNR1, CNR2, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 5.64865
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.60167
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.38036
[MF] GO:0004872 receptor activity ADORA3, CNR1, CNR2, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 4.97211
[MF] GO:0099600 transmembrane receptor activity ADORA3, CNR1, CNR2, DRD1, DRD3, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.82882
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, CNR1, CNR2, DRD1, DRD3, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.82882
[MF] GO:0060089 molecular transducer activity ADORA3, CNR1, CNR2, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 4.78767
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2 4.63088
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 4.50968
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2 4.44162
[MF] GO:0004871 signal transducer activity ADORA3, CNR1, CNR2, DRD1, DRD3, ESR1, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 4.38779
[MF] GO:0008144 drug binding ABCB1, ACHE, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD3, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PPARA 4.34947
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.34799
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2 4.17232
[MF] GO:0005506 iron ion binding ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.09561
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA4, CA7, CA9 3.97
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, ALOX15, ALPL, CA12, CA14, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FUT7, HSD11B1, HSD11B2, HSD17B1, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, TNKS, TNKS2, TUBB3, XDH 3.64024
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.48708
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA4, CA7, CA9 3.38066
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1, XDH 3.36235
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.95749
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.95749
[MF] GO:0003845 None HSD11B1, HSD11B2 2.95749
[MF] GO:0071886 None HTR2A, HTR2C 2.95749
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.72945
[MF] GO:0008270 zinc ion binding CA12, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, TNKS 2.6664
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1 2.55473
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.55473
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.55473
[MF] GO:0004949 None CNR1, CNR2 2.55473
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.31119
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.31119
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1 2.21973
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1 2.14664
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13867
[MF] GO:0005496 steroid binding CYP3A4, ESR1, HSD11B2, HSD17B1 2.02144


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7 17.0777
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, DRD1, DRD3 14.6887
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.7572
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, DRD1, PPARA, HTR4 8.2099
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, DRD1, HTR5A, HTR4 6.1529
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.1736
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.038
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1 5.3799
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 5.1752
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA4, CA7, CA9, CA14 7.6287
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 4.1921
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, HTR2A 4.0886
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB, F3 4.0761
Gap junction_Homo sapiens_hsa04540 TUBB3, HTR2B, HTR2C, HTR2A, DRD1 4.2352
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 4.0886
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15, PTGS2, PTGS1 3.6353
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.1461
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.2333
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4776
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, CYP1B1, PTGS2, MMP9 2.9978
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1944
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.9069
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.9069
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.9069
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.8066
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, BCL2, PIK3CB, MMP9 2.5255
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.8202
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.9978
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.5474
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 2.0663
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.2635
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.1355
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.5402
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1 2.3887
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.9686
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9838
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 1.9889
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.9303
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0926
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.5057
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.8545
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.8545
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.8339
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.8441
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.7055
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.7219
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7395
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6498
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6651
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIK3CB 1.6202
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.6202
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.5779
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.4508
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB 1.413
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.3423
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.5045
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB 1.2859
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4932
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.5091
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.3114
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.5045
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, BCL2, PIK3CB 1.0148
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5553
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.3538
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.3084
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3973
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4055
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6287
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.3973
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3913
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2777
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3973
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5904
Alcoholism_Homo sapiens_hsa05034 DRD1 0.3973
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.4988
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2859
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.1026
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.5832
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2777
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.1414
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.4593
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.5045
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.1015
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0947
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD3 1.1156
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4729
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB 1.0652
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4342
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.2546
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0591
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.077
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4602
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.8407
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2646
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4593
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, PIK3CB 0.8182
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.2777
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4729
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2646
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.4833
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.7115
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.9435
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4833
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.9031
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.4306
Bile secretion_Homo sapiens_hsa04976 ABCB1, CYP3A4 1.4833
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.4878
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.671
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7055
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5738
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5936
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.6064
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6064
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.6064
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6064
Peroxisome_Homo sapiens_hsa04146 XDH 0.6276
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6983
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.643
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6666
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.6649
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6792
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6927
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7357
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.76
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7867
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.7989
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8119
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.8306
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9594
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.95
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.9031
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9435
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0148
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA4 1.0574
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2611
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2254


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)